Browse Items · NEOMED Bibliography Database

Animal Models of Tinnitus: A Review.

Animal models have significantly contributed to understanding the pathophysiology of chronic subjective tinnitus. They are useful because they control etiology, which in humans is heterogeneous; employ random group assignment; and often use methods…

Tags: 2020, Acoustic startle reflex, Animal models, Brozoski Thomas J, Department of Anatomy & Neurobiology, Galazyuk Alexander, journalArticle, June 2020 Update II, NEOMED College of Medicine, Operant behavioral methods, Otolaryngologic clinics of North America, Psychophysics, Tinnitus

Gap-Prepulse Inhibition of the Acoustic Startle Reflex (GPIAS) for Tinnitus Assessment: Current Status and Future Directions.

The progress in the field of tinnitus largely depends on the development of a reliable tinnitus animal model. Recently, a new method based on the acoustic startle reflex modification was introduced for tinnitus screening in laboratory animals. This…

Tags: 2015, animal model of tinnitus, Department of Anatomy & Neurobiology, Frontiers in neurology, Galazyuk Alexander, gap-prepulse inhibition of the startle reflex, Hebert Sylvie, human tinnitus, NEOMED College of Medicine, tinnitus assessment

The Potential Tinnitus Treatment.

Tags: 2021, Department of Anatomy & Neurobiology, Galazyuk AV, journalArticle, June 2021 List, NEOMED College of Medicine, Online Journal Of Otolaryngology

Temporal features of spectral integration in the inferior colliculus: effects of stimulus duration and rise time.

This report examines temporal features of facilitation and suppression that underlie spectrally integrative responses to complex vocal signals. Auditory responses were recorded from 160 neurons in the inferior colliculus (IC) of awake mustached bats.…

Early development of intrinsic and synaptic properties of chicken nucleus laminaris neurons.

Onset of auditory brainstem responses in chickens takes place at about embryonic day 11/12 (E11/12). We investigated early development of neuronal properties of chicken nucleus laminaris neurons, the third-order auditory neurons critically involved…

Evolution of Carpal Morphology during the Land-to-Water Transition in Whales

Tags: 2019, Anatomy & Morphology, Cooper L N, Department of Anatomy & Neurobiology, Gavazzi L M, Journal of morphology, June 2019 Update, NEOMED College of Medicine, Thewissen J G M

Carpal morphology and function in the earliest cetaceans

During the land-to-water transition in the Eocene epoch, the cetacean skeleton underwent modifications to accommodate life in the seas. These changes are well-documented in the fossil record. The forelimb transformed from a weight-bearing limb with…

Tags: 2021, ARTICLES, Cooper LN, Department of Anatomy & Neurobiology, Fish FE, Gavazzi LM, Hussain ST, January 2021 List, Journal of Vertebrate Paleontology, journalArticle, NEOMED College of Medicine, NEOMED Student Publications, Thewissen JGM

Effects of gap position on perceptual gap detection across late childhood and adolescence.

The ability to detect a silent gap within a sound is critical for accurate speech perception, and gap detection has been shown to have an extended developmental trajectory. In certain conditions, the detectability of the gap decreases as the gap is…

Developmental hearing loss impairs signal detection in noise: putative central mechanisms.

Listeners with hearing loss have difficulty processing sounds in noisy environments. This is most noticeable for speech perception, but is reflected in a basic auditory processing task: detecting a tonal signal in a noise background, i.e.,…

Tags: 2014, auditory cortex, conductive hearing loss, Department of Anatomy & Neurobiology, Electrophysiology, Frontiers in systems neuroscience, Galazyuk Alexander V, Gay Jennifer D, gerbil, intracellular, masking, NEOMED College of Medicine, Noise, Rosen Merri J, signal detection, Voytenko Sergiy V

Parkinson's disease biomarker: a patent evaluation of WO2013153386.

INTRODUCTION: Parkinson's disease (PD) is a neurodegenerative movement disorder resultant from the loss of dopaminergic neurons in the brain. There is an urgent need for effective biomarkers that can be used in the early diagnosis of PD.…

A novel biomechanical analysis of gait changes in the MPTP mouse model of Parkinson's disease.

Parkinson's disease (PD) is an age-associated neurodegenerative disorder hallmarked by a loss of mesencephalic dopaminergic neurons. Accurate recapitulation of the PD movement phenotype in animal models of the disease is critical for understanding…

Tags: 2015, Behavior, Department of Anatomy & Neurobiology, Dluzen Dean E, Gait, Geldenhuys Werner J, Gender-bias, Guseman Tamara L, Locomotion, MPTP, NEOMED College of Medicine, PeerJ, Pienaar Ilse S, Young Jesse W

Severe Bone Loss as Part of the Life History Strategy of Bowhead Whales.

The evolution of baleen constituted a major evolutionary change that made it possible for baleen whales to reach enormous body sizes while filter feeding on tiny organisms and migrating over tremendous distances. Bowhead whales (Balaena mysticetus)…

Development of Feeding and Airway Protection in Preterm Infant Mammals as a Model of Altricial Evolution

12th International Congress of Vertebrate Morphology, held July 21 – 25, 2019 in Prague, Czech Republic
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During the land‐to‐water transition in the Eocene, the cetacean skeleton underwent modifications that are well‐documented in the fossil…

Tags: 2019, Anatomy & Morphology, Department of Anatomy & Neurobiology, German R Z, Gould F H, Journal of morphology, June 2019 Update, Mayerl C J, McGrattan K E, NEOMED College of Medicine

Animal Models for Dysphagia Studies: What Have We Learnt So Far.

Research using animal models has contributed significantly to realizing the goal of understanding dysfunction and improving the care of patients who suffer from dysphagia. But why should other researchers and the clinicians who see patients day in…

Glutamate and metabotropic glutamate receptors associated with innervation of the uterine cervix during pregnancy: receptor antagonism inhibits c-Fos expression in rat lumbosacral spinal cord at parturition.

Dorsal root ganglia (DRG) neurons connect the spinal cord and uterine cervix, and are activated at parturition with subsequent stimulation of secondary neurons in the spinal dorsal horn and autonomic areas. Neuropeptide neurotransmitters and…

Tags: 2007, Animals, Cervix Uteri/*innervation, Department of Anatomy & Neurobiology, Excitatory Amino Acid Antagonists/pharmacology, Female, Ganglia, Gene Expression Regulation/drug effects/*physiology, Ghosh Chaitali, Glutamates/*metabolism, Hafemeister Jen, Journal of neuroscience research, Lumbosacral Region, Messenger/biosynthesis, Metabotropic Glutamate 5, Metabotropic Glutamate/*metabolism, Miller Kenneth E, NEOMED College of Medicine, Neurons/drug effects, Oncogene Proteins v-fos/metabolism, Papka Raymond E, Parturition/*metabolism, Pregnancy/*metabolism, Pyridines/pharmacology, Rats, Receptor, Receptors, Reverse Transcriptase Polymerase Chain Reaction/methods, RNA, Spinal Cord/drug effects/*physiology, Spinal/cytology, Sprague-Dawley, Storey-Workley Megan, Usip Sharon, Vesicular Glutamate Transport Protein 1/metabolism

Update on the diagnostic considerations for neurogenic nasal and sinus symptoms: A current review suggests adding a possible diagnosis of migraine.

BACKGROUND: Treatment of rhinosinusitis (RS) is one of the leading reasons for prescriptions of antibiotics, although they often fail to provide symptomatic relief. Appropriately diagnosing and treating patients presenting with RS for whom antibiotic…

Tags: 2019, American journal of otolaryngology, Antibiotics, Casiano Roy R, Department of Anatomy & Neurobiology, Failed treatment, Godley Frederick A, Gottschalk Christopher, McGeeney Brian, Mehle Mark, Migraine, NEOMED College of Medicine, Paranasal sinuses, Rhinology, Rhinosinusitis, Sinus CT scan, sinusitis

Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.

The ability of humans and animals to localize the source of a sound in a complex acoustic environment facilitates communication and survival. Two cues are used for sound localization at horizontal planes, interaural time and level differences (ITD …

Tags: 2020, December 2020 List, Department of Anatomy & Neurobiology, Frontiers in neural circuits, Goel N, ILD, ITD, journalArticle, Lu Y, mGluR, NEOMED College of Medicine, NEOMED Postdoc Publications, NEOMED Student Publications, neuromodulation, Peng K, Sound Localization

Heterogeneity of variance partitioning between kinematics and electromyography (EMG) of swallowing following nerve lesion in pigs

Tags: 2021, Department of Anatomy & Neurobiology, German RZ, Gould FDH, Integrative and comparative biology, journalArticle, July 2021 List, Lammers AR, Mayerl CM, NEOMED College of Medicine, NEOMED Postdoc Publications

Muscle activity and kinematics show different responses to recurrent laryngeal nerve lesion in mammal swallowing.

Understanding the interactions between neural and musculoskeletal systems is key to identifying mechanisms of functional failure. Mammalian swallowing is a complex, poorly understood motor process. Lesion of the recurrent laryngeal nerve, a sensory…

Tags: 2020, Aspiration, Department of Anatomy & Neurobiology, German RZ, Gould FDH, Journal of neurophysiology, journalArticle, Lammers Andrew R, Mayerl CJ, NEOMED College of Medicine, NEOMED Postdoc Publications, neuromuscular function, Ohlemacher J, September 2020 List, swallowing, Variation

Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson's Disease.

Swallowing disorders in Parkinson's disease are not responsive to dopamine depletion therapy and contribute to morbidity. They are poorly understood owing to a lack of adequate models. We present the first evidence of oropharyngeal changes in a…

Specific Vagus Nerve Lesion Have Distinctive Physiologic Mechanisms of Dysphagia.

Swallowing is complex at anatomical, functional, and neurological levels. The connections among these levels are poorly understood, yet they underpin mechanisms of swallowing pathology. The complexity of swallowing physiology means that multiple…

Tags: 2019, Animal model, Department of Anatomy & Neurobiology, Dysphagia, Frontiers in neurology, German Rebecca Z, Gould François D H, Kinematics, Lammers Andrew R, Mayerl Christopher J, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Recurrent laryngeal nerve, Superior laryngeal nerve

The Physiologic Impact of Unilateral Recurrent Laryngeal Nerve (RLN) Lesion on Infant Oropharyngeal and Esophageal Performance.

Recurrent laryngeal nerve (RLN) injury in neonates, a complication of patent ductus arteriosus corrective surgery, leads to aspiration and swallowing complications. Severity of symptoms and prognosis for recovery are variable. We transected the RLN…

Tags: 2015, Animal, Animals, Aspiration, Ballester Ashley, Biological, Deglutition, Deglutition – Physiology, Deglutition disorders, Deglutition Disorders – Etiology, Deglutition Disorders – Physiopathology, Deglutition Disorders/*etiology/physiopathology, Deglutition/*physiology, Department of Anatomy & Neurobiology, Disease Models, Dysphagia, Esophagus, Esophagus – Physiopathology, Esophagus/*physiopathology, Fraley Luke, German Rebecca Z, Gould François D H, Gross Andrew, Human, Infant, Lammers Andrew R, Laryngeal Nerves – Injuries, Laryngeal Nerves – Physiopathology, Models, NEOMED College of Medicine, Ohlemacher Jocelyn, Oropharynx – Physiopathology, Oropharynx/*physiopathology, Recurrent laryngeal nerve, Recurrent Laryngeal Nerve Injuries/*complications/physiopathology, Recurrent Laryngeal Nerve/*physiopathology, Swine

Central nervous system integration of sensorimotor signals in oral and pharyngeal structures: oropharyngeal kinematics response to recurrent laryngeal nerve lesion.

Safe, efficient liquid feeding in infant mammals requires the central coordination of oropharyngeal structures innervated by multiple cranial and spinal nerves. The importance of laryngeal sensation and central sensorimotor integration in this system…

Pre-pharyngeal Swallow Effects of Recurrent Laryngeal Nerve Lesion on Bolus Shape and Airway Protection in an Infant Pig Model.

Recurrent laryngeal nerve (RLN) damage in infants leads to increased dysphagia and aspiration pneumonia. Recent work has shown that intraoral transport and swallow kinematics change following RLN lesion, suggesting potential changes in bolus…

A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice

Located in the midbrain, the inferior colliculus (IC) is the hub of the central auditory system. Although the IC plays important roles in speech processing, sound localization, and other auditory computations, the organization of the IC…

Brief Stimulus Exposure Fully Remediates Temporal Processing Deficits Induced by Early Hearing Loss.

In childhood, partial hearing loss can produce prolonged deficits in speech perception and temporal processing. However, early therapeutic interventions targeting temporal processing may improve later speech-related outcomes. Gap detection is a…

Benefits of Stimulus Exposure: Developmental Learning Independent of Task Performance.

Perceptual learning (training-induced performance improvement) can be elicited by task-irrelevant stimulus exposure in humans. In contrast, task-irrelevant stimulus exposure in animals typically disrupts perception in juveniles while causing little…

Tags: 2016, Adolescent, Adult, Auditory Perception, Department of Anatomy & Neurobiology, development, experience, Frontiers in neuroscience, gap detection, Green David B, Learning, NEOMED College of Medicine, Ohlemacher Jocelyn, prepulse inhibition, Rosen Merri J

tRNA-derived fragments (tRFs) regulate post-transcriptional gene expression via

OBJECTIVES: Recent studies have shown that tRNA-derived RNA fragments (tRFs) are novel regulators of post-transcriptional gene expression. However, the expression profiles and their role in post-transcriptional gene regulation in chondrocytes is…

Tags: 2020, Ansari M Y, Ball H C, chondrocyte, Department of Anatomy & Neurobiology, Green J A, Haqqi Tariq M, JAK3, journalArticle, June 2020 Update II, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Noncoding RNA, Osteoarthritis, Osteoarthritis and cartilage, Transfer RNA, tRNA-derived fragments

An improved approach to separating startle data from noise.

BACKGROUND: The acoustic startle reflex (ASR) is a rapid, involuntary movement to sound, found in many species. The ASR can be modulated by external stimuli and internal state, making it a useful tool in many disciplines. ASR data collection and…

Automated classification of mouse pup isolation syllables: from cluster analysis to an Excel-based "mouse pup syllable classification calculator".

Mouse pups vocalize at high rates when they are cold or isolated from the nest. The proportions of each syllable type produced carry information about disease state and are being used as behavioral markers for the internal state of animals. Manual…

Tags: 2012, Cluster Analysis, College of Anatomy & Neurobiology, communication call, Department of Anatomy & Neurobiology, Frontiers in behavioral neuroscience, Gadziola Marie A, Grimsley Jasmine M S, isolation calls, mouse pup calls, mouse song, NEOMED College of Medicine, Vocalization, Wenstrup Jeffrey J

Coding the meaning of sounds: contextual modulation of auditory responses in the basolateral amygdala.

Female mice emit a low-frequency harmonic (LFH) call in association with distinct behavioral contexts: mating and physical threat or pain. Here we report the results of acoustic, behavioral, and neurophysiological studies of the contextual analysis…

Development of social vocalizations in mice.

Adult mice are highly vocal animals, with both males and females vocalizing in same sex and cross sex social encounters. Mouse pups are also highly vocal, producing isolation vocalizations when they are cold or removed from the nest. This study…

Contextual Modulation of Vocal Behavior in Mouse: Newly Identified 12 kHz "Mid-Frequency" Vocalization Emitted during Restraint.

While several studies have investigated mouse ultrasonic vocalizations (USVs) emitted by isolated pups or by males in mating contexts, studies of behavioral contexts other than mating and vocalization categories other than USVs have been limited. By…

Tags: 2016, Bhattal Jyoti, College of Anatomy & Neurobiology, context, Department of Anatomy & Neurobiology, Frontiers in behavioral neuroscience, Grimsley Calum A, Grimsley Jasmine M S, isolation, Jasnow Aaron, Latsko Maeson, mouse, NEOMED College of Medicine, Restraint, Sheth Saloni, Stress, Vallabh Neil, Vocalization, Wenstrup Jeffrey J

LVC Timing in Infant Pig Swallowing and the Effect of Safe Swallowing.

Recurrent laryngeal nerve (RLN) injury in neonates, a complication of head and neck surgeries, leads to increased aspiration risk and swallowing dysfunction. The severity of resulting sequelae range from morbidity, such as aspiration pneumonia, to…

Intrinsic plasticity induced by group II metabotropic glutamate receptors via enhancement of high-threshold KV currents in sound localizing neurons.

Intrinsic plasticity has emerged as an important mechanism regulating neuronal excitability and output under physiological and pathological conditions. Here, we report a novel form of intrinsic plasticity. Using perforated patch clamp recordings, we…

Interplay between low threshold voltage-gated K(+) channels and synaptic inhibition in neurons of the chicken nucleus laminaris along its frequency axis.

Central auditory neurons that localize sound in horizontal space have specialized intrinsic and synaptic cellular mechanisms to tightly control the threshold and timing for action potential generation. However, the critical interplay between…

Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes.

There is growing evidence in support of the involvement of inflammatory response in the pathogenesis of osteoarthritis (OA). Harpagoside, one of the bioactive components of Harpagophytum procumbens (Hp), has been shown to possess anti-inflammatory…

Tags: *c-FOS/AP-1, *harpagoside, *IL-6, *MMP-13, *OSTEOARTHRITIS, 2017, Ansari Mohammad Yunus, CCAAT-Enhancer-Binding Protein-beta/metabolism, Chemokines/metabolism, Chondrocytes/*drug effects/metabolism, Department of Anatomy & Neurobiology, Drug Evaluation, Glycosides/pharmacology/*therapeutic use, Haqqi Tariq M, Harpagophytum, Haseeb Abdul, Humans, Interleukin-1beta, Interleukin-6/antagonists & inhibitors/*metabolism, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Matrix Metalloproteinase 13/metabolism, NEOMED College of Medicine, NF-kappa B/metabolism, Osteoarthritis/*drug therapy/metabolism, Phytotherapy, Plant Extracts/pharmacology/therapeutic use, Preclinical, Primary Cell Culture, Proto-Oncogene Proteins c-fos/metabolism, Pyrans/pharmacology/*therapeutic use, Reactive Oxygen Species/metabolism, Transcription Factor AP-1/metabolism

Immunopathogenesis of osteoarthritis.

Even though osteoarthritis (OA) is mainly considered as a degradative condition of the articular cartilage, there is increasing body of data demonstrating the involvement of all branches of the immune system. Genetic, metabolic or mechanical factors…

Tags: 2013, Adaptive Immunity, Animals, Clinical immunology (Orlando, Fla.), Department of Anatomy & Neurobiology, Haqqi Tariq M, Haseeb Abdul, Humans, Immunity, Innate, NEOMED College of Medicine, Osteoarthritis/*immunology, Signal Transduction

A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-kappaB and IL-6 Expression by Blocking the Activation of IKKbeta and NIK in Primary Human Chondrocytes.

Pomegranate fruit extract (PE) rich in polyphenols has been shown to exert chondroprotective effects, but the mechanism is not established. Here, we used an in vitro model of inflammation in osteoarthritis (OA) to investigate the potential of PE to…

Tags: 2017, Ashruf Omer S, Chondrocytes, Chondrocytes – Drug Effects, Chondrocytes/drug effects, Department of Anatomy & Neurobiology, Fruit, Fruit/chemistry, Gene Expression Regulation/drug effects, Genes – Drug Effects, Haqqi Tariq M, Haseeb Abdul, Humans, I-kappa B Kinase/genetics/*metabolism, IkappaB, IKKbeta, IL-1beta, Interleukin 1 – Metabolism, Interleukin-1beta/metabolism, Interleukin-6/genetics/*metabolism, Interleukins, Interleukins – Metabolism, Khan Nazir M, NEOMED College of Medicine, NF-kappa B, NF-kappa B – Metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, NIK, Osteoarthritis, Phosphorylation – Drug Effects, Phosphorylation/drug effects, Phytotherapy research : PTR, Plant Extracts, Plant Extracts – Pharmacodynamics, Plant Extracts/chemistry/*pharmacology, Polyphenols – Pharmacodynamics, Polyphenols/pharmacology, Pomegranate, Protein-Serine-Threonine Kinases/genetics/*metabolism, Proteins – Metabolism, Punicaceae/*chemistry, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Transcription Factor RelA/metabolism, Transferases, Transferases – Metabolism

Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, alpha-Ketoglutarate (alpha-KG), and DNA hydroxymethylation levels by interleukin-1beta in primary human chondrocytes.

5-Hydroxymethylcytosine (5-hmC) generated by ten-eleven translocation 1-3 (TET1-3) enzymes is an epigenetic mark present in many tissues with different degrees of abundance. IL-1beta and TNF-alpha are the two major cytokines present in arthritic…

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