Browse Items · NEOMED Bibliography Database

HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).

The gene for cholesterol 7alpha-hydroxylase (CYP7A1) contains a sequence at nt -149 to -118 that was found to play a large role in determining the overall transcriptional activity and regulation of the promoter. Hepatocyte nuclear factor 4 (HNF4) and…

American College of Rheumatology–63rd annual meeting. 13-17 November 1999, Boston, MA, USA.

The 63rd National Scientific Meeting of the American College of Rheumatology was quite general in scope, with clinical and animal model studies forming the basis for this report. Arthritis-suppressive medications were further analyzed as to morbidity…

Tags: 2000, IDrugs : the investigational drugs journal, Rothschild B

Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.

Fibrates are widely used hypolipidemic drugs that regulate the expression of many genes involved in lipid metabolism by activating the peroxisome proliferator-activated receptor alpha (PPARalpha). The objective of this study was to investigate the…

Tags: *DNA-Binding Proteins, *Regulatory Sequences, 2000, Animals, Anticholesteremic Agents/pharmacology, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Clofibric Acid/pharmacology, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Enzymologic, Gene Expression Regulation, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Marrapodi M, Models, NEOMED College of Medicine, Nucleic Acid, Peroxisome Proliferators/pharmacology, Phosphoproteins/metabolism, Promoter Regions, Protein Binding, Pyrimidines/pharmacology, Rats, Receptors, Reporter, Response Elements, Retinoic Acid/metabolism, Retinoid X Receptors, Species Specificity, Transcription, Transcription Factors/*agonists/metabolism, Transcriptional Activation

Rat alpha1-macroglobulin enhances nerve growth factor-promoted neurite outgrowth, TrkA phosphorylation, and gene expression of pheochromocytoma PC12 cells.

Monoamine-activated human alpha2-macroglobulin (alpha2M) has been previously demonstrated to inhibit TrkA-, TrkB-, and TrkC-mediated signal transduction. Rat alpha1-macroglobulin (alpha1M) and alpha2M are structural homologues of human alpha2M, but…

Learning to be present to dying patients.

Tags: *Attitude to Death, *Physician's Role, 2000, Hospices, Humans, Kohn M, Medical/psychology, Minnesota medicine, Students, Terminal Care/*psychology

Differences in the preparation and practice of male and female physicians from combined baccalaureate–MD degree programs.

OBJECTIVE: To account for age and premedical education in determining whether or not men and women medical school graduates differ significantly in opinions of their medical school preparation, in professional activities, and in personal qualities…

Oxytocin induces preservation of social recognition in male rats by activating alpha-adrenoceptors of the olfactory bulb.

In this report, a series of four experiments was performed to evaluate the relationship between the olfactory bulb norepinephrine system and intra-olfactory bulb infusion of oxytocin in the preservation of social memory responses. The present data…

Neuroprotective effects of estrogen upon the nigrostriatal dopaminergic system.

In this mini-review are first presented data which highlight the capacity and characteristics for estrogen to act as a neuroprotectant of the nigrostriatal dopaminergic system. Estrogen administration significantly attenuates the degree of striatal…

Tags: 2000, Animals, Corpus Striatum/metabolism, Dluzen D E, Dopamine/*physiology, Estrogens/*metabolism, Humans, Journal of neurocytology, Neurons/*metabolism, Neuroprotective Agents/*metabolism, Substantia Nigra/*metabolism

Gender differences in neurotoxicity of the nigrostriatal dopaminergic system: implications for Parkinson's disease.

This article describes the progression of steps followed to demonstrate a gender difference associated with Parkinson's disease (PD) and to gain an understanding of the basis, mechanisms, and implications of this gender specificity. First, a review…

Tags: 2000, Animal, Corpus Striatum/pathology/*physiopathology, Disease Models, Dluzen D E, Dopamine/metabolism, Estrogens/*pharmacology, Female, Humans, Male, McDermott J L, Neurotoxins/*antagonists & inhibitors, Parkinson Disease/metabolism/pathology/*physiopathology, Postmenopause, Sex Distribution, Sex Factors, Substantia Nigra/pathology/*physiopathology, The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia

Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.

Cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription is repressed by bile acids. The goal of this study is to elucidate the mechanism of CYP7A1 transcription by bile acid-activated farnesoid X receptor (FXR) in its native promoter and cellular…

Update on antiviral therapy for genital herpes infection.

For the primary infection of genital herpes, antiviral therapy with acyclovir is the gold standard. For recurrences, there are two options: antiviral treatment of each outbreak as it arises, or suppression of outbreaks with daily oral therapy.…

Underlying causes of erythema nodosum. Lesions may provide clue to systemic disease.

Tags: *Erythema Nodosum/diagnosis/drug therapy/etiology, 2000, Administration, Adult, Anti-Inflammatory Agents/therapeutic use, Brodell R T, Clobetasol/*analogs & derivatives/therapeutic use, Contraceptives, Female, Glucocorticoids, Humans, Mehrabi D, Oral/adverse effects, Postgraduate medicine, Pregnancy, Pregnancy Complications, Topical

Antifungal drug interactions. Avoidance requires more than memorization.

Tags: *Drug Interactions, 2000, Antifungal Agents/*adverse effects, Brodell R T, Cardiotonic Agents/*adverse effects, Digoxin/*adverse effects, Elewski B, Humans, Itraconazole/*adverse effects, Male, Middle Aged, Nail Diseases/*drug therapy, Postgraduate medicine, Tinea Pedis/*drug therapy

Review of the sulfonamides and trimethoprim.

Tags: 2000, Anti-Infective Agents/adverse effects/pharmacology/*therapeutic use, Bacterial Infections/*drug therapy, Child, Drug Interactions, Humans, Pediatrics in review, Powell K R, Smith C L, Sulfamethoxazole Drug Combination/*therapeutic use, Sulfonamides/adverse effects/pharmacology/*therapeutic use, Trimethoprim, Urinary Tract Infections/drug therapy

Spectral integration in the inferior colliculus of the mustached bat.

Acoustic behaviors including orientation and social communication depend on neural integration of information across the sound spectrum. In many species, spectral integration is performed by combination-sensitive neurons, responding best when…

Asian/Pacific Islander women in medical education: personal and professional challenges.

PURPOSE: The purpose of this qualitative study was to identify the complex issues facing Asian/Pacific Islander (API) women students at one Midwestern medical school as they subjectively experience their medical training. Of particular interest was…

Tags: *Asian Americans, 2000, Career Choice, Cultural Diversity, Decision Making, Department of Family & Community Medicine, Family, Female, Humans, Medical/*psychology, NEOMED College of Medicine, Students, Teaching and learning in medicine, Wear D, Women/*psychology

Gemifloxacin versus amoxicillin/clavulanate in the treatment of acute exacerbations of chronic bronchitis. The 070 Clinical Study group.

Six hundred patients were evaluated in this randomized, double-blind, double-dummy, multicenter, parallel-group study comparing the efficacy and safety of gemifloxacin (320 mg once-daily for 5 days) and amoxicillin/clavulanate (500/125 mg three-times…

Tags: *Fluoroquinolones, 2000, 80 and over, Acute-Phase Reaction, Adult, Aged, Amoxicillin/pharmacology/therapeutic use, Anti-Infective Agents/adverse effects/pharmacology/*therapeutic use, Bronchitis/*drug therapy, Chronic Disease, Clavulanic Acid/pharmacology/therapeutic use, Combination/pharmacology/*therapeutic use, Department of Internal Medicine, Double-Blind Method, Drug Therapy, Female, File T, Garau J, Gemifloxacin, Haemophilus influenzae/drug effects, Humans, Journal of chemotherapy (Florence, Italy), Lode H, Lynch S, Male, Microbial Sensitivity Tests, Middle Aged, Moraxella (Branhamella) catarrhalis/drug effects, Multicenter Studies as Topic, Naphthyridines/adverse effects/pharmacology/*therapeutic use, NEOMED College of Medicine, Schlemmer B, Streptococcus pneumoniae/drug effects, Treatment Outcome, Young C

Inactivation of one copy of the mouse neurotrophin-3 gene induces cardiac sympathetic deficits.

Whether two copies of the neurotrophin-3 (NT3) gene are necessary for proper development of cardiac sympathetic innervation was investigated in mice carrying a targeted inactivation of the NT3 gene. Heterozygous (+/-) and null (-/-) mutant mice had…

Differential glycosylation of the Cas-Br-E env protein is associated with retrovirus-induced spongiform neurodegeneration.

The wild mouse ecotropic retrovirus, Cas-Br-E, induces progressive, noninflammatory spongiform neurodegenerative disease in susceptible mice. Functional genetic analysis of the Cas-Br-E genome indicates that neurovirulence maps to the env gene, which…

Tags: 2000, Animals, Brain/metabolism/*pathology/*virology, Gammaretrovirus/genetics/metabolism/*pathogenicity, Glycosylation, Journal of virology, Lynch W P, Mice, Protein Isoforms, Retroviridae Infections/pathology/*virology, Sharpe A H, Viral Envelope Proteins/chemistry/genetics/*metabolism

Neuroprotective role of estrogen upon methamphetamine and related neurotoxins within the nigrostriatal dopaminergic system.

In this report we describe some of the data on the capacity for estrogen to function as a neuroprotectant of the nigrostriatal dopaminergic (NSDA) system. The data show that estrogen (E) can alter two different response characteristics to NSDA…

Tags: 2000, Animals, Annals of the New York Academy of Sciences, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Drug Interactions, Estrogens/*administration & dosage, McDermott J L, Methamphetamine/antagonists & inhibitors/*toxicity, Neurotoxins/antagonists & inhibitors/*toxicity, Substantia Nigra/*drug effects/metabolism, Time Factors

Experimental use of fibrin glue to induce site-directed osteogenesis from cultured periosteal cells.

The purpose of this study was to determine whether a combination of fibrin glue and cultured periosteal cells will result in new bone formation at heterotopic sites in nude mice. Growing cells and developing matrices surrounding periosteal explants…

Streptococcus pneumoniae antimicrobial susceptibility testing.

Tags: *Drug Resistance, 2000, Anti-Bacterial Agents/*pharmacology, Child, Humans, Infant, Microbial, Microbial Sensitivity Tests/*methods, Preschool, Sensitivity and Specificity, Streptococcus pneumoniae/*drug effects/isolation & purification, The Pediatric infectious disease journal, Venglarcik J S 3rd

Testicular health awareness in pubertal males.

PURPOSE: We examined the knowledge and understanding of male teenagers of the necessity for genital examination, and signs and symptoms of serious testicular pathology. Furthermore, current national guidelines for health education were reviewed to…

Anomalous dose assessment associated with film badge storage in a controlled area.

Higher than expected film badge readings were obtained for radiologic technologists operating computed tomography scanners. The cause of the erroneous dose assignments was determined to be improper storage of the film packet in the console area.…

Tags: *Occupational Exposure, *Photons, *Radiation Dosage, *Technology, *Tomography, 2000, Film Dosimetry/*instrumentation, Health physics, Hedrick W R, Humans, Radiation Protection, Radiologic, Reproducibility of Results, Starchman D E, Workforce, X-Ray Computed

Painless enlarging subcutaneous mass in a 58-year-old woman.

Functioning liver metastases on an I-131 whole-body scan: a case of malignant struma ovarii.

A 46-year-old women was examined for severe constipation. Pelvic examination revealed a large pelvic mass extending to the level of the umbilicus. Computed tomography showed a large multicystic, septated mass in the pelvis and a small amount of fluid…

The development of professionalism: curriculum matters.

The authors propose that professionalism, rather than being left to the chance that students will model themselves on ideal physicians or somehow be permeable to other elements of professionalism, is fostered by students' engagement with significant,…

Tags: *Clinical Competence, 2000, Academic medicine : journal of the Association of American Medical Colleges, Castellani B, Curriculum/standards, Delivery of Health Care/economics, Department of Family & Community Medicine, Education, Humans, Medical/standards, NEOMED College of Medicine, Professional Practice/*standards, Research, Schools, Science, Wear D

Creating a culture of professionalism: an integrated approach.

Tags: *Education, *Professional Practice, 2000, Academic medicine : journal of the Association of American Medical Colleges, Coldwell L L, Department of Family & Community Medicine, Gibson D D, Kiewit S F, Medical, NEOMED College of Medicine, Ohio

Measuring the costs of primary care education in the ambulatory setting.

In 1995, the authors obtained cost, operations, and educational activity data from 98 ambulatory care sites across the United States in which primary care teaching was occurring and compared those data with the corresponding data from 84 ambulatory…

Tags: *Ambulatory Care, 2000, Academic medicine : journal of the Association of American Medical Colleges, Boex J R, Boll A, Budgets, Costs and Cost Analysis, Department of Family & Community Medicine, Education, Franzini L, Hogan A J, Irby D, Medical/*economics, Meservey P M, NEOMED College of Medicine, Rubin R M, Seifer S D, United States, Veloski J J

First European exposure to syphilis: the Dominican Republic at the time of Columbian contact.

Recognition of syphilis in Europe in the late 15th century and its prior absence suggest New World origin. Skeletal populations were examined from sites with documented Columbian contact in the Dominican Republic. Examination of 536 skeletal remains…

Using O2 to probe membrane immersion depth by 19F NMR.

A fluorinated detergent, CF(3)(CF(2))(5)C(2)H(4)-O-maltose, was reconstituted into a lipid bilayer model membrane system to demonstrate the feasibility of determining solvent accessibility and membrane immersion depth of each fluorinated group by…

Tags: *Hydrocarbons, *Oxygen, 2000, Biological, Cyclic N-Oxides, Dimyristoylphosphatidylcholine/*chemistry, Fluorinated, Fluorine, Lipid Bilayers/*chemistry, Luchette P A, Magnetic Resonance Spectroscopy/*methods, Maltose/*analogs & derivatives, Models, Phospholipid Ethers/*chemistry, Pressure, Proceedings of the National Academy of Sciences of the United States of America, Prosser R S, Spin Labels, Westerman P W

Panniculectomy at the time of gynecologic surgery in morbidly obese patients.

OBJECTIVE: Our goal was to demonstrate that panniculectomy performed at the time of gynecologic surgery aids in reducing the operative time and exposure and does not increase the wound infection rate in morbidly obese patients. STUDY DESIGN: A…

The myths of laparoscopic surgery.

Laparoscopic surgery has been rapidly accepted without rigorous scientific study. New procedures and technologies have advanced rapidly, and most gynecologists have embraced these techniques. I believe that the new technology has given rise to the…

Tags: *Laparoscopy/economics, 2000, American journal of obstetrics and gynecology, Costs and Cost Analysis, Female, Female/surgery, General Surgery/education, Genital Neoplasms, Gynecologic Surgical Procedures/methods, Hopkins M P, Humans

The prevalence of thromboembolic events among women with extended bed rest prescribed as part of the treatment for premature labor or preterm premature rupture of membranes.

OBJECTIVE: This study was undertaken to determine the prevalence of thromboembolic events among women with extended bed rest prescribed as part of the treatment of premature labor or preterm premature rupture of membranes. STUDY DESIGN: A…

The bronchodilator effect of intravenous glucagon in asthma exacerbation: a randomized, controlled trial.

STUDY OBJECTIVE: Glucagon is a rapid-acting smooth muscle relaxant with a short half-life. Previous studies suggested glucagon may have bronchodilator effects. We sought to determine whether intravenous glucagon produces clinically important…

Chlamydia pneumoniae pneumonia.

Chlamydia pneumoniae is a common cause of community-acquired pneumonia. At present there is no "gold” standard for diagnosis and there is no easily accessible means of rapid diagnosis available. The best indication of acute C. pneumoniae infection is…

Tags: 2000, Department of Internal Medicine, File T M Jr, NEOMED College of Medicine, Seminars in respiratory and critical care medicine, Tan J S

The epidemiology of respiratory tract infections.

Respiratory tract infections (RTIs) are the most common, and potentially most severe, of infections treated by health care practitioners. Lower RTIs along with influenza, are the most common cause of death by infection in the United States. Risk…

Urokinase Plasminogen Activator Receptor (uPAR): A Potential Indicator of Invasion for In Situ Breast Cancer.

Urokinase plasminogen activator (uPA) and its cellular receptor (uPAR) are important mediators in the cellular process of cancer invasion and metastasis. Ductal carcinoma in situ (DCIS) is classified by lack of invasion into the adjacent stroma, yet…

Tags: 2000, Evans Douglas M, Guyton Daniel P, Sloan-Stakleff Kimberly D, The breast journal

Long-term evaluation of the long-pulsed alexandrite laser for the removal of bikini hair at shortened treatment intervals.

BACKGROUND: Laser-assisted hair removal is becoming the treatment of choice for removing unwanted hair. OBJECTIVE: The purpose of this work was to determine the long-term efficacy of the long-pulsed infrared (LPIR) laser at shortened treatment…

Tags: *Laser Therapy, 2000, Adolescent, Adult, Department of Internal Medicine, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], Female, Hair Removal/*methods, Humans, Lloyd J R, Male, Middle Aged, Mirkov Mirko, NEOMED College of Medicine, Time Factors, Treatment Outcome

Female circumcision: at our doorsteps and beyond.

Recent trends in international travel and emigration have brought the practice of female circumcision, also known as female genital mutilation, to the awareness of an increasing number of physicians and public policy agencies in developed countries.…

Tags: 2000, Hecht, Hopkins, Meniru, Primary care update for Ob/Gyns

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