Browse Items · NEOMED Bibliography Database

Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro.

We have previously identified osteoactivin (OA), encoded by Gpnmb, as an osteogenic factor that stimulates osteoblast differentiation in vitro. To elucidate the importance of OA in osteogenesis, we characterized the skeletal phenotype of a mouse…

Isolated Post-Shunt Metopic Synostosis and Neural Tube Defects.

BACKGROUND: Craniosynostosis is an uncommon complication after shunting procedures for congenital hydrocephalus. We report a case of a child with myelomeningocele and normocephaly at the time of birth. She underwent ventricular shunting for Chiari…

Tags: 2018, Abouhassan William, Arnold-Chiari Malformation/complications/*surgery, Chao John Kuang, Craniosynostoses/*etiology, Female, Humans, Hydrocephalus/complications/congenital/*surgery, Infant, Meningomyelocele/complications/*surgery, Murthy Ananth S, Newborn, Postoperative Complications/*etiology, Slit Ventricle Syndrome/etiology, The Journal of craniofacial surgery, Third Ventricle, Ventriculoperitoneal Shunt/*adverse effects

Neonatal glycine encephalopathy: biochemical and neuropathologic findings.

A patient with neonatal glycine encephalopathy who had severe neurologic retardation, spasticity, and seizures died at 17 years of age. Glycine concentration was markedly elevated in brain tissue, especially in the cerebellum. Neuropathologic study…

Effects of neonatal and prepubertal hormonal manipulations upon estrogen neuroprotection of the nigrostriatal dopaminergic system within female and male mice.

Estrogen (E) can function as a neuroprotectant of the nigrostriatal dopaminergic (NSDA) system against methamphetamine (MA) neurotoxicity in female, but not male, mice. In the present report we examined whether the organizational effects of gonadal…

Maturation of the Coordination Between Respiration and Deglutition with and Without Recurrent Laryngeal Nerve Lesion in an Animal Model.

The timing of the occurrence of a swallow in a respiratory cycle is critical for safe swallowing, and changes with infant development. Infants with damage to the recurrent laryngeal nerve, which receives sensory information from the larynx and…

Electromagnetic fields and infant incubators.

Two models of infant incubators were studied to determine the strength of the magnetic field generated by the heater and fan motors. Measurements were taken at intervals along the center line of the incubator. The results show that fields greater…

Tags: *Electromagnetic Fields, *Incubators, 1994, Archives of environmental health, Bearer C F, Humans, Infant, Newborn, Premature

Defining Success in Pediatric Palliative Care While Tackling the Quadruple Aim.

Tags: *Attitude of Health Personnel, 2017, Adolescence, American Academy of Pediatrics, Bogetz Jori F, Child, Friebert Sarah, Health Personnel/*psychology, Hospice and Palliative Care Nursing/*organization & administration, Humans, Infant, Journal of palliative medicine, Newborn, Organizational Objectives, Palliative Care – In Infancy and Childhood, Pediatric Nursing/*organization & administration, Preschool, Success

Unexplained fever in infants and young children: when is it serious?

When an infant or child younger than 36 months presents with fever that has no obvious source, the major concern is overlooking a serious bacterial infection. Ask about underlying medical problems, previous hospitalizations, recent infectious…

Tags: 2001, Age Factors, Bacterial Infections – Diagnosis – In Infancy and Childhood, Blood – Analysis – In Infancy and Childhood, Body Temperature, Bower J R, Clinical Assessment Tools, Consultant (00107069), Diagnosis, Fever – Etiology – In Infancy and Childhood, Infant, Laboratory, Newborn, Patient History Taking, Physical Examination, Powell K R, Urinalysis – In Infancy and Childhood

During the Emergency Department Evaluation of a Well-Appearing Neonate with Fever, Should Empiric Acyclovir Be Initiated?

BACKGROUND: Herpes simplex virus (HSV) infection represents significant morbidity and mortality in the neonatal period. Although clear guidelines exist on the evaluation and management of the otherwise well-appearing febrile neonate pertaining to…

Tags: 2018, acyclovir, Acyclovir – Therapeutic Use, Acyclovir/*therapeutic use, Antiviral Agents – Therapeutic Use, Antiviral Agents/therapeutic use, Bruno Eric, Cheng David, Decision Making, Department of Emergency Medicine, febrile neonate, Female, Ferrans and Powers Quality of Life Index, Fever – Etiology, Fever/etiology, Guidelines as Topic/standards, Herpes Simplex – Complications, Herpes Simplex – Diagnosis, Herpes Simplex – Drug Therapy, herpes simplex virus, Herpes Simplex/complications/diagnosis/*drug therapy, Herpesviruses, HSV, Humans, Infant, Infectious – Diagnosis, Infectious/diagnosis, Male, NEOMED College of Medicine, neonatal fever, Newborn, Pillus David, Pokrajac Nicholas, Practice Guidelines – Standards, Pregnancy Complications, Scales, Simplexvirus/pathogenicity, The Journal of emergency medicine, Vilke Gary

Repackaging of Intravenous Fat Emulsions: A Clinical Conundrum.

To accommodate small fluid volumes, repackaging of intravenous fat emulsions (IVFEs) is frequently performed in institutions providing parenteral nutrition to neonates and smaller pediatric patients. However, some consider this an unsafe practice.…

Evolution of hyperphalangy and digit reduction in the cetacean manus.

Cetaceans (whales, dolphins, and porpoises) have a soft tissue flipper that encases most of the forelimb, and elongated digits with an increased number of phalanges (hyperphalangy). In addition, some cetaceans exhibit a reduction in digit number.…

Tags: *Adaptation, *Biological Evolution, 2007, Anatomical record (Hoboken, N.J. : 2007), Animals, Berta Annalisa, Cetacea/*anatomy & histology/physiology, Cooper Lisa Noelle, Dawson Susan D, Department of Anatomy & Neurobiology, Forelimb/*anatomy & histology/physiology, Morphogenesis, NEOMED College of Medicine, Newborn, Phylogeny, Physiological, Reidenberg Joy S

A thyroglossal duct cyst causing apnea and cyanosis in a neonate.

This is a case of a 3-week-old male who presented to the emergency department with intermittent apnea and cyanosis. While in the emergency department, he had respiratory compromise with stress and required intubation. Further evaluation confirmed the…

Tags: 2005, Airway Obstruction/etiology/therapy, Akron Children's Hospital, Apnea/*etiology/therapy, Christopher Norman C, Cyanosis/*etiology/therapy, Department of Emergency Medicine, Department of Pediatrics, Diaz Maria Carmen G, Humans, Infant, Intratracheal, Intubation, Male, NEOMED College of Medicine, Newborn, Pediatric emergency care, Stormorken Anne, Thyroglossal Cyst/*complications/*congenital

A thyroglossal duct cyst causing apnea and cyanosis in a neonate.

This is a case of a 3-week-old male who presented to the emergency department with intermittent apnea and cyanosis. While in the emergency department, he had respiratory compromise with stress and required intubation. Further evaluation confirmed the…

Tags: 2005, Apnea, Christopher NC, Cyanosis, Cysts – Diagnosis, Department of Emergency Medicine, Diaz MCG, Infant, Male, NEOMED College of Medicine, Newborn, Pediatric emergency care, Stormorken A, Thyroid Gland – Physiopathology, Tomography, X-Ray Computed

The epidemiology of respiratory tract infections.

Respiratory tract infections (RTIs) are the most common, and potentially most severe, of infections treated by health care practitioners. Lower RTIs along with influenza, are the most common cause of death by infection in the United States. Risk…

Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011.

IMPORTANCE: The National Action Plan for Combating Antibiotic-Resistant Bacteria set a goal of reducing inappropriate outpatient antibiotic use by 50% by 2020, but the extent of inappropriate outpatient antibiotic use is unknown. OBJECTIVE: To…

Tags: 2016, Adolescence, Adolescent, Adult, Aged, Ambulatory Care – Statistics and Numerical Data, Ambulatory Care/*statistics & numerical data, Anti-Bacterial Agents/*therapeutic use, Antibiotics – Therapeutic Use, Bartoces Monina, Child, Department of Internal Medicine, Enns Eva A, Female, File Thomas M Jr, Finkelstein Jonathan A, Fleming-Dutra Katherine E, Gerber Jeffrey S, Health Care Surveys, Hersh Adam L, Hicks Lauri A, Human, Humans, Hyun David Y, Inappropriate Prescribing – Statistics and Numerical Data, Inappropriate Prescribing/*statistics & numerical data, Infant, JAMA, Linder Jeffrey A, Lynfield Ruth, Male, Margolis David J, May Larissa S, Merenstein Daniel, Metlay Joshua P, Middle Age, Middle Aged, NEOMED College of Medicine, Newborn, Newland Jason G, Otitis Media, Otitis Media – Drug Therapy, Pharyngitis – Drug Therapy, Pharyngitis/drug therapy, Physicians'/*statistics & numerical data, Piccirillo Jay F, Practice Patterns, Preschool, Prevalence, Respiratory Tract Infections – Drug Therapy, Respiratory Tract Infections/drug therapy, Roberts Rebecca M, Sanchez Guillermo V, Shapiro Daniel J, Suda Katie J, Suppurative/*drug therapy, Surveys, Thomas Ann, United States, Woo Teri Moser, Zetts Rachel M

Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses.

We hypothesized that congenital diaphragmatic hernia (CDH) may decrease distal air space fluid absorption due to immaturity of alveolar epithelial cells from a loss of the normal epithelial Na+ transport, as assessed by amiloride and epithelial Na+…

Leading inhibition to neural oscillation is important for time-domain processing in the auditory midbrain.

A number of central auditory neurons exhibit paradoxical latency shift (PLS), a response characterized by longer response latencies at higher sound levels. PLS neurons are known to play a role in target ranging for echolocating bats that emit…

Update on antiviral therapy for genital herpes infection.

For the primary infection of genital herpes, antiviral therapy with acyclovir is the gold standard. For recurrences, there are two options: antiviral treatment of each outbreak as it arises, or suppression of outbreaks with daily oral therapy.…

Central nervous system integration of sensorimotor signals in oral and pharyngeal structures: oropharyngeal kinematics response to recurrent laryngeal nerve lesion.

Safe, efficient liquid feeding in infant mammals requires the central coordination of oropharyngeal structures innervated by multiple cranial and spinal nerves. The importance of laryngeal sensation and central sensorimotor integration in this system…

Pre-pharyngeal Swallow Effects of Recurrent Laryngeal Nerve Lesion on Bolus Shape and Airway Protection in an Infant Pig Model.

Recurrent laryngeal nerve (RLN) damage in infants leads to increased dysphagia and aspiration pneumonia. Recent work has shown that intraoral transport and swallow kinematics change following RLN lesion, suggesting potential changes in bolus…

Postnatal developmental changes in the medial nucleus of the trapezoid body in a mouse model of auditory pathology.

Age-related hearing loss (AHL) is a multifactorial disorder characterized by a decline in peripheral and central auditory function. Here, we examined synaptic transmission in DBA/2 mice, which carry the AHL8 gene, at the identifiable glutamatergic…

Development of social vocalizations in mice.

Adult mice are highly vocal animals, with both males and females vocalizing in same sex and cross sex social encounters. Mouse pups are also highly vocal, producing isolation vocalizations when they are cold or removed from the nest. This study…

LVC Timing in Infant Pig Swallowing and the Effect of Safe Swallowing.

Recurrent laryngeal nerve (RLN) injury in neonates, a complication of head and neck surgeries, leads to increased aspiration risk and swallowing dysfunction. The severity of resulting sequelae range from morbidity, such as aspiration pneumonia, to…

Direct care staff and parents'/legal guardians' perspectives on end-of-life care in a long-term care facility for medically fragile and intellectually disabled pediatric and young adult residents.

OBJECTIVE: Children and young adults with severe disabilities and their families are faced with enormous challenges throughout the lifespan, including admitting the child to a long-term care facility (LTCF) and making end-of-life (EOL) care…

Review of fluconazole treatment and prophylaxis for invasive candidiasis in neonates.

Invasive candidiasis accounts for approximately 10% of nosocomial infections in preterm infants, with an incidence of 1% to 4% among neonatal intensive care unit (NICU) admissions and a mortality as high as 20% to 30%. These outcomes warrant improved…

Review of fluconazole treatment and prophylaxis for invasive candidiasis in neonates.

Invasive candidiasis accounts for approximately 10% of nosocomial infections in preterm infants, with an incidence of 1% to 4% among neonatal intensive care unit (NICU) admissions and a mortality as high as 20% to 30%. These outcomes warrant improved…

Tags: 2021, amphotericin B, ANTIFUNGAL agents, Candida, Candidiasis, fluconazole, Newborn, pharmacokinetics

Postmortem vitreous bevacizumab levels of an infant treated for retinopathy of prematurity.

We report the vitreous concentration of bevacizumab after injection for the treatment of retinopathy of prematurity (ROP). A premature neonate diagnosed with type 1 ROP was treated in both eyes with 0.625 mg intravitreal bevacizumab injection at 32…

Analysis of connective tissues by laser capture microdissection and reverse transcriptase-polymerase chain reaction.

Studies of gene expression from bone, cartilage, and other tissues are complicated by the fact that their RNA, collected and pooled for analysis, often represents a wide variety of composite cells distinct in individual phenotype, age, and state of…

Neonatal renal cystic diseases.

PURPOSE: Neonatal renal cystic diseases have a great impact on the morbidity and mortality of the affected neonates and infants. A good insight into the pathophysiology, diagnosis and treatment options of various neonatal renal cystic diseases aid in…

Automated identification of antibiotic overdoses and adverse drug events via analysis of prescribing alerts and medication administration records.

Objectives: Electronic trigger detection tools hold promise to reduce Adverse drug event (ADEs) through efficiencies of scale and real-time reporting. We hypothesized that such a tool could automatically detect medication dosing errors as well as…

Tags: *Algorithms, *Medical Order Entry Systems, 2017, Adolescence, Adolescent, adverse drug event, Adverse Drug Event – Prevention and Control, Age Distribution, Algorithms, Anti-Bacterial Agents/*administration & dosage/adverse effects, Antibiotics – Administration and Dosage, Antibiotics – Adverse Effects, Child, Clinical, Computer Assisted, Computer-Assisted, Courter Joshua D, CPOE, Damania Rahul, Decision Support Systems, Demography, Dexheimer Judith W, Drug Overdose/diagnosis/*prevention & control, Drug Therapy, Drug-Related Side Effects and Adverse Reactions/*prevention & control, electronic health record, Electronic Health Records, electronic medical record, Electronic Order Entry, Female, Funding Source, Hagedorn Philip, Hospitals, Humans, Infant, Journal of the American Medical Informatics Association : JAMIA, Kirkendall Eric S, Kouril Michal, Li Dan, Male, medical order entry system, Medication Errors – Prevention and Control, Medication Errors – Statistics and Numerical Data, Medication Errors/*prevention & control/statistics & numerical data, Minich Thomas, Newborn, Overdose – Diagnosis, Overdose – Prevention and Control, Patient Safety, Pediatric, Preschool, Risk Management, Spooner S Andrew, Szczesniak Rhonda, Young Adult

Monoamine-activated alpha 2-macroglobulin inhibits neurite outgrowth, survival, choline acetyltransferase, and dopamine concentration of neurons by blocking neurotrophin-receptor (trk) phosphorylation and signal transduction.

Lung fluid absorption is induced in preterm guinea pigs ventilated with low tidal volumes.

The objective of this study was to determine if low tidal volume (V(t)) ventilation was beneficial when ventilating preterm fetuses. The authors ventilated preterm guinea pig fetuses at gestation day (GD) 67, 3 days before birth, newborn, and…

Innate and adaptive host response during the initial phase of herpes simplex virus encephalitis in the neonatal mouse.

To study early events of neonatal herpes simplex virus (HSV) encephalitis and its sequelae, the authors induced a controlled infection in the brains of mice using HSVgH, a genetically modified Disabled Infective Single Cycle virus. Neonatal Balb/C…

Analysis of osteopontin in mouse growth plate cartilage by application of laser capture microdissection and RT-PCR.

Gene expression of osteopontin (OPN) has been investigated in mice by application of laser capture microdissection (LCM) and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. LCM permits individual cells to be isolated ("captured")…

Targeted Extended Cystic Fibrosis Mutation Testing On Known And At-risk Patients And Relatives

This paper reports mathematically derived residual risks of being a carrier or being affected with cystic fibrosis following various screening scenarios to assist in interpreting test results and advising patients. While parental screening with 23…

Tags: 2007, Blood, cftr mutations, early-diagnosis, experience, Genetic Testing, Genetics & Heredity, immunoreactive trypsinogen, Journal Article or Conference Abstract Publication, Lebo R V, midlands, Newborn, Omlor G J, outcomes, Research & Experimental Medicine, vas-deferens, west, Wisconsin

Analyzing the most frequent disease loci in targeted patient categories optimizes disease gene identification and test accuracy worldwide.

BACKGROUND: Our genomewide studies support targeted testing the most frequent genetic diseases by patient category: (1) pregnant patients, (2) at-risk conceptuses, (3) affected children, and (4) abnormal adults. This approach not only identifies most…

RNA interference for CFTR attenuates lung fluid absorption at birth in rats.

BACKGROUND: Small interfering RNA (siRNA) against alphaENaC (alpha-subunit of the epithelial Na channel) and CFTR (cystic fibrosis transmembrane conductance regulator) was used to explore ENaC and CTFR function in newborn rat lungs. METHODS:…

Non-health Care Facility Medication Errors Associated with Hormones and Hormone Antagonists in the United States.

INTRODUCTION: Hormones and hormone antagonists are frequently associated with medication errors and may result in important adverse outcomes. The purpose of this study is to investigate non-health care facility (non-HCF) medication errors associated…

Delays in immunizations of high-risk infants during the first two years of life: special care for the high-risk infant should not mean special immunization schedules.

Because experience in our newborn intensive care unit follow-up clinic since 1982 suggested that immunizations of newborn intensive care unit graduates in the first 2 years of life were inappropriately delayed, questionnaires were sent to families…

Pediatric airway management in COVID-19 patients: consensus guidelines from the society for pediatric anesthesia's pediatric difficult intubation collaborative and the Canadian Pediatric Anesthesia Society.

The severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019 [COVID-19]) pandemic has challenged medical systems and clinicians globally to unforeseen levels. Rapid spread of COVID-19 has forced clinicians to care for patients with a…

Tags: 2020, Adolescent, Airway Management/ methods, Anesthesia and Analgesia, Anesthesia/methods, Anesthesiology/ methods/standards, Asaf S, Ayad I, Bhalla T, Castro P, Chiao F, Child, Consensus, Coronavirus Infections/ therapy, Crockett C, Dalesio N, Denning S, Department of General Surgery, Disma N, Engelhardt T, Evans F, Fiadjoe JE, Galvez I, Gálvez J, Garcia-Marcinkiewicz A, Glover C, Gooden C, Greenberg R, Greenwood E, Guidelines as Topic, Gumaney H, Haydar B, Hervías M, Hsu G, Humans, Hunyady A, Infant, Infection Control, Infectious Disease Transmission, Ingelmo P, Intratracheal/ methods/standards, Intubation, Jagannathan N, Javia L, journalArticle, July 2020 List, Kiss EE, Kovatsis PG, Lardner D, Lau J, Lee JK, Lee LK, Lockman JL, Matava CT, Matuszczak M, McCloskey J, Mireles S, NEOMED College of Medicine, Newborn, Olomu P, Pandemics, Park R, Patient-to-Professional/prevention & control, Pediatrics/ methods/standards, Pérez-Pradilla C, Peyton J, Pneumonia, Polaner D, Preschool, Raman VT, Rehman M, Reynolds P, Sabato S, Stein ML, Szmuk P, Szolnoki J, Taicher B, Tan J, Templeton T, Theroux MC, Thompson N, Viral/ therapy, Von Ungern-Sternberg B, Whyte S, Yaster M, Yu J

Browse Items (65 total)