Browse Items · NEOMED Bibliography Database

Extinction of cocaine-induced place approach in rats: a validation of the "biased" conditioning procedure.

It has often been demonstrated that when a rat is conditioned in a cue-specific environment that has been repeatedly paired with cocaine injections, it will spend more time in that environment than it does in a saline-paired environment. This…

Tags: 1993, Animals, Brain research bulletin, Calcagnetti D J, Classical, Cocaine/*pharmacology, Conditioning, Extinction, Habituation, Inbred Strains, Male, Operant/*drug effects, Psychological/*drug effects, Psychophysiologic/drug effects, Rats, Reward, Schechter M D

Calcium channel blockade attenuates angiotensin II-induced drinking in rats.

Lateral ventricular administration of angiotensin II (ANG II) produces potent dipsogenic effects in water-sated rats. ANG II seems to require functional voltage-gated calcium channels on neurons throughout circumventricular brain sites to exert its…

Tags: 1993, Amino Acid Sequence, Angiotensin II/*antagonists & inhibitors/pharmacology, Animals, Brain research bulletin, Calcagnetti D J, Calcium Channel Blockers/administration & dosage/*pharmacology, Dimethyl Sulfoxide/pharmacology, Dose-Response Relationship, Drinking Behavior/*drug effects, Drug, Injections, Intraventricular, Isradipine/pharmacology, Male, Molecular Sequence Data, Rats, Schechter M D, Sprague-Dawley

Topographic organization of efferent projections of medial frontal cortex.

By using fluorescent retrograde tracers, we compared efferent projections of the medial frontal cortex to two subcortical areas: the superior colliculus, a somatic motor area, and the laterodorsal tegmental nucleus, a visceral motor area. Neurons…

Tags: 1993, Animals, Brain Mapping/*methods, Brain research bulletin, Efferent Pathways/physiology, Female, Fluorescent Dyes, Frontal Lobe/*physiology, Male, Microinjections, Rats, Sprague-Dawley, Stuesse S L, Superior Colliculi/physiology, Tegmentum Mesencephali/physiology, Zeng D

Role of adenosine in heterosynaptic, posttetanic depression in area CA1 of hippocampus.

Conditioning stimulation of afferent fibers in hippocampal area CA1 produced heterosynaptic, posttetanic depression (PTD) of responses evoked by stimulation of an independent set of afferent fibers. PTD was present within 5 s of conditioning…

Dopaminergic mediation of the stimulant generalization of nicotine.

1. Experiments were conducted to investigate if the psychostimulant cathinone, like d-amphetamine, would produce generalization of the discriminative stimulus effects of nicotine. 2. Rats were trained to discriminate either 0.8 mg/kg cathinone from…

Differential training sequence effect upon psychostimulant discrimination.

1. Previous studies indicate that rats trained to discriminate either cathinone or cathine from its vehicle have a diminished discriminative performance when tested 24 hours after a drug administration when compared to tests conducted after a vehicle…

Tags: 1993, Alkaloids/pharmacology, Animals, Appetite Depressants/pharmacology, Central Nervous System Stimulants/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Food, Male, Phenylpropanolamine/pharmacology, Progress in neuro-psychopharmacology & biological psychiatry, Psychotropic Drugs/pharmacology, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley

Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.

1. The objective of Exp. 1 was to determine whether intracerebroventricular (ICV) injection of cathinone CATH (8.0-32 micrograms) would produce a dose-dependent conditioned place preference (CPP) and/or activation in rats. Results indicate that rats…

Spindle cell carcinoma of the larynx with simultaneous carcinoma of the thyroid gland.

Tags: 1993, American journal of otolaryngology, Carcinoma/diagnosis/*pathology/surgery/ultrastructure, Clarke R E, Humans, Laryngeal Neoplasms/complications/diagnosis/*pathology/surgery, Laryngectomy, Larynx/*pathology/surgery, Male, Middle Aged, Park Y W, Thyroid Gland/*pathology/surgery, Thyroid Neoplasms/complications/*pathology/surgery, Thyroidectomy

Para-chlorophenylalanine treatment inhibits the expression of vasoactive intestinal peptide messenger RNA in rat anterior pituitary.

Adult male Sprague-Dawley rats were treated with para-chlorophenylalanine (pCPA) or alpha-methyl tyrosine (alpha-MT) to study the effect of serotonin or catecholamine depletion on the expression of vasoactive intestinal peptide (VIP) messenger RNA in…

Differential expression of the mRNAs for the soluble and membrane-bound forms of rabbit cytochrome b5.

Total RNA was extracted from a variety of rabbit tissues and reverse transcribed for use in the polymerase chain reaction technique. Using primers designed to amplify the membrane-bound liver cytochrome b5 cDNA, products of two sizes were observed.…

A system for measuring electrophysiological multiple unit activity and extracellular dopamine concentration at single electrodes.

A technique is described for measuring electrophysiological multiple-unit activity and extracellular dopamine concentration with in vivo voltammetry at an array of 8 electrodes. In addition, new procedures in the construction of the voltammetric…

P and NP rats respond differently to the discriminative stimulus effects of nicotine.

Rats selectively bred for ethanol preference, that is, alcohol-preferring (P) and -nonpreferring (NP) rats, were trained to discriminate the interoceptive stimuli produced by IP-administered 1,000 mg/kg ethanol (10% v/v) in a two-lever,…

Tags: 1993, Alcoholism/genetics, Animals, Behavioral, Discrimination Learning/*drug effects/physiology, Drug Tolerance/genetics, Ethanol/administration & dosage/*pharmacology, Genetics, Gordon T L, Male, Meehan S M, Nicotine/administration & dosage/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Schechter M D

Cocaine discrimination is attenuated by isradipine and CGS 10746B.

The discriminative stimulus properties of cocaine are thought to be mediated by dopaminergic mechanisms that may be modulated by calcium ion influx and/or interact with 5-hydroxytryptamine3 (5-HT3) receptors. To test these possibilities, rats were…

Differential effects of nicotine but not cathinone on motor activity of P and NP rats.

The locomotor stimulatory effects of nicotine (0.4 and 0.8 mg/kg) and cathinone (0.5 and 1.0 mg/kg) were assessed in alcohol-preferring (P) and -nonpreferring (NP) rats. Whereas P rats demonstrated enhanced (0.8 mg/kg) or no change (0.4 mg/kg) in…

Tags: 1993, Alcohol Drinking/*psychology, Alkaloids/*pharmacology, Animals, Dextroamphetamine/pharmacology, Discrimination (Psychology)/drug effects, Genotype, Gordon T L, Male, Meehan S M, Motor Activity/*drug effects, Nicotine/*pharmacology, Pharmacology, biochemistry, and behavior, Psychotropic Drugs/*pharmacology, Rats, Schechter M D

Cytometric study of the female Syrian hamster gallbladder epithelium following sex steroid administration.

This report is a cytometric study of the female Syrian hamster gallbladder epithelium following 1-, 2-, and 3-month administration of female sex steroids. Nulliparous, multiparous, young, old and pregnant hamsters were used in this study. A 1 month…

Tags: 1993, Adamiec-Beyga E, Animals, Cell Count, Cholelithiasis/*chemically induced/pathology, Cricetinae, Cytoplasm/drug effects, Drug Administration Schedule, Epithelial Cells, Epithelium/drug effects, Estrogens/*pharmacology, Female, Gallbladder/cytology/*drug effects, Gilloteaux J, Karkare S, Kelly T R, Mesocricetus, Progesterone/*pharmacology, Tissue & cell

Role of olfactory bulb norepinephrine in the identification and recognition of chemical cues.

In this report the role of olfactory bulb (OB) norepinephrine (NE) in the identification and recognition of urinary chemical cues was examined. In Experiment 1, sexually naive adult male Sprague-Dawley rats were treated with either the noradrenergic…

Gastroschisis: an 18-year review.

From 1972 to 1990, 69 cases of gastroschisis were treated at Akron Children's Hospital Medical Center. Eighty-one percent of these patients underwent primary closure of their abdominal wall defect. Thirteen of 69 patients (19%) required Silastic…

Tags: 1993, Abdominal Muscles/*abnormalities/surgery, Abnormalities, Boeckman C R, Cesarean Section, Congenital Abnormalities/surgery, Female, Humans, Infant, Journal of pediatric surgery, Klein R L, Male, Methods, Multiple, Newborn, Novotny D A, Postoperative Complications, Retrospective Studies

Conditioned place preference produced by the psychostimulant cathinone.

Previous work has indicated that the psychostimulant cathinone produces a location preference in the conditioned place preference task. The present study expanded upon this earlier work by examining the dose-response nature of cathinone-induced…

Tags: 1993, Alkaloids/administration & dosage/*pharmacology, Animals, Central Nervous System Stimulants/administration & dosage/*pharmacology, Choice Behavior/drug effects, Conditioning (Psychology)/drug effects, Dose-Response Relationship, Drug, European journal of pharmacology, Habituation, Male, Meehan S M, Motor Activity/*drug effects, Psychophysiologic, Rats, Schechter M D, Sprague-Dawley

Comparison of the behavioral effects of ibogaine from three sources: mediation of discriminative activity.

Ibogaine is an alkaloid employed for its hallucinatory properties in West Central Africa which has been the subject of alleged efficacy as an aid in the interruption and treatment of chemical dependency. The major sources of the Schedule I agent are:…

Tags: *Discrimination (Psychology), 1993, Animal/*drug effects, Animals, Behavior, Dose-Response Relationship, Drug, European journal of pharmacology, Gordon T L, Ibogaine/*pharmacology, Male, Rats, Schechter M D, Serotonin Receptor Agonists/pharmacology, Sprague-Dawley

Ablation of the hypothalamic arcuate-median eminence region reduces the concentration of vasoactive intestinal peptide in the anterior pituitary gland of male rats.

This study was designed to determine the influence of the hypothalamus on the content of vasoactive intestinal peptide (VIP) in the anterior pituitary. Disruption of the hypothalamic-pituitary connection was performed by ablating the arcuate-median…

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) disrupts social memory/recognition processes in the male mouse.

Male mice treated with MPTP or vehicle were tested for their ability to demonstrate a memory-recognition response as evaluated in a habituation-dishabituation task. Treatment with MPTP severely disrupted the male's habituation-dishabituation response…

Depletion of olfactory bulb norepinephrine by 6-OHDA disrupts chemical cue but not social recognition responses in male rats.

In the present experiment, 6-OHDA was infused directly into the olfactory bulb (OB) to produce a localized neurotoxic lesion. Habituation/dishabituation behavioral tests were then conducted to measure recognition responses to chemical cues (urine as…

Adverse reactions to aspartame: double-blind challenge in patients from a vulnerable population.

This study was designed to ascertain whether individuals with mood disorders are particularly vulnerable to adverse effects of aspartame. Although the protocol required the recruitment of 40 patients with unipolar depression and a similar number of…

Tags: 1993, Adult, Aspartame/*adverse effects/*therapeutic use, Biological psychiatry, Cross-Sectional Studies, Depressive Disorder/diagnosis/*drug therapy/psychology, Double-Blind Method, Eye Diseases/etiology/physiopathology, Female, Green-Waite R J, Headache/etiology, Hudak R, Humans, Male, Middle Aged, Placebos, Psychiatric Status Rating Scales, Vision Disorders/etiology/physiopathology, Walton R G

The human cytochrome b5 gene and two of its pseudogenes are located on chromosomes 18q23, 14q31-32.1 and 20p11.2, respectively.

Using very high stringency hybridization conditions for the Southern blot hybridization analysis of hamster-human cell hybrid DNA, we were able to map the human cytochrome b5 gene and two of its pseudogenes (psgb(5)1 and psgb(5)2) unambiguously to…

Metastatic carcinoma of the spine with neurologic complications: an autopsy review.

We conducted post-mortem examinations on 12 patients who had documented metastatic carcinoma to the spine with attendant neurologic complications. The examinations were studied to determine the location of the metastatic lesion in relation to the…

Tags: 1993, Adult, Aged, Autopsy, Female, Humans, Leeson M C, Male, Middle Aged, Orthopedics, Spinal Cord Compression/*etiology/pathology, Spinal Neoplasms/*complications/pathology/*secondary, Zechmann J P

The effect of immediate intraperitoneal carboplatinum on wound healing.

The effect of introducing intraperitoneal carboplatinum on wound healing immediately after wound closure was studied using a rat model. All animals were opened through a midline incision. A bowel anastomosis was then performed in a single-or…

Tags: 1993, Animals, Carboplatin/*administration & dosage/pharmacology, Clark T, Dose-Response Relationship, Drug, Gynecologic oncology, Hopkins M P, Injections, Intraperitoneal, Jenison E L, Male, Postoperative Period, Rats, Shellhaas C, Sprague-Dawley, Stakleff K S, Tissue Adhesions/etiology, Wound Healing/*drug effects

The isolation and characterization of the bovine cytochrome b5 gene, and a transcribed pseudogene.

This is the first isolation and characterization of a cytochrome b5(b5) gene. The bovine b5 gene is quite large, spanning about 28 kb and contains six exons. One of these exons appears to code for a reticulocyte-specific sequence similar to that…

Subcellular localization and antiviral activity of carminic acid/poly r(A-U) combinations.

Carminic acid (CAR) enhances the antiviral activity of poly r(A-U) twelve-fold without increasing interferon induction, inactivating the vesicular stomatitis virus or inducing host cell cytotoxicity. Phase contrast photomicrographs of human foreskin…

Comparative binding of neurotrophins (NT-3, CNTF and NGF) and various cytokines to alpha 2-macroglobulin.

All the nine common cytokines in this study (including NT-3, IGF-1, CNTF and

Genomic cloning, sequencing, and analysis of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7).

Cholesterol 7 alpha-hydroxylase is the rate limiting enzyme in bile acid biosynthesis and plays an important role in cholesterol homeostasis. The Golden Syrian hamster has been used as an animal model for the study of atherosclerosis and cholesterol…

Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors.

The expression of the rat cytochrome P450 CYP4 family was studied in hepatic tumors. In most of the primary and transplantable hepatic tumors studied, lauric acid omega-hydroxylase activity associated with the CYP4A subfamily enzymes decreased. The…

Presynaptic mechanism for heterosynaptic, posttetanic depression in area CA1 of rat hippocampus.

Conditioning stimulation applied to afferent fibers in stratum radiatum or stratum oriens of hippocampal area CA1 produced heterosynaptic, posttetanic depression (PTD) of excitatory postsynaptic potentials (EPSPs). PTD amounted to a

Serotonin-activated alpha 2-macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons.

Methylamine-modified alpha-2-macroglobulin (MA-alpha 2M) has been recently shown to inhibit the biological activity of beta-nerve growth factor (NGF) in promoting neurite outgrowth by embryonic dorsal root ganglia in culture (Koo PH, Liebl DJ, J…

Vocal cord paralysis from prostatic carcinoma metastasizing to the larynx.

According to 1992 Cancer Statistics, prostate carcinoma is once again predicted to be the most common cancer in men, exceeding the incidence of lung cancer. In American men, this cancer is estimated to be the second most frequent cause of cancer…

Tags: 1993, Adenocarcinoma/*pathology/*secondary, Aged, Head & neck, Humans, Laryngeal Neoplasms/*secondary, Male, Park M H, Park Y W, Prostatic Neoplasms/*pathology, Thyroid Cartilage/pathology, Vocal Cord Paralysis/*etiology

Apical excrescences in the gallbladder epithelium of the female Syrian hamster in response to medroxyprogesterone.

All the intact female Syrian hamsters treated with medroxyprogesterone (MP) for a one-month period, without dietary manipulation, display gallbladder surface epithelial changes, and intraluminal deposits. These changes include excrescences in various…

Antigenic stimulation and multiple myeloma. A prospective study.

BACKGROUND: A causal relationship between antigenic conditions and multiple myeloma was suggested by case reports. Although controlled studies identified associations with individual conditions, they failed to give overall support to the hypothesis.…

Verruca vulgaris. Treatment with natural interferon alfa using a needleless injector.

Tags: 1993, Adult, Archives of dermatology, Brodell R T, Child, Department of Family & Community Medicine, Female, Foot Diseases/therapy, Hand, Humans, Injections, Interferon-alpha/*administration & dosage, Intralesional, Jet, Naples S P, NEOMED College of Medicine, Warts/*therapy

Browse Items (197 total)