Browse Items (35 total)
- Tags: Journal of lipid research
Saturated Fatty Acids Activate Erk Signaling To Downregulate Hepatic Sortilin 1 In Obese And Diabetic Mice
Tags: 2013, apolipoprotein-b secretion, Bi L P, Biochemistry & Molecular Biology, Cells, Chiang J Y L, Diabetes, Ding W X, Dunn W, extracellular signal-regulated kinase, Fatty Liver, Function, induced insulin-resistance, Journal of lipid research, LDL, Li T G, Lipid Metabolism, Liver, mitogen-activated protein kinase, Obesity, overproduction, Oxidative Stress, Roberts B, ubiquitination, Vascular, vldl production
Saturated Fatty Acids Activate Erk Signaling To Downregulate Hepatic Sortilin 1 In Obese And Diabetic Mice
Tags: 2013, apolipoprotein-b secretion, Bi L P, Biochemistry & Molecular Biology, Cells, Chiang J Y L, Diabetes, Ding W X, Dunn W, extracellular signal-regulated kinase, Fatty Liver, Function, induced insulin-resistance, Journal Article or Conference Abstract Publication, Journal of lipid research, LDL, Li T G, Lipid Metabolism, Liver, mitogen-activated protein kinase, Obesity, overproduction, Oxidative Stress, Roberts B, ubiquitination, Vascular, vldl production
Nuclear receptor-mediated repression of human cholesterol 7 alpha-hydroxylase gene transcription by bile acids
Tags: 2001, activation, Bile acid synthesis, Biochemistry & Molecular Biology, Chen W L, Chiang J Y L, cyp7a, cytochrome P450, expression, hepg2 cells, identification, Journal Article or Conference Abstract Publication, Journal of lipid research, Liver, mechanism of gene regulation, messenger-rna, orphan receptor, Owsley E, promoter, SHP, Stroup D, Yang Y Z
Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids.
Tags: *Hydroxysteroid Dehydrogenases, *Membrane Glycoproteins, 2001, Animals, Bile Acids and Salts/*pharmacology, Caco-2 Cells, Carrier Proteins/genetics/physiology, Cell Line, Chen W, Chiang J Y, CHO Cells, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear/genetics/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/drug effects/genetics/physiology, DNA/metabolism, Embryo, Gene Expression/*drug effects, Genetic, Genetic/drug effects, Humans, Journal of lipid research, Kidney, Liver/metabolism, Luciferases/genetics, Mammalian, Messenger/analysis, NEOMED College of Medicine, Owsley E, Promoter Regions, Rats, Receptors, Recombinant Fusion Proteins/metabolism, Retinoic Acid/genetics/physiology, Retinoid X Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Stroup D, Taurocholic Acid/pharmacology, Transcription, Transcription Factors/drug effects/genetics/physiology, Transfection, Tumor Cells, Yang Y
Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice
Tags: 1, 2014, 25-dihydroxyvitamin d-3, Absorption, BILE acids, bile-acid, Biochemistry & Molecular Biology, Cheng J, Chiang J Y L, cytochrome-p450 3a4, Disease, expression, Fang Z Z, Gonzalez F J, Journal Article or Conference Abstract Publication, Journal of lipid research, Kim J H, Krausz K W, Metabolomics, Permeability, Tanaka N, vitamin D receptor
Bile acids: regulation of synthesis.
Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Biological, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Humans, Journal of lipid research, Models, NEOMED College of Medicine, Receptors, Signal Transduction/physiology
Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.
Tags: *Receptors, *Transcriptional Activation, 1998, Animals, Base Sequence, Bile Acids and Salts/biosynthesis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, DNA/metabolism, Galli G, Genes, Genetic, Hepatocyte Nuclear Factor 4, Hormones/*physiology, Journal of lipid research, Luciferases/genetics, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid, Oligonucleotide Probes/metabolism, Phosphoproteins/metabolism, Promoter Regions, Rats, Receptors, Repetitive Sequences, Reporter, Retinoic Acid/metabolism, Retinoid X Receptors, Sadeghpour A, Site-Directed, Steroid, Stroup D, Transcription Factors/metabolism, Tumor Cells
Transcriptional activation of the cholesterol 7 alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors
Tags: 1998, alpha-hydroxylase, bile acid response element, Bile acid synthesis, Biochemistry & Molecular Biology, Chiang J Y L, cholesterol 7, Crestani M, cytochrome P450, elements, expression, factor coup-tf, Galli G, gene transcription and regulation, hormone receptor, Journal Article or Conference Abstract Publication, Journal of lipid research, Liver, messenger-rna, Metabolism, mutations, nuclear, promoter, rat, retinoic acid receptors, Sadeghpour A, Stroup D
Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7).
Tags: *Promoter Regions, *Transcription, 1995, Animals, Base Sequence, Cell Count, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Crestani M, Cultured, Cyclic AMP/pharmacology, Department of Integrative Medical Sciences, Enzymologic/*physiology, Gene Expression Regulation, Genetic, Hormones/*pharmacology, Journal of lipid research, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Phorbol Esters/pharmacology, Rats, Second Messenger Systems/physiology, Stroup D, Transfection, Tumor Cells
Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.
Tags: *bile acids and salt/metabolism, *cholesterol/diet, *Lipids, *Liver, 2016, Animal, Animals, Bile Acids and Salts/genetics/metabolism, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Diet, Disease Models, Exhalation/genetics, Ferrell Jessica M, Glucose/metabolism, High-Fat, Homeostasis, Humans, Journal of lipid research, Li Feng, Lipid Metabolism/genetics, Liver/enzymology/pathology, Metabolic Diseases/*genetics/metabolism, Mice, NEOMED College of Medicine
Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis.
Tags: *Aldehyde Reductase/genetics/metabolism, 2011, Adenoviridae, Animal, Animals, Blood Glucose/*metabolism, Chiang John Y L, Cholesterol/analysis, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism/physiopathology, Disease Models, Fatty Liver/genetics/*metabolism/physiopathology, Ge Xuemei, Gene Expression, Genetic Vectors, Gluconeogenesis/genetics, Homeostasis, Humans, Journal of lipid research, Li Tiangang, Liver/*metabolism/physiopathology, Ma Huiyan, Malondialdehyde/blood, Mice, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, Transfection, Transgenic, Triglycerides/analysis, Yin Liya, Zhang Yanqiao
Cholesterol 7-alpha-hydroxylase - Evidence For Transcriptional Regulation By Cholesterol Or Metabolic Products Of Cholesterol In The Rat
Tags: 1993, bile fistula, bile-acid synthesis, Biochemistry & Molecular Biology, biosynthesis, Chiang J Y L, Cloning, enterohepatic circulation, enzyme, hepatic cholesterol, hepatocytes, Heuman D M, HMG-CoA reductase, Hylemon P B, Jones M P, Journal Article or Conference Abstract Publication, Journal of lipid research, liver microsomes, lovastatin, messenger-rna, mevalonate, Pandak W M, Stimulation, Vlahcevic Z R
Expression and purification of human cholesterol 7 alpha-hydroxylase in Escherichia coli.
Tags: 1994, Animals, Base Sequence, Catalysis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/genetics/*isolation & purification, Cytochrome P-450 Enzyme System/biosynthesis/isolation & purification, Department of Integrative Medical Sciences, Escherichia coli, Humans, Immunochemistry, Journal of lipid research, Karam W G, Kinetics, Molecular Sequence Data, NEOMED College of Medicine, Rats, Recombinant Proteins/biosynthesis, Solubility, Subcellular Fractions/enzymology
Fluorocholesterols, In Contrast To Hydroxycholesterols, Exhibit Interfacial Properties Similar To Cholesterol
Tags: 2000, A, bile-acids, Biochemistry & Molecular Biology, Carey M C, condensation, enzyme-catalyzed oxidation, isotherm, Journal Article or Conference Abstract Publication, Journal of lipid research, Kauffman J M, monolayers, Orientation, orphan nuclear receptor, phosphatidylcholine, phosphatidylcholines, reductase-activity, side-chain, spectroscopic imaging, sterol synthesis, surface balance, surface potential, Westerman P W
Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: *Gene Expression Regulation, 2010, Acetylation, AMP-Activated Protein Kinases/metabolism, ATP Citrate (pro-S)-Lyase/genetics/metabolism, Bile Acids and Salts/metabolism, Cells, Chanda Dipanjan, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Epigenesis, Genes, Genetic, Glucose/*administration & dosage, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*enzymology/metabolism, Histones/metabolism, Humans, Hyperglycemia/enzymology/*metabolism, Journal of lipid research, Li Tiangang, Messenger/metabolism, Methylation, NEOMED College of Medicine, Reporter, RNA, RNA Interference, Zhang Yanqiao
PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine.
Tags: *Lipid Metabolism, 2007, ATP Binding Cassette Transporter, ATP Binding Cassette Transporter 1, ATP-Binding Cassette Transporters/genetics, Base Sequence, Cell Line, Chen Wenling, Chiang John Y L, Cholestanetriol 26-Monooxygenase/*metabolism, Cholesterol, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Fluorinated, Genes, Genetic/drug effects, Genetic/genetics, HDL/metabolism, Hepatocytes/drug effects/enzymology/metabolism, Humans, Hydrocarbons, Hydroxycholesterols/metabolism/pharmacology, Intestinal Mucosa/metabolism, Intestines/cytology/drug effects/enzymology, Journal of lipid research, Li Tiangang, Member 1, Messenger/genetics/metabolism, Molecular Sequence Data, NEOMED College of Medicine, Pregnane X Receptor, Promoter Regions, Receptors, Reporter, Response Elements/genetics, Rifampin/pharmacology, RNA, Steroid/*metabolism, Subfamily G, Sulfonamides/pharmacology, Transcription, Up-Regulation/drug effects
TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression.
Tags: *Gene Expression Regulation, 2008, Animals, Cell Line, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Department of Integrative Medical Sciences, Enzymologic, Forkhead Transcription Factors/physiology, Humans, Insulin/*physiology, Journal of lipid research, Li Tiangang, Ma Huiyan, Male, NEOMED College of Medicine, Nerve Tissue Proteins/physiology, Rats, Signal Transduction, Smad3 Protein/antagonists & inhibitors/pharmacology, Sprague-Dawley, Transforming Growth Factor beta1/*physiology, Tumor, Tumor Necrosis Factor-alpha/*physiology
Cholesterol 7alpha-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.
Tags: *bile acid, *Cholesterol 7-alpha-Hydroxylase/genetics/metabolism, *Farnesoid X receptor, *Homeostasis, *Liver Cirrhosis/chemically induced/enzymology/genetics/prevention & control, *Liver/enzymology/pathology, *nuclear receptor, *Takeda G protein-coupled receptor 5, 2016, Animals, Boehme Shannon, Chiang John Y L, Cholesterol/genetics/*metabolism, Department of Integrative Medical Sciences, G-Protein-Coupled/genetics/metabolism, Hep G2 Cells, Humans, Journal of lipid research, Knockout, Liu Hailiang, Mice, NEOMED College of Medicine, NF-kappa B/genetics/metabolism, Oxidative Stress, Pathak Preeti, Receptors, Tumor Necrosis Factor-alpha/genetics/metabolism
Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *DNA-Binding Proteins, *Regulatory Sequences, 2000, Animals, Anticholesteremic Agents/pharmacology, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Clofibric Acid/pharmacology, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Enzymologic, Gene Expression Regulation, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Marrapodi M, Models, NEOMED College of Medicine, Nucleic Acid, Peroxisome Proliferators/pharmacology, Phosphoproteins/metabolism, Promoter Regions, Protein Binding, Pyrimidines/pharmacology, Rats, Receptors, Reporter, Response Elements, Retinoic Acid/metabolism, Retinoid X Receptors, Species Specificity, Transcription, Transcription Factors/*agonists/metabolism, Transcriptional Activation
Peroxisome Proliferator-activated Receptor Alpha (ppar Alpha) And Agonist Inhibit Cholesterol 7 Alpha-hydroxylase Gene (cyp7a1) Transcription
Tags: 2000, bezafibrate, Bile acid synthesis, Biochemistry & Molecular Biology, Chiang J Y L, cytochrome P450, Drugs, elements, expression, fatty-acids, gallstones, HNF-4, hypolipidemic, hypolipidemic drugs, isoform, Journal of lipid research, lipoprotein metabolism, Marrapodi M, Nuclear Receptors, peroxisome proliferators, rat, suppression
Cholesteryl ester transfer protein alters liver and plasma triglyceride metabolism through two liver networks in female mice.
Tags: *estrogen, *estrogen receptor alpha, *lipid and lipoprotein metabolism, *small heterodimer partner, *triglycerides, *very low density lipoprotein, 2016, Animals, Cholesterol Ester Transfer Proteins/*physiology, Department of Integrative Medical Sciences, Estrogen Receptor alpha/metabolism, Estrogens/physiology, Female, Inbred C57BL, Journal of lipid research, Le Thao D, Lee Yoon-Kwang, Lipid Metabolism, Liver/*metabolism, Metabolic Networks and Pathways, Mice, NEOMED College of Medicine, Oxidation-Reduction, Palmisano Brian T, Stafford John M, Transgenic, Triglycerides/biosynthesis/*blood, Zhu Lin
Hormonal regulation of cholesterol 7 alpha-hydroxylase specific activity, mRNA levels, and transcriptional activity in vivo in the rat
Tags: 1997, bile-acid biosynthesis, Biochemistry & Molecular Biology, Chiang J Y L, Cholesterol, cholesterol 7 alpha-hydroxylase, cultures, gene, gene cyp7, Glucocorticoid, hepatic cholesterol, hepatocyte cultures, Heuman D M, Hylemon P B, Journal Article, Journal of lipid research, Liver, messenger-rna levels, monolayer-cultures, Pandak W M, primary, protein-kinase-c, Redford K, regulation, sterol 27-hydroxylase, Stravitz R T, thyroid, thyroid-hormone, Vlahcevic Z R
BILE-ACID SYNTHESIS .6. REGULATION OF CHOLESTEROL 7-ALPHA-HYDROXYLASE BY TAUROCHOLATE AND MEVALONATE
Tags: 1992, 3-hydroxy-3-methylglutaryl, 7-alpha-hydroxylase, BILE acids, Biochemistry & Molecular Biology, biosynthesis, Chiang J Y L, circadian-rhythm, Cloning, coenzyme, enzyme, hepatocytes, Heuman D M, HMG-CoA reductase, Hylemon P B, Journal Article, Journal of lipid research, Liver, messenger-rna, Pandak W M, rat-liver microsomes, reductase, substrate, Vlahcevic Z R
Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner
Tags: 2011, Anakk S, beta-oxidation, Biochemistry & Molecular Biology, birth-weight, Choi J S, diet-induced obesity, fatty-acid oxidation, hepatic steatosis, Induced, insulin sensitivity, insulin-resistance, Jang H C, Journal Article, Journal of lipid research, Kim J, Kim S C, Lee J M, Lee K U, Lee Y K, lipid-metabolism, Liver, Moore D D, negative feedback-regulation, Novak C M, Oxygen Consumption, Park J, Park Y J, quotient, respiratory, retinoic acid, signaling pathways, skeletal-muscle, Tseng H T, Yechoor V
The stimulatory effect of LXR alpha is blocked by SHP despite the presence of a LXR alpha binding site in the rabbit CYP7A1 promoter
Tags: 2006, alpha-fetoprotein transcription, bile-acid biosynthesis, Biochemistry & Molecular Biology, Chiang J Y L, cholesterol 7 alpha-hydroxylase, cholesterol 7-alpha-hydroxylase gene, dietary-cholesterol, factor, Farnesoid X receptor, inhibition, Journal Article, Journal of lipid research, liver X receptor, messenger-rna levels, Nuclear Receptor, orphan, Pan L X, rat, Salen G, Saumoy M, Shang Q, SHP, taurocholate, Tint G S, Transcription, Xu G R
A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.
Tags: 2010, 3' Untranslated Regions/genetics, Base Sequence, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Department of Integrative Medical Sciences, Enzymologic/drug effects/*genetics, Fibroblast Growth Factors/pharmacology, Gene Expression Regulation, Genetic/drug effects/genetics, Hep G2 Cells, Hepatocytes/drug effects/enzymology/*metabolism, Humans, Isoxazoles/pharmacology, Journal of lipid research, Li Tiangang, MicroRNAs/*genetics/*metabolism, NEOMED College of Medicine, Oligonucleotide Array Sequence Analysis, Owsley Erika, Post-Transcriptional/drug effects/genetics, RNA Processing, Song Kwang-Hoon, Transcription
HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).
Tags: *Receptors, *Transcription, 2000, Animals, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Cultured, Department of Integrative Medical Sciences, DNA Primers, DNA-Binding Proteins/*metabolism, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Luciferases/genetics, Mutation, NEOMED College of Medicine, Phosphoproteins/*metabolism, Promoter Regions, Rats, Recombinant Proteins/metabolism, Reporter, Sprague-Dawley, Steroid, Stroup D, Transcription Factors/*metabolism, Tumor Cells
HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7 alpha-hydroxylase gene (CYP7A1)
Tags: 2000, BILE acids, bile-acid synthesis, Biochemistry & Molecular Biology, Chiang J Y L, chicken ovalbumin, cholesterol metabolism, dna-binding, Hepatocyte Nuclear Factor 4, hormone-receptor superfamily, Journal Article, Journal of lipid research, messenger-rna, orphan receptors, promoter, Receptors, Response Elements, retinoic acid, Stroup D, thyroid-hormone, transcriptional regulation, upstream promoter transcription factor II
Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells.
Tags: *Promoter Regions, *Transcription, *Transcription Factors, 1996, Base Sequence, Binding Sites, Cell Line, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Consensus Sequence, Crestani M, Department of Integrative Medical Sciences, DNA-Binding Proteins/genetics/metabolism, Enzyme Repression, Enzymologic/*drug effects, Galli G, Gene Expression Regulation, Genes, Genetic, Glucocorticoid/genetics/metabolism, Glucocorticoids/pharmacology, Hepatocyte Nuclear Factor 3-alpha, Humans, Insulin/pharmacology, Journal of lipid research, Marrapodi M, Molecular Sequence Data, NEOMED College of Medicine, Nuclear Proteins/genetics/metabolism, Phorbol Esters/pharmacology, Receptors, Recombinant Fusion Proteins/biosynthesis, Reporter, Stroup D, Thyroid Hormones/pharmacology, Transfection, Wang D P
Physicochemical characterization of a model digestive mixture by 2H NMR.
Physicochemical characterization of a model digestive mixture by H-2 NMR
Tags: 1995, adult human-beings, bile salts, bile-salt, biliary lipid systems, Biochemistry & Molecular Biology, c-13 nmr, Cholesterol, contents, digestion, fat, H-2-labeled lipids, human intestinal, intestinal lipids, Journal Article, Journal of lipid research, liquid-crystalline phases, nuclear magnetic-resonance, phosphatidylcholine mixed micelles, physical-chemical behavior, Westerman P W
Structure and functions of human oxysterol 7 alpha-hydroxylase cDNAs and gene CYP7B1
Tags: 1999, 27-hydroxycholesterol, 7-alpha-hydroxylase, bile-acid synthesis, Biochemistry & Molecular Biology, Brain, Chiang J Y L, Cholesterol, cholesterol 7 alpha-hydroxylase, cytochrome P450, dehydroepiandrosterone (DHEA), human liver-microsomes, identification, Javitt N B, Journal Article, Journal of lipid research, Martin K O, neurosteroids, Transcription, Wu Z L
Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1.
Tags: 1999, Animals, Base Sequence, Blotting, Cell Line, Chiang J Y, Chromosome Mapping, Cloning, Codon, Complementary/biosynthesis/*isolation & purification, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA, Genetic, Genetic/genetics, Humans, Hydroxycholesterols/metabolism, Initiator, Javitt N B, Journal of lipid research, Luciferases/genetics, Martin K O, Mice, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Northern, Nucleic Acid, Promoter Regions, Regulatory Sequences, Steroid Hydroxylases/*genetics/metabolism, Transcription, Transfection, Wu Z