Browse Items (132 total)
- Tags: Dose-Response Relationship
A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE.
Tags: 1989, 5)-, Ala(2)-MePhe(4)-Gly(5)-, Amines – Physiology, Anesthetics – Pharmacodynamics, Anesthetics/*pharmacology, Animals, Biogenic Monoamines/*physiology, Cell Surface – Drug Effects, Cell Surface – Physiology, Crisp T, D-Penicillamine (2, Dose-Response Relationship, Drug, Enkephalin, Enkephalins, Enkephalins – Pharmacodynamics, Enkephalins/*pharmacology, Inbred Strains, Injections, Intraspinal, Male, Naloxone – Pharmacodynamics, Naloxone/pharmacology, Opioid/drug effects/*physiology, Pain, Pain – Metabolism, Pain/*metabolism, Rats, Receptors, Spanos L J, Spinal, Spinal Cord – Drug Effects, Spinal Cord – Metabolism, Spinal Cord – Physiopathology, Spinal Cord/drug effects/metabolism/*physiopathology, Stafinsky J L
A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.
Tags: 1995, 5)-, Ala(2)-MePhe(4)-Gly(5)-, Animals, Crisp T, D-Penicillamine (2, Dose-Response Relationship, Drug, Enkephalin, Enkephalins/*pharmacology, General pharmacology, Keck B J, Male, Naltrexone/analogs & derivatives/pharmacology, Narcotic Antagonists/*pharmacology, Opioid/*drug effects, Rats, Receptors, Somatostatin/analogs & derivatives/pharmacology, Species Specificity, Spinal Cord/*drug effects, Sprague-Dawley, Stafinsky J L, Uram M
A novel binding assay identifies high affinity ligands to the rosiglitazone binding site of mitoNEET.
Tags: 2011, Awale Prabha S, Binding Sites/drug effects, Bioorganic & medicinal chemistry letters, Carroll Richard T, Dose-Response Relationship, Drug, Funk Max O, Geldenhuys Werner J, Ligands, Lin Li, Mitochondrial Proteins/*antagonists & inhibitors/metabolism, Molecular Structure, Recombinant Proteins/antagonists & inhibitors/metabolism, Rosiglitazone, Stereoisomerism, Structure-Activity Relationship, Thiazolidinediones/chemical synthesis/chemistry/*pharmacology
A Rare Case of Tubulointerstitial Nephritis and Uveitis Syndrome Treated with a Multi-Specialty Approach.
Tags: 2016, Biopsy, Combination, Department of Internal Medicine, Diagnosis, Differential, Dose-Response Relationship, Drug, Drug Therapy, Erzurum Sergul, Female, Follow-Up Studies, Glucocorticoids/administration & dosage, Hiremath Siri, Humans, Interstitial/diagnosis/*drug therapy, Kidney/*diagnostic imaging, NEOMED College of Medicine, Nephritis, Prednisolone/administration & dosage/*analogs & derivatives, Prednisone/*administration & dosage, Purt Boonkit, Recurrence, Sarac Erdal, Smith Sarah, The American journal of case reports, Uveitis/diagnosis/*drug therapy, Young Adult
A standardized extract of Butea monosperma (Lam.) flowers suppresses the
Tags: *Butea, 2017, Aged, Ansari Mohammad Y, Autophagy, Autophagy/drug effects/physiology, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Butea monosperma (Lam.), Chondrocytes/drug effects/*metabolism, Department of Anatomy & Neurobiology, Dose-Response Relationship, Drug, Flowers, Gene Expression, Haqqi Tariq M, Humans, Interleukin-1beta/*pharmacology, Interleukin-6/*biosynthesis/genetics, Khan Nazir M, Matrix Metalloproteinase 13/biosynthesis/genetics, Matrix Metalloproteinase 3/biosynthesis/genetics, Matrix Metalloproteinase 9/biosynthesis/genetics, Matrix Metalloproteinases/*biosynthesis/genetics, Middle Aged, mTOR, NEOMED College of Medicine, Nutraceuticals, Osteoarthritis, Osteoarthritis/*metabolism, Plant Extracts/isolation & purification/pharmacology
A subtherapeutic international normalized ratio despite increasing doses of warfarin: could this be malabsorption?
Tags: *Drug Resistance, 2000, Administration, Adult, Anticoagulants/administration & dosage/metabolism/pharmacokinetics/therapeutic use, Area Under Curve, Biological Availability, Delgado L L, Department of Family & Community Medicine, Department of Internal Medicine, Dose-Response Relationship, Drug, Female, Frazee L A, Haupt K M, Humans, Injections, Intestinal Absorption/*physiology, Intravenous, Kidney Transplantation, Lara L F, NEOMED College of Medicine, Oral, Rutecki G W, The American journal of the medical sciences, Warfarin/*administration & dosage/*metabolism/pharmacokinetics/therapeutic use
Activation of metabotropic glutamate receptor 1 dimers requires glutamate binding in both subunits.
Tags: 2005, Blotting, Calcium Channels/drug effects/metabolism, Department of Integrative Medical Sciences, DNA/biosynthesis/genetics, Dose-Response Relationship, Drug, Fluorescent Antibody Technique, Genes, Glutamic Acid/*metabolism, Humans, Kammermeier Paul J, Membrane Potentials/drug effects, Metabotropic Glutamate/genetics/*metabolism, myc/genetics, NEOMED College of Medicine, Patch-Clamp Techniques, Plasmids/genetics, Receptors, Signal Transduction/drug effects, Superior Cervical Ganglion/cytology/drug effects/metabolism, Sympathetic Nervous System/cytology/drug effects/metabolism, The Journal of pharmacology and experimental therapeutics, Western, Yun June
Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat.
Tags: 1989, 3, 4-methylenedioxyamphetamine, 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology, Amphetamines/*pharmacology, Animal/*drug effects, Animals, Behavior, Designer Drugs/*pharmacology, Dose-Response Relationship, Drug, Inbred Strains, Male, Motor Activity/*drug effects, N-Methyl-3, Pharmacology, biochemistry, and behavior, Rats, Receptors, Serotonin/*drug effects, Spanos L J, Time Factors, Yamamoto B K
Acute exercise attenuates phenylephrine-induced contraction of rabbit isolated aortic rings.
Tags: *Physical Conditioning, 1992, Adrenergic, alpha/physiology, Animal, Animals, Aorta/physiology, DiCarlo S E, Dose-Response Relationship, Drug, Howard M G, In Vitro Techniques, Medicine and science in sports and exercise, Muscle, Muscle Contraction/*drug effects, Phenylephrine/*pharmacology, Rabbits, Receptors, Smooth, Stallone J N, Vascular/*drug effects/physiology
Acute exercise enhances nitric oxide modulation of vascular response to phenylephrine.
Tags: *Physical Exertion, 1993, Animals, Arginine/analogs & derivatives/pharmacology, Blood Flow Velocity, Blood Pressure/drug effects, Blood Vessels/*drug effects, Collins H L, DiCarlo S E, Dose-Response Relationship, Drug, Female, Heart Rate/drug effects, Iliac Artery/drug effects/physiology, Male, NG-Nitroarginine Methyl Ester, Nitric Oxide/antagonists & inhibitors/*physiology, Patil R D, Phenylephrine/*pharmacology, Rats, Sprague-Dawley, The American journal of physiology, Time Factors, Vasoconstriction/drug effects/physiology
Advantages and disadvantages of a rapid method to train drug discrimination.
Tags: 1988, 3, 4-methylenedioxyamphetamine, 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology, Amphetamines/*pharmacology, Animals, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Tolerance, Male, Methods, N-Methyl-3, Pharmacology, biochemistry, and behavior, Rats, Schechter M D
Age-related changes in the spinal antinociceptive effects of DAGO, DPDPE and beta-endorphin in the rat.
Tags: 1994, 5)-, Aging/*physiology, Ala(2)-MePhe(4)-Gly(5)-, Analgesics/*pharmacology, Analysis of Variance, Animals, beta-Endorphin/administration & dosage/*pharmacology, Brain research, Crisp T, D-Penicillamine (2, Dose-Response Relationship, Drug, Enkephalin, Enkephalins/administration & dosage/*pharmacology, Gordon T L, Hoskins D L, Inbred F344, Injections, Male, Pain/*physiopathology, Perni V C, Rats, Spinal, Spine/drug effects/growth & development/*physiology, Stafinsky J L, Uram M
An open-label dose escalation study to evaluate the safety of administration of nonviral stromal cell-derived factor-1 plasmid to treat symptomatic ischemic heart failure.
Tags: *Plasmids, 2013, Aged, Aras Rahul, Brain/blood, Chemokine CXCL12/*genetics/metabolism, Circulation research, Clemens Ruth, Cohort Studies, Dose-Response Relationship, Drug, Echocardiography, Exercise Tolerance, Farr Maryjane, Female, Follow-Up Studies, Genetic Therapy/*adverse effects/*methods, Heart Failure/metabolism/pathology/*therapy, Humans, Losordo Douglas W, Male, Mendelsohn Farrell O, Middle Aged, Myocardium/metabolism/pathology, Natriuretic Peptide, Pastore Joseph, Penn Marc S, Peptide Fragments/blood, Positron-Emission Tomography, Quality of Life, Rouy Didier, Schaer Gary L, Sherman Warren, Treatment Outcome
Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-kappaB and Nrf2 Signaling Pathways.
Tags: 10-Dimethyl-1, 2-benzanthracene/toxicity, 2017, 9, Animal Studies, Animals, Anti-Inflammatory Agents/*pharmacology, anti-inflammatory effects, Anticarcinogenic Agents/pharmacology, Apoptosis/drug effects, Bhatia Deepak, Bishayee Anupam, Breast Neoplasms, breast tumor, Cell Transformation, Chemoprevention, COX-2, Cyclooxygenase 2/genetics/metabolism, DMBA, Dose-Response Relationship, Drug, Experimental/*prevention & control, Female, Gene Expression Regulation, HSP90, HSP90 Heat-Shock Proteins/genetics/metabolism, I-kappa B Kinase/genetics/metabolism, Inflammation Mediators, Mammary Neoplasms, Mandal Animesh, Neoplasms – Prevention and Control, Neoplastic, Neoplastic/drug effects, NF-E2-Related Factor 2/genetics/*metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, Nrf2, Nutrients, Physical Education and Training, Plant Preparations/*pharmacology, Pomegranate, Punica granatum, Punicaceae/*chemistry, Rats, Signal Transduction
Antiepileptics inhibit cortical N-methyl-D-aspartate-evoked [3H]norepinephrine efflux.
Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells.
Tags: 2013, Aerial, Antineoplastic Agents, Bishayee Anupam, Carcinoma, Desert Climate, Dose-Response Relationship, Drug, Harlev Eli, Hep G2 Cells, Hepatocellular/*drug therapy/pathology, Humans, Inhibitory Concentration 50, Liver Neoplasms/*drug therapy/pathology, Mandal Animesh, Medicinal/chemistry, Nevo Eviatar, Pharmaceutical biology, Phytogenic/administration & dosage/*pharmacology, Plant Components, Plant Extracts/administration & dosage/*pharmacology, Plants, Tetrazolium Salts/chemistry, Thiazoles/chemistry, Thoppil Roslin J, Time Factors
Antitumor efficacy and tolerability of systemically administered gallium acetylacetonate-loaded gelucire-stabilized nanoparticles.
Tags: *Lethal Dose 50, 2013, Adenocarcinoma/*drug therapy/pathology, Animals, Antineoplastic Agents/administration & dosage/pharmacokinetics/toxicity, Bi Lipeng, Cell Line, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Drug Stability, Drug Tolerance, Gallium/*administration & dosage/pharmacokinetics/*toxicity, Geldenhuys Werner J, Humans, Journal of biomedical nanotechnology, Metabolic Clearance Rate, Mice, Nanocapsules/*administration & dosage/chemistry/*toxicity, NEOMED College of Pharmacy, Nude, Organ Specificity, Oyewumi Moses O, Tissue Distribution, Treatment Outcome, Triglycerides/chemistry, Tumor, Wehrung Daniel
Attenuation of drinking sweetened water following calcium channel blockade.
Tags: 1992, Animals, Brain research bulletin, Calcagnetti D J, Calcium Channel Blockers/*pharmacology, Cocaine/pharmacology, Dihydropyridines/pharmacology, Dose-Response Relationship, Drinking Behavior/*drug effects, Drug, Female, Inbred Strains, Injections, Intraventricular, Isradipine, Male, Rats, Reward, Schechter M D, Taste/*drug effects
Behavioral effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE; "EVE").
Tags: 1987, 3, 4-methylenedioxyamphetamine, 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology, Amphetamines/*pharmacology, Animals, Boja J W, Discrimination (Psychology), Dose-Response Relationship, Drug, Inbred Strains, Legislation, Male, N-Methyl-3, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Time Factors, United States
Biphasic effects of ethanol tested with drug discrimination in HAD and LAD rats.
Tags: 1992, Alcohol Drinking/genetics/*psychology, Animals, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Inbred Strains, Krimmer E C, Male, Pentobarbital/pharmacology, Pharmacology, biochemistry, and behavior, Rats, Serotonin Antagonists/pharmacology, Sleep/drug effects, Time Factors, Tropanes/pharmacology
Calcium channel blockade attenuates angiotensin II-induced drinking in rats.
Tags: 1993, Amino Acid Sequence, Angiotensin II/*antagonists & inhibitors/pharmacology, Animals, Brain research bulletin, Calcagnetti D J, Calcium Channel Blockers/administration & dosage/*pharmacology, Dimethyl Sulfoxide/pharmacology, Dose-Response Relationship, Drinking Behavior/*drug effects, Drug, Injections, Intraventricular, Isradipine/pharmacology, Male, Molecular Sequence Data, Rats, Schechter M D, Sprague-Dawley
CGS 10746B is able to attenuate the effects of amphetamine: further evidence for dopaminergic mediation.
Tags: 1988, Alkaloids/pharmacology, Animals, Antipsychotic Agents/*pharmacology, Apomorphine/pharmacology, Boja J W, Cocaine/pharmacology, Conditioning, Dextroamphetamine/antagonists & inhibitors/*pharmacology, Discrimination (Psychology)/*drug effects, Dopamine/*physiology, Dose-Response Relationship, Drug, Male, Operant/drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Thiazepines/*pharmacology
Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma.
Tags: *Chemoprevention, 2011, Analysis of Variance, Animal, Animal Studies, Animal/drug effects, Animals, Antioxidants, Behavior, Bishayee Anupam, Blotting, Booth Tristan D, Carcinoma, Cardiotoxicity, Cardiotoxins/*toxicity, Chemoprevention, Data Analysis Software, Department of Integrative Medical Sciences, Descriptive Statistics, Disease Models, Doppler, Dose-Response Relationship, Drug, Echocardiography, Feeding Behavior/drug effects, Female, Fisher's Exact Test, Funding Source, Heart – Drug Effects, Heart/drug effects/physiopathology, Hepatocellular – Prevention and Control, Hepatocellular/*drug therapy/pathology/physiopathology, Hepatocytes/drug effects/pathology, Hodnichak Cheryl M, Humans, Investigational new drugs, Liver Neoplasms/*drug therapy/pathology/physiopathology, Liver/drug effects/pathology/physiopathology, Luther Daniel J, Meszaros J Gary, NEOMED College of Medicine, Ohanyan Vahagn, Polyphenols – Therapeutic Use, Rats, Resveratrol, Shamhart Patricia E, Sisakian Hamayak, Sprague-Dawley, Stilbenes/*therapeutic use, Systole/drug effects, Western
Clinical impact of temporary therapy interruptions on anticoagulation control in patients treated with warfarin.
Tags: 2013, Aged, American journal of therapeutics, Anticoagulants – Administration and Dosage, Anticoagulants – Therapeutic Use, Atrial Fibrillation – Drug Therapy, Blood Coagulation Disorders – Drug Therapy, Boros Melanie L, Coronary Thrombosis – Drug Therapy, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Monitoring, Euthanasia, Female, Gallegos Patrick J, Human, International Normalized Ratio, Male, Middle Age, NEOMED College of Pharmacy, Passive, Postoperative Care, Preoperative Care, Prospective Studies, Retrospective Design, Rybarczyk Amy M, Treatment Outcomes, Venous Thromboembolism – Drug Therapy, Warfarin – Administration and Dosage, Warfarin – Therapeutic Use, Zimmerman Jacob P
Cocaethylene produces discriminative stimulus properties in the rat: effect of cocaine and ethanol coadministration.
Tags: 1995, Animals, Cocaine/*analogs & derivatives/pharmacokinetics/*pharmacology, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Ethanol/pharmacokinetics/*pharmacology, Male, Pharmacology, biochemistry, and behavior, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley
Cocaethylene-induced lethality in mice is potentiated by alcohol.
Cocaine discrimination is attenuated by isradipine and CGS 10746B.
Tags: 1993, Animals, Antipsychotic Agents/*pharmacology, Calcium Channel Blockers/*pharmacology, Cocaine/antagonists & inhibitors/*pharmacology, Conditioning, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Ibogaine/pharmacology, Isradipine/*pharmacology, Male, Operant/drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Serotonin Antagonists/pharmacology, Sprague-Dawley, Thiazepines/*pharmacology, Tropanes/pharmacology
Comparison of anorectic drugs in rats trained to discriminate between satiation and deprivation.
Tags: *Food Deprivation, 1990, Amphetamine/*pharmacology, Analysis of Variance, Animals, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Fenfluramine/*analogs & derivatives/*pharmacology, Inbred Strains, Life sciences, Male, Norfenfluramine/*pharmacology, Rats, Satiation/*drug effects, Schechter M D
Comparison of the behavioral effects of ibogaine from three sources: mediation of discriminative activity.
Conditioned place aversion produced by dopamine release inhibition.
Tags: 1994, Analysis of Variance, Animal, Animals, Antipsychotic Agents/administration & dosage/*pharmacology, Aversive Therapy, Conditioning (Psychology), Disease Models, Dopamine Antagonists/administration & dosage/*pharmacology, Dose-Response Relationship, Drug, European journal of pharmacology, Injections, Intraperitoneal, Male, Meechan S M, Motor Activity/*drug effects, Random Allocation, Rats, Schechter M D, Sprague-Dawley, Thiazepines/administration & dosage/*pharmacology
Conditioned place preference produced by the psychostimulant cathinone.
Tags: 1993, Alkaloids/administration & dosage/*pharmacology, Animals, Central Nervous System Stimulants/administration & dosage/*pharmacology, Choice Behavior/drug effects, Conditioning (Psychology)/drug effects, Dose-Response Relationship, Drug, European journal of pharmacology, Habituation, Male, Meehan S M, Motor Activity/*drug effects, Psychophysiologic, Rats, Schechter M D, Sprague-Dawley
Differences in response to the aversive properties and activity effects of low dose ethanol in LAS and HAS selectively bred rats.
Differential training sequence effect upon psychostimulant discrimination.
Tags: 1993, Alkaloids/pharmacology, Animals, Appetite Depressants/pharmacology, Central Nervous System Stimulants/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Food, Male, Phenylpropanolamine/pharmacology, Progress in neuro-psychopharmacology & biological psychiatry, Psychotropic Drugs/pharmacology, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley
Direct microinjection of cathinone into the rat brain produces discriminative stimuli.
Tags: *Brain/anatomy & histology, 1992, Alkaloids/administration & dosage/*pharmacology, Animals, Calcagnetti D J, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, Inbred Strains, Injections, Intraventricular, Male, Microinjections, Nucleus Accumbens/anatomy & histology, Pharmacology, biochemistry, and behavior, Psychotropic Drugs/*pharmacology, Rats, Schechter J B, Schechter M D
Discrete versus cumulative dosing in dose-response discrimination studies.
Tags: 1997, 4-methylenedioxyamphetamine/*pharmacology, Animals, Chemical, Cocaine/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Evaluation, European journal of pharmacology, Male, N-Methyl-3, Preclinical, Rats, Schechter M D, Sprague-Dawley, Stimulation
Discrimination of cocaethylene in rats trained to discriminate between its components.
Discriminative characteristics of high and low cocaine administration: effect of other psychostimulants.
Tags: 1997, Amphetamine/pharmacology, Animals, Central Nervous System Stimulants/pharmacology, Cocaine/*pharmacology, Conditioning, Discrimination Learning/*drug effects, Dopamine Agents/*pharmacology, Dose-Response Relationship, Drug, Drug Evaluation, Generalization, Male, Methamphetamine/pharmacology, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Preclinical, Propiophenones/pharmacology, Psychotropic Drugs/*pharmacology, Rats, Response/*drug effects, Schechter M D
Discriminative effects of cocaethylene in rats trained to discriminate cocaine or ethanol.
Discriminative stimulus effect of phenylephrine.
Tags: 1991, Adrenergic, Adrenergic alpha-Agonists/pharmacology, Adrenergic alpha-Antagonists/pharmacology, alpha/drug effects, Animals, Archives internationales de pharmacodynamie et de therapie, Cues, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Generalization, Inbred Strains, Male, Phenylephrine/*pharmacology, Rats, Receptors, Reinforcement Schedule, Schechter M D, Stimulus/drug effects
Discriminative stimulus properties of CGS 10746B: similarity to dopamine D1 receptor antagonists.
Tags: 1996, Amphetamines/pharmacology, Animals, Antipsychotic Agents/*pharmacology, Behavioural brain research, Cholinergic Agents/pharmacology, Clozapine/pharmacology, Cues, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dopamine D1/*antagonists & inhibitors, Dose-Response Relationship, Drug, Generalization, Male, Meehan S M, Rats, Receptors, Response/drug effects, Schechter M D, Serotonin Agents/pharmacology, Serotonin Receptor Agonists/pharmacology, Sprague-Dawley, Thiazepines/*pharmacology