Browse Items · NEOMED Bibliography Database

A three-dimensional digital neurological atlas of the mustached bat (Pteronotus parnellii).

Substantial knowledge of auditory processing within mammalian nervous systems emerged from neurophysiological studies of the mustached bat (Pteronotus parnellii). This highly social and vocal species retrieves precise information about the velocity…

Postsynaptic FMRP Regulates Synaptogenesis In Vivo in the Developing Cochlear Nucleus.

A global loss of the fragile X mental retardation protein (FMRP; encoded by the Fmr1 gene) leads to sensory dysfunction and intellectual disabilities. One underlying mechanism of these phenotypes is structural and functional deficits in synapses.…

Tags: 2018, auditory processing, dendritic maturation, Department of Anatomy & Neurobiology, endbulb synapse, fragile X mental retardation protein, Lu Yong, NEOMED College of Medicine, Schecterson Leslayann, The Journal of neuroscience : the official journal of the Society for Neuroscience, trans-synaptic regulation, Wang Xiaoyu, Wang Yuan, Zorio Diego A R

Synaptic activity-induced Ca(2+) signaling in avian cochlear nucleus magnocellularis neurons.

Neurons of the avian cochlear nucleus magnocellularis (NM) receive glutamatergic inputs from the spiral ganglion cells via the auditory nerve and feedback GABAergic inputs primarily from the superior olivary nucleus. We investigated regulation of…

Intracellular recording reveals temporal integration in inferior colliculus neurons of awake bats.

The central nucleus of the inferior colliculus (IC) is a major integrative center in the central auditory system. It receives information from both the ascending and descending auditory pathways. To determine how single IC neurons integrate…

Tags: 2007, Acoustic Stimulation, Animals, Chiroptera/*physiology, Data Interpretation, Department of Anatomy & Neurobiology, Electrophysiology, Excitatory Postsynaptic Potentials/physiology, Galazyuk A V, Inferior Colliculi/cytology/*physiology, Inhibitory Postsynaptic Potentials/physiology, Journal of neurophysiology, Microelectrodes, NEOMED College of Medicine, Neurons/*physiology, Pitch Perception, Statistical, Voytenko S V

Timing of sound-evoked potentials and spike responses in the inferior colliculus of awake bats.

Neurons in the inferior colliculus (IC), one of the major integrative centers of the auditory system, process acoustic information converging from almost all nuclei of the auditory brain stem. During this integration, excitatory and inhibitory inputs…

mGluRs modulate neuronal firing in the auditory midbrain.

The mechanisms underlying sound-evoked suppression of neuronal firing in the auditory system are poorly understood. To explore these mechanisms in the inferior colliculus (IC), agonists and antagonists targeting different groups of metabotropic…

The Masticatory Apparatus of Humans (Homo sapiens): Evolution and Comparative Functional Morphology

Feeding and diet played key roles in human evolution. It is well known that modern humans have a small masticatory apparatus for their body size among primates. However, identifying gracility does not necessarily tell us about the relative functional…

Synergistic antitumour activity of vitamins C and K3 against human prostate carcinoma cell lines.

Vitamins C, K3 (VC, VK3) and a VC/VK3 combination with a VC:VK3 ratio of 100:1 were assayed for their antitumour activity against two human prostatic carcinoma cell lines. Co-administration of the vitamins enhanced the antitumour activity 5- to…

Identification of Novel Agents for the Treatment of Brain Metastases of Breast Cancer.

BACKGROUND: Brain cancer from metastasized breast cancer has a high mortality rate in women. The treatment of lesions is hampered in large part by the blood-brain barrier (BBB), which prevents adequate distribution of anti-cancer compounds to brain…

Sauce it up: influence of condiment properties on oral processing behavior, bolus formation and sensory perception of solid foods.

Condiments are rarely consumed on their own. Although addition of condiments to carrier foods is known to affect oral processing behavior and sensory perception, an understanding of how different condiment properties impact oral processing behavior…

Tags: 2020, Department of Anatomy & Neurobiology, Fogliano V, Food & function, Franks E, Galindo-Cuspinera V, journalArticle, July 2020 List, NEOMED College of Medicine, Scholten E, Stieger M, van Eck A, Vinyard CJ

Monkey business: Collaborating to grow an ecological physiology of primates

The lab and field provide differing approaches to studying primate biology. We outline the challenges and benefits of these approaches and demonstrate how collaboration can help bridge these perspectives to provide complementary insight into primate…

Tags: 2019, adaptive pathways, American journal of primatology, collaboration, Department of Anatomy & Neurobiology, ecological physiology, field studies, June 2019 Update, laboratory experiments, NEOMED College of Medicine, Thompson Cynthia L, Vinyard Christopher J

Callitrichid responses to dead and dying infants: the effects of paternal bonding and cause of death.

Many primates show responses to dead infants, yet testing explanations for these behaviors has been difficult. Callitrichids present a unique opportunity to delineate between hypotheses, since unlike most species, male caretakers form closer social…

Nocturnal foragers exploit tree exudates from holes gouged by diurnal common marmoset monkeys (Callithrix jacchus).

Tags: 2020, de Oliveira Maria A B, Department of Anatomy & Neurobiology, Gapp Lauren M, Integrative zoology, journalArticle, June 2020 Update II, Melo Leonardo C O, NEOMED College of Medicine, Thompson Cynthia L, Vinyard Christopher J

What smells? Developing in-field methods to characterize the chemical composition of wild mammalian scent cues

Olfactory cues play an important role in mammalian biology, but have been challenging to assess in the field. Current methods pose problematic issues with sample storage and transportation, limiting our ability to connect chemical variation in scents…

Getting humans off monkeys' backs: Using primate acclimation as a guide for habitat management efforts.

Wild primates face grave conservation challenges, with habitat loss and climate change projected to cause mass extinctions in the coming decades. As large-bodied Neotropical primates, mantled howling monkeys (Alouatta palliata) are predicted to fare…

Tags: 2020, acclimation, Alouatta, climate change, Department of Anatomy & Neurobiology, Glander Kenneth E, habitat management, Integrative and comparative biology, journalArticle, July 2020 List, NEOMED College of Medicine, Primates, Teaford MF, Thompson CL, Vinyard CJ, Williams SH

DOES SCENT MARK COMPOSITION DEMONSTRATE A RELATIONSHIP WITH FEEDING BEHAVIOR IN WILD COMMON MARMOSET MONKEYS (CALLITHRIX JACCHUS) IN PERNAMBUCO, BRAZIL?

Tags: 2020, American journal of primatology, Bottenberg Kimberly N, de Oliveira M A, Department of Anatomy & Neurobiology, Journal Article, journalArticle, June 2020 Update I, Lantz A W, Melo L C, NEOMED College of Medicine, Thompson C L, Vinyard Christopher J

Skeletons of terrestrial cetaceans and the relationship of whales to artiodactyls.

Modern members of the mammalian order Cetacea (whales, dolphins and porpoises) are obligate aquatic swimmers that are highly distinctive in morphology, lacking hair and hind limbs, and having flippers, flukes, and a streamlined body. Eocene fossils…

Tags: *Biological Evolution, *Fossils, 2001, Animals, Bone and Bones/*anatomy & histology, Cetacea/anatomy & histology/*classification, Department of Anatomy & Neurobiology, Hussain S T, Nature, NEOMED College of Medicine, Phylogeny, Roe L J, Skeleton, Thewissen J G, Whales/anatomy & histology/*classification, Williams E M

Ankle morphology of the earliest Cetaceans and its implications for the phylogenetic relations among ungulates.

Recent molecular studies are inconsistent with ungulate phylogenetic trees that are based on morphological traits. These inconsistencies especially relate to the position of cetaceans and perissodactyls. Evaluation of the close phylogenetic ties…

Tags: *Phylogeny, 1999, Animals, Cetacea/*anatomy & histology/classification, Department of Anatomy & Neurobiology, Hindlimb/anatomy & histology, Joints/*anatomy & histology, Madar S I, NEOMED College of Medicine, Ruminants/*anatomy & histology/classification, Systematic biology, Thewissen J G

New Kohatius (Omomyidae) from the Eocene of Pakistan.

Tags: *Primates, 1997, Animals, Arif M, Department of Anatomy & Neurobiology, Hussain S T, Journal of human evolution, NEOMED College of Medicine, Pakistan, Thewissen J G, Tooth/*ultrastructure

Evolutionary aspects of the development of teeth and baleen in the bowhead whale.

In utero, baleen whales initiate the development of several dozens of teeth in upper and lower jaws. These tooth germs reach the bell stage and are sometimes mineralized, but toward the end of prenatal life they are resorbed and no trace remains…

Thewissen et al. reply.

Replying to: J. H. Geisler & J. M. Theodor 458, 10.1038/nature07776 (2009)The analysis of Geisler and Theodor confirms our main phylogenetic result, that raoellids are, or include, the sister group to cetaceans. Their study expands on our findings by…

Tags: 2009, Bajpai Sunil, Clementz Mark T, Cooper Lisa Noelle, Department of Anatomy & Neurobiology, LETTERS to the editor, Nature, NEOMED College of Medicine, Thewissen J G M, Tiwari B N, WHALES

Whales originated from aquatic artiodactyls in the Eocene epoch of India.

Although the first ten million years of whale evolution are documented by a remarkable series of fossil skeletons, the link to the ancestor of cetaceans has been missing. It was known that whales are related to even-toed ungulates (artiodactyls), but…

Developmental basis for hind-limb loss in dolphins and origin of the cetacean bodyplan.

Among mammals, modern cetaceans (whales, dolphins, and porpoises) are unusual in the absence of hind limbs. However, cetacean embryos do initiate hind-limb bud development. In dolphins, the bud arrests and degenerates around the fifth gestational…

Tags: *Body Patterning, 2006, Animals, Bajpai S, Cell Polarity, Cohn M J, Department of Anatomy & Neurobiology, Developmental, Dolphins/*embryology/genetics/metabolism, Gene Expression Regulation, Heyning J, Hindlimb/cytology/*embryology/metabolism, Horton W E Jr, Limb Buds/cytology/embryology/metabolism, NEOMED College of Medicine, Phylogeny, Proceedings of the National Academy of Sciences of the United States of America, Stevens L S, Thewissen J G M

The dental microwear of hard-object feeding in laboratory Sapajus apella and its implications for dental microwear formation.

OBJECTIVES: This study seeks to determine if (a) consumption of hard food items or a mixture of food items leads to the formation of premolar or molar microwear in laboratory capuchin monkeys (Sapajus apella) in one feeding session and (b) rates of…

Tags: 2020, American journal of physical anthropology, dental impressions, Department of Anatomy & Neurobiology, ingestion, Mastication, NEOMED College of Medicine, New World monkey, Ross Callum F, Scanning Electron Microscopy, Taylor Andrea B, Teaford Mark F, Ungar Peter S, Vinyard Christopher J

Dental microwear in laboratory primates: Insights into the complexity of dental microwear formation

Dental microwear analysis has been employed in studies of a wide range of modern and fossil animals, yielding many insights into the biology/ecology of those taxa. Paleoanthropological studies have produced both expected and unexpected results (e.g.,…

Tags: 2019, 88th Annual Meeting of the American Association of Physical Anthropologists (2019), American journal of physical anthropology, Anthropology, Department of Anatomy & Neurobiology, Evolutionary Biology, Journal Article, Laird M F, NEOMED College of Medicine, Ross C F, Taylor A B, Teaford M F, Ungar P S, Vinyard C J

The influence of masseter and temporalis sarcomere length operating ranges as determined by laser diffraction on architectural estimates of muscle force and excursion in macaques (Macaca fascicularis and Macaca mulatta)

OBJECTIVE: Determine sarcomere length (Ls) operating ranges of the superficial masseter and temporalis in vitro in a macaque model and examine the impact of position-dependent variation on Ls and architectural estimates of muscle function (i.e.,…

Tags: 2019, Archives of oral biology, Department of Anatomy & Neurobiology, fiber length, Macaque, Masseter, NEOMED College of Medicine, Sarcomere length, September 2019 Update, Taylor Andrea B, Temporalis, Terhune Claire E, Vinyard Christopher J

Putting it on display: The musculoskeletal consequences of large gapes in male Old World monkeys

Tags: 2020, American journal of physical anthropology, Department of Anatomy & Neurobiology, Journal Article, journalArticle, June 2020 Update I, NEOMED College of Medicine, Ross Callum F, Taylor Andrea B, Teaford Mark F, Terhune Claire E, Vinyard Christopher J

In situ fiber length estimates from sectioned muscle bellies are not systematically shorter compared with fiber length estimates obtained using chemical digestion.

Architectural characteristics of skeletal muscles are important determinants of whole muscle function. Fiber length (Lf) and physiologic cross‐sectional area (PCSA) are correlated with skeletal muscle excursion/contraction velocity and force,…

Tags: 2020, Department of Anatomy & Neurobiology, Faseb Journal, journalArticle, NEOMED College of Medicine, September 2020 List, Taylor A, Vinyard CJ

Development of GPCR modulation of GABAergic transmission in chicken nucleus laminaris neurons.

Neurons in the nucleus laminaris (NL) of birds act as coincidence detectors and encode interaural time difference to localize the sound source in the azimuth plane. GABAergic transmission in a number of CNS nuclei including the NL is subject to a…

Tags: *Synaptic Transmission, 2012, Animals, Brain/*cytology, Chickens/*metabolism, Department of Anatomy & Neurobiology, G-Protein-Coupled/*metabolism, GABA-A/metabolism, GABA-B/metabolism, gamma-Aminobutyric Acid/*metabolism, Lu Yong, Metabotropic Glutamate/metabolism, NEOMED College of Medicine, Neurons/*metabolism, Patch-Clamp Techniques, PloS one, Receptors, Synapses/metabolism, Tang Zheng-Quan

Two GABAA responses with distinct kinetics in a sound localization circuit.

The temporal characteristics and functional diversity of GABAergic inhibition are determined by the spatiotemporal neurotransmitter profile, intrinsic properties of GABAA receptors, and other factors. Here, we report two distinct GABAA responses and…

Tags: *Sound, 2012, Animals, Chick Embryo, Chickens, Department of Anatomy & Neurobiology, Female, GABA-A/*physiology, gamma-Aminobutyric Acid/metabolism, Lu Yong, Male, NEOMED College of Medicine, Neurons/*metabolism, Pitch Discrimination, Receptors, Sound Localization/*physiology, Synapses/physiology, Tang Zheng-Quan, The Journal of physiology

Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons.

Metabotropic glutamate receptor (mGluR)-dependent homosynaptic long-term depression (LTD) has been studied extensively at glutamatergic synapses in the CNS. However, much less is known about heterosynaptic long-term plasticity induced by mGluRs at…

Tags: 2013, Amino Acids/pharmacology, Animals, Chick Embryo, Cochlear Nucleus/drug effects/metabolism, Curry Rebecca J, Cyclopropanes/pharmacology, Department of Anatomy & Neurobiology, Dinh Emilie Hoang, Excitatory Amino Acid Agonists/pharmacology, Excitatory Amino Acid Antagonists/pharmacology, Excitatory Postsynaptic Potentials/drug effects/physiology, GABAergic Neurons/drug effects/*metabolism, Glycine/analogs & derivatives/pharmacology, Hamlet William R, Inhibitory Postsynaptic Potentials/drug effects/physiology, Liu Yu-Wei, Long-Term Synaptic Depression/drug effects/*physiology, Lu Yong, Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism, NEOMED College of Medicine, Neural Inhibition/drug effects/physiology, Receptors, Shi Wei, Synapses/drug effects/*metabolism, Synaptic Transmission/drug effects/*physiology, Tang Zheng-Quan, The Journal of neuroscience : the official journal of the Society for Neuroscience, Xanthenes/pharmacology

Control of a depolarizing GABAergic input in an auditory coincidence detection circuit.

Neurons in the chicken nucleus laminaris (NL), the third-order auditory neurons that detect the interaural time differences that enable animals to localize sounds in the horizontal plane, receive glutamatergic excitation from the cochlear nucleus…

Ambient GABA-activated tonic inhibition sharpens auditory coincidence detection via a depolarizing shunting mechanism.

Tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABA(A)Rs) has emerged as a novel form of neural inhibition in the CNS. However, little is known about its presence and function in the auditory system. Using whole-cell recordings in…

Canertinib induces ototoxicity in three preclinical models.

Neuregulin-1 (NRG1) ligand and its epidermal growth factor receptor (EGFR)/ERBB family regulate normal cellular proliferation and differentiation in many tissues including the cochlea. Aberrant NRG1 and ERBB signaling cause significant hearing…

Microglial proliferation in the spinal cord of aged rats with a sciatic nerve injury.

Nerve injury may lead to chronic neuropathic pain syndromes. We determined whether the extent of central nervous system microglial activation that accompanies nerve injury is age dependent and correlated with behavioral manifestations of pain. We…

Neuropathic pain in aged rats: behavioral responses and astrocytic activation.

We used the Bennett and Xie (1988) model of chronic neuropathic pain to study the effect of age on thermal and tactile sensitivity and on astrocytic activation in the dorsal horn of the spinal cord after nerve injury. Fischer 344 FBNF1 hybrid rats in…

Swallow Safety in Infant Pigs With and Without Recurrent Laryngeal Nerve Lesion.

Aerodigestive coordination is critical for safe feeding in mammals, and failure to do so can result in aspiration. Using an infant pig model, we analyzed the impact of recurrent laryngeal nerve (RLN) lesion on aerodigestive coordination and swallow…

Tags: 2020, aerodigestive, Animal model, Bond Laura E, Department of Anatomy & Neurobiology, Dysphagia, German Rebecca Z, Gould François D H, Mayerl Christopher J, NEOMED College of Medicine, NEOMED Postdoc Publications, neonate, Respiration, Stricklen Bethany M

Palaeontological evidence for an Oligocene divergence between Old World monkeys and apes.

Apes and Old World monkeys are prominent components of modern African and Asian ecosystems, yet the earliest phases of their evolutionary history have remained largely undocumented. The absence of crown catarrhine fossils older than ∼20 million years…

Pathophysiology of aspiration in a unilateral SLN lesion model using quantitative analysis of VFSS.

OBJECTIVE: The purpose of this study was to elucidate the pathophysiology of aspiration in previously studied female infant piglets after a unilateral superior laryngeal nerve (uSLN) lesion. METHODS: Videofluoroscopic swallow studies (VFSS) were…

Tags: 2021, Barkmeier-Kraemer JM, Bond L, Department of Anatomy & Neurobiology, Dysphagia, German RZ, International journal of pediatric otorhinolaryngology, January 2021 List, journalArticle, Mayerl CJ, NEOMED College of Medicine, Pathophysiology, Stevens M, Superior laryngeal nerve, Swallow, Videofluoroscopy

The impact of automated milk delivery on infant feeding performance

Tags: 2021, Adjerid K, Bond LE, Department of Anatomy & Neurobiology, Edmonds CE, German RZ, Gould FDH, Integrative and comparative biology, journalArticle, July 2021 List, Mayerl CJ, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Steer KE

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