Browse Items · NEOMED Bibliography Database

Use of brain slices to study long-term potentiation and depression as examples of synaptic plasticity.

Brain slices have been responsible for the majority of advances in our understanding of the cellular aspects of altered synaptic strength underlying memory, long-term potentiation (LTP) and long-term depression (LTD), and increases and decreases,…

Tags: *Long-Term Potentiation, *Neuronal Plasticity, 1999, Animals, Brain/*physiology, Electrophysiology/methods, Glutamic Acid/physiology, In Vitro Techniques, Memory/*physiology, Methods (San Diego, Calif.), Models, Neurological, Synapses/*physiology, Synaptic Transmission, Teyler T J

Control of a depolarizing GABAergic input in an auditory coincidence detection circuit.

Neurons in the chicken nucleus laminaris (NL), the third-order auditory neurons that detect the interaural time differences that enable animals to localize sounds in the horizontal plane, receive glutamatergic excitation from the cochlear nucleus…

Mesenteric vascular responses to vasopressin during development of DOCA-salt hypertension in male and female rats.

Deoxycorticosterone acetate (DOCA)-salt hypertension develops to a greater extent in male (M) than in female (F) rats. To determine the role of the vasculature, reactivity to arginine vasopressin (AVP) and prostanoid output were examined in the…

Sex differences in nitric oxide-mediated attenuation of vascular reactivity to vasopressin are abolished by gonadectomy.

In the rat thoracic aorta, contractile responses to vasopressin are two-fold higher in females than in males, primarily because nitric oxide-mediated attenuation of contraction is greater in males than in females. To determine the role of the gonadal…

Localization and function of NK(3) subtype tachykinin receptors of layer V pyramidal neurons of the guinea-pig medial prefrontal cortex.

The NK(3) subtype of tachykinin receptor has been implicated as a modulator of synaptic transmission in several brain regions, including the cerebral cortex. The localization and expression of NK(3) receptors within the brain vary from species to…

Tags: 2008, Animals, Autoradiography/methods, Dose-Response Relationship, Drug, Drug Interactions, Excitatory Amino Acid Antagonists/pharmacology, Excitatory Postsynaptic Potentials/drug effects/radiation effects, Guinea Pigs, In Vitro Techniques, Iodine Isotopes/pharmacokinetics, Male, Medd A M, Membrane Potentials/drug effects/physiology/radiation effects, Neurokinin B/analogs & derivatives/pharmacokinetics, Neurokinin-3/agonists/antagonists & inhibitors/*metabolism, Neuroscience, Patch-Clamp Techniques, Peptide Fragments/pharmacology, Prefrontal Cortex/*cytology, Protein Binding/drug effects, Pyramidal Cells/drug effects/*metabolism, Quinolines/pharmacology, Quinoxalines/pharmacology, Receptors, Simmons M A, Sobotka-Briner C D, Substance P/analogs & derivatives/pharmacology, Valine/analogs & derivatives/pharmacology

Redox-dependent coronary metabolic dilation.

We have observed that hydrogen peroxide (H2O2), the dismutated product of superoxide, is a coronary metabolic dilator and couples myocardial oxygen consumption to coronary blood flow. Because the chemical activity of H2O2 favors its role as an…

Tags: *Paracrine Communication, *Vasodilation/drug effects, 2007, Acetylcysteine/pharmacology, American journal of physiology. Heart and circulatory physiology, Animals, Antioxidants/pharmacology, Cardiac/drug effects/*metabolism, Chilian William M, Conditioned/metabolism, Coronary Vessels/drug effects/enzymology/*metabolism, Culture Media, Department of Integrative Medical Sciences, Dick Gregory M, Dithiothreitol/pharmacology, Enzyme Activation, Fluorescence, Hydrogen Peroxide/metabolism, Imidazoles/pharmacology, In Vitro Techniques, Kiyooka Takahiko, Microscopy, Myocytes, NEOMED College of Medicine, Nitroprusside/pharmacology, Oxidation-Reduction, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism, Park Yoonjung, Phosphorylation, Protein Kinase Inhibitors/pharmacology, Pyridines/pharmacology, Rats, Reactive Oxygen Species/*metabolism, Reducing Agents/pharmacology, Rocic Petra, Rogers Paul A, Saitoh Shu-ichi, Sulfhydryl Compounds/*metabolism, Swafford Albert, Vasodilator Agents/pharmacology, Viswanathan Chandrasekar, Wistar, Zhang Cuihua

Herpes simplex virus type 1 penetration initiates mobilization of cell surface proteins.

Changes in membrane structure resulting from herpes simplex virus 1 (HSV-1) penetration were detected using fluorescence photobleaching recovery methods. The effect could be blocked by inhibitors of viral and cellular processes involved in virus…

Role of EDRF in the cardiopulmonary dysfunction produced by massive sympathetic activation.

This study was undertaken to determine whether endothelium-derived relaxing factor (EDRF) modulates the pulmonary and systemic hemodynamic responses to massive sympathetic nervous system (SNS) activation and, in so doing, also modulates the degree of…

Persistent left ventricular dysfunction after cocaine treatment in rabbits.

The present study was undertaken to determine whether the diminished cardiac performance associated with cocaine administration persists after the drug has been eliminated from the body. Cocaine (5 or 10 mg/kg iv) was administered to conscious (n =…

Factors involved in left ventricular dysfunction after massive sympathetic activation.

We sought to determine whether catecholamines are responsible for the depressed left ventricular (LV) function that follows massive sympathetic nervous system (SNS) activation and whether the additional myocardial energy demands of

Tags: *Ventricular Function, 1992, Animals, Blood Pressure/drug effects/physiology, Bosso F J, Catecholamines/physiology, Female, Heart Conduction System/*physiology, Heart Diseases/*physiopathology, Heart Rate/drug effects, In Vitro Techniques, Left, Male, Maron M B, Pilati C F, Rabbits, Sympathetic Nervous System/drug effects/*physiology, The American journal of physiology, Veratrine/pharmacology

A critical period for long-term potentiation in the developing rat visual cortex.

The in vitro rodent visual cortical slice preparation demonstrates a critical period for long-term potentiation (LTP). Current source density (CSD) analysis reveals peak potentiation of both supra-(layers II-III) and infragranular (layers V) layers…

Tags: 1988, Aging, Animals, Brain research, Electric Stimulation, In Vitro Techniques, Neuronal Plasticity, Newborn, Perkins A T 4th, Rats, Teyler T J, Visual Cortex/*growth & development/physiology

Effect of peak inspiratory pressure on the filtration coefficient in the isolated perfused rat lung.

Positive inspiratory pressure- (PIP) ventilated, isolated rat lungs become edematous when perfused at rates approximately the normal cardiac output. The study was conducted to test the hypothesis that high peak inspiratory pressures contribute to the…

The modulation of long-term potentiation by delta-9-tetrahydrocannabinol in the rat hippocampus, in vitro.

The duration of long-term potentiation (LTP) of the CA1 evoked field potential in rat hippocampal slices was significantly modulated by pre-treatment of slices with delta-9-tetrahydrocannabinol (THC) added to the incubation media. The three THC doses…

Tags: 1987, Animals, Brain research bulletin, Dronabinol/*pharmacology, Evoked Potentials/drug effects, Hippocampus/*drug effects/physiology, In Vitro Techniques, Kinetics, Male, Nowicky A V, Pyramidal Tracts/drug effects/physiology, Rats, Teyler T J, Time Factors, Vardaris R M

Estrogen, but not testosterone, attenuates methamphetamine-evoked dopamine output from superfused striatal tissue of female and male mice.

The gonadal steroid hormone, estrogen, has the capacity to function as a neuroprotectant against methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic system within female, but not male, mice. In an attempt to understand some…

Tags: 2003, Anderson L I, Animals, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Estrogens/*metabolism, Female, In Vitro Techniques, Male, Methamphetamine/*pharmacology, Mice, Myers R E, Neuropharmacology, Orchiectomy, Ovariectomy, Perfusion, Testosterone/*metabolism

Aging and sex differences in striatal dopaminergic function.

In this report the potassium- (30 mM) and amphetamine- (10 microM) stimulated responses of dopamine (DA) and 3,4-dihydroxy phenylacetic acid (DOPAC) from superfused striatal tissue of female and male mice as sampled at 2, 6, 18 and 24 months of age…

Effect of papaverine on pulmonary vascular permeability to proteins.

Previous studies have suggested that papaverine, a drug commonly used in studies of transvascular fluid and solute exchange to eliminate confounding effects of changes in vascular tone, may itself increase vascular permeability. In this study, we…

Tags: 1988, Animals, Blood Proteins/*metabolism, Capillary Permeability/*drug effects, Dogs, Female, In Vitro Techniques, Journal of applied physiology (Bethesda, Md. : 1985), Male, Maron M B, Osmosis, Papaverine/blood/*pharmacology, Pilati C F, Pulmonary Circulation/*drug effects, Serotonin/pharmacology, Vasodilation/drug effects, Water-Electrolyte Balance/drug effects

Effect of extreme elevations in venous pressure on reflection coefficient in the lung.

We determined whether the solvent drag reflection coefficient (sigma f) for total proteins of a canine perfused left lower lung lobe (LLL) preparation decreases at elevated venous pressures (Pv). We found that sigma f (estimated using the…

Time course of blood volume changes in an isolated lung lobe after venous pressure elevation.

The elevation of venous pressure (Pv) in isolated perfused organs causes organ weight to increase in a biphasic manner. The initial rapid phase results primarily from an increase in blood volume (BV), whereas the second slower phase is generally…

Tags: *Blood Volume/drug effects, *Pulmonary Circulation, *Venous Pressure, 1994, Animals, Dogs, Extravascular Lung Water/metabolism, Female, In Vitro Techniques, Indicator Dilution Techniques, Indocyanine Green, Journal of applied physiology (Bethesda, Md. : 1985), Lane S M, Lung/*physiology, Male, Maron M B, Papaverine/pharmacology, Perfusion, Time Factors

Pulmonary vasoconstriction in a canine model of neurogenic pulmonary edema.

The intracisternal administration of veratrine to the chloralose-anesthetized dog produces pulmonary hypertension (PH) and neurogenic pulmonary edema (NPE). To determine whether pulmonary vasoconstriction, mediated by a circulating agent, contributes…

Effect of elevated vascular pressure transients on protein permeability in the lung.

Neurogenic pulmonary edema (NPE) may develop in individuals with head trauma or seizures and is generally thought to have a hydrostatic basis in the severe degree of pulmonary hypertension that occurs. Recently, it has been suggested that vascular…

Tags: *Blood Pressure, 1989, Animals, Blood Proteins/*metabolism, Dogs, Female, Hypertension/physiopathology, In Vitro Techniques, Journal of applied physiology (Bethesda, Md. : 1985), Lung/metabolism/*physiopathology, Male, Maron M B, Pulmonary Edema/*etiology/metabolism/physiopathology

Endogenous mGluR activity suppresses GABAergic transmission in avian cochlear nucleus magnocellularis neurons.

GABAergic transmission in the avian cochlear nucleus magnocellularis (NM) of the chick is subject to modulation by gamma-aminobutyric acid type B (GABA(B)) autoreceptors. Here, I investigated modulation of GABAergic transmission in NM by metabotropic…

Tags: 2-Amino-5-phosphonovalerate/pharmacology, 2007, Amino Acids/pharmacology, Animals, Chickens/*physiology, Cochlear Nucleus/*cytology/*physiology, Department of Anatomy & Neurobiology, Electric Stimulation, Excitatory Amino Acid Antagonists/pharmacology, Excitatory Postsynaptic Potentials/physiology, GABA-B Receptor Agonists, GABA-B Receptor Antagonists, GABA-B/physiology, gamma-Aminobutyric Acid/*physiology, Glycine/analogs & derivatives/pharmacology, In Vitro Techniques, Journal of neurophysiology, Kinetics, Lu Yong, Membrane Potentials/drug effects, Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism/physiology, Models, NEOMED College of Medicine, Neurological, Neurons/*physiology, Patch-Clamp Techniques, Receptors, Resorcinols/pharmacology, Synapses/physiology, Synaptic Transmission/*physiology, Xanthenes/pharmacology

Selective photothermolysis of the sebaceous glands for acne treatment.

BACKGROUND AND OBJECTIVES: The purpose of this study is to evaluate the efficacy of a long pulse diode laser (Cynosure, Inc.) to target and destroy enlarged sebaceous glands that are preloaded with Indocyanine green (ICG) chromophore. STUDY…

Tags: *Hyperthermia, *Photolysis, *Phototherapy, 2002, Acne Vulgaris/pathology/*therapy, Combined Modality Therapy, Department of Internal Medicine, Feasibility Studies, Follow-Up Studies, Humans, In Vitro Techniques, Induced, Lasers in surgery and medicine, Lloyd Jenifer R, Mirkov Mirko, NEOMED College of Medicine, Sebaceous Glands/pathology/*radiation effects, Time Factors, Treatment Outcome

Metabotropic glutamate receptor antagonist, (R,S)-alpha-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus.

The necessity of metabotropic glutamate receptors (mGluRs) in the induction of long-term potentiation (LTP) has recently been questioned. We examined the effect of (R,S)-alpha-methyl-4-caboxyphenylglycine (MCPG), a selective mGluR antagonist, on two…

Tags: 1995, Animals, Benzoates/*pharmacology, Calcium Channels/drug effects/metabolism/physiology, Electric Stimulation, Electrophysiology, Excitatory Amino Acid Antagonists/*pharmacology, Glycine/*analogs & derivatives/pharmacology, Grover L M, Hippocampus/drug effects/*physiology, In Vitro Techniques, Ion Channel Gating/drug effects, Little Z, Long-Term Potentiation/*drug effects, Metabotropic Glutamate/*antagonists & inhibitors, Neuroscience letters, Rats, Receptors, Teyler T J

GABAa receptor-mediated field potentials are enhanced in area CA1 following prenatal cocaine exposure.

Prenatal cocaine exposure results in several documented changes in neurotransmitter receptor number and structure. Increases have been reported for cortical catecholamine and indoleamine receptor number and binding affinity, in the subunit expression…

Prenatal cocaine exposure leads to enhanced long-term potentiation in region CA1 of hippocampus.

Cocaine use by pregnant women is currently of concern for its social and economic impact. Clinical studies of cocaine exposed offspring are limited by methodological constraints. In this study we used a rabbit model to examine the effects of…

Tags: *Prenatal Exposure Delayed Effects, 1996, Animals, Brain research. Developmental brain research, Cocaine/*administration & dosage/pharmacology, Electrophysiology, Female, Hippocampus/*drug effects/physiology, In Vitro Techniques, Little J Z, Long-Term Potentiation/*drug effects, Narcotics/*administration & dosage/pharmacology, Neuronal Plasticity/drug effects, Pregnancy, Rabbits, Reference Values, Synapses/drug effects, Teyler T J

Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells.

Cholesterol 7 alpha-hydroxylase (CYP7A1) of the bile acid biosynthesis pathway is suppressed by bile acids and inflammatory cytokines. Bile acids are known to induce inflammatory cytokines to activate the mitogen-activated protein kinase/c-Jun…

Circulating neuropeptide Y does not produce pulmonary hypertension during massive sympathetic activation.

We tested the possibility that neuropeptide Y (NPY) may contribute to the pulmonary hypertension that occurs after massive sympathetic activation produced by intracisternal veratrine administration in the chloralose-anesthetized dog. In six dogs,…

Tags: 1992, Adrenal Glands/drug effects/physiology, Adrenalectomy, Animals, Dogs, Hypertension, In Vitro Techniques, Journal of applied physiology (Bethesda, Md. : 1985), Lang S A, Maender K C, Maron M B, Neuropeptide Y/*physiology, Norepinephrine/pharmacology, Pilati C F, Pulmonary Circulation/drug effects, Pulmonary/chemically induced/*physiopathology, Sympathetic Nervous System/*physiology, Veratrine/pharmacology

Effect of neuropeptide Y on hemodynamics of the rabbit lung.

We evaluated the effect of neuropeptide Y (NPY) on the hemodynamics of the isolated rabbit lung perfused at constant flow and outflow pressure. Doses of 10(-8) and 10(-7) M NPY increased pulmonary arterial pressure (Ppa) from 11.5 +/- 1.0 (SE) mmHg…

Tags: 1998, Animals, Cisterna Magna, Hemodynamics/*physiology, In Vitro Techniques, Injections, Journal of applied physiology (Bethesda, Md. : 1985), Lang S A, Maron M B, Neuropeptide Y/blood/pharmacology/*physiology, Norepinephrine/pharmacology, Perfusion, Pulmonary Circulation/drug effects/*physiology, Rabbits, Sympathetic Nervous System/drug effects/physiology, Vascular Resistance/drug effects/physiology, Vasoconstriction/drug effects/physiology, Vasoconstrictor Agents/pharmacology, Veratrine/administration & dosage/pharmacology

Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus.

The effects of adenosine on inhibitory synaptic transmission in area CA1 were examined using the rat hippocampal slice preparation and intracellular recording. Adenosine did not change fast inhibitory synaptic potentials (IPSPs) but depressed late…

Tags: 1991, 2-Amino-5-phosphonovalerate/pharmacology, Adenosine/*pharmacology, Animals, Evoked Potentials/drug effects, Hippocampus/drug effects/*physiology, In Vitro Techniques, Lambert N A, Membrane Potentials/drug effects, Neuroscience letters, Quinoxalines/pharmacology, Rats, Synapses/*drug effects, Synaptic Transmission/*drug effects, Teyler T J, Theophylline/analogs & derivatives/pharmacology

Cholinergic disinhibition in area CA1 of the rat hippocampus is not mediated by receptors located on inhibitory neurons.

We studied the effects of carbamylcholine (carbachol; CCh) on monosynaptic inhibitory postsynaptic potentials (IPSPs) evoked in the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and…

Induction of giant depolarizing potentials by zinc in area CA1 of the rat hippocampus does not result from block of GABAB receptors.

The possibility that zinc (Zn2+) induces giant depolarizing potentials (GDPs) by blocking pre- and postsynaptic gamma-aminobutyric acidB (GABAB) receptors in area CA1 of rat hippocampal slices was investigated. Monosynaptic GABAA receptor-mediated…

Tags: *GABA-A Receptor Antagonists, 1992, 2-Amino-5-phosphonovalerate/pharmacology, Animals, Baclofen/pharmacology, Harrison N L, Hippocampus/cytology/*drug effects, In Vitro Techniques, Interneurons/drug effects/physiology, Lambert N A, Levitin M, Membrane Potentials/drug effects, Neuroscience letters, Quinoxalines/pharmacology, Rats, Synapses/drug effects, Zinc/*pharmacology

Baclofen-induced disinhibition in area CA1 of rat hippocampus is resistant to extracellular Ba2+.

The mechanism of disinhibition produced by (+/-)-baclofen was studied using intracellular recording in area CA1 of rat hippocampal slices. Baclofen reversibly depressed monosynaptic IPSPs evoked by direct activation of interneurons in the presence of…

Tags: 1991, 2-Amino-5-phosphonovalerate/pharmacology, Animals, Baclofen/antagonists & inhibitors/*pharmacology, Barium/*pharmacology, Brain research, Drug Resistance/physiology, Evoked Potentials/drug effects, GABA-A/*drug effects, Harrison N L, Hippocampus/*drug effects, In Vitro Techniques, Interneurons/drug effects, Lambert N A, Neural Inhibition/drug effects, Quinoxalines/pharmacology, Rats, Receptors, Teyler T J

Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen.

The effects of the GABAB receptor antagonist 2-hydroxy-saclofen were studied using intracellular recording of synaptic potential from CA1 hippocampal neurons.

Tags: 1989, Action Potentials/drug effects, Animals, Baclofen/*analogs & derivatives/pharmacology, GABA-A Receptor Antagonists, GABA-A/*physiology, Harrison N L, Hippocampus/drug effects/*physiology, In Vitro Techniques, Kerr D I, Lambert N A, Neural Inhibition/*drug effects, Neuroscience letters, Ong J, Prager R H, Rats, Receptors, Teyler T J

Hyperpolarizing and depolarizing GABAA receptor-mediated dendritic inhibition in area CA1 of the rat hippocampus.

1. gamma-Aminobutyric acidA (GABAA) receptor-mediated inhibition of pyramidal neuron dendrites was studied in area CA1 of the rat hippocampal slice preparation with the use of intracellular and extracellular recording and one-dimensional current…

Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins.

BACKGROUND: Metabotropic glutamate receptors (mGluRs) regulate neuronal excitability and synaptic strength. The group I mGluRs, mGluR1 and 5, are widespread in the brain and localize to post-synaptic sites. The Homer protein family regulates group I…

Acute exercise attenuates phenylephrine-induced contraction of rabbit isolated aortic rings.

Factors associated with a single bout of dynamic exercise (increased circulating catecholamines, increased body temperature, and decreased pH) are known to attenuate the vascular response to alpha-adrenergic receptor activation. Therefore, we…

Reduced vascular responsiveness after a single bout of dynamic exercise in the conscious rabbit.

We measured agonist-induced changes in the iliac artery blood flow velocity (IFV) independent of baroreflex-mediated compensatory mechanisms in chronically instrumented New Zealand White rabbits (n = 8). Animals were instrumented with a Doppler flow…

Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation.

Enduring synaptic potentiation can be induced in area CA1 of hippocampus by tetanic stimulation and by exposure to a medium containing high Ca2+ concentration. Both tetanic stimulation and high Ca2+ induce potentiation through voltage-dependent,…

Tags: 1990, 2-Amino-5-phosphonovalerate/*pharmacology, Action Potentials/drug effects, Animals, Calcium/*pharmacology, Electric Stimulation, Grover L M, Hippocampus/drug effects/*physiology, In Vitro Techniques, N-Methyl-D-Aspartate, Neuronal Plasticity/*drug effects, Neuroscience letters, Neurotransmitter/antagonists & inhibitors/*physiology, Receptors, Teyler T J

Two components of long-term potentiation induced by different patterns of afferent activation.

Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in…

Tags: 1990, 2-Amino-5-phosphonovalerate/*pharmacology, Afferent Pathways/physiology, Animals, Calcium/*physiology, Grover L M, Hippocampus/*physiology, In Vitro Techniques, Membrane Potentials, Memory/*physiology, N-Methyl-D-Aspartate/*physiology, Nature, Neuronal Plasticity, Receptors, Synaptic Transmission, Teyler T J, Time Factors

N-methyl-D-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus: input-specific induction and preclusion in a non-tetanized pathway.

We previously reported that an N-methyl-D-aspartate receptor-independent component of long-term potentiation with an apparent delayed onset can be induced in area CA1 of the hippocampus. Here we show that some but not all of this delay in onset can…

Tags: 1992, 2-Amino-5-phosphonovalerate/*pharmacology, Animals, Electron, Evoked Potentials/drug effects, Grover L M, Hippocampus/*physiology, In Vitro Techniques, Microscopy, N-Methyl-D-Aspartate/*physiology, N-Methylaspartate/*pharmacology, Neuroscience, Pyramidal Tracts/drug effects/*physiology, Rats, Receptors, Teyler T J, Time Factors

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