Browse Items · NEOMED Bibliography Database

Pathological phalanges in a camarasaurid sauropod dinosaur and implications on behaviour

Several types of pathological bony overgrowth are known from various dinosaur taxa but, except for stress fractures, are rarely reported from appendicular elements. Herein we describe pathological manual and pedal phalanges of a camarasaurid sauropod…

ZYGAPOPHYSEAL AND COSTOVERTEBRAL COSTOTRANSVERSE JOINTS - AN ANATOMIC ASSESSMENT OF ARTHRITIS IMPACT

Reduction of Knee Pain by Effusion Reduction.

Tags: 2016, ELSAMAN AHMED, Exudates and Transudates, Journal of Rheumatology, Knee, Knee Joint, MOHAMMED WALAA, OHRNDORF SARAH, Osteoarthritis, Pain, RADWAN AHMED, Rothschild Bruce

Distinguishing erosive osteoarthritis and calcium pyrophosphate deposition disease.

Erosive osteoarthritis is a term utilized to describe a specific inflammatory condition of the interphalangeal and first carpal metacarpal joints of the hands. The term has become a part of medical philosophical semantics and paradigms, but the issue…

Tags: 2013, Calcium pyrophosphate deposition disease, Erosive osteoarthritis, Hydroxychloroquine, Osteoarthritis, Rheumatoid arthritis, Rothschild Bruce M, Spondyloarthropathy, World journal of orthopedics

GEOGRAPHIC-DISTRIBUTION OF CALCIUM PYROPHOSPHATE (CPPD) DEPOSITION DISEASE IN PRE-COLUMBIAN NORTH-AMERICA - INDEPENDENT VALIDATION OF CPPD CRITERIA

Calcium pyrophosphate deposition disease (CPPD), a form of crystalline arthritis, has a unique distribution in the Early to Middle Archaic Periods (3000 to 8000 years before the present) of North America, contrasting with the generalized geographic…

Tags: 1993, Arthritis, Arthropathy, Calcium pyrophosphate deposition disease, chondrocalcinosis, Clinical and experimental rheumatology, Epidemiology, Journal Article, Osteoarthritis, Paleopathology, Pathology, Rheumatology, Rothschild B M, Woods R J

OSTEOARTHRITIS, CALCIUM PYROPHOSPHATE DEPOSITION DISEASE, AND OSSEOUS INFECTION IN OLD-WORLD PRIMATES

Uncertainties as to the nature and implications of osteoarthritis and calcium pyrophosphate deposition disease (CPPD) in primates were subject to critical review through examination of 153 prosimians and 1,250 Old World non-prosimian primates.…

Tags: 1992, American journal of physical anthropology, Anthropology, crystal, Evolutionary Biology, Journal Article, Osteoarthritis, Primates, rhesus-monkeys, Rothschild B M, skeletal pathology, Woods R J

ARTHRITIS IN NEW-WORLD MONKEYS - OSTEOARTHRITIS, CALCIUM PYROPHOSPHATE DEPOSITION DISEASE, AND SPONDYLOARTHROPATHY

Analyses of New World skeletal populations for the presence of erosions an other osseous alterations and their character, distribution, and radiologic appearance shows that osteoarthritis is predominantly a disease of animals raised in artificially…

Inflammatory arthritis in canids: Spondyloarthropathy

Spondyloarthropathy was observed in 25 (2.8%) of 895 preserved canid museum specimens and was catalogued by species. The associated skeletal alterations in canids are indistinguishable grossly and physiologically from those in humans with…

Tags: 2001, Canidae, Disease, erosive arthritis, Journal Article, Journal of Zoo and Wildlife Medicine, Osteoarthritis, Pathology, reactive arthritis, rheumatoid-arthritis, Rothschild B M, Rothschild C, Sacroiliac Joint, santiago rhesus macaques, Spondyloarthropathy, Veterinary Sciences, Woods R J

NO LAUGHING MATTER - SPONDYLOARTHROPATHY AND OSTEOARTHRITIS IN HYAENIDAE

The etiology of arthritis in Hyaenidae has been a subject of conjecture. While osteoarthritis has been considered, the observation of an erosive arthritis prompted a systematic survey of museum specimens to define its nature and frequency.…

Tags: 1994, aardwolves, enthesopathy, erosive arthritis, hyaenidae, hyenas, Journal Article, Journal of Zoo and Wildlife Medicine, Osteoarthritis, Rothschild B M, Rothschild C, Spondyloarthropathy, Veterinary Sciences

Osteoarthritis is for the birds

The purpose of this study was to assess birds as a potential model for osteoarthritis. Compromised by confounding factors, it has not been possible to clearly delineate causation in humans. Nonhuman mammals manifest osteoarthritis in the natural…

Tags: 2006, Animal models, Birds, classification, Clinical rheumatology, guinea-pigs, inflammatory arthritis, Journal Article, Knee, monkeys, of-rheumatology criteria, Osteoarthritis, Panza R, pyrophosphate deposition disease, rhesus macaques, Rheumatology, Rothschild B M, santiago, Spondyloarthropathy

Decompression syndrome and diving behavior in Odontochelys, the first turtle

Odontochelys semitestacea, the oldest known turtle, from the Late Triassic of China, shows a pathology. Sharply defined, focal depressions were noted on the articular surfaces of both humeri, documenting avascular necrosis. Diving habits of Mesozoic…

What is this disease we call spondyloarthropathy?

Paleopathology as a clinical science with implications for patient care, education, and research

Tags: 1996, defleshed bones, Diagnosis, erosive arthritis, Journal Article, Journal of Rheumatology, Osteoarthritis, pyrophosphate deposition disease, rheumatoid-arthritis, Rheumatology, Rothschild B M, Spondyloarthropathy

PARAVERTEBRALMASSES IN BLUE-TAILED MONITOR, VARANUS DORIANUS, INDICATIVE OF SOFT-TISSUE INFECTION WITH ASSOCIATED OSTEOMYELITIS

Paravertebral osseous masses in reptiles have been attributed to Paget's disease on the basis of histology. Histologically recognized mosaic architecture and cement lines, however, lack specificity. A Varanus dorianus with this condition was…

Nondestructive, Epi-Illumination Surface Microscopic Characterization of Surface Discontinuity in Bone: A New Approach Offers a Descriptive Vocabulary and New Insights

Perspectives are in the eye of the beholder and are expanded with increased scrutiny (e.g., magnification). The term porosity' for macroscopically or radiologically identifiable discontinuity in bone is so variably applied as to be incomprehensible…

Untitled

Tags: 2004, Arthritis, Journal Article, Osteoarthritis, pyrophosphate deposition disease, Rothschild B, Spondyloarthropathy, Veterinary Radiology & Ultrasound, Veterinary Sciences

Response of engineered cartilage tissue to biochemical agents as studied by proton magnetic resonance microscopy

Objective, To test the hypothesis that magnetic resonance imaging (MRI) results correlate with the biochemical composition of cartilage matrix and can therefore be used to evaluate natural tissue development and the effects of biologic interventions.…

Tags: 2000, acid, anterior cruciate ligament, Arthritis and rheumatism, Butler J J, canine articular-cartilage, Chondrocytes, Horton W E, interleukin-1, Journal Article, matrix, nmr, Osteoarthritis, Potter K, Rheumatology, self-diffusion, Spencer R G S, Water

Advanced osteoarthritis in humans is associated with altered collagen VI expression and upregulation of ER-stress markers Grp78 and bag-1.

To test the hypothesis that a perturbation of endoplasmic reticulum (ER) function is involved in the pathogenesis of osteoarthritis (OA), articular cartilage was isolated from non-OA patients secondary to resection of osteo- or chondrosarcomas.…

Degenerative sternoclavicular arthritis and hyperostosis.

Symptomatic arthritic involvement of the sternoclavicular joint is relatively uncommon and can be a result of distant trauma, infection, and sternocostoclavicular hyperostosis, post-menopausal arthritis, condensing osteitis of the proximal clavicle,…

Tags: 2003, Adult, Arthritis, Arthritis – Classification, Arthritis – Drug Therapy, Arthritis – Surgery, Arthroplasty, Athletic Injuries – Complications, Clinics in sports medicine, Female, Heterotopic, Male, Middle Age, Noble J S, Ossification, Osteitis, Osteoarthritis, Sternoclavicular Joint – Pathology

Comparison of changes in blood pressure measurements and antihypertensive therapy in older, hypertensive, ambulatory care patients prescribed celecoxib or rofecoxib

Study Objective. To determine if changes in blood pressure and changes in class or dosing of antihypertensive drugs were significantly different in patients treated with celecoxib versus rofecoxib, two cyclooxygenase (COX)-2 inhibitors. Design.…

Tags: 2003, congestive-heart-failure, controlled trial, cox-2 inhibitor, Dickerson L M, elderly-patients, gastrointestinal toxicity, Journal Article, Nietert P J, nonsteroidal antiinflammatory drugs, nsaids, Ornstein S M, Osteoarthritis, Pharmacology & Pharmacy, Pharmacotherapy, renal-function, rheumatoid-arthritis, Rothenberg R J

MicroRNA-9 promotion of interleukin-6 expression by inhibiting monocyte chemoattractant protein-induced protein 1 expression in interleukin-1beta-stimulated human chondrocytes.

OBJECTIVE: Enhanced expression of interleukin-6 (IL-6) plays an important role in the pathogenesis of osteoarthritis (OA). Monocyte chemoattractant protein-induced protein 1 (MCPIP-1) is a novel posttranscriptional regulator of IL-6 expression and is…

Tags: 2015, Academic Medical Centers, Aged, Arthritis & rheumatology (Hoboken, N.J.), Articular/drug effects/*metabolism, Cartilage, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism, Cultured, Department of Anatomy & Neurobiology, Enzyme-Linked Immunosorbent Assay, Funding Source, Gene Knockdown Techniques, Haqqi Tariq M, Haseeb Abdul, Hip/*genetics/metabolism, Human, Humans, Immunoblotting – Utilization, Immunoprecipitation, Interleukin-1beta/pharmacology, Interleukin-6/*genetics/metabolism, Interleukins – Physiology, Makki Mohammad S, Messenger/drug effects/*metabolism, MicroRNAs/drug effects/*genetics/metabolism, Middle Aged, NEOMED College of Medicine, Ohio, Osteoarthritis, Osteoarthritis – Complications, Osteoarthritis – Physiopathology, Reverse Transcriptase Polymerase Chain Reaction, Ribonucleases/drug effects/*genetics/metabolism, RNA, T-Tests, Transcription Factors/drug effects/*genetics/metabolism

Fourier Transform Infrared Imaging Spectroscopic Analysis Of Tissue Engineered Cartilage: Histologic And Biochemical Correlations

The composition of cartilage is predictive of its in vivo performance. Therefore, the ability to assess its primary macromolecular components, proteoglycan (PG) and collagen, is of great importance. In the current study, we hypothesized that PG…

Dataset of effect of Wogonin, a natural flavonoid, on the viability and activation of NF-kappaB and MAPKs in IL-1beta-stimulated human OA chondrocytes.

This article contains data related to the article "Wogonin, a plant derived small molecule exerts potent anti-inflammatory and chondroprotective effects through activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes" (Khan…

Tags: 2017, Ansari Mohammad Y, Data in brief, Department of Anatomy & Neurobiology, Devarapalli Pratap, Haqqi Tariq M, Haseeb Abdul, Haynie Sara, Khan Nazir M, MAPK, Mass-spectrometry, NEOMED College of Medicine, NF-kappaB, Nrf2, Osteoarthritis, Wogonin

Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1beta stimulated osteoarthritis chondrocytes.

Wogonin has recently been shown to possess anti-inflammatory and chondroprotective properties and is of considerable interest due to its broad pharmacological activities. The present study highlights that Wogonin binds DNA and exerts…

Medical Care Perceptions In Elderly Patients With Musculoskeletal Complaints

Background: Musculoskeletal complaints represent the second most common reason for visits to a physician, second only to the common cold. The limited capability of medical. treatment for musculoskeletal disease requires modification of communication…

A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-kappaB and IL-6 Expression by Blocking the Activation of IKKbeta and NIK in Primary Human Chondrocytes.

Pomegranate fruit extract (PE) rich in polyphenols has been shown to exert chondroprotective effects, but the mechanism is not established. Here, we used an in vitro model of inflammation in osteoarthritis (OA) to investigate the potential of PE to…

Tags: 2017, Ashruf Omer S, Chondrocytes, Chondrocytes – Drug Effects, Chondrocytes/drug effects, Department of Anatomy & Neurobiology, Fruit, Fruit/chemistry, Gene Expression Regulation/drug effects, Genes – Drug Effects, Haqqi Tariq M, Haseeb Abdul, Humans, I-kappa B Kinase/genetics/*metabolism, IkappaB, IKKbeta, IL-1beta, Interleukin 1 – Metabolism, Interleukin-1beta/metabolism, Interleukin-6/genetics/*metabolism, Interleukins, Interleukins – Metabolism, Khan Nazir M, NEOMED College of Medicine, NF-kappa B, NF-kappa B – Metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, NIK, Osteoarthritis, Phosphorylation – Drug Effects, Phosphorylation/drug effects, Phytotherapy research : PTR, Plant Extracts, Plant Extracts – Pharmacodynamics, Plant Extracts/chemistry/*pharmacology, Polyphenols – Pharmacodynamics, Polyphenols/pharmacology, Pomegranate, Protein-Serine-Threonine Kinases/genetics/*metabolism, Proteins – Metabolism, Punicaceae/*chemistry, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Transcription Factor RelA/metabolism, Transferases, Transferases – Metabolism

Delphinidin Inhibits Il-1 Beta-induced Activation Of Nf-kappa B By Modulating The Phosphorylation Of Irak-1(ser376) In Human Articular Chondrocytes

Objective. In OA, there is enhanced expression of pro-inflammatory cytokines such as IL-1 beta in the affected joint. Delphinidin, an anthocyanidin found in pigmented fruits and vegetables, has been shown to possess anti-inflammatory and antioxidant…

Modification Of Osteoarthritis In The Guinea Pig With Pulsed Low-intensity Ultrasound Treatment

Objective: The Hartley guinea pig develops articular cartilage degeneration similar to that seen in idiopathic human osteoarthritis (OA). We investigated whether the application of pulsed low-intensity ultrasound (PLIUS) to the Hartley guinea pig…

tRNA-derived fragments (tRFs) regulate post-transcriptional gene expression via

OBJECTIVES: Recent studies have shown that tRNA-derived RNA fragments (tRFs) are novel regulators of post-transcriptional gene expression. However, the expression profiles and their role in post-transcriptional gene regulation in chondrocytes is…

Tags: 2020, Ansari M Y, Ball H C, chondrocyte, Department of Anatomy & Neurobiology, Green J A, Haqqi Tariq M, JAK3, journalArticle, June 2020 Update II, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Noncoding RNA, Osteoarthritis, Osteoarthritis and cartilage, Transfer RNA, tRNA-derived fragments

Sacroiliac joint bridging: Demographical and anatomical aspects

Study Design. A descriptive study of the association between sacroiliac joint bridging ( SIB) and age, gender, laterality, and ethnic origin in a normal skeletal population. The effectiveness of radiographs in identifying SIB was also evaluated.…

Patients' reasons for electing to undergo total knee arthroplasty impact post-operative pain severity and range of motion

The present study examines the reasons cited by 103 patients for their electing to undergo total knee arthroplastic surgery and the relationship between these reasons and their post-operative pain and range of motion. Results suggest that individuals…

Contributions of symptomatic osteoarthritis and physical function to incident cardiovascular disease.

BACKGROUND: Osteoarthritis (OA) is associated with worsening physical function and a high prevalence of comorbid health conditions. In particular, cardiovascular disease (CVD) risk is higher in individuals with OA than the general population.…

Tags: 2018, Allen Kelli D, Alvarez Carolina, BMC musculoskeletal disorders, Callahan Leigh F, CARDIOVASCULAR DISEASE, Cleveland Rebecca J, Corsi Michela, Function, Golightly Yvonne M, Jordan Joanne M, Nelson Amanda E, Osteoarthritis, Renner Jordan, Tsai Allen

ECM Production of Primary Human and Bovine Chondrocytes in Hybrid PEG Hydrogels Containing Type I Collagen and Hyaluronic Acid

The development of advanced materials that facilitate hyaline cartilage formation and regeneration in aging populations is imperative. Critical to the success of this endeavor is the optimization of ECM production from clinically relevant cells.…

Associations between biomarkers of joint metabolism, hand osteoarthritis, and hand pain and function: the Johnston County Osteoarthritis Project.

OBJECTIVE: To determine the associations between joint metabolism biomarkers and hand radiographic osteoarthritis [(rOA), based on Kellgren Lawrence (KL) grade \textgreater/= 2], symptoms, and function. METHODS: Cross-sectional data were available…

Tags: 2014, Adult, Aged, Arthralgia – Metabolism, Arthralgia – Physiopathology, Arthralgia – Radiography, Arthralgia/*diagnostic imaging/*metabolism/physiopathology, Aslam Imran, Biological Markers – Blood, Biomarkers, Biomarkers/blood, Carpometacarpal Joints – Metabolism, Carpometacarpal Joints – Physiopathology, Carpometacarpal Joints – Radiography, Carpometacarpal Joints/diagnostic imaging/metabolism/physiopathology, Cross Sectional Studies, Cross-Sectional Studies, Female, Finger Joint – Metabolism, Finger Joint – Physiopathology, Finger Joint – Radiography, Finger Joint/diagnostic imaging/metabolism/physiopathology, Golightly Yvonne M, HAND JOINTS, Hand Joints – Metabolism, Hand Joints – Physiopathology, Hand Joints – Radiography, Hand Joints/*diagnostic imaging/*metabolism/physiopathology, Human, Humans, Jordan Joanne M, Kraus Virginia B, Male, Metacarpophalangeal Joint – Metabolism, Metacarpophalangeal Joint – Physiopathology, Metacarpophalangeal Joint – Radiography, Metacarpophalangeal Joint/diagnostic imaging/metabolism/physiopathology, Middle Age, Middle Aged, Nelson Amanda E, Osteoarthritis, Osteoarthritis – Metabolism, Osteoarthritis – Physiopathology, Osteoarthritis – Radiography, Osteoarthritis/*diagnostic imaging/*metabolism/physiopathology, Perjar Irina, Radiography, Renner Jordan B, Severity of Illness Index, Severity of Illness Indices, Shi Xiaoyan A, The Journal of rheumatology

Assessing chondrocyte status by immunofluorescence-mediated localization of parkin relative to mitochondria.

Tags: 2020, Autophagy, CCCP, Chondrocytes, Confocal microscopy, IL-1β, immunofluorescence, Inflammation, Mitochondria, Mitochondrial dysfunction, mitophagy, MitoTracker Deep Red, Osteoarthritis, Oxidative Stress, Parkin, PINK1

Assessing chondrocyte status by immunofluorescence-mediated localization of parkin relative to mitochondria.

Immunofluorescence staining is a widely used and powerful tool for the visualization and colocalization of two or more proteins and/or cellular organelles. For colocalization studies in fixed cells, one target protein/organelle is immunostained and…

Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols.

Osteoarthritis (OA) is the most prevalent joint degenerative disease leading to irreversible structural and functional changes in the joint and is a major cause of disability and reduced life expectancy in ageing population. Despite the high …

Tags: 2020, Ahmad N, Ansari MY, August 2020 List, Biomedicine & Pharmacotherapy, Chondrocytes, Department of Anatomy & Neurobiology, Haqqi TM, Inflammation, journalArticle, NEOMED College of Medicine, Nrf2, Osteoarthritis, Polyphenols, Redox

A standardized extract of Butea monosperma (Lam.) flowers suppresses the

BACKGROUND/OBJECTIVE: Osteoarthritis (OA) is a leading cause of joint dysfunction, disability and poor quality of life in the affected population. The underlying mechanism of joint dysfunction involves increased oxidative stress, inflammation, high…

Genetic Inactivation of ZCCHC6 Suppresses Interleukin‐6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice.

Objective: Cytokine expression is tightly regulated posttranscriptionally, but high levels of interleukin‐6 (IL‐6) in patients with osteoarthritis (OA) indicate that regulatory mechanisms are disrupted in this disorder. The enzyme ZCCHC6 (zinc‐finger…

Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1beta Stimulated Human Chondrocytes.

BACKGROUND/AIMS: Butein (2',3,4,4'-Tetrahydroxychalcone), a polyphenol produced by several plants including Butea monoserpma, has been reported to exert potent anti-inflammatory activity but the mechanism remains unknown. In the present work we…

Tags: 2018, Ahmad Nashrah, AMP-Activated Protein Kinases/metabolism, AMPK, Ansari Mohammad Y, Articular/cytology/pathology, Autophagy, Autophagy-Related Protein 5/antagonists & inhibitors/genetics/metabolism, Autophagy-Related Protein-1 Homolog/metabolism, Autophagy/*drug effects, Butein, Cartilage, Cell Survival/drug effects, Cells, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Chalcones/*pharmacology, Chondrocytes/cytology/drug effects/metabolism, Cultured, Department of Anatomy & Neurobiology, Haqqi Tariq M, Humans, Inflammation, Interleukin-1beta/*pharmacology, Interleukin-6/genetics/*metabolism, Intracellular Signaling Peptides and Proteins/metabolism, mTOR, NEOMED College of Medicine, Osteoarthritis, Osteoarthritis/metabolism/pathology, Phosphorylation/drug effects, Reactive Oxygen Species/metabolism, RNA, RNA Interference, Signal Transduction/*drug effects, Small Interfering/metabolism, TOR Serine-Threonine Kinases/metabolism, TSC2, Tuberous Sclerosis Complex 2 Protein, Tumor Suppressor Proteins/metabolism, ULK1

Browse Items (47 total)