Browse Items · NEOMED Bibliography Database

Osteoactivin induces transdifferentiation of C2C12 myoblasts into osteoblasts.

Osteoactivin (OA) is a novel osteogenic factor important for osteoblast differentiation and function. Previous studies showed that OA stimulates matrix mineralization and transcription of osteoblast specific genes required for differentiation. OA…

Osteoactivin inhibition of osteoclastogenesis is mediated through CD44-ERK signaling.

Osteoactivin is a heavily glycosylated protein shown to have a role in bone remodeling. Previous studies from our lab have shown that mutation in Osteoactivin enhances osteoclast differentiation but inhibits their function. To date, a classical…

The Role of MicroRNAs and Their Targets in Osteoarthritis.

Micro ribonucleic acid (microRNA) regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Several studies have focused on specific microRNAs that are differentially…

Tags: *Cartilage, *Inflammation, *MicroRNA, *OSTEOARTHRITIS, *Targets, 2016, Articular/*metabolism, Cartilage, Current rheumatology reports, Department of Anatomy & Neurobiology, Haqqi Tariq M, Inflammation/genetics/*metabolism, Intracellular Signaling Peptides and Proteins, MicroRNAs/genetics/*metabolism, NEOMED College of Medicine, Osteoarthritis/genetics/*metabolism, Sondag Gregory R

Zcchc6 and Zcchc11 exhibit cell autonomous effects on bone remodeling in mice.

Tags: 2017, Department of Anatomy & Neurobiology, Haqqi T M, Haynie S, NEOMED College of Medicine, Osteoarthritis & Cartilage, Safadi F F, Sondag G

Semaphorin-3F, a potential biomarker for lymphatic anomalies and bone cell function

Lymphatic anomalies (LA) are rare conditions characterized by abnormal vascularization of lymphatic vessels (lymphangiogenesis). Gorham‐Stout Disease (GSD) is an aggressive type of LA which invades cortical bone and makes it “disappear”. There is…

Tags: 2020, Akron Children's Hospital, Department of Anatomy & Neurobiology, Faseb Journal, journalArticle, Kelly M, NEOMED College of Medicine, NEOMED College of Medicine Student, NEOMED Student Publications, Safadi F, September 2020 List, Solorzano E

Ontogenetic differences in the midline cranial synchondroses of primates

Tags: 2020, American journal of physical anthropology, Corbin Hayley, Cray James J, DeLeon Valerie B, Department of Anatomy & Neurobiology, Durham Emily, Journal Article, journalArticle, June 2020 Update I, Mano Nanami, NEOMED College of Medicine, Oladipupo Lanre, Smith Tim D, Taylor Jane, Ufelle Alexander, Vinyard Christopher J, Wood Brody

Cranial synchondroses of primates at birth.

Cranial synchondroses are cartilaginous joints between basicranial bones or between basicranial bones and septal cartilage, and have been implicated as having a potential active role in determining craniofacial form. However, few studies have…

Presence of lipocalin in the vomeronasal gland of primates: a preliminary study

Conference: The annual meeting for The Society for Integrative and Comparative Biology., At Tampa, FL

Tags: 2019, Department of Anatomy & Neurobiology, Integrative and comparative biology, June 2019 Update, McBurney D M, NEOMED College of Medicine, Rehorek S J, Smith T, Smith T D, Zoology

Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucoma.

Axonal transport defects are an early pathology occurring within the retinofugal projection of the DBA/2J mouse model of glaucoma. Retinal ganglion cell (RGC) axons and terminals are detectable after transport is affected, yet little is known about…

Tags: *Axonal Transport/physiology, *bouton, *Mitochondria, *neurodegeneration, *retinal, *RRID:IMSRJAX:000671, *RRID:IMSRJAX:007048, *RRID:SCR002716, *RRID:SCR002865, *superior colliculus, *synapse, 2016, Animal, Animals, Crish Samuel D, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Disease Models, Electron, Fening Kelly M, Glaucoma/metabolism/*pathology, Imaging, Inbred DBA, Inman Denise M, Mice, Microscopy, Mitochondria/pathology, NEOMED College of Medicine, NEOMED College of Pharmacy, Neuroanatomical Tract-Tracing Techniques, Regression Analysis, Retinal Ganglion Cells/metabolism/*pathology, Scanning, Schofield Brett R, Smith Matthew A, Superior Colliculi/metabolism/*pathology, Synapses/metabolism/*pathology, The Journal of comparative neurology, Three-Dimensional, Visual Pathways/metabolism/pathology, Xia Christina Z

A comparative analysis of cone photoreceptor morphology in bowhead and beluga whales.

The cetacean visual system is a product of selection pressures favoring underwater vision, yet relatively little is known about it across taxa. Previous studies report several mutations in the opsin genetic sequence in cetaceans, suggesting the …

Neuropeptide Y expression defines a novel class of GABAergic projection neuron in the inferior colliculus.

Located in the midbrain, the inferior colliculus (IC) integrates information from numerous auditory nuclei and is an important hub for sound processing. Despite its importance, little is known about the molecular identity and functional roles of…

Tags: 2020, Anair Justin D, Beebe Nichole L, Department of Anatomy & Neurobiology, journalArticle, June 2020 Update II, Mirjalili Pooyan, NEOMED College of Medicine, Roberts Michael T, Schofield Brett R, Silveira Marina A, The Journal of neuroscience : the official journal of the Society for Neuroscience

Trabecular ontogeny of the mandibular condyle in callitrichids

Several bony and soft tissue structures of the callitrichid masticatory apparatus have been studied to understand how gouging behavior in marmosets is facilitated by specific morphologies. While marmoset craniofacial anatomy indicates features that…

Tags: 2019, 88th Annual Meeting of the American Association of Physical Anthropologists (2019), American journal of physical anthropology, Anthropology, Department of Anatomy & Neurobiology, Evolutionary Biology, Journal Article, NEOMED College of Medicine, NEOMED College of Medicine Student, NEOMED Student Publications, Siegel N D, Vinyard C J

Metabotropic glutamate and GABA receptors modulate cellular excitability and glutamatergic transmission in chicken cochlear nucleus angularis neurons.

Neurons in the avian cochlear nucleus angularis (NA) receive glutamatergic input from the auditory nerve, and GABAergic input from the superior olivary nucleus. Physiologically heterogeneous, NA neurons perform multiple functions including encoding…

Body size and the small branch niche: using marsupial ontogeny to model primate locomotor evolution.

Recently proposed ancestral locomotor and morphological 'stages' leading to the evolution of primates have emphasized small body size, and a transition from a clawed non-grasping stage, to a clawed, grasping stage with clawless opposable hallux, to a…

Effects of Substrate Size and Orientation on Quadrupedal Gait Kinematics in Mouse Lemurs (Microcebus murinus).

As the smallest living primate, the mouse lemur is a suitable model for reconstructing the locomotor mechanisms by which primate ancestors might have responded to the challenges of an arboreal environment. In this study, we tested the effects of…

Tags: 2016, Animals, Biomechanical Phenomena, Cheirogaleidae/*physiology, Department of Anatomy & Neurobiology, Female, Gait/*physiology, Journal of experimental zoology. Part A, Ecological genetics and physiology, Kemp Addison D, Male, NEOMED College of Medicine, Shapiro Liza J, Young Jesse W

Human quadrupeds, primate quadrupedalism, and Uner Tan Syndrome.

Since 2005, an extensive literature documents individuals from several families afflicted with "Uner Tan Syndrome (UTS)," a condition that in its most extreme form is characterized by cerebellar hypoplasia, loss of balance and coordination, impaired…

Assessing the determinants of primate gait kinematics in an ecological and phylogenetic framework, Part II: Platyrrhine quadrupedalism

Tags: 2019, American journal of physical anthropology, Anthropology, Department of Anatomy & Neurobiology, Dunham N T, Evolutionary Biology, Hieronymous T L, Journal Article, McNamara A, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Shapiro L J, Young J W

The spiral ganglion and Rosenthal's canal in beluga whales.

With the increase of human activity and corresponding increase in anthropogenic sounds in marine waters of the Arctic, it is necessary to understand its effect on the hearing of marine wildlife. We have conducted a baseline study on the spiral…

Projections from the dorsal and ventral cochlear nuclei to the medial geniculate body.

Direct projections from the cochlear nucleus (CN) to the medial geniculate body (MG) mediate a high-speed transfer of acoustic information to the auditory thalamus. Anderson etal. (2006) used anterograde tracers to label the projection from the…

Tags: 2014, collateral projections, Department of Anatomy & Neurobiology, fear conditioning, Foster Nichole L, Frontiers in neuroanatomy, lemniscal pathway, magnocellular pathway, Mellott Jeffrey G, Motts Susan D, multimodal processing, multipolar cells, NEOMED College of Medicine, Schofield Brett R, T-stellate, thalamus

Cholinergic cells of the pontomesencephalic tegmentum: connections with auditory structures from cochlear nucleus to cortex.

Acetylcholine (ACh) is a neuromodulator that is likely to play a role in plasticity as well as other phenomena at many sites in the auditory system. The auditory cortex receives cholinergic innervation from the basal forebrain, whereas the cochlea…

Projections from auditory cortex to cholinergic cells in the midbrain tegmentum of guinea pigs.

Anterograde and retrograde tracing techniques were used to characterize projections from the auditory cortex to the pedunculopontine and laterodorsal tegmental nuclei (PPT and LDT, respectively) in the midbrain tegmentum in guinea pigs. For…

Subcollicular projections to the auditory thalamus and collateral projections to the inferior colliculus.

Experiments in several species have identified direct projections to the medial geniculate nucleus (MG) from cells in subcollicular auditory nuclei. Moreover, many cochlear nucleus cells that project to the MG send collateral projections to the…

Tags: 2014, binaural, brain evolution, Department of Anatomy & Neurobiology, Frontiers in neuroanatomy, lateral lemniscus, medial geniculate nucleus, Mellott Jeffrey G, Motts Susan D, NEOMED College of Medicine, paralemniscal area, parallel pathways, reticular formation, Schofield Brett R, superior olive

Cells in auditory cortex that project to the cochlear nucleus in guinea pigs.

Fluorescent retrograde tracers were used to identify the cells in auditory cortex that project directly to the cochlear nucleus (CN). Following injection of a tracer into the CN, cells were labeled bilaterally in primary auditory cortex and the…

Tags: 2006, Animals, Auditory Cortex/*cytology, Cochlear Nucleus/*cytology, Coomes Diana L, Department of Anatomy & Neurobiology, Fluorescent Dyes, Guinea Pigs, Journal of the Association for Research in Otolaryngology : JARO, NEOMED College of Medicine, Pyramidal Cells/*cytology, Schofield Brett R, Schofield Ryan M

Pathways from auditory cortex to the cochlear nucleus in guinea pigs.

The inferior colliculus (IC) and superior olivary complex (SOC) are important sources of descending pathways to the cochlear nucleus. The IC and SOC are also targets of direct projections from the auditory cortex but it is not known if cortical axons…

Subtypes of GABAergic cells in the inferior colliculus

The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to…

Tags: 2019, Auditory system, Beebe Nichole L, Cell type, Department of Anatomy & Neurobiology, GABA, Hearing research, inhibition, June 2019 Update, NEOMED College of Medicine, perineuronal net, Schofield Brett R

Subtypes of GABAergic cells in the inferior colliculus.

The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to…

Tags: 2018, Auditory system, Beebe Nichole L, Cell type, Department of Anatomy & Neurobiology, GABA, Hearing research, inhibition, NEOMED College of Medicine, perineuronal net, Schofield Brett R

Retrograde axonal tracing with fluorescent markers.

The growth of fluorescence imaging technology and the development of sensitive fluorescent retrograde tracers has provided many new approaches for analyzing neuronal circuits. Fluorescent markers provide unparalleled opportunity for combining axonal…

Tags: *Fluorescent Dyes, 2008, Animals, Axons/*ultrastructure, Current protocols in neuroscience, Department of Anatomy & Neurobiology, Fluorescent Antibody Technique/*methods, Humans, NEOMED College of Medicine, Neural Pathways/*anatomy & histology, Schofield Brett R

On the use of retrograde tracers for identification of axon collaterals with multiple fluorescent retrograde tracers.

A common method for identifying collateral projections is to inject different retrograde tracers into two targets and examine labeled cells for the presence of both tracers. Double-labeled cells are considered to have collateral projections to the…

Projections from auditory cortex to midbrain cholinergic neurons that project to the inferior colliculus.

We have shown that auditory cortex projects to cholinergic cells in the pedunculopontine tegmental nucleus (PPT) and laterodorsal tegmental nucleus (LDT). PPT and LDT are the sources of cholinergic projections to the inferior colliculus, but it is…

Projections to the inferior colliculus from layer VI cells of auditory cortex.

A large injection of a retrograde tracer into the inferior colliculus of guinea pigs labeled two bands of cells in the ipsilateral auditory cortex: a dense band of cells in layer V and a second band of cells in layer VI. On the contralateral side,…

Tags: 2009, Amidines/metabolism, Animals, Auditory Cortex/*cytology/*physiology, Cholera Toxin/metabolism, Department of Anatomy & Neurobiology, Efferent Pathways/physiology, Fluorescent Dyes/metabolism, Functional Laterality, Guinea Pigs, Inferior Colliculi/*physiology, NADPH Dehydrogenase/metabolism, NEOMED College of Medicine, Neurons/classification/*physiology, Neuroscience, Nitric Oxide Synthase Type I/metabolism, Schofield B R

The anabolic effects of vitamin D-binding protein-macrophage activating factor (DBP-MAF) and a novel small peptide on bone.

Vitamin D-binding protein-macrophage activating factor (DBP-MAF) has previously been shown to stimulate bone resorption and correct the skeletal defects associated with osteopetrosis in two nonallelic mutations in rats. This same protein and a small…

The NMDA receptor antagonist MK-801 produces ethanol-like discrimination in the rat.

Two groups of rats, one derived from N/Nih stock and the second from the (putatively) serotonin-compromised Fawn-Hooded line, were trained to discriminate ethanol from its vehicle in a drug discrimination paradigm. Once each of the two groups…

Tags: 1993, Alcohol (Fayetteville, N.Y.), Animals, Department of Anatomy & Neurobiology, Discrimination Learning/*drug effects, Dizocilpine Maleate/*pharmacology, Ethanol/*pharmacology, Gordon T L, McBurney D M, Meehan S M, N-Methyl-D-Aspartate/physiology, NEOMED College of Medicine, Rats, Receptors, Schechter M D

Effect of repeated administrations upon cathinone discrimination and conditioned place preference.

1. Eight male rats were trained to discriminate the interoceptive cues produced by 0.8 mg/kg l-cathinone in a two-lever, food-motivated operant task and they were, subsequently, tested for preference to cathinone in a conditioned place preference…

Tags: 1991, Alkaloids/*pharmacology, Animals, Conditioning, Department of Anatomy & Neurobiology, Discrimination (Psychology)/*drug effects, Drug Tolerance/physiology, General pharmacology, Inbred Strains, Male, McBurney D, NEOMED College of Medicine, Operant/*drug effects, Psychotropic Drugs/*pharmacology, Rats, Schechter M D

Phentermine+fenfluramine produce cocaine-like discriminative cues.

Drug discrimination studies were conducted in six male Sprague-Dawley rats trained to discriminate the interoceptive cues produced by 10 mg/kg cocaine in an effort to investigate if there is stimulus generalization to phentermine or phentermine +…

Tags: *Discrimination (Psychology), 1996, Animals, Cocaine/*pharmacology, Department of Anatomy & Neurobiology, Dose-Response Relationship, Drug, Fenfluramine/administration & dosage/*pharmacology, Life sciences, Male, McBurney D, NEOMED College of Medicine, Phentermine/administration & dosage/*pharmacology, Rats, Schechter M D, Sprague-Dawley

Effects of compliant substrates on gait kinematics in squirrel monkeys (Saimiri boliviensis)

Tags: 2020, American journal of physical anthropology, Chadwell Brad A, Department of Anatomy & Neurobiology, Journal Article, journalArticle, June 2020 Update I, NEOMED College of Graduate Studies, NEOMED College of Medicine, Schapker Nicole M, Young Jesse W

Glycinergic "inhibition" mediates selective excitatory responses to combinations of sounds.

In the mustached bat's inferior colliculus (IC), combination-sensitive neurons display time-sensitive facilitatory interactions between inputs tuned to distinct spectral elements in sonar or social vocalizations. Here we compare roles of ionotropic…

Tags: *Sound, 2008, Acoustic Stimulation/methods, Action Potentials/drug effects/physiology, Animals, Auditory Pathways/*physiology, Chiroptera/physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Dose-Response Relationship, Drug Interactions, Excitatory Amino Acid Antagonists/pharmacology, GABA Agents/pharmacology, GABA/physiology, Gans Donald, Glycine Agents/pharmacology, Glycine/*physiology, Inferior Colliculi/cytology/drug effects/*physiology, Iontophoresis/methods, N-Methyl-D-Aspartate/antagonists & inhibitors/physiology, NEOMED College of Medicine, Neural Inhibition/drug effects/*physiology, Neurons/drug effects/physiology/radiation effects, Piperazines/pharmacology, Radiation, Receptors, Sanchez Jason Tait, The Journal of neuroscience : the official journal of the Society for Neuroscience, Wenstrup Jeffrey J

Contribution of NMDA and AMPA receptors to temporal patterning of auditory responses in the inferior colliculus.

Although NMDA receptors (NMDARs) are associated with synaptic plasticity, they form an essential part of responses to sensory stimuli. We compared contributions of glutamatergic NMDARs and AMPA receptors (AMPARs) to auditory responses in the inferior…

Tags: *Attention, *Behavior, 2012, Afferent/pathology, Animal, Animals, Conductive/pathology/*physiopathology, Department of Anatomy & Neurobiology, Female, Gerbillinae, Hearing Loss, Kelly Jack B, Male, NEOMED College of Medicine, Neurons, PloS one, Rosen Merri J, Sanes Dan H, Sarro Emma C

Browse Items (436 total)