Browse Items · NEOMED Bibliography Database

Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis.

The gene encoding cholesterol 7alpha-hydroxylase (CYP7A1) is tightly regulated to control bile acid synthesis and maintain lipid homeostasis. Recent studies in mice suggest that bile acid synthesis is regulated by the fasted-to-fed cycle, and fasting…

Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis.

UNLABELLED: Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. TGR5 activation also inhibits nuclear factor kappaB (NF-kappaB)-mediated inflammation. Here we…

Salvianolate reduces murine myocardial ischemia and reperfusion injury via ERK1/2 signaling pathways in vivo.

OBJECTIVE: To analyze the effects of salvianolate on myocardial infarction in a murine in vivo model of ischemia and reperfusion (I/R) injury. METHODS: Myocardial I/R injury model was constructed in mice by 30 min of coronary occlusion followed by 24…

Tags: *MAP Kinase Signaling System/drug effects, 2017, Animal Studies, Animals, Blotting, Cardiotonic Agents/pharmacology/therapeutic use, Chinese journal of integrative medicine, Chinese medicine, Descriptive Statistics, extracellular signal-regulated kinase 1/2, Flavonoids/pharmacology, Guo Liheng, Heart Ventricle, Heart Ventricles/drug effects/pathology, Huang Dong-Hui, Huang Hai-Ding, Huang Xin, In Vivo Studies, Inbred C57BL, ischemia and reperfusion injury, Left, Male, Mice, Mitogen-Activated Protein Kinase 1/*metabolism, Mitogen-Activated Protein Kinase 3/*metabolism, Molecular Structure, Myocardial Ischemia – Drug Therapy, Myocardial Reperfusion Injury – Drug Therapy, Myocardial Reperfusion Injury/*drug therapy/enzymology/pathology, Organ Size/drug effects, P-Value, Phosphorylation, Phosphorylation/drug effects, Plant Extracts – Administration and Dosage, Plant Extracts/chemistry/pharmacology/*therapeutic use, protein kinase B, Protein Kinase Inhibitors – Administration and Dosage, Protein Kinase Inhibitors/pharmacology, Protein Kinases – Analysis, Protein Kinases – Drug Effects, Qi Jianyong, salvianolate, Signal Transduction, Staining and Labeling, Wang Lei, Western, Wu Jiashin, Yu Juan, Zhang Minzhou, Zhou Miao

Phosphatidylinositide 3-kinase regulates angiotensin II-induced cytosolic phospholipase A2 activity and growth in vascular smooth muscle cells.

Angiotensin (Ang) II via the AT(1) receptor acts as a mitogen in vascular smooth muscle cells (VSMC) through stimulation of multiple signaling mechanisms, including tyrosine kinases and mitogen-activated protein kinase (MAPK). In addition, cytosolic…

Members of the novel UBASH3/STS/TULA family of cellular regulators suppress

The UBASH3/STS/TULA family consists of two members sharing substantial homology and a similar multi-domain architecture, which includes a C-terminal histidine phosphatase domain capable of dephosphorylating phosphotyrosine-containing substrates.…

Mechanisms of Chinese Medicine Xinmailong's protection against heart failure in pressure-overloaded mice and cultured cardiomyocytes.

Patients with heart failure (HF) have high mortality and mobility. Xinmailong (XML) injection, a Chinese Medicine, is clinically effective in treating HF. However, the mechanism of XML's effectiveness on HF was unclear, and thus, was the target of…

Generation and characterization of ATP analog-specific protein kinase Cdelta.

To better study the role of PKCdelta in normal function and disease, we developed an ATP analog-specific (AS) PKCdelta that is sensitive to specific kinase inhibitors and can be used to identify PKCdelta substrates. AS PKCdelta showed nearly 200…

Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway.

Bcl-2 is an anti-apoptotic protein that has recently been shown to regulate other cellular functions. We previously reported that Bcl-2 regulates chondrocyte matrix gene expression, independent of its anti-apoptotic function. Here, we further…

Tags: *Gene Expression Regulation, 2005, Adenoviridae/genetics, Animals, Apoptosis, beta-Galactosidase/metabolism, Blotting, Butadienes/pharmacology, Caspase Inhibitors, Cell Differentiation, Cell Line, Chondrocytes/*metabolism, Collagen Type II/metabolism, Department of Anatomy & Neurobiology, Down-Regulation, Enzyme Inhibitors/pharmacology, Fibroblasts/metabolism, Fluorescence, Genetic, High Mobility Group Proteins/*metabolism, Horton Walter E Jr, Lac Operon, Luciferases/metabolism, MAP Kinase Kinase Kinases/*metabolism, McBurney Denise, Messenger/metabolism, Microscopy, Mitogen-Activated Protein Kinase 1/*metabolism, Mitogen-Activated Protein Kinase 3/*metabolism, NEOMED College of Medicine, NF-kappa B/metabolism, Nitriles/pharmacology, Phenotype, Phosphorylation, Promoter Regions, Protein Kinase C-alpha, Protein Kinase C/antagonists & inhibitors, Proteoglycans/metabolism, Proto-Oncogene Proteins c-bcl-2/*metabolism, Rats, Reverse Transcriptase Polymerase Chain Reaction, RNA, Signal Transduction, Small Interfering/metabolism, SOX9 Transcription Factor, Sprague-Dawley, The Journal of biological chemistry, Time Factors, Transcription, Transcription Factors/*metabolism, Transfection, Western, Yagi Rieko

Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4.

VEGF signaling via VEGF receptor-2 (VEGFR2) is a major regulator of endothelial cell (EC) functions, including angiogenesis. Although most studies of angiogenesis focus on soluble VEGF signaling, mechanical signaling also plays a critical role. Here,…

Tags: 2019, Adapala Ravi K, angiogenesis, Cappelli Holly C, Chilian William M, Department of Integrative Medical Sciences, endothelial cell, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Kanugula Anantha K, Meszaros J Gary, Midha Priya, NEOMED College of Medicine, Paruchuri Sailaja, Phosphorylation, Thodeti Charles K

Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2'-deoxyuridine.

The mechanism responsible for the decreased sensitivity of a clinical herpes simplex virus type 1 (HSV-1) isolate, HSV-145, to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) was examined. Measurements of 50% inhibitory doses of several drugs…

Neurokinin-1 receptor resensitization precedes receptor recycling.

Following agonist binding, neurokinin-1 receptors undergo rapid desensitization followed by internalization and recycling. Desensitization requires receptor phosphorylation but does not require internalization, whereas resensitization is thought to…

Tags: 2005, Adenosine Triphosphate/pharmacology, Animals, Bennett V J, Binding, Calcium/metabolism, CHO Cells, Competitive, Cricetinae, Guanylyl Imidodiphosphate/pharmacology, Neurokinin-1/*metabolism, Perrine S A, Phosphorylation, Rats, Receptors, Simmons M A, Substance P/metabolism, The Journal of pharmacology and experimental therapeutics

Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.

Sterol 12alpha-hydroxylase (CYP8B1) catalyzes cholic acid synthesis in the liver and is feedback inhibited by bile acids. In addition to activating farnesoid X receptor (nuclear receptor subfamily 1H4), bile acids also induce inflammatory cytokines…

Tags: 2005, American journal of physiology. Gastrointestinal and liver physiology, Cell Line, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Chromosome Mapping, Department of Integrative Medical Sciences, DNA-Binding Proteins/genetics/metabolism, Enzyme Inhibitors/pharmacology, Gene Expression Regulation/*drug effects, Genetic/drug effects, Genetic/physiology, Hepatocyte Nuclear Factor 4, Hepatocytes/metabolism, Humans, Interleukin-1/*pharmacology, Jahan Asmeen, MAP Kinase Signaling System/drug effects/physiology, Messenger/antagonists & inhibitors, Mitogen-Activated Protein Kinase 8/metabolism, Mitogen-Activated Protein Kinases/antagonists & inhibitors, NEOMED College of Medicine, Phosphoproteins/genetics/metabolism, Phosphorylation, Promoter Regions, Response Elements/genetics, RNA, Steroid 12-alpha-Hydroxylase/antagonists & inhibitors/*genetics, Transcription, Transcription Factors/genetics/metabolism

PKCalpha mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells.

Transient receptor potential vanilloid channel 4 (TRPV4) is a polymodally activated nonselective cationic channel implicated in the regulation of vasodilation and hypertension. We and others have recently shown that cyclic stretch and shear stress…

Tags: 2011, Acetylcholine/*pharmacology, Adapala Ravi K, American journal of physiology. Heart and circulatory physiology, Animals, Bratz Ian N, Calcium Signaling/*drug effects, Carbazoles/pharmacology, Cells, Cultured, Department of Integrative Medical Sciences, Endothelial Cells/*drug effects/enzymology, Enzyme Activation, Inbred C57BL, Knockout, Male, Mesenteric Arteries/drug effects/enzymology, Meszaros J Gary, Mice, Mutation, NEOMED College of Medicine, Nitric Oxide Synthase Type III/metabolism, Phosphorylation, Protein Kinase C-alpha/genetics/*metabolism, Protein Kinase Inhibitors/pharmacology, Suzuki Makoto, Talasila Phani K, Tetradecanoylphorbol Acetate/pharmacology, Thodeti Charles K, Time Factors, Transfection, TRPV Cation Channels/*agonists/deficiency/genetics/metabolism, Vasodilation/*drug effects, Vasodilator Agents/*pharmacology, Zhang David X

Redox-dependent coronary metabolic dilation.

We have observed that hydrogen peroxide (H2O2), the dismutated product of superoxide, is a coronary metabolic dilator and couples myocardial oxygen consumption to coronary blood flow. Because the chemical activity of H2O2 favors its role as an…

Tags: *Paracrine Communication, *Vasodilation/drug effects, 2007, Acetylcysteine/pharmacology, American journal of physiology. Heart and circulatory physiology, Animals, Antioxidants/pharmacology, Cardiac/drug effects/*metabolism, Chilian William M, Conditioned/metabolism, Coronary Vessels/drug effects/enzymology/*metabolism, Culture Media, Department of Integrative Medical Sciences, Dick Gregory M, Dithiothreitol/pharmacology, Enzyme Activation, Fluorescence, Hydrogen Peroxide/metabolism, Imidazoles/pharmacology, In Vitro Techniques, Kiyooka Takahiko, Microscopy, Myocytes, NEOMED College of Medicine, Nitroprusside/pharmacology, Oxidation-Reduction, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism, Park Yoonjung, Phosphorylation, Protein Kinase Inhibitors/pharmacology, Pyridines/pharmacology, Rats, Reactive Oxygen Species/*metabolism, Reducing Agents/pharmacology, Rocic Petra, Rogers Paul A, Saitoh Shu-ichi, Sulfhydryl Compounds/*metabolism, Swafford Albert, Vasodilator Agents/pharmacology, Viswanathan Chandrasekar, Wistar, Zhang Cuihua

Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts.

Angiotensin II (Ang II)-induced proliferation of cardiac fibroblasts is a major contributing factor to the pathogenesis of cardiac fibrosis. Ang II activates extracellular signal-regulated kinase (ERK) 1/2 to induce cardiac fibroblast proliferation,…

Characterization of vascular endothelial growth factor (VEGF) in the uterine cervix over pregnancy: effects of denervation and implications for cervical ripening.

Bilateral neurectomy of the pelvic nerve (BLPN) that carries uterine cervix-related sensory nerves induces dystocia, and administration of its vasoactive neuropeptides induces changes in the cervical microvasculature, resembling those that occur in…

Tags: 2004, Animal/*metabolism, Animals, Cervical Ripening/*metabolism, Cervix Uteri/blood supply/innervation/*metabolism, Denervation, Department of Anatomy & Neurobiology, Down-Regulation, Enzyme-Linked Immunosorbent Assay, Female, Hattori Y, Immunohistochemistry, Jesmin S, Microcirculation, Mowa C N, NEOMED College of Medicine, Nitric Oxide Synthase Type III, Nitric Oxide Synthase/biosynthesis, Papka R, Phosphorylation, Pregnancy, Protein Isoforms/biosynthesis/metabolism, Protein-Serine-Threonine Kinases/biosynthesis, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins/biosynthesis, Rats, Reverse Transcriptase Polymerase Chain Reaction, Sakuma I, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Togashi H, Usip S, Vascular Endothelial Growth Factor A/biosynthesis/*metabolism, Vascular Endothelial Growth Factor Receptor-2/biosynthesis, Wistar, Yoshioka M

Parkinson's disease biomarker: a patent evaluation of WO2013153386.

INTRODUCTION: Parkinson's disease (PD) is a neurodegenerative movement disorder resultant from the loss of dopaminergic neurons in the brain. There is an urgent need for effective biomarkers that can be used in the early diagnosis of PD.…

Lung fluid absorption is induced in preterm guinea pigs ventilated with low tidal volumes.

The objective of this study was to determine if low tidal volume (V(t)) ventilation was beneficial when ventilating preterm fetuses. The authors ventilated preterm guinea pig fetuses at gestation day (GD) 67, 3 days before birth, newborn, and…

Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease.

Reduced bone mineral density (BMD) and its clinical sequelae, osteoporosis, occur at a much greater rate in patients with Alzheimer's disease (AD), often emerging early in the disease before significant cognitive decline is seen. Reduced BMD…

Tags: *Alzheimer Disease/complications/genetics/pathology, *Alzheimer's disease, *bone density, *microtubule-associated protein, *serotonin, *tau proteins, *tauopathies, 2017, Age Factors, Alzheimer's disease, Alzheimer's Disease – Complications, Alzheimer's Disease – Pathology, Animal, Animal Studies, Animals, Biological, Body Composition, Body Composition/genetics, Body Weight, Body Weight/genetics, Bone Density – Physiology, Bone Density/*physiology, Bone Diseases – Etiology, Bone Diseases/*etiology, Brain Stem – Pathology, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Disease Models, Dorsal Raphe Nucleus/*pathology, Female, Inbred C57BL, Journal of Alzheimer's disease : JAD, Male, Mice, Models, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurons – Metabolism, Neurons – Pathology, Neurons/metabolism/pathology, Oxidoreductases – Metabolism, Phosphorylation, Serotonin – Metabolism, Serotonin/*metabolism, Smith Matthew A, tau Proteins/*genetics/metabolism, Tauopathies/complications/genetics, Transgenic, Tryptophan Hydroxylase/metabolism, Wilson Gina N

Early Cytoskeletal Protein Modifications Precede Overt Structural Degeneration in the DBA/2J Mouse Model of Glaucoma.

Axonal transport deficits precede structural loss in glaucoma and other neurodegenerations. Impairments in structural support, including modified cytoskeletal proteins, and microtubule-destabilizing elements, could be initiating factors in glaucoma…

Tags: 2016, amyloid-beta, Axonal Transport, Crish Samuel D, cytoskeleton, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Frontiers in neuroscience, Glaucoma, Inman Denise M, NEOMED College of Pharmacy, neurofilament, Phosphorylation, Smith Matthew A, spectrin, Tau, Wilson Gina N

Inhibition of phosphorylation of TrkB and TrkC and their signal transduction by alpha2-macroglobulin.

Monoamine-activated alpha2-macroglobulin (alpha2M) was shown to reduce the dopamine concentration in corpus striatum of adult rat brains and inhibit other neuronal functions in vivo and in vitro. As brain-derived neurotrophic factor, neurotrophin-4,…

Tags: *Mitogen-Activated Protein Kinases, 1998, 3T3 Cells/chemistry/cytology/enzymology, alpha-Macroglobulins/*pharmacology, Animals, Antineoplastic Agents/pharmacology, Brain-Derived Neurotrophic Factor/pharmacology, Calcium-Calmodulin-Dependent Protein Kinases/metabolism, Cell Differentiation/drug effects, Ciliary Neurotrophic Factor, Cultured/chemistry/cytology/enzymology, Hu Y Q, Humans, Isoenzymes/metabolism, Journal of neurochemistry, Koo P H, Mice, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3, Nerve Growth Factor/*metabolism, Nerve Growth Factors/pharmacology, Neuroblastoma, Neuroprotective Agents/*metabolism, Neurotrophin 3, Phospholipase C gamma, Phosphorylation, Receptor, Receptor Protein-Tyrosine Kinases/*metabolism, Receptors, Serotonin/metabolism, Signal Transduction/drug effects/*physiology, Tretinoin/pharmacology, trkC, Tumor Cells, Type C Phospholipases/metabolism

Monoamine-activated alpha 2-macroglobulin binds trk receptor and inhibits nerve growth factor-stimulated trk phosphorylation and signal transduction.

Monoamine-activated alpha 2-macroglobulin (alpha 2M) has been shown to inhibit beta-nerve growth factor (NGF)-promoted neurite outgrowth and the survival of embryonic sensory and forebrain neurons, whereas normal alpha 2M has little or no such…

Tags: 1994, Adrenal Gland Neoplasms, alpha-Macroglobulins/isolation & purification/*metabolism/pharmacology, Animals, ErbB Receptors/isolation & purification/metabolism, Fibrinolysin/metabolism, Humans, Koo P H, Male, Mice, Mitogen-Activated Protein Kinase 1, Nerve Growth Factor/drug effects/isolation & purification/*metabolism, Nerve Growth Factors/*pharmacology, Neurites/drug effects/*physiology, PC12 Cells, Pheochromocytoma, Phosphorylation, Platelet-Derived Growth Factor/isolation & purification/metabolism, Protein-Serine-Threonine Kinases/metabolism, Protein-Tyrosine Kinases/metabolism, Proto-Oncogene Proteins/drug effects/isolation & purification/*metabolism, Qiu W S, Receptor, Receptor Protein-Tyrosine Kinases/drug effects/isolation & purification/*metabolism, Receptors, Serotonin/*metabolism/pharmacology, Signal Transduction/drug effects/*physiology, The Journal of biological chemistry, trkA

Rat alpha(2)-macroglobulin inhibits NGF-promoted neurite outgrowth, TrK phosphorylation, and gene expression of pheochromocytoma PC12 cells.

Rat alpha-1-macroglobulin (alpha(1)M) and alpha-2-macroglobulin (alpha(2)M) are murine homologs of human alpha(2)M, and rat alpha(2)M is generally known as an acute-phase protein. Monoamine-activated forms of human alpha(2)M have been shown to…

Tags: 1999, Adrenal Gland Neoplasms/metabolism, alpha-Macroglobulins/*pharmacology, Animals, Gene Expression Regulation, Journal of neuroscience research, Koo P H, Lee P G, Neoplastic/*drug effects, Nerve Growth Factors/*antagonists & inhibitors, Neurites/*drug effects, PC12 Cells, Pheochromocytoma/metabolism, Phosphorylation, Proto-Oncogene Proteins c-jun/genetics, Rats, Receptor, Sprague-Dawley, trkA/*metabolism

alpha(2)-Macroglobulin modulates the immunoregulatory function of the lipocalin placental protein 14

Human placental protein 14 (PP14; also known as glycodelin and progesterone-associatcd endometrial protein) is an immuno-suppressive protein of the lipocalin structural superfamily. Mechanisms regulating serum PP14's inmunosuppressive activity remain…

Changes of the responses of single sympathetic ganglionic neurones to substance P following desensitization

1 The neuropeptide substance P (SP) exerts an excitatory effect on sympathetic neurones by inhibiting a time- and voltage-dependent potassium current. During prolonged application of SP, the response desensitizes. The changes in kinetics of the SP…

The antiviral xanthate compound D609 inhibits herpes simplex virus type 1 replication and protein phosphorylation

The mechanism of antiviral action of tricyclodecan-9-yl-xanthogenate (D609) was investigated in vitro. D609 inhibited herpes simplex virus type 1 (HSV-1) replication without apparent cytotoxicity. It reduced phosphorylation of virus-infected cell…

Low-density lipoprotein receptor-related protein mediates in PC12 cell cultures the inhibition of nerve growth factor-promoted neurite outgrowth by pregnancy zone protein and alpha(2)-macroglobulin

Human pregnancy zone protein (PZP) is a major pregnancy-associated plasma protein closely related to human alpha(2)-macroglobulin (alpha(2)M). It has been demonstrated that monoamine-activated forms of human and rat alpha(2)M and rat alpha(2)M can…

Curcumin Differentially Regulates Endoplasmic Reticulum Stress through Transcriptional Corepressor SMILE (Small Heterodimer Partner-interacting Leucine Zipper Protein)-mediated Inhibition of CREBH (cAMP Responsive Element-binding Protein H)

Curcumin (diferuloylmethane), a major active component of turmeric (Curcuma longa), is a natural polyphenolic compound. Herein the effect of curcumin on endoplasmic reticulum (ER) stress responsive gene expression was investigated. We report that…

Angiotensin Type I Receptor Blockade In Conjunction With Enhanced Akt Activation Restores Coronary Collateral Growth In The Metabolic Syndrome

Jadhav R, Dodd T, Smith E, Bailey E, DeLucia AL, Russell JC, Madison R, Potter B, Walsh K, Jo H, Rocic P. Angiotensin type I receptor blockade in conjunction with enhanced Akt activation restores coronary collateral growth in the metabolic syndrome.…

Ampk-dependent Repression Of Hepatic Gluconeogenesis Via Disruption Of Creb Center Dot Crtc2 Complex By Orphan Nuclear Receptor Small Heterodimer Partner

Orphan nuclear receptor small heterodimer partner (SHP) plays a key role in transcriptional repression of gluconeogenic enzyme gene expression. Here, we show that SHP inhibited protein kinase A-mediated transcriptional activity of cAMP-response…

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