Browse Items · NEOMED Bibliography Database

A metabolic stress-inducible miR-34a-HNF4alpha pathway regulates lipid and lipoprotein metabolism.

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, but its underlying mechanism is poorly understood. Here we show that hepatocyte nuclear factor 4alpha (HNF4alpha), a liver-enriched nuclear hormone receptor, is…

An outcomes analysis and satisfaction survey of 199 consecutive abdominoplasties.

Abdominoplasty is a popular body-contouring procedure. In this study the authors review retrospectively 199 abdominoplasty patients during a 15-year period to identify factors that affect overall outcome. Patients included 190 women and 9 men. The…

Bile acids as metabolic regulators.

PURPOSE OF REVIEW: This review focuses on the latest understanding of the molecular mechanisms underlying the complex interactions between intestine and liver bile acid signaling, gut microbiota, and their impact on whole-body lipid, glucose and…

Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice.

UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease that ranges from simple steatosis to nonalcoholic steatohepatitis (NASH). So far, the underlying mechanism remains poorly understood. Here, we show that hepatic…

Tags: *Lipid Metabolism, 2016, Adiposity, Animals, Carboxylesterase/*metabolism, Carboxylic Ester Hydrolases/genetics/*metabolism, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Endoplasmic Reticulum Stress, Energy Metabolism, Experimental/enzymology, Gene Knockdown Techniques, Glucose Tolerance Test, Glucose/metabolism, Hepatocyte Nuclear Factor 4/*metabolism, Hepatology (Baltimore, Md.), High-Fat/adverse effects, Homeostasis, Humans, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Li Yuanyuan, Lipogenesis, Lipolysis, Liver/enzymology, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*etiology/metabolism, Obesity/enzymology/etiology, Sterol Regulatory Element Binding Protein 1/metabolism, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao

Cyclosporine disposition and long-term renal function in a 500-pound kidney transplant recipient.

Patient size has been suggested as a risk factor in kidney transplantation. We have followed a recipient of a cadaver kidney who became massively obese (232 kg, 511 lbs) 5 years posttransplantation. He has maintained stable renal function with no…

Diabetes reduces growth and body composition more in male than in female rats.

Food restriction and/or starvation has a consistently greater and more permanent effect on physical growth in males than in females. Because diabetes may be viewed as being analogous to starvation, we tested the hypothesis that diabetes would reduce…

Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels.

We have previously shown transient receptor potential vanilloid subtype 1 (TRPV1) channel-dependent coronary function is compromised in pigs with metabolic syndrome (MetS). However, the mechanisms through which TRPV1 channels couple coronary blood…

Tags: 13-dienoic Acid/pharmacology, 15-Hydroxy-11 alpha, 2012, 9 alpha-(epoxymethano)prosta-5, American journal of physiology. Heart and circulatory physiology, Anilides/pharmacology, Animals, Bratz Ian N, Capsaicin/analogs & derivatives/pharmacology, Cinnamates/pharmacology, Coronary Vessels/drug effects/*metabolism/physiopathology, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Cardiomyopathies/drug therapy/*metabolism, Enzyme Inhibitors/pharmacology, Guarini Giacinta, Inbred C57BL, Kmetz John G, Large-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors/*metabolism, Male, Meszaros J Gary, Mice, Microvessels/drug effects/physiopathology, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Nitric Oxide/*metabolism, Ohanyan Vahagn A, Peptides/pharmacology, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/agonists/antagonists & inhibitors/biosynthesis/*metabolism, Type 2/drug therapy/*metabolism, Vasoconstrictor Agents/pharmacology, Vasodilation/drug effects

Endothelin-mediated in vivo pressor responses following TRPV1 activation.

Transient receptor potential vanilliod 1 (TRPV1) channels have recently been postulated to play a role in the vascular complications/consequences associated with diabetes despite the fact that the mechanisms through which TRPV1 regulates vascular…

Evaluation of factors associated with achieving glycemic control in a pharmacist-managed diabetes clinic.

The aim of this study was to identify factors that are associated with patients achieving goal A1c after 6 months in a pharmacist-managed diabetes clinic. This study is a descriptive, retrospective chart review of patients with type 2 diabetes…

Tags: 2014, Ambulatory Care, Ambulatory Care/organization & administration, American journal of therapeutics, Blood Glucose – Drug Effects, Blood Glucose/drug effects, Boros Melanie L, Department of Internal Medicine, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Diabetes Mellitus, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Frazee Lawrence A, Glycated Hemoglobin A/metabolism, Glycosylated – Metabolism, Hemoglobin A, Human, Humans, Hypoglycemic Agents – Administration and Dosage, Hypoglycemic Agents – Therapeutic Use, Hypoglycemic Agents/administration & dosage/*therapeutic use, Insulin – Administration and Dosage, Insulin – Therapeutic Use, Insulin/administration & dosage/therapeutic use, Kostoff Matthew D, Male, Middle Age, Middle Aged, Moorman John M, NEOMED College of Medicine, NEOMED College of Pharmacy, Pharmaceutical Services/*organization & administration, Pharmacists – Administration, Pharmacists/*organization & administration, Pharmacy Service – Administration, Prospective Studies, Retrospective Design, Retrospective Studies, Social Work – Statistics and Numerical Data, Social Work/statistics & numerical data, Treatment Outcome, Treatment Outcomes, Type 2 – Drug Therapy, Type 2/*drug therapy

Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity.

Bile acids facilitate postprandial absorption of nutrients. Bile acids also activate the farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5 and play a major role in regulating lipid, glucose, and energy metabolism. Transgenic…

Glycation Reduces the Stability of ApoAI and Increases HDL Dysfunction in Diet-Controlled Type 2 Diabetes.

Context: Hyperglycemia plays a key role in the pathogenesis of cardiovascular complications of diabetes. Type 2 diabetes mellitus (T2DM) is associated with high-density lipoprotein (HDL) dysfunction and increased degradation of apolipoprotein I…

Tags: 2018, Adult, Aged, Animal Studies, Animals, Apolipoprotein A-I/blood/*metabolism, Apolipoproteins – Blood, Apolipoproteins – Metabolism, Bena James, Biochemical Phenomena, Case Control Studies, Case-Control Studies, Cells, Comparative Studies, Cultured, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Dyslipidemias/complications/diet therapy/*metabolism, Evaluation Research, Female, Funding Source, Glycosylation, Golizeh Makan, HDL – Metabolism, HDL/*metabolism, Human, Humans, Hyperglycemia – Complications, Hyperglycemia – Diet Therapy, Hyperglycemia – Metabolism, Hyperglycemia/complications/diet therapy/*metabolism, Hyperlipidemia – Complications, Hyperlipidemia – Diet Therapy, Hyperlipidemia – Metabolism, Ilchenko Serguei, Kashyap Sangeeta R, Kasumov Takhar, Lee Kwangwon, Lipoproteins, Male, Mice, Middle Age, Middle Aged, Multicenter Studies, NEOMED College of Pharmacy, Osme Abdullah, Previs Stephen F, Protein Stability, Smith Jonathan D, The Journal of clinical endocrinology and metabolism, Type 2 – Complications, Type 2 – Diet Therapy, Type 2 – Metabolism, Type 2/complications/*diet therapy/metabolism, Validation Studies, Wang Shuhui

Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair.

The process of wound repair requires the coordinated participation of multiple types of cells, which are sequentially recruited during the healing process. In response to tissue injury, both macrophages and mesenchymal stem cells (MSCs) are recruited…

Hepatic Cannabinoid Receptor Type 1 Mediates Alcohol-Induced Regulation of Bile Acid Enzyme Genes Expression Via CREBH

Bile acids concentration in liver is tightly regulated to prevent cell damage. Previous studies have demonstrated that deregulation of bile acid homeostasis can lead to cholestatic liver disease. Recently, we have shown that ER-bound transcription…

Tags: 2013, Acids, activation, Ahn S H, Alcohol, Alcohols, Bile, BILE acids, bound, cb1 receptors, Chanda D, Chiang J Y L, Choi H S, cholesterol 7-alpha-hydroxylase, Damage prevention, Deregulation, Diabetes Mellitus, element-binding protein, endocannabinoid system, endoplasmic-reticulum stress, er stress, exposure, Fatty Liver, gene-expression, Genes, hepatocytes, Homeostasis, human hepatocytes, insulin, insulin-resistance, Jeong W I, Journal Article or Conference Abstract Publication, Kim D K, Kim J R, Kim Y H, Koo S H, Kwon J, Lee C H, leptin resistance, Li T, Liver, Liver Diseases, Metabolism, Mice, Misra J, Muridae, Ohio, Park T S, PloS one, Regulatory mechanisms (biology), RNA extraction, Rodents, Science & Technology - Other Topics, Sciences: Comprehensive Works, Signal Transduction, Signaling, Synthesis, transcription factor

Hyperinsulinemia associated with acanthosis nigricans, finger pebbles, acrochordons, and the sign of Leser-Trelat.

OBJECTIVE: To review common skin manifestations associated with type 2 diabetes mellitus (DM), and to discuss a potential underlying mechanism for these manifestations. METHODS: A PubMed literature search was conducted for articles describing the…

Tags: 2013, Acanthosis Nigricans/diagnosis/etiology/metabolism, Al-Shoha Ahmad, Brodell Robert T, Department of Internal Medicine, Diabetes Mellitus, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, Humans, NEOMED College of Medicine, Receptors, Saraiya Ami, Skin Diseases/diagnosis/*etiology/metabolism, Somatomedin/metabolism, Type 2/*complications/metabolism

Impact of type 1 diabetes on cardiac fibroblast activation: enhanced cell cycle progression and reduced myofibroblast content in diabetic myocardium.

Diabetic patients are prone to developing myocardial fibrosis and suffer from decreased wound healing capabilities. The purpose of this study was to determine whether diabetes alters cardiac fibroblast activity in the myocardium in a 6-wk…

Improved A1C and Lipid Profile in Patients Referred to Diabetes Education Programs in a Wide Health Care Network: A Retrospective Study.

Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes.

Type 2 diabetes mellitus (T2DM) is associated with oxidative stress and perturbed iron metabolism. Serotransferrin (Trf) and ceruloplasmin (Cp) are two key proteins involved in iron metabolism and anti-oxidant defense. Non-enzymatic glycation and…

Tags: *Ceruloplasmin, *Deamidation, *Heavy water metabolic labeling, *High resolution mass spectrometry, *Iron metabolism, *LC-MS/MS, *Non-enzymatic glycation, *Oxidative Stress, *Protein Processing, *Proteome dynamics, *Serotransferrin, *Type 2 diabetes mellitus, 2017, Adult, Amino Acid Sequence, Bena James, Case-Control Studies, Ceruloplasmin/genetics/*metabolism, Department of Pharmaceutical Sciences, Deuterium/metabolism, Diabetes Mellitus, Diabetic, Diet, Female, Free radical biology & medicine, Gene Expression Regulation, Glycated Hemoglobin A/genetics/metabolism, Glycosylation, Golizeh Makan, Humans, Ilchenko Serguei, Iron/*metabolism, Isotope Labeling, Kashyap Sangeeta R, Kasumov Takhar, Lee Kwangwon, Male, Middle Aged, NEOMED College of Pharmacy, Osme Abdullah, Oxidation-Reduction, Oxidative Stress, Post-Translational, Proteolysis, Sadygov Rovshan G, Transferrin/genetics/*metabolism, Type 2/diet therapy/genetics/*metabolism/pathology

Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus.

Neuropathy is a major diabetic complication. While the mechanism of this neuropathy is not well understood, it is believed to result in part from deficient nerve regeneration. Work from our laboratory established that gp130 family of cytokines are…

Tags: *Axon regeneration, *Axotomy, *Diabetes, *Neuropathy, *Peripheral nervous system, 2017, Animal, Animals, Antibiotics, Antineoplastic/toxicity, Blood Glucose/drug effects, Body Weight/drug effects, Crish Samuel D, Cytokine Receptor gp130/genetics/*metabolism, Cytokines/metabolism, DeFrancesco Alicia, Department of Pharmaceutical Sciences, Diabetes Mellitus, Disease Models, Experimental neurology, Experimental/chemically induced/complications/*pathology, Fasting/blood, Filous Angela R, Gene Expression Regulation/*physiology, Hyperalgesia/etiology, Hyperglycemia/etiology, Inbred C57BL, Lindborg Jane A, Male, Malhotra Nisha A, Mice, NEOMED College of Pharmacy, Nerve Degeneration/*etiology/pathology, Nerve Tissue Proteins/metabolism, Niemi Jon P, Pain Measurement, Signal Transduction/drug effects/*physiology, Streptozocin/toxicity, Superior Cervical Ganglion/drug effects/*metabolism, Sweating/drug effects, Wilson Gina N, Zhou Bowen, Zigmond Richard E

Management of asymptomatic bacteriuria in patients with diabetes mellitus

OBJECTIVE: To review the literature regarding the management of asymptomatic bacteriuria (ASB) in patients with diabetes mellitus. DATA SOURCES: A MEDLINE (1967-June 2003) and bibliographic search of the English-language literature was conducted…

Tags: 2004, Annals of Pharmacotherapy, bacteriuria, Department of Internal Medicine, Diabetes Mellitus, Frazee L A, Gardner W G, Journal Article, NEOMED College of Medicine, Ooi S T, Pharmacology & Pharmacy, urinary-tract infections, Women

Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE(-/-) mice.

Increasing evidence suggests thrombospondin-1 (TSP-1), a potent proatherogenic matricellular protein, as a putative link between hyperglycemia and atherosclerotic complications in diabetes. We previously reported that the micronutrient chromium…

Overcoming missed opportunities in diabetes management to improve outcomes for hospitalized patients with diabetes.

AIMS: The purpose of this study is to assess the impact of hospitalization on

Pharmacists' role in glycemic management in the inpatient setting: An opinion of the endocrine and metabolism practice and research network of the American College of Clinical Pharmacy.

The objective of this opinion paper was to identify and describe the role of pharmacists in ensuring safe and optimal management of patients with glycemic excursions in the inpatient setting. The role of the pharmacist includes involvement in…

Tags: 2019, Abla Alicia, Carneal Dustin, Department of Pharmacy Practice, Diabetes Mellitus, Donihi Amy C, Hanania Raja, hyperglycemia, hypoglycemia, Inpatients, JACCP: Journal of the American College of Clinical Pharmacy, June 2019 Update, MacMaster Heidemarie Windham, Moorman John M, NEOMED College of Pharmacy, Pharmacists

Prevalence and Predictors of Metformin Prescribing in Adults with Type 2 Diabetes Mellitus: A National Cross-Sectional Study.

OBJECTIVE: Metformin is the first-line oral type 2 diabetes treatment. Despite an abundance of evidence, metformin is routinely underused. This study evaluated the rates of metformin use in an appropriate outpatient type 2 diabetes population and…

Remission of nephrotic syndrome in type 1 diabetes: long-term follow-up of patients in the Captopril Study.

In 1994, we reported a 3.4 +/- 0.8 year follow-up of the eight patients who experienced remission of nephrotic syndrome during the Collaborative Study Group-sponsored, multicenter trial of captopril therapy in patients with type 1 diabetes with…

Tags: 1999, Adult, American journal of kidney diseases : the official journal of the National Kidney Foundation, Angiotensin-Converting Enzyme Inhibitors/*therapeutic use, Antihypertensive Agents/*therapeutic use, Bain R P, Blood Pressure/drug effects, Blumenthal S, Captopril/*therapeutic use, Cattran D, Chronic/etiology, Creatinine/blood, Department of Internal Medicine, Diabetes Mellitus, Diabetic Nephropathies/*drug therapy/physiopathology, Disease Progression, Female, Follow-Up Studies, Hebert L A, Humans, Kidney Failure, Levey A S, Lewis E J, Lewis J B, Male, Middle Aged, NEOMED College of Medicine, Nephrotic Syndrome/complications/*drug therapy/physiopathology, Prospective Studies, Proteinuria, Randomized Controlled Trials as Topic, Remission Induction, Rohde R D, Spitalewitz S, Type 1/*complications, Whittier F, Wilmer W A

Retinoic acid-related orphan receptor alpha regulates diurnal rhythm and fasting induction of sterol 12alpha-hydroxylase in bile acid synthesis.

Sterol 12alpha-hydroxylase (CYP8B1) is required for cholic acid synthesis and plays a critical role in intestinal cholesterol absorption and pathogenesis of cholesterol gallstone, dyslipidemia, and diabetes. In this study we investigated the…

Screening for nephropathy and antiangiotensin use among diabetic patients in an academic community medical center.

The American Diabetes Association recommends routine screening for albuminuria to detect early nephropathy in all patients with diabetes mellitus. If nephropathy is identified, treatment with an antiangiotensin agent decreases progression and…

Screening for nephropathy and antiangiotensin use among diabetic patients in an academic community medical center.

The American Diabetes Association recommends routine screening for albuminuria to detect early nephropathy in all patients with diabetes mellitus. If nephropathy is identified, treatment with an antiangiotensin agent decreases progression and…

Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice.

Nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner (SHP) are important regulators of bile acid, lipid, and glucose homeostasis. Here, we show that global Fxr (-/-) Shp(-/-) double knockout (DKO) mice are refractory to weight…

The Effect of Pharmacy-Led, Small-Group Academic Detailing on Prescribing Patterns in an Ambulatory Care Clinic.

Background: While academic detailing seems to be the most promising intervention to improve prescribing patterns, implementation could be challenging for small community practices. Objective: A pharmacy-led, interactive, and tailored small-group…

The incidence of COVID-19 in patients with metabolic syndrome and non-alcoholic steatohepatitis: A population-based study.

BACKGROUND: The novel coronavirus disease (COVID-19) emerged from China in 2019 and rapidly spread worldwide. Patients with metabolic comorbid conditions are more susceptible to infection by severe acute respiratory syndrome coronavirus 2 …

Tags: 2020, african american, Asaad I, Butt MU, COVID-19, Diabetes Mellitus, Ghoneim S, Hamid O, Hospital List, journalArticle, Metabolic syndrome, Metabolism Open, Non-alcoholic steatohepatitis, Obesity, Shah A

The therapeutic efficacy of intensive medical therapy in ameliorating high-density lipoprotein dysfunction in subjects with type two diabetes.

BACKGROUND: To determine whether 12 months of intensive medical therapy (IMT) improves HDL functionality parameters in subjects with type II diabetes (T2D). METHODS: Retrospective, randomized, and controlled 12-month IMT intervention trial that…

Browse Items (31 total)