Browse Items · NEOMED Bibliography Database

Development of potentiation in the dentate gyrus of rat: physiology and anatomy.

The physiological development of potentiating processes in the rat dentate gyrus were compared to morphological development. Rapid Golgi techniques were coupled with in vitro studies of dentate granule cell frequency potentiation, post-tetanic…

Tags: 1978, Animals, Brain research bulletin, Duffy C J, Female, Hippocampus/anatomy & histology/growth & development/*physiology, In Vitro Techniques, Inbred Strains, Male, Rats, Teyler T J

A rapid and simple HPLC microassay for biogenic amines in discrete brain regions.

A rapid microassay is described for the measurement of biogenic amines using an isocratic HPLC system with electrochemical detection. Catecholamines, indoleamines and their major metabolites were extracted with 150 microliters of perchloric acid from…

Tags: *Brain Chemistry, 1988, Animals, Biogenic Amines/*analysis, Chromatography, Corpus Striatum/analysis, Donzanti B A, High Pressure Liquid/methods, Inbred Strains, Indicators and Reagents, Male, Nucleus Accumbens/analysis, Organ Specificity, Pharmacology, biochemistry, and behavior, Rats, Reference Values, Yamamoto B K

An improved and rapid HPLC-EC method for the isocratic separation of amino acid neurotransmitters from brain tissue and microdialysis perfusates.

An improved, HPLC with electrochemical detection method for the isocratic separation and determination of amino acids from post-mortem brain tissue and from microdialysates of awake-behaving animals is described. Optimal conditions that maximize…

Tags: *Brain Chemistry, 1988, Amino Acids/*analysis, Animals, Chromatography, Corpus Striatum/analysis, Dialysis, Donzanti B A, Electrochemistry, High Pressure Liquid/*methods, Inbred Strains, Life sciences, Male, Neurotransmitter Agents/*analysis, Rats, Yamamoto B K

Modulatory effects of testosterone on

In this experiment, we examined the modulatory effects of testosterone on the parkinsonism-inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in two strains of mice. Orchidectomized male CD-1 and C57/B1 mice were implanted with either…

Methamphetamine-gonadal steroid hormonal interactions: effects upon acute toxicity and striatal dopamine concentrations.

Methamphetamine (MA)-related deaths and nigrostriatal dopaminergic (NSDA) neurotoxicity are greater in males. The exact basis for this gender difference is not known, but data, which show that estrogen (E) can function as a protectant of both the…

Spinal beta-endorphin analgesia involves an interaction with local monoaminergic systems.

beta-Endorphin administered intrathecally (i.t.) in rats produced a dose-dependent elevation in tail-flick latency. Naltrexone administered i.t. as a pretreatment reversed the spinal antinociceptive action of beta-endorphin, suggesting that the…

The antinociceptive effects of 3,4-methylenedioxymethamphetamine (MDMA) in the rat.

The antinociceptive effects of MDMA and morphine were examined in rats using the tail-flick and hot-plate analgesiometric tests. MDMA, in the dose range of 1.5-6.0 mg/kg IP, produced a dose-dependent elevation in hot-plate latency, but did not…

Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord.

1. Serotonin (5-HT) and selective 5-HT receptor agonists were administered intrathecally (i.t.) in rats, and the antinociceptive efficacy of these agents was assessed on the tail-flick and hot plate tests. 2. The 5-HT receptor agonists examined in…

Regulation of cholesterol 7 alpha-hydroxylase in the liver. Purification of cholesterol 7 alpha-hydroxylase and the immunochemical evidence for the induction of cholesterol 7 alpha-hydroxylase by cholestyramine and circadian rhythm.

Two cholesterol 7 alpha-hydroxylase isozymes were purified from liver microsomes of cholestyramine-treated female rats by using anion exchange high performance liquid chromatography. These two cytochrome P-450 isozymes were similar in electrophoretic…

Possible serotonergic and dopaminergic mediation of the

Eight male rats previously trained to discriminate 2.0 mg/kg

Norfenfluramine, the fenfluramine metabolite, provides stimulus control: evidence for serotonergic mediation.

Nine male rats were trained to discriminate 1.4 mg/kg norfenfluramine (NF) from its vehicle using a two-lever, food-motivated, operant discrimination task. Once trained, the rats showed a dose-dependent decrease in responding on the

Tags: 1988, Animal/*drug effects, Animals, Behavior, Boja J W, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Fenfluramine/*analogs & derivatives/*pharmacology, Inbred Strains, Male, Norfenfluramine/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Serotonin/pharmacology, Serotonin/physiology, Time Factors

Increased drug sensitivity in the drug discrimination procedure afforded by drug versus drug training.

Rats were trained to discriminate norfenfluramine (NF) 1.4 mg/kg from its vehicle or amphetamine (AMPH) 0.8 mg/kg or pentobarbital (PB) 6.0 mg/kg in order to determine the role that drug combination training plays in the rate of learning and…

Tags: 1990, Amphetamine/pharmacology, Animals, Boja J W, Discrimination (Psychology)/*drug effects, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Inbred Strains, Male, Norfenfluramine/pharmacology, Pentobarbital/pharmacology, Psychopharmacology, Rats, Reinforcement Schedule, Schechter M D

Behavioral effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE; "EVE").

Eight male rats were trained to discriminate 2.0 mg/kg

Tags: 1987, 3, 4-methylenedioxyamphetamine, 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology, Amphetamines/*pharmacology, Animals, Boja J W, Discrimination (Psychology), Dose-Response Relationship, Drug, Inbred Strains, Legislation, Male, N-Methyl-3, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Time Factors, United States

A slice preparation preserving the callosal projection to contralateral visual cortex.

Due to the curved path they follow, the visual callosal projections to areas OC1 and OC2 of the rat visual cortex have been inaccessible to studies using brain slices. In this paper we describe a new slice preparation in which a curved cutting blade…

Tags: *Synaptic Transmission, 1990, Animals, Berry R L, Corpus Callosum/*physiology, Electrophysiology, Female, In Vitro Techniques, Inbred Strains, Journal of neuroscience methods, Male, Neurology/instrumentation, Nowicky A, Rats, Teyler T J, Visual Cortex/*physiology

Preferential increase in pituitary prolactin versus vasoactive intestinal peptide as a function of estradiol benzoate dose in the ovariectomized rat.

Vasoactive intestinal peptide (VIP) is synthesized in various tissues, including the anterior pituitary gland, where it may stimulate the release of PRL. Because estrogen plays a central role in the regulation of PRL, it becomes important to…

Quantification of vasoactive intestinal peptide immunoreactivity in the anterior pituitary glands of intact male and female, ovariectomized, and estradiol benzoate-treated rats.

There are considerable data suggesting that vasoactive intestinal peptide (VIP) is involved in the regulation of PRL secretion; however, the role and cell of origin of anterior pituitary VIP remain to be determined. Immunocytochemical (ICC) studies…

Tags: *Ovariectomy, 1992, Animals, Anterior/*chemistry/drug effects/metabolism, Carrillo A J, Diestrus, Endocrinology, Estradiol/*pharmacology, Female, Immunohistochemistry, Inbred Strains, Male, Phelps C J, Pituitary Gland, Prolactin/blood/metabolism, Rats, Vasoactive Intestinal Peptide/*analysis/metabolism

Gender differences in methamphetamine-induced mRNA associated with neurodegeneration in the mouse nigrostriatal dopaminergic system.

In this report female and male CD-1 mice were treated with a neurotoxic regimen of methamphetamine (MA) to compare gender differences in striatal dopamine depletion and concordant changes in mRNA markers of the transforming growth factor-beta injury…

The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis.

Although there are multiple rodent models of the metabolic syndrome, very few develop vascular complications. In contrast, the JCR:LA-cp rat develops both metabolic syndrome and early atherosclerosis in predisposed areas. However, the pathology of…

Brain reactive antibodies and the blood-brain barrier: observations in aging rodents and the effects of peripheral kainic acid.

This study was initiated to confirm the existence of brain-reactive autoantibodies and to determine if such antibodies have higher affinity for brain regions especially affected in Alzheimer's disease. Serum collected from 90, 300, and 600 day old…

Tags: 1987, Aging/*immunology/physiology, Albrecht J W, Animals, Autoantibodies/blood/*physiology, Blood-Brain Barrier/*drug effects, Boja J W, Brain/*immunology/physiology, Experimental aging research, Hippocampus/immunology/physiology, Hutton J T, Inbred C57BL, Inbred Strains, Kainic Acid/*pharmacology, Kulmala H K, Male, Mice, Rats

Norepinephrine is lateralized within the olfactory bulbs of male mice.

Concentrations and in vitro release of norepinephrine were determined from left and right olfactory bulbs of adult male CD-1 mice. Norepinephrine concentrations from the left olfactory bulbs were significantly greater than those of the right (p…

Tags: *Functional Laterality, *Sex Characteristics, 1996, Animals, Dluzen D E, Dopamine/metabolism, Inbred Strains, Journal of neurochemistry, Kreutzberg J D, Male, Mice, Norepinephrine/*metabolism, Olfactory Bulb/*metabolism, Osmolar Concentration, Potassium/pharmacology, Tissue Distribution

Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release.

The effects of estrogen on MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in C57Bl and CD-1 mice. Ovariectomized mice with and without estrogen were treated with MPTP or its vehicle. The effects of these treatments…

Tags: *MPTP Poisoning, 1996, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Animals, Corpus Striatum/*drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Estradiol/*pharmacology, Female, Inbred C57BL, Inbred Strains, Journal of neurochemistry, Levodopa/pharmacology, Liu B, McDermott J L, Mice, Osmolar Concentration, Ovariectomy

Tamoxifen diminishes methamphetamine-induced striatal dopamine depletion in intact female and male mice.

It has been demonstrated that the nigrostriatal dopaminergic system of male mice is more sensitive to the neurotoxic effects of methamphetamine (MA). The basis for this difference can be related to oestrogen, which has the capacity to function as a…

The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus.

The effects of phenobarbital, phenytoin, and valproic acid on pharmacologically isolated NMDA-EPSP, AMPA-EPSP, and GABA-IPSPs were examined in rat hippocampal slices. Phenobarbital (0.05 mg/ml) had no effect on the NMDA-EPSP, but decreased the slope…

Tags: 1997, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/*pharmacology, Animals, Anticonvulsants/*pharmacology, Brain research bulletin, Brown-Croyts L M, Electrophysiology, gamma-Aminobutyric Acid/*pharmacology, Hippocampus/*drug effects/physiology, Inbred Strains, Ko G Y, Male, N-Methylaspartate/*pharmacology, Phenobarbital/pharmacology, Phenytoin/pharmacology, Rats, Teyler T J, Valproic Acid/pharmacology

Tamoxifen abolishes estrogen's neuroprotective effect upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.

The effects of 17beta-estradiol and the anti-estrogen, tamoxifen, on methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in ovariectomized CD-1 mice. In Experiment 1, striatal dopamine concentrations from…

Tags: 2001, Animals, Corpus Striatum/chemistry/*drug effects/metabolism, Dluzen D E, Dopamine/analysis/*metabolism, Estrogen Antagonists/*pharmacology, Estrogens/blood/*pharmacology, Female, Gao X, Inbred Strains, Methamphetamine/*toxicity, Mice, Neuroprotective Agents/pharmacology, Neuroscience, Ovariectomy, Substantia Nigra/chemistry/*drug effects/metabolism, Sympathomimetics/*toxicity, Tamoxifen/*pharmacology

Modulation of olfactory bulb tyrosine hydroxylase and catecholamine transporter mRNA by estrogen.

Since estrogen exerts wide ranging effects within the central nervous system, it is important to investigate the sites and actions of this gonadal steroid hormone at extra-hypothalamic locations. In the present report, the effects of estrogen upon…

MDMA-like stimulus effects of hallucinogens in male Fawn-Hooded rats.

A two-lever, food-motivated, operant technique was employed to train the purportedly serotonergically dysfunctional Fawn-Hooded (FH) rat to discriminate 1.5 mg/kg MDMA. Once all 10 male subjects learned the MDMA-vehicle discrimination at criterion…

LSD produces conditioned place preference in male but not female fawn hooded rats.

Male and female Fawn Hooded rats were examined for conditioned place preference (CPP) or aversion (CPA) to lysergic acid diethylamide (LSD). Using a biased design, experimental animals were trained with LSD (0.2 mg/kg, I.P.) administered in…

Tags: *Cues, *Sex Characteristics, 1998, Analysis of Variance, Animals, Choice Behavior/*drug effects, Conditioning, Female, Humans, Inbred Strains, Lysergic Acid Diethylamide/*pharmacology, Male, Meehan S M, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D

Markers associated with testosterone enhancement of methamphetamine-induced striatal dopaminergic neurotoxicity.

Intact male CD-1 mice received an injection of testosterone propionate (TP–5 ug), progesterone (P–5 mg), the oil vehicle or remained untreated (control). At 24 hours after hormonal treatments the mice received an injection of methamphetamine (MA–40…

MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains.

Continuing our previous work in which we showed wide-ranging strain differences in MPTP neurotoxicity in male mice among ten BXD recombinant inbred strains, we replicated our work in females from nine of the same strains. Mice received a single s.c.…

Tamoxifen increases methamphetamine-evoked dopamine output from superfused striatal tissue fragments of male mice.

The antiestrogen, tamoxifen (TMX), has been shown to function as a neuroprotectant against the nigrostriatal dopaminergic (NSDA) neurotoxin, methamphetamine (MA), within male mice. In the present report, we examined the effects of a combined infusion…

Tags: 2004, Animals, Brain research, Corpus Striatum/*drug effects/*metabolism, Dluzen Dean E, Dopamine Agents/*pharmacology, Dopamine Plasma Membrane Transport Proteins, Dopamine/*metabolism, Drug Synergism, Estrogen Antagonists/*pharmacology, Inbred Strains, Male, Membrane Glycoproteins/metabolism, Membrane Transport Proteins/metabolism, Methamphetamine/*pharmacology, Mice, Nerve Tissue Proteins/metabolism, Tamoxifen/*pharmacology, Willett Matthew C

Analysis of connective tissues by laser capture microdissection and reverse transcriptase-polymerase chain reaction.

Studies of gene expression from bone, cartilage, and other tissues are complicated by the fact that their RNA, collected and pooled for analysis, often represents a wide variety of composite cells distinct in individual phenotype, age, and state of…

Cocaethylene-induced lethality in mice is potentiated by alcohol.

Mice of the heterogeneously bred HS line were concurrently administered intraperitoneal injections of either 95, 75, 60, or 48 mg/kg cocaethylene or 48, 38, or 30 mg/kg cocaethylene in conjunction with the non-lethal dose of 6.0 g/kg (20% w/v)…

Tags: 1995, Alcohol (Fayetteville, N.Y.), Animals, Cocaine/*analogs & derivatives/poisoning, Dose-Response Relationship, Drug, Drug Synergism, Ethanol/*pharmacology, Female, Inbred Strains, Lethal Dose 50, Male, Meehan S M, Mice, Schechter M D

Deficits in shock-induced freezing and naltrexone enhancement of freezing in fawn hooded rats.

When a rat is returned to a context associated with mild electric foot shock (1 mA/0.75 s), the environmental cues elicit a species-specific defensive behavior termed freezing. Genetically divergent strains of rats given identical shock conditioning…

Tags: *Fear, 1994, Animals, Brain research bulletin, Calcagnetti D J, Classical/*drug effects, Conditioning, Electroshock, Female, Inbred Strains, Naltrexone/*pharmacology, Rats, Schechter M D

Extinction of cocaine-induced place approach in rats: a validation of the "biased" conditioning procedure.

It has often been demonstrated that when a rat is conditioned in a cue-specific environment that has been repeatedly paired with cocaine injections, it will spend more time in that environment than it does in a saline-paired environment. This…

Tags: 1993, Animals, Brain research bulletin, Calcagnetti D J, Classical, Cocaine/*pharmacology, Conditioning, Extinction, Habituation, Inbred Strains, Male, Operant/*drug effects, Psychological/*drug effects, Psychophysiologic/drug effects, Rats, Reward, Schechter M D

Attenuation of drinking sweetened water following calcium channel blockade.

Recent reports cite results that both cocaine-induced conditioned place preference and activity stimulation are attenuated by pretreatment with the calcium channel blocker isradipine (ISR) in rats. By blocking voltage-dependent

Conditioned place preference/aversion to fenfluramine in fawn hooded and sprague-Dawley rats.

The Fawn Hooded (FH) rat strain possesses a genetic platelet storage pool deficiency which leads to an impaired capacity for platelets to store and release serotonin. While the relationship between this deficit and possible alterations in brain…

Tags: 1994, Animals, Avoidance Learning/*drug effects, Blood Platelets/metabolism, Brain Chemistry/genetics, Fenfluramine/*pharmacology, Habituation, Inbred Strains, Meehan S M, Platelet Storage Pool Deficiency/physiopathology, Progress in neuro-psychopharmacology & biological psychiatry, Psychophysiologic/drug effects, Rats, Schechter M D, Serotonin/metabolism/physiology, Species Specificity, Sprague-Dawley

Reducing the time needed to conduct conditioned place preference testing.

The objective of the present experiment was to demonstrate whether four days of twice-a-day conditioned place conditioning produces a preference that is equivalent to that produced by using eight days of once-a-day training. Two doses of the…

Tags: 1992, Alkaloids/pharmacology, Animals, Calcagnetti D J, Choice Behavior/*drug effects, Conditioning, Experimental/instrumentation/methods, Inbred Strains, Male, Motor Activity/drug effects, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Psychology, Psychotropic Drugs/pharmacology, Rats, Schechter M D

Striatal dopamine release in vitro from immature male rats shows enhanced responsiveness to pulsatile, but not continuous, infusions of L-dopa.

In the present experiment we compared the effects of continuous versus pulsed infusions of L-beta-3,4,dihydroxyphenylalanine (L-DOPA) upon dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro from superfused corpus striatal tissue…

Tags: 1991, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Aging/*metabolism, Animals, Brain research. Developmental brain research, Corpus Striatum/*metabolism, Dluzen D, Dopamine/*metabolism, Inbred Strains, Levodopa/*administration & dosage/pharmacology, Male, McDermott J, Pulsatile Flow, Rats

Cocaethylene-induced kindling of seizure effects: cross-specificity with cocaine.

Sensitization and cross-sensitization to the seizurogenic effects of cocaine and cocaethylene were examined in the HS strain of mice. Animals were administered IP injections of either 48 mg/kg cocaine or 32 mg/kg cocaethylene once per day for 4 days.…

Tags: 1996, Animals, Cocaine/*analogs & derivatives/pharmacology, Convulsants/*pharmacology, Dopamine Uptake Inhibitors/*pharmacology, Drug Interactions, Epilepsy, Female, Inbred Strains, Kindling, Male, Meehan S M, Mice, Neurologic/*drug effects, Pharmacology, biochemistry, and behavior, Schechter M D, Seizures/*chemically induced, Status Epilepticus/chemically induced, Tonic-Clonic/chemically induced

Role of dopamine D1 receptors in cocaine lethality.

One group of heterogeneously bred HS mice was assigned to test coadministration of the selective D1 antagonist SCH 23390 with a dose of cocaine (95 mg/kg) that was observed to produce 80% lethality, whereas a second group was tested by cotreatment…

Tags: 1995, Animals, Benzazepines/pharmacology, Cocaine/*toxicity, Dopamine Agonists/pharmacology, Dopamine D1/agonists/antagonists & inhibitors/*drug effects, Female, Inbred Strains, Lethal Dose 50, Male, Meehan S M, Mice, Pharmacology, biochemistry, and behavior, Phenanthridines/pharmacology, Receptors, Schechter M D, Sex Characteristics

Browse Items (97 total)