Background The purpose of this initial investigation was to begin to understand the routine twin anemia-polycythemia sequence (TAPS) monitoring practices of maternal-fetal medicine specialists (MFM specialists) in the United States in the absence of…
Career counseling practitioners hope that clients leave career counseling having experienced a process of transformative learning that has brought them into contact with their deepest sense of vitality. If so, clients are able to narrate a more…
OBJECTIVE: Hyperleptinemia, hallmark of obesity, is a putative pathophysiologic trigger for atherosclerosis. We previously reported a stimulatory effect of leptin on TSP-1 (thrombospondin-1) expression, a proatherogenic matricellular protein …
Cardiac fibrosis caused by adverse cardiac remodeling following myocardial infarction can eventually lead to heart failure. Although the role of soluble factors such as TGF-beta is well studied in cardiac fibrosis following myocardial injury, the…
OBJECTIVES: Recent studies have shown that tRNA-derived RNA fragments (tRFs) are novel regulators of post-transcriptional gene expression. However, the expression profiles and their role in post-transcriptional gene regulation in chondrocytes is…
PURPOSE: To describe a patient with chronic periocular pain after bilateral photorefractive keratectomy (PRK), termed ocular neuralgia, that was controlled with regular orbital steroid and anesthetic injections. METHODS: Case report. RESULTS: A…
Background Community-acquired pneumonia (CAP) guidelines have improved the treatment and outcomes of patients with CAP, primarily by standardization of initial empirical therapy. But current society-published guidelines exclude immunocompromised…
Asthma is characterized by pathological airway remodeling resulting from persistent myofibroblast activation. Although transforming growth factor beta 1 (TGFβ1), mechanical signals, and reactive oxygen species (ROS) are implicated in fibroblast…
Transient receptor potential vanilloid 4 (TRPV4) channels are mechanosensitive ion channels that regulate systemic endothelial cell (EC) functions such as vasodilation, permeability, and angiogenesis. TRPV4 is expressed in retinal ganglion cells,…
Parkinson's disease (PD) is a progressive neurodegenerative disease highlighted by a marked loss of dopaminergic cell loss and motor disturbances. Currently, there are no drugs that slow the progression of the disease. A myriad of factors have been…
The need to remain current with updated skills continues as a challenge for adults and older adult workers. Learning new information and skills to keep abreast with changes in everyday activities and in the workplace is a lifelong challenge. In this…
Several bony and soft tissue structures of the callitrichid masticatory apparatus have been studied to understand how gouging behavior in marmosets is facilitated by specific morphologies. While marmoset craniofacial anatomy indicates features that…
Purpose: To determine the ocular and systemic safety of using topical Lambda-Cyhalothrin (LCL) in a canine model of infantile nystagmus syndrome (INS). The rationale for this proposal is based on a case study of a patient whose INS improved after…
BACKGROUND: The impact of freestanding emergency departments (FSEDs) on timeliness of care for trauma patients is not well understood. This quality improvement project had 2 objectives: (1) to determine whether significant delays in definitive care…
Animal models that accurately recapitulate the accumulation of alpha-synuclein (α-syn) inclusions, progressive neurodegeneration of the nigrostriatal system and motor deficits can be useful tools for Parkinson's disease (PD) research. The preformed…
BACKGROUND: The risk of cardiac injury in blunt thoracic trauma is quite rare, occurring in only 0.1% of patients. The least common cardiac injury is coronary artery dissection. Most cardiac injuries result from high-energy mechanisms such as motor…
ABSTRACT: Much of COVID-19 disease can be attributed to the stable structure of the envelope, which facilitates its transmission; the spike protein and its receptor which determine which tissues get infected and are susceptible to viral and immune…
Work in the 21st century leaves people feeling anxious and insecure. Jobless work and automation have produced 'insecure workers,' especially those peripheral and external employees who perform temporary assignments. Depending upon a client's needs,…
The basicranium of anthropoid primates is more flexed than in lemurs and lorises (strepsirrhines), which has implications for orientation of facial growth. Differential growth among cranial synchondroses is one suggested mechanism for variation in…
Film emphasizes an ironic history of racism in gun control and ownership and a justification for seeking justice among the Black community, but film also perpetuates structural racism and bias, segregating Black from White, and failing to promote…
Transient potential receptor vanilloid 4 (TRPV4) is an ion channel responsible for sensing osmotic and mechanical signals, which in turn regulates calcium signaling across cell membranes. TRPV4 is widely expressed throughout the body, and plays an…
In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE)…
BACKGROUND: mir-RNAs play a role in regulating bone homeostasis. In this study we assessed the functional role of mir-RNA 150 in bone homeostasis. We also assess the effects of miR-150 deficiency on osteoblast and osteoclast differentiation and…
The external acoustic meatus (EAM) of most baleen whales accumulates cellular debris annually in the lumen as whales age, forming a lamellated ear plug. The bowhead whale ear plug is formed from annually molting lining of the EAM as the entire…
This article summarizes the literature describing how antimicrobial stewardship and telemedicine interventions affect antimicrobial resistance. Discussion includes why we need stewardship, how to collaborate with team members, and the evidence of …
The Rapid Risk of Violence Screen (RROVS) is a brief screening tool that is designed for use in community-based behavioral health service settings to identify people who may need comprehensive violence risk assessment. This study examined the…
Background: Predicting mortality risk in patients is important in research settings. The Pitt bacteremia score (PBS) is commonly used as a predictor of early mortality risk in patients with bloodstream infections (BSI). Here, we determined whether…
Sequential intercept mapping is an approach to address the overrepresentation of adults with mental illness in the criminal justice system. This approach follows the sequential intercept model, a nationally recognized framework conceptualizing the…
In 1959, Maroteaux and Lamy initially designated pseudoachondroplasia as a distinct dysplasia different from achondroplasia, which is the most common form of skeletal dysplasia associated with dwarfism. Pseudoachondroplasia is the second-most common…
Feeding and diet played key roles in human evolution. It is well known that modern humans have a small masticatory apparatus for their body size among primates. However, identifying gracility does not necessarily tell us about the relative functional…
Peste-des-petits-ruminants is a highly contagious and fatal disease of goats and sheep caused by non-segmented, negative strand RNA virus belonging to the Morbillivirus genus-Peste-des-petits-ruminants virus (PPRV) which is evolutionarily closely…
The patient was a 33-year-old, highly educated, white female. She was pregnant with monochorionic-diamniotic identical twins, or twins that shared the same placenta but were in separate amniotic sacs. She had been cleared from her reproductive…
OBJECTIVE: Determine sarcomere length (Ls) operating ranges of the superficial masseter and temporalis in vitro in a macaque model and examine the impact of position-dependent variation on Ls and architectural estimates of muscle function (i.e.,…
