Browse Items · NEOMED Bibliography Database

Apical excrescences in the gallbladder epithelium of the female Syrian hamster in response to medroxyprogesterone.

All the intact female Syrian hamsters treated with medroxyprogesterone (MP) for a one-month period, without dietary manipulation, display gallbladder surface epithelial changes, and intraluminal deposits. These changes include excrescences in various…

Age- and site-specific decline in insulin-like growth factor-I receptor expression is correlated with differential growth plate activity in the mouse hindlimb.

The proximal and distal growth plates of the principal long bones do not contribute equally to longitudinal growth. Most forelimb elongation occurs at the shoulder and wrist, while most hindlimb growth occurs at the knee. This study examined whether…

Tags: 2007, Age Factors, Anatomical record (Hoboken, N.J. : 2007), Animals, Biological Evolution, Growth Plate/*metabolism/physiology, Hindlimb/*growth & development/metabolism, IGF Type 1/*metabolism, Inbred C57BL, King Donna, Lovejoy C Owen, Mice, Proliferating Cell Nuclear Antigen/metabolism, Receptor, Serrat Maria A

Sound transmission in archaic and modern whales: anatomical adaptations for underwater hearing.

The whale ear, initially designed for hearing in air, became adapted for hearing underwater in less than ten million years of evolution. This study describes the evolution of underwater hearing in cetaceans, focusing on changes in sound transmission…

Evolution of hyperphalangy and digit reduction in the cetacean manus.

Cetaceans (whales, dolphins, and porpoises) have a soft tissue flipper that encases most of the forelimb, and elongated digits with an increased number of phalanges (hyperphalangy). In addition, some cetaceans exhibit a reduction in digit number.…

Tags: *Adaptation, *Biological Evolution, 2007, Anatomical record (Hoboken, N.J. : 2007), Animals, Berta Annalisa, Cetacea/*anatomy & histology/physiology, Cooper Lisa Noelle, Dawson Susan D, Department of Anatomy & Neurobiology, Forelimb/*anatomy & histology/physiology, Morphogenesis, NEOMED College of Medicine, Newborn, Phylogeny, Physiological, Reidenberg Joy S

Neuromuscular anatomy and evolution of the cetacean forelimb.

The forelimb of cetaceans (whales, dolphins, and porpoises) has been radically modified during the limb-to-flipper transition. Extant cetaceans have a soft tissue flipper encasing the manus and acting as a hydrofoil to generate lift. The…

Murine metapodophalangeal sesamoid bones: morphology and potential means of mineralization underlying function.

Normal murine metapodophalangeal sesamoid bones, closely associated with tendons, were examined in terms of their structure and mineralization with reference to their potential function following crystal deposition. This study utilized radiography,…

A preliminary analysis of the relationship between jaw-muscle architecture and jaw-muscle electromyography during chewing across primates.

The architectural arrangement of the fibers within a muscle has a significant impact on how a muscle functions. Recent work on primate jaw-muscle architecture demonstrates significant associations with dietary variation and feeding behaviors. In this…

Tags: *Mastication, 2010, Anatomical record (Hoboken, N.J. : 2007), Animals, Electromyography, Jaw/*anatomy & histology/physiology, Masseter Muscle/*anatomy & histology/physiology, Primates/*anatomy & histology/physiology, Taylor Andrea B, Temporal Muscle/*anatomy & histology/physiology, Vinyard Christopher J

Fetal lung epithelial ion channels relocate in the cell membrane during late gestation.

Near the end of gestation, the direction of ion and fluid flow across the alveolar epithelium rapidly changes from secretion to absorption. Thus, the relative cell membrane location of epithelial Na channels (ENaCs) and cystic fibrosis transmembrane…

Development of the skull of the pantropical spotted dolphin (Stenella attenuata).

We describe the bony and cartilaginous structures of five fetal skulls of Stenella attenuata (pantropical spotted dolphin) specimens. The specimens represent early fetal life as suggested by the presence of rostral tactile hairs and the beginnings of…

Tags: 2011, Anatomical record (Hoboken, N.J. : 2007), Animals, Department of Anatomy & Neurobiology, Ear, Ear Ossicles/anatomy & histology/growth & development, Middle/anatomy & histology/growth & development, Moran Meghan M, NEOMED College of Medicine, Nummela Sirpa, Skull/*anatomy & histology/*growth & development, Stenella/*anatomy & histology/*growth & development, Thewissen J G M

Are we looking for loads in all the right places? New research directions for studying the masticatory apparatus of New World monkeys.

New World monkeys display a wide range of masticatory apparatus morphologies related to their diverse diets and feeding strategies. While primatologists have completed many studies of the platyrrhine masticatory apparatus, particularly morphometric…

Tags: 2011, Anatomical record (Hoboken, N.J. : 2007), Animals, Biological Evolution, Eating/physiology, Feeding Behavior/*physiology, Glander Kenneth E, Jaw/anatomy & histology/physiology, Mandible/anatomy & histology/*physiology, Mastication/*physiology, Platyrrhini/anatomy & histology/*physiology, Ravosa Matthew J, Rossie James B, Ryan Timothy M, Taylor Andrea B, Teaford Mark F, Vinyard Christopher J, Williams Susan H

Seasonal and Ontogenetic Variation in Subcutaneous Adipose Of the Bowhead Whale (Balaena mysticetus).

Cetacean evolution was shaped by an extraordinary land-to-sea transition in which the ancestors of whales became fully aquatic. As part of this transition, these mammals evolved unusually thick blubber which acts as a metabolic reservoir as well as…

Sensory Hairs in the Bowhead Whale, Balaena mysticetus (Cetacea, Mammalia).

We studied the histology and morphometrics of the hairs of bowhead whales (Balaena mysticetus). These whales are hairless except for two patches of more than 300 hairs on the rostral tip of the lower lip and chin, the rostral tip of the upper lip,…

Dental maturation, eruption, and gingival emergence in the upper jaw of newborn primates.

In this report we provide data on dental eruption and tooth germ maturation at birth in a large sample constituting the broadest array of non-human primates studied to date. Over 100 perinatal primates, obtained from natural captive deaths, were…

Ontogeny of the Orbital Glands and Their Environs in the Pantropical Spotted Dolphin (Stenella attenuata: Delphinidae).

The nasolacrimal duct (NLD) connects the orbital (often associated with the Deep Anterior Orbital gland: DAOG, a.k.a. Harderian gland) and nasal regions in many tetrapods. Adult cetaceans are usually said to lack an NLD, and there is little agreement…

Jaw-Muscle Fiber Architecture and Leverage in the Hard-Object Feeding Sooty Mangabey are not Structured to Facilitate Relatively Large Bite Forces Compared to Other Papionins.

Numerous studies have sought to link craniofacial morphology with behavioral ecology in primates. Extant hard-object feeders have been of particular interest because of their potential to inform our understanding about the diets of early fossil…

A Comparison of the Cortical Structure of the Bowhead Whale (Balaena mysticetus), a Basal Mysticete, with Other Cetaceans.

Few studies exist of the bowhead whale brain and virtually nothing is known about its cortical cytoarchitecture or how it compares to other cetaceans. Bowhead whales are one of the least encephalized cetaceans and occupy a basal phylogenetic position…

Getting into Shape: Limb Bone Strength in Perinatal Lemur catta and Propithecus coquereli.

Functional studies of skeletal anatomy are predicated on the fundamental assumption that form will follow function. For instance, previous studies have shown that the femora of specialized leaping primates are more robust than those of more…

Tags: 2018, Anatomical record (Hoboken, N.J. : 2007), cross-sectional geometry, Department of Anatomy & Neurobiology, Jankord Kathryn, material properties, NEOMED College of Medicine, ontogeny, quadrupedalism, Saunders Marnie M, Smith Timothy D, vertical clinging and leaping, Young Jesse W

Masticatory Apparatus Performance and Functional Morphology in the Extremely Large Mice from Gough Island.

Since their arrival approximately 200 years ago, the house mice (Mus musculus) on Gough Island (GI) rapidly increased in size to become the largest wild house mice on record. Along with this extreme increase in body size, GI mice adopted a predatory…

Tags: 2018, Anatomical record (Hoboken, N.J. : 2007), biomechanics, biting, gape, Gray Melissa M, Islands, Mandible, Nelson Jacob P, Parmenter Michelle D, Payseur Bret A, Vinyard Christopher J, Weigel Sara E

Age-related expression patterns of Bag-1 and Bcl-2 in growth plate and articular chondrocytes.

Aging cartilage displays increased chondrocyte apoptosis and decreased responsiveness of chondrocytes to growth factors. The molecular mechanisms responsible for these changes have not been identified. Bag-1 is a Bcl-2-binding protein that promotes…

Synthesis and Biological Evaluation of Pentacycloundecylamines and Triquinylamines as Voltage-Gated Calcium Channel Blockers.

Preclinical studies for neurodegenerative diseases have shown a multi-targeted approach to be successful in the treatment of these complex disorders with several pathoetiological pathways. Polycyclic compounds, such as NGP1-01 (7a), have demonstrated…

A comparison of the full and short versions of the Arthritis Impact Measurement Scales.

This study examined the validity and reliability of full and short versions of the Arthritis Impact Measurement Scales (AIMS). One hundred fifty-five patients with Rheumatoid Arthritis followed at a University Hospital Rheumatology Clinic completed…

Tags: *Disability Evaluation, *Severity of Illness Index, 1991, Abraham N, Activities of Daily Living, Adult, Aged, Alarcon G S, Arthritis, Arthritis care and research : the official journal of the Arthritis Health Professions Association, Austin J S, Bradley L A, Female, Humans, Lorish C D, Male, Middle Aged, Reproducibility of Results, Rheumatoid/*diagnosis/rehabilitation

Ethnic/National origin influence on normal range of motion: comment on the article by Assassi et Al.

Tags: 2015, Academic Medical Centers, Anthropometry, Arthritis & rheumatology (Hoboken, N.J.), Articular/*physiology, Ethnology, Female, Human, Humans, Male, Ohio, Range of Motion, Rothschild Bruce, Spine/*physiology

MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes.

OBJECTIVE: Hedgehog (HH) signaling has recently been associated with cartilage degradation in osteoarthritis (OA). Because interleukin-1beta (IL-1beta) has been implicated as a principal instigator of OA, we sought to determine whether

Tags: 2015, Academic Medical Centers, Aged, Akhtar Nahid, Analysis of Variance, Animal, Animals, Anterior Cruciate Ligament/surgery, Arthritis & rheumatology (Hoboken, N.J.), Blotting, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism/pathology, Cultured, Department of Anatomy & Neurobiology, Disease Models, Female, Funding Source, Gene Expression Regulation/genetics/*physiology, Haqqi Tariq M, Hedgehog Proteins/genetics/*metabolism, HEK293 Cells, Human, Humans, Immunohistochemistry, In Vitro Techniques, Interleukin-1beta/pharmacology, Knee/etiology/*metabolism/pathology, Makki Mohammad S, Male, Matrix Metalloproteinase 13/metabolism, MicroRNAs/genetics/*metabolism, Middle Age, Middle Aged, NEOMED College of Medicine, Ohio, Open Reading Frames/genetics/*physiology, Osteoarthritis, Osteoarthritis – Epidemiology, Osteoarthritis – Physiopathology, Polymerase Chain Reaction, Rabbits, Signal Transduction/genetics/physiology, T-Tests, Transfection, Up-Regulation/drug effects/genetics/physiology, Western

MicroRNA-9 promotion of interleukin-6 expression by inhibiting monocyte chemoattractant protein-induced protein 1 expression in interleukin-1beta-stimulated human chondrocytes.

OBJECTIVE: Enhanced expression of interleukin-6 (IL-6) plays an important role in the pathogenesis of osteoarthritis (OA). Monocyte chemoattractant protein-induced protein 1 (MCPIP-1) is a novel posttranscriptional regulator of IL-6 expression and is…

Tags: 2015, Academic Medical Centers, Aged, Arthritis & rheumatology (Hoboken, N.J.), Articular/drug effects/*metabolism, Cartilage, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism, Cultured, Department of Anatomy & Neurobiology, Enzyme-Linked Immunosorbent Assay, Funding Source, Gene Knockdown Techniques, Haqqi Tariq M, Haseeb Abdul, Hip/*genetics/metabolism, Human, Humans, Immunoblotting – Utilization, Immunoprecipitation, Interleukin-1beta/pharmacology, Interleukin-6/*genetics/metabolism, Interleukins – Physiology, Makki Mohammad S, Messenger/drug effects/*metabolism, MicroRNAs/drug effects/*genetics/metabolism, Middle Aged, NEOMED College of Medicine, Ohio, Osteoarthritis, Osteoarthritis – Complications, Osteoarthritis – Physiopathology, Reverse Transcriptase Polymerase Chain Reaction, Ribonucleases/drug effects/*genetics/metabolism, RNA, T-Tests, Transcription Factors/drug effects/*genetics/metabolism

Primary or Secondary Effect of Quadriceps Exercises on Subsequent Need for Knee Replacement? Comment on the Article by Culvenor et al.

Tags: *Arthroplasty, *Quadriceps Muscle, 2016, Arthritis & rheumatology (Hoboken, N.J.), Arthroplasty, Exercise Therapy, Humans, Joint Instability, Knee, Knee – Utilization, Knee Pain – Etiology, Muscle Strengthening – Methods, Quadriceps Muscles – Physiology, Replacement, Rothschild Bruce

Genetic inactivation of ZCCHC6 suppresses IL-6 expression and reduces the severity of experimental osteoarthritis in mice.

OBJECTIVE: Cytokine expression is tightly regulated post-transcriptionally but high levels of IL-6 in osteoarthritis (OA) indicate disruption of regulatory mechanisms. ZCCHC6 enzyme is implicated in post-transcriptional regulation of inflammatory…

Tags: 2018, Ahmad Nashrah, Ansari Mohammad Y, Arthritis & rheumatology (Hoboken, N.J.), Department of Anatomy & Neurobiology, Green Jonathan, Haqqi Tariq M, Khan Nazir M, NEOMED College of Medicine, Novak Kimberly

Design and use of peptide-based antibodies decreasing superoxide production by mitochondrial complex I and complex II.

Mitochondria are the major source of reactive oxygen species. Both complex I and complex II mediate O2*- production in mitochondria and host reactive protein thiols. To explore the functions of the specific domains involved in the redox modifications…

Methyl Yellow: A Potential Drug Scaffold for Parkinson's Disease.

Parkinson's disease (PD) is an age-related neurodegenerative disease affecting movement. To date, there are no currently available therapeutic agents which can prevent or slow disease progression. Here, we evaluated an azobenzene derivative, methyl…

Tags: *MAO-B inhibitor, *methyl yellow, *MPTP mouse model, *Parkinson's disease, *TMRM, 2014, Chembiochem : a European journal of chemical biology, Dluzen Dean E, Geldenhuys Werner J, Kochi Akiko, Lim Mi Hee, Lin Li, Sutariya Vijaykumar, Van der Schyf Cornelis J

Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucoma.

Axonal transport defects are an early pathology occurring within the retinofugal projection of the DBA/2J mouse model of glaucoma. Retinal ganglion cell (RGC) axons and terminals are detectable after transport is affected, yet little is known about…

Tags: *Axonal Transport/physiology, *bouton, *Mitochondria, *neurodegeneration, *retinal, *RRID:IMSRJAX:000671, *RRID:IMSRJAX:007048, *RRID:SCR002716, *RRID:SCR002865, *superior colliculus, *synapse, 2016, Animal, Animals, Crish Samuel D, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Disease Models, Electron, Fening Kelly M, Glaucoma/metabolism/*pathology, Imaging, Inbred DBA, Inman Denise M, Mice, Microscopy, Mitochondria/pathology, NEOMED College of Medicine, NEOMED College of Pharmacy, Neuroanatomical Tract-Tracing Techniques, Regression Analysis, Retinal Ganglion Cells/metabolism/*pathology, Scanning, Schofield Brett R, Smith Matthew A, Superior Colliculi/metabolism/*pathology, Synapses/metabolism/*pathology, The Journal of comparative neurology, Three-Dimensional, Visual Pathways/metabolism/pathology, Xia Christina Z

Perineuronal nets in subcortical auditory nuclei of four rodent species with differing hearing ranges.

Perineuronal nets (PNs) are aggregates of extracellular matrix molecules that surround some neurons in the brain. While PNs occur widely across many cortical areas, subcortical PNs are especially associated with motor and auditory systems. The…

Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees.

In Alzheimer's disease (AD), the brain's primary immune cells, microglia, become activated and are found in close apposition to amyloid beta (Abeta) protein plaques and neurofibrillary tangles (NFT). The present study evaluated microglia density and…

Bilateral projections to the thalamus from individual neurons in the inferior colliculus.

The medial geniculate body (MG) receives a large input from the ipsilateral inferior colliculus (IC) and a smaller but substantial input from the contralateral IC. Both crossed and uncrossed inputs comprise a large percentage of glutamatergic cells…

Tags: 2019, Beebe Nichole L, collateral, Department of Anatomy & Neurobiology, GABA, inferior colliculus, medial geniculate body, Mellott Jeffrey G, NEOMED College of Medicine, RRID:AB2278725, RRID:AB260754, Schofield Brett R, synchronization, The Journal of comparative neurology

Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees.

Astrocytes are the main homeostatic cell of the central nervous system. In addition, astrocytes mediate an inflammatory response when reactive to injury or disease known as astrogliosis. Astrogliosis is marked by an increased expression of glial…

Immunohistochemical localization of substance P, somatostatin, enkephalin, and serotonin in the spinal cord of the northern leopard frog, Rana pipiens.

Using the indirect antibody peroxidase-antiperoxidase method of Sternberger, we localized substance P (SP), somatostatin (SOM), enkephalin (ENK), and serotonin (5HT, 5-hydroxytryptamine) in the spinal cord of Rana pipiens. This is the first study to…

Tags: 1988, Adli D S, Animals, Cruce W L, Enkephalins/analysis, Ho R H, Immunoenzyme Techniques, Male, Neuropeptides/*analysis, Rana pipiens/anatomy & histology/*metabolism, Rosenthal B M, Serotonin/analysis, Somatostatin/analysis, Spinal Cord/*analysis, Substance P/analysis, The Journal of comparative neurology, Yuen G L

Localization of serotonin, tyrosine hydroxylase, and leu-enkephalin immunoreactive cells in the brainstem of the horn shark, Heterodontus francisci.

In previous studies on reptiles and elasmobranchs, we determined that some reticular groups are either absent or may be displaced compared to their locations in mammals. For example, nucleus raphe dorsalis, the largest serotoninergic cell group in…

Immunohistochemical localization of serotoninergic, enkephalinergic, and catecholaminergic cells in the brainstem and diencephalon of a cartilaginous fish, Hydrolagus colliei.

We localized serotonin (5-HT), leu-enkephalin (LENK), and tyrosine hydroxylase (TH) immunoreactive cells in the brain of a holocephalian, Hydrolagus colliei, by use of antibodies made in rabbit and the peroxidase-antiperoxidase technique. Only three…

Tags: 1991, Animals, Brain Stem/cytology/*metabolism, Catecholamines/*metabolism, Cruce W L, Diencephalon/cytology/*metabolism, Enkephalins/*metabolism, Female, Fishes/*metabolism, Immunohistochemistry, Male, Neurons/metabolism, Serotonin/*metabolism, Stuesse S L, The Journal of comparative neurology, Tissue Distribution

Projections of physiologically defined subdivisions of the inferior colliculus in the mustached bat: targets in the medial geniculate body and extrathalamic nuclei.

This study examined the output of the central nucleus of the inferior colliculus to the medial geniculate body and other parts of the nervous system in the mustached bat (Pteronotus parnellii). Small deposits of anterograde tracers (horseradish…

Tags: 1994, Acoustic Stimulation, Animals, Axons/ultrastructure, Brain Mapping, Chiroptera/*physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Geniculate Bodies/*physiology, Inferior Colliculi/*physiology, Larue D T, NEOMED College of Medicine, Neural Pathways/*physiology, Synaptic Transmission, Thalamic Nuclei/*physiology, The Journal of comparative neurology, Wenstrup J J, Winer J A

Raphe nuclei in three cartilaginous fishes, Hydrolagus colliei, Heterodontus francisci, and Squalus acanthias.

The vertebrate reticular formation, containing over 30 nuclei in mammals, is a core brainstem area with a long evolutionary history. However, not all reticular nuclei are equally old. Nuclei that are widespread among the vertebrate classes are…

Tags: *Biological Evolution, 1995, Animals, Cruce W L, Dogfish/*anatomy & histology/metabolism, Elasmobranchii/*anatomy & histology/metabolism, Enkephalin, Immunohistochemistry, Leucine/analysis, Raphe Nuclei/*anatomy & histology/chemistry, Serotonin/analysis, Sharks/*anatomy & histology/metabolism, Stuesse D C, Stuesse S L, The Journal of comparative neurology

Bile acid metabolism and signaling.

Bile acids are important physiological agents for intestinal nutrient absorption and biliary secretion of lipids, toxic metabolites, and xenobiotics. Bile acids also are signaling molecules and metabolic regulators that activate nuclear receptors and…

Images in cytology. Fine-needle aspiration of a lumbar chordoma.

Tags: 2010, Biopsy, Chordoma/diagnosis/*pathology, Diagnosis, Diagnostic cytopathology, Differential, Female, Fine-Needle, Ganesan Santhi, Humans, Immunohistochemistry, Lumbar Vertebrae/*pathology, Middle Aged, Moonda Afreen H

Browse Items (9303 total)