Browse Items (315 total)
- Tags: Mice
Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists.
Tags: 2017, Animals, Antagonist, Benzopyrans/chemical synthesis/*pharmacology, Chalcones, Chalcones/chemical synthesis/*pharmacology, Chen Yuan, Chromenes, Cytoplasmic and Nuclear/*antagonists & inhibitors, Deng Ruitang, European journal of medicinal chemistry, Fang Weishuo, Farnesoid X receptor, Flavones/chemical synthesis/*pharmacology, Huan Yi, Jiang Qian, Liu Jinsong, Liu Shuainan, Liver Diseases/drug therapy, Liver/chemistry/*drug effects/metabolism, Mice, Receptors, Shen Zhufang, Sun Deyang, Tan Wenjuan, Triglycerides/analysis, Verma Ruchi, Wang Na, Wang Xing, Wong Chiwai, Xu Yang, Zhang Guoning, Zhang Yanqiao
Formulation and photoirradiation parameters that influenced photoresponsive drug delivery using alkoxylphenacyl-based polycarbonates.
Tags: 2014, Animals, Biocompatibility, Cardiotoxicity, Cell Line, Chamsaz Elaheh A, Chemistry, Department of Pharmaceutical Sciences, Dose-Response Relationship, Doxorubicin, Drug, Drug Delivery Systems/*methods, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Heart/drug effects, Humans, Inbred BALB C, Joy Abraham, Mice, Nanotechnology, NEOMED College of Pharmacy, Oyewumi Moses O, Pharmaceutical, Photic Stimulation/*methods, Photoresponsive, Photosensitizing Agents/*chemical synthesis/radiation effects/toxicity, Polycarboxylate Cement/*chemical synthesis/radiation effects/toxicity, Polymer chain scission, Stimuli-responsive, Tumor, Wehrung Daniel
Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue.
Tags: 2009, Animals, Bezuidenhout Lois-May, Biological Transport/drug effects, Buffers, Calcium Channels/metabolism, Dluzen Dean E, Dopamine Plasma Membrane Transport Proteins/metabolism, Dopamine Uptake Inhibitors/*pharmacology, Dopamine/*metabolism, European journal of pharmacology, Extracellular Space/*drug effects/*metabolism, Geldenhuys Werner J, In Vitro Techniques, Male, Methamphetamine/pharmacology, Mice, Neostriatum/*cytology/drug effects, PC12 Cells, Perfusion, Potassium Channel Blockers/pharmacology, Potassium Channels, Potassium Chloride/pharmacology, Rats, Voltage-Gated/antagonists & inhibitors
Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma.
Tags: *Astrocyte, *Axonopathy, *Glaucoma, *Gliosis, *neurodegeneration, *Retinal ganglion cell, 2016, Animal, Animals, Astrocytes/*pathology, Axons/pathology, Calkins David J, Cooper Melissa L, Crish Samuel D, Department of Pharmaceutical Sciences, Disease Models, Experimental eye research, Glaucoma, Horner Philip J, Imaging, Inbred DBA, Inman Denise M, Mice, NEOMED College of Pharmacy, Nerve Degeneration/etiology/*pathology, Open-Angle/*pathology, Optic Nerve Diseases/etiology/*pathology, Optic Nerve/*pathology, Photomicrography, Retinal Ganglion Cells/*pathology, Three-Dimensional, Time Factors
Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus.
Tags: *Axon regeneration, *Axotomy, *Diabetes, *Neuropathy, *Peripheral nervous system, 2017, Animal, Animals, Antibiotics, Antineoplastic/toxicity, Blood Glucose/drug effects, Body Weight/drug effects, Crish Samuel D, Cytokine Receptor gp130/genetics/*metabolism, Cytokines/metabolism, DeFrancesco Alicia, Department of Pharmaceutical Sciences, Diabetes Mellitus, Disease Models, Experimental neurology, Experimental/chemically induced/complications/*pathology, Fasting/blood, Filous Angela R, Gene Expression Regulation/*physiology, Hyperalgesia/etiology, Hyperglycemia/etiology, Inbred C57BL, Lindborg Jane A, Male, Malhotra Nisha A, Mice, NEOMED College of Pharmacy, Nerve Degeneration/*etiology/pathology, Nerve Tissue Proteins/metabolism, Niemi Jon P, Pain Measurement, Signal Transduction/drug effects/*physiology, Streptozocin/toxicity, Superior Cervical Ganglion/drug effects/*metabolism, Sweating/drug effects, Wilson Gina N, Zhou Bowen, Zigmond Richard E
Protein thiyl radical mediates S-glutathionylation of complex I.
Tags: *Oxidative Stress, 2012, Amino Acid Motifs, Amino Acid Sequence, Animals, Binding Sites, Cattle, Cell Line, Chen Chwen-Lih, Chen Jingfeng, Chen Yeong-Renn, Cyclic N-Oxides/chemistry/pharmacology, Cysteine/chemistry/*metabolism, Department of Integrative Medical Sciences, Electron Transport Complex I/chemistry/*metabolism, Free radical biology & medicine, Free Radical Scavengers/chemistry/pharmacology, Free Radicals/chemistry/*metabolism, Glutathione/chemistry/*metabolism, Green Kari B, Heart/enzymology/metabolism, Kang Patrick T, Mice, Mitochondria, Models, Molecular, Molecular Sequence Data, Muscle Cells/drug effects/metabolism, NEOMED College of Medicine, Onium Compounds/pharmacology, Peptide Fragments/chemistry, Peptide Mapping, Protein, Rats, Rotenone/pharmacology, Structural Homology, Superoxides/metabolism, Zhang Liwen
Increased mitochondrial prooxidant activity mediates up-regulation of Complex I
Tags: *Up-Regulation, 2015, Animals, Chen Chwen-Lih, Chen Yeong-Renn, Complex I, Department of Integrative Medical Sciences, Electron Spin Resonance Spectroscopy, eNOS(-/-) murine heart, Free radical biology & medicine, Glutathione/*metabolism, Heart/*metabolism, Kang Patrick T, Knockout, Mice, Mitochondria, Myocardium/enzymology/*metabolism, NEOMED College of Medicine, Nitric Oxide Synthase Type III/genetics/*metabolism, Oxidation-Reduction, Oxidative Stress, Protein thiyl radical, Reactive Oxygen Species/*metabolism, S-Glutathionylation, Superoxides/metabolism
A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis.
Tags: *Flux, *Glutathione, *Heavy water, *Mass spectrometer, *NAFLD, *NASH, *Oxidative Stress, *Western Diet, 2016, Animal, Animals, Antioxidants/metabolism, Department of Pharmaceutical Sciences, Diet, Disease Models, Free radical biology & medicine, Glutathione/blood/*metabolism, Humans, Kasumov Takhar, LDL/blood/*genetics/metabolism, Lee Kwangwon, Li Ling, Liver/*metabolism/pathology, Lopez Rocio, McCullough Arthur, Mice, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/blood/*genetics/pathology, Oxidative Stress/genetics, Previs Stephen F, Receptors, Western/adverse effects, Willard Belinda, Zhang Guo-Fang
4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling.
Tags: *4-Hydroxynonenal, *Coronary regulation, *Lipid peroxidation, *Post-translational modification, *Protein Processing, *Reactive oxygen species, *Signal Transduction, *TRPV1, 2016, Action Potentials/drug effects, Aldehydes/antagonists & inhibitors/metabolism/*pharmacology, Animal, Animals, Blood Flow Velocity, Bratz Ian N, Calcium Signaling/drug effects, Cappelli Holly C, Capsaicin/*pharmacology, Cardiovascular Agents/*pharmacology, Connell Patrick J, Coronary Circulation/drug effects, Coronary Vessels/metabolism/physiopathology, Cysteine/genetics/metabolism, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/*metabolism/physiopathology, Disease Models, Fahmy Joseph N, Femoral Artery/metabolism/physiopathology, Free radical biology & medicine, Geldenhuys Werner J, HEK293 Cells, Humans, Inbred C57BL, Lipid Peroxidation, Male, Mice, NEOMED College of Medicine, Patch-Clamp Techniques, Post-Translational, Sinharoy Pritam, Thodeti Charles K, TRPV Cation Channels/genetics/*metabolism, Vasodilation/drug effects
Differential protein acetylation assists import of excess SOD2 into mitochondria and mediates SOD2 aggregation associated with cardiac hypertrophy in the murine
Tags: *Cardiac-specific transgenic mouse, *Mitochondria, *Mitochondrial translocation, *Protein acetylation, *Protein aggregation, *SOD2, 2017, Acetylation, Animals, Cardiomegaly/*metabolism, Chen Chwen-Lih, Chen Yeong-Renn, Cytosol/*metabolism, Department of Integrative Medical Sciences, Free radical biology & medicine, Heart/*physiology, Jin Zhicheng, Kang Patrick T, Mice, Mitochondria/*metabolism, NEOMED College of Medicine, Pathological, Post-Translational, Protein Aggregation, Protein Folding, Protein Processing, Protein Transport, Reactive Oxygen Species/metabolism, Sirtuin 3/metabolism, Superoxide Dismutase/genetics/*metabolism, Transgenic, Zhang Liwen
Canertinib induces ototoxicity in three preclinical models.
Tags: 2015, Animals, Antineoplastic Agents/*adverse effects/pharmacology, Antitumor, Auditory, Bao Jianxin, Canertinib, Carcinoma, Chen Xiaojie, DeCook Rhonda, Department of Anatomy & Neurobiology, Ding Dalian, Drug Screening Assays, Ear, Electrophysiology, ERBB, ErbB Receptors/*antagonists & inhibitors, Female, Hair Cells, Hearing Loss/*chemically induced, Hearing research, Hearing/*drug effects, Inbred C57BL, Inbred CBA, Kobel Megan, Kopecky Benjamin J, Li Hui, Lung Neoplasms/drug therapy, Male, Mice, Morpholines/*adverse effects/pharmacology, NEOMED College of Medicine, Neuregulin-1/metabolism, Non-small cell lung cancer, Non-Small-Cell Lung/drug therapy, NRG1, Ototoxicity, Ou Henry C, Outer hair cell, Outer/*drug effects, Qian Yi, Signal Transduction/drug effects, Sun Zhenyu, Tang Jian, Zebrafish
Prepulse inhibition of the acoustic startle reflex vs. auditory brainstem response for hearing assessment.
Tags: *Audiometric functions, *Hearing loss, *Mouse, *Permanent threshold shift, *Sound exposure, *Temporary threshold shift, 2016, Acoustic Stimulation/*methods, Alghamdi F, Animal, Animals, Audiometry, Auditory, Auditory Threshold/*physiology, Brain Stem/*physiology, Department of Anatomy & Neurobiology, Evoked Potentials, Galazyuk A V, Hearing, Hearing research, Inbred CBA, Longenecker R J, Male, Mice, Models, NEOMED College of Medicine, Noise, Prepulse Inhibition/*physiology, Pure-Tone/*methods, Reflex, Rosen M J, Startle/*physiology
Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3.
Tags: 2016, Al-Azzam Nosayba, Animals, Boyce Joshua A, c-fos, Capillary Permeability, Cell Line, CysLT(1)R, Department of Integrative Medical Sciences, Dinoprostone/*immunology, Duah Ernest, E-prostanoid receptor 3, Edema/immunology, EP3 Subtype/*immunology, extracellular signal-regulated kinase, Humans, Inbred BALB C, Inbred C57BL, Inflammation/immunology, Kondeti Vinay, leukotriene D(4), Leukotriene D4/*immunology, Leukotriene/*immunology, macrophage inflammatory protein 1beta, Mast cells, Mast Cells/*immunology, Mice, NEOMED College of Medicine, Paruchuri Sailaja, prostaglandin D(2), Prostaglandin E, prostaglandin E(2), protein kinase G, Receptors, The Journal of allergy and clinical immunology, Thodeti Charles K, Transgenic, Tumor
A quantitative LC-MS/MS method for determination of thiazolidinedione mitoNEET ligand NL-1 in mouse serum suitable for pharmacokinetic studies.
Tags: %CV, %RE, 1-Methyl-4-phenyl-1, 2, 2014, 3, 3-thiazolidine-2, 4-dione, 5-[3, 5-[4-hydroxy-3, 5-di-tert-butyl-4-hydroxyphenyl)methyl]-1, 5-dimethyl-phenyl)methyl]thiazolidine-2, 6-tetrahydropyridine, Anderson David J, Animals, Carroll Richard T, Carry-over, Chromatography, Department of Internal Medicine, Geldenhuys Werner J, High Pressure Liquid/*methods, internal standard, IS, Jogiraju Harini, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, LC-MS/MS, Limit of Detection, Lin Li, LLOQ, lower limit of quantification, Methanol, Mice, mitoNEET, Mouse serum, MPTP, MRM, multiple reaction monitoring, NEOMED College of Medicine, NL-1, NL-2, Pedada Kiran K, percent coefficient of variation, peroxisome proliferator activated receptor-gamma, pharmacokinetic, PK, PPAR-gamma, QC, Quality Control, relative error, relative matrix effect, RME, SD, standard deviation, Tandem Mass Spectrometry/*methods, thiazolidinedione, Thiazolidinedione (TZD), Thiazolidinediones/*blood, TZD, Zhou Xiang
Development and validation of an LC-MS/MS method for determination of the L-type voltage-gated calcium channel/NMDA receptor antagonist NGP1-01 in mouse serum.
Tags: 2014, Anderson David J, Animals, Bridged-Ring Compounds/*blood, Calcium Channel Blockers/*blood, Chromatography, Crish Samuel D, Department of Pharmaceutical Sciences, Geldenhuys Werner J, Gobburi Ashta Lakshmi Prasad, Jogiraju Harini, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, LC-MS/MS, Limit of Detection, Liquid/*methods, Mice, Mouse serum, Multifunctional drug, N-Methyl-D-Aspartate/*antagonists & inhibitors, NEOMED College of Pharmacy, Neuroprotective agent, NGP1-01, Pedada Kiran K, Pentacycloundecylamine, Receptors, Reproducibility of Results, Tandem Mass Spectrometry/*methods, Van der Schyf Cornelis J, Zhou Xiang
The effect of freezing and extraction upon striatal dopaminergic function.
An improved approach to separating startle data from noise.
Tags: *Electronic Data Processing, *Noise, 2015, Acoustic startle reflex, Acoustic Stimulation/methods, Analysis of Variance, Animal locomotion, Animals, Auditory/*physiology, Automated classification, Department of Anatomy & Neurobiology, Evoked Potentials, Galazyuk Alexander V, Grimsley Calum A, Grimsley Jasmine M S, Inbred CBA, Journal of neuroscience methods, Longenecker Ryan J, Male, Mice, NEOMED College of Medicine, Reflex, Rosen Merri J, Startle waveform analysis, Startle/*physiology, Time Factors, Video Recording, Young Jesse W
An operant-based detection method for inferring tinnitus in mice.
Tags: *Conditioning, *Disease Models, *Inferior colliculus, *Mouse model, *Noise-induced hearing loss, *Operant conditioning, *Sodium salicylate, *Tinnitus, 2017, Acoustic Stimulation, Analysis of Variance, Animal, Animals, Auditory, Avoidance Learning, Bao Jianxin, Brain Stem/physiology, Department of Anatomy & Neurobiology, Electroshock, Equipment Design, Evoked Potentials, Female, Howie Benjamin, Inbred C57BL, Inferior Colliculi/physiopathology, Journal of neuroscience methods, Lei Debin, Male, Mice, Motor Activity, Mulvany Jessica, NEOMED College of Medicine, Neurons/physiology, Operant, Otoacoustic Emissions, Sivaramakrishnan Shobhana, Sodium Salicylate, Spontaneous/physiology, Tinnitus/*diagnosis/physiopathology, Tissue Culture Techniques, Voltage-Sensitive Dye Imaging, Zuo Hongyan
Anti-edema action of thyroid hormone in MCAO model of ischemic brain stroke: Possible association with AQP4 modulation.
Tags: 2015, Animals, Aquaporin 4/*physiology, Aquaporin-4, Brain Edema/*drug therapy/pathology, Burke Jamie, Cerebral edema, Cerebrovascular Circulation/drug effects/physiology, Coughlin Lucy, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Diiodothyronines/*administration & dosage, Erythropoietin, Infarction, Injections, Intravenous, Ischemic brain stroke, Journal of the neurological sciences, Male, Mdzinarishvili Alexander, Mice, Middle cerebral artery occlusion (MCAO), Middle Cerebral Artery/*drug therapy/pathology, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Sadana Prabodh, Stroke/*drug therapy/pathology, Thyroid hormone, Triiodothyronine/*administration & dosage, Woods Robert
Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide.
Tags: 2017, Alam Gelerah, Animals, Astrocytes/immunology/pathology, Beier Eric E, Cell Death/physiology, Corpus Striatum/immunology/pathology, Cytokines/metabolism, Department of Pharmaceutical Sciences, Disease Progression, Dopaminergic Neurons/*immunology/pathology, Edler Melissa, Inbred C57BL, Inflammation/pathology/physiopathology, Lipopolysaccharides/*toxicity, Male, Messenger/metabolism, Mice, Microglia/*immunology/pathology, Neal Matthew, NEOMED College of Pharmacy, Nerve Degeneration/*immunology/pathology, Neurobiology of disease, Neurodegenerative Diseases/immunology/pathology, Neuroimmunomodulation/physiology, Random Allocation, Richardson Jason R, RNA, Time Factors, Wu Long-Jun
Parity decreases methamphetamine-induced striatal dopaminergic perturbation.
Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion.
Tags: 2012, Animals, Corpus Striatum/*drug effects/metabolism, Darvesh Altaf S, Department of Pharmaceutical Sciences, Dluzen Dean E, Dopamine/*metabolism, Drug Synergism, Geldenhuys Werner J, Inbred C57BL, Indoles/*pharmacology, Methamphetamine/*pharmacology, Mice, NEOMED College of Pharmacy, Neurochemistry international
The effect of gender and the neurotrophin, BDNF, upon methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system in mice.
Tags: 2004, Animals, Brain-Derived Neurotrophic Factor/deficiency/genetics/*metabolism, Central Nervous System Stimulants/poisoning, Corpus Striatum/*drug effects/*metabolism, Dluzen Dean E, Dopamine/*metabolism, Dose-Response Relationship, Drug, Female, Humans, Male, Methamphetamine/*poisoning, Mice, Mutation, Neuroscience letters, Neurotoxicity Syndromes/*etiology/*metabolism, Sex Factors, Structure-Activity Relationship, Substantia Nigra/drug effects/metabolism, Transgenic
Testosterone enhances dopamine depletion by methamphetamine in male, but not female, mice.
Tags: *Sex Characteristics, 2008, Animals, Castration/methods, Corpus Striatum/drug effects/metabolism, Dluzen Dean E, Dopamine Uptake Inhibitors/*pharmacology, Dopamine/*metabolism, Dose-Response Relationship, Drug, Female, Lewis Chandani, Male, Methamphetamine/*pharmacology, Mice, Neuroscience letters, Testosterone Propionate/*pharmacology
Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice.
Tags: 2010, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Aging/*physiology, Animals, Corpus Striatum/*metabolism, Dluzen Dean E, Dopamine Plasma Membrane Transport Proteins/*genetics, Dopamine/*metabolism, Heterozygote, Inbred C57BL, Ji Jing, Knockout, Male, McDermott Janet L, Mice, Motor Activity, Mutation, Neuroscience letters, Substantia Nigra/*metabolism
mGluRs modulate neuronal firing in the auditory midbrain.
Tags: 2011, Acoustic Stimulation/methods, Action Potentials/drug effects/*physiology, Animals, Auditory Perception/drug effects/physiology, Department of Anatomy & Neurobiology, Excitatory Amino Acid Agonists/pharmacology, Excitatory Amino Acid Antagonists/pharmacology, Galazyuk A V, Glutamic Acid/physiology, Inbred CBA, Inferior Colliculi/drug effects/metabolism/*physiology, Metabotropic Glutamate/agonists/antagonists & inhibitors/*physiology, Mice, NEOMED College of Medicine, Neural Inhibition/drug effects/physiology, Neurons/drug effects/*physiology, Neuroscience letters, Perceptual Masking/physiology, Receptors, Synaptic Transmission/drug effects/physiology, Voytenko S V
Postnatal developmental changes in the medial nucleus of the trapezoid body in a mouse model of auditory pathology.
Tags: *Disease Models, 2014, AHL, Animal, Animals, Auditory brainstem responses, Auditory Pathways/*growth & development/*pathology, Auditory system, DBA/2, Grimsley Calum A, Hearing Loss/*pathology, Inbred CBA, Inbred DBA, Mice, MNTB, Neuroscience letters, Newborn, Olivary Nucleus/*growth & development/*pathology, Organ Culture Techniques, Sivaramakrishnan Shobhana
Trimethyltin intoxication induces the migration of ventricular/subventricular zone cells to the injured murine hippocampus.
Tags: *Brain injury, *Hippocampus, *Neural stem cells, *Neurogenesis, *Subventricular stem cells, *Trimethyltin, 2016, Amino Acids/metabolism, Animals, Brain Injuries/*pathology, Bromodeoxyuridine/metabolism, Cell Movement/*drug effects, Department of Pharmaceutical Sciences, Functional Laterality, Glial Fibrillary Acidic Protein/metabolism, Hippocampus/*pathology, Inbred C3H, Lateral Ventricles/drug effects/*pathology, Lowndes Herbert E, Male, Mice, NEOMED College of Pharmacy, Neurogenesis/drug effects/physiology, Neurotoxicology, Reuhl Kenneth R, Richardson Jason R, Trimethyltin Compounds/*toxicity, Weig Blair C
Developmental pyrethroid exposure causes long-term decreases of neuronal sodium channel expression.
Tags: 2017, Animals, BDNF, Brain-Derived Neurotrophic Factor/metabolism, Cerebral Cortex/*drug effects/growth & development/metabolism, Corpus Striatum/*drug effects/growth & development/metabolism, Deltamethrin, Department of Pharmaceutical Sciences, Female, Inbred C57BL, Insecticides/*toxicity, Magby Jason P, Male, Messenger/metabolism, Mice, NEOMED College of Pharmacy, Neurodevelopmental, Neurons/*drug effects/metabolism, Neurotoxicology, Nitriles/*toxicity, Pregnancy, Prenatal Exposure Delayed Effects/*metabolism, Pyrethrins/*toxicity, Pyrethroid, Richardson Jason R, RNA, Sodium channel, Voltage-Gated Sodium Channels/*metabolism
MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains.
Tags: *QTL, *Recombinant inbred mice, *Sex Characteristics, *Sex differences, 1-Methyl-4-phenyl-1, 2, 2016, 3, 4-Dihydroxyphenylacetic Acid/metabolism, 6-tetrahydropyridine/pharmacology, Alam Gelareh, Animal, Animals, Corpus Striatum/drug effects/*metabolism, Department of Family & Community Medicine, Disease Models, Dopamine/metabolism, Female, Gene Expression Regulation/drug effects/*genetics, Glial Fibrillary Acidic Protein/*metabolism, Homovanillic Acid/metabolism, Inbred Strains, Jones Byron C, Lu Lu, Male, Mice, Miller Diane B, MPTP Poisoning/chemically induced/*pathology, NEOMED College of Medicine, Neurotoxicology, O'Callaghan James P, Serotonin/metabolism, Species Specificity, Tyrosine 3-Monooxygenase/metabolism, Williams Robert W
Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss.
Tags: 1-Methyl-4-phenyl-1, 2, 2017, 3, 6-tetrahydropyridine/*administration & dosage, Alam Gelareh, Animals, Burchfield Shelbie L, Catecholamines/metabolism, Cell Count, Corpus Striatum/*drug effects/metabolism, Department of Pharmaceutical Sciences, Dopamine, Dopamine transporter, Dopaminergic Neurons/*drug effects/metabolism, Edler Melissa, Inbred C57BL, Male, Mice, MPTP, MPTP Poisoning, NEOMED College of Pharmacy, Neurotoxicology, Parkinsonian Disorders/*metabolism/*pathology, Richardson Jason R, Stereology, Substantia Nigra/*drug effects/metabolism, Tyrosine 3-Monooxygenase/*metabolism, Tyrosine hydroxylase, Vesicular monoamine transporter
Evidence of Wnt/beta-catenin alterations in brain and bone of a tauopathy mouse model of Alzheimer's disease.
Tags: *Alzheimer's disease, *Beta catenin, *Bone mineral density, *neurodegeneration, *Tauopathy, *Wnt proteins, *Wnt Signaling Pathway, 2018, Alzheimer Disease/*genetics/*metabolism, Animal, Animals, Ball Hope C, beta Catenin/metabolism, Bone and Bones/*metabolism, Bone Density, Bone Remodeling/genetics, Brain/*metabolism, Cooper Lisa Noelle, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Disease Models, Female, Gene Expression, Lin Li, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Neurobiology of aging, Novak Kimberly M, Osteogenesis/genetics, Osteoporosis/etiology/genetics, tau Proteins/*metabolism, Tauopathies/genetics/*metabolism, Wnt Proteins/metabolism
Age-related changes in nigrostriatal dopaminergic function are accentuated in +/- brain-derived neurotrophic factor mice.
Tags: *Aging, 2004, Anderson L I, Animals, Brain-Derived Neurotrophic Factor/*genetics/*metabolism, Corpus Striatum/*metabolism, Dluzen D E, Dopamine/*biosynthesis, Joyce J N, Kucera J, McDermott J L, Mice, Motor Activity/physiology, Mutant Strains, Mutation, Neuroscience, Osredkar T, Substantia Nigra/*metabolism, Walro J M
Effects of neonatal and prepubertal hormonal manipulations upon estrogen neuroprotection of the nigrostriatal dopaminergic system within female and male mice.
Tags: *Sex Characteristics, 2005, Aging/metabolism, Anderson L I, Animal, Animals, Disease Models, Dluzen D E, Dopamine/metabolism, Estrogens/metabolism/*pharmacology, Female, Gonads/growth & development/metabolism, Leipheimer R E, Male, Methamphetamine/antagonists & inhibitors/toxicity, Mice, Neostriatum/*drug effects/metabolism/physiopathology, Neural Pathways/drug effects/metabolism/physiopathology, Neuroprotective Agents/metabolism/*pharmacology, Neuroscience, Newborn, Orchiectomy, Ovariectomy, Sexual Maturation/physiology, Substantia Nigra/*drug effects/metabolism/physiopathology, Testosterone/metabolism/*pharmacology
Aging and sex differences in striatal dopaminergic function.
Tags: 2007, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Aging/*physiology, Amphetamine/pharmacology, Animals, Chemical, Dluzen D E, Dopamine Uptake Inhibitors/pharmacology, Dopamine/metabolism/*physiology, Female, In Vitro Techniques, Male, McDermott J L, Mice, Neostriatum/metabolism/*physiology, Neuroscience, Organ Size/physiology, Potassium/pharmacology, Sex Characteristics, Stimulation, Uterus/physiology
Differences in reserpine-induced striatal dopamine output and content between female and male mice: implications for sex differences in vesicular monoamine transporter 2 function.
Tags: *Sex Characteristics, 2008, Adrenergic Uptake Inhibitors/*pharmacology, Animals, Bhatt S, Chromatography, Corpus Striatum/drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Female, High Pressure Liquid, Male, McDermott J L, Mice, Neuroscience, Orchiectomy, Ovariectomy, Reserpine/*pharmacology, Vesicular Monoamine Transport Proteins/*metabolism
Relationships among gender, age, time, and temperature in methamphetamine-induced striatal dopaminergic neurotoxicity.
Tags: 2010, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Age Factors, Animals, Body Temperature/drug effects, Central Nervous System Stimulants/*toxicity, Corpus Striatum/*drug effects/metabolism, Darvesh A S, Department of Pharmaceutical Sciences, Dluzen D E, Dopamine/*metabolism, Female, In Vitro Techniques, Male, McDermott J L, Methamphetamine/*toxicity, Mice, NEOMED College of Pharmacy, Neuroscience, Neurotoxicity Syndromes/etiology/*metabolism/physiopathology, Sex Factors, Time Factors
Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target.
Tags: 2013, Animal, Animals, Astrocytes/*metabolism, Axonal Transport/*physiology, Balaram P, Brain-Derived Neurotrophic Factor/*metabolism, Calkins D J, Crish S D, Dapper J D, Department of Pharmaceutical Sciences, Disease Models, Glaucoma/genetics/*metabolism, Lambert W S, MacNamee S E, Messenger/genetics/metabolism, Mice, NEOMED College of Pharmacy, Neuroscience, Optic Nerve Diseases/genetics/metabolism, Rats, Retinal Ganglion Cells/*metabolism, RNA, Sidorova T N, Superior Colliculi/metabolism, Synapses/*metabolism, Visual Pathways/metabolism
Sex differences in methamphetamine-evoked striatal dopamine of mice are reversed by nomifensine.
Tags: *Sex Characteristics, 2006, Animals, Corpus Striatum/*drug effects, Dluzen Dean E, Dopamine Agents/pharmacology, Dopamine Uptake Inhibitors/*pharmacology, Dopamine/*metabolism, Drug Interactions, Female, Kunnathur Vidhya, Liu Bin, Male, Methamphetamine/pharmacology, Mice, Neurotoxicology and teratology, Nomifensine/*pharmacology, Potassium/pharmacology, Salvaterra Ty J, Shemisa Kamal
Markers associated with testosterone enhancement of methamphetamine-induced striatal dopaminergic neurotoxicity.
Tags: 2012, Animals, Biomarkers/metabolism, Blotting, Body Temperature/drug effects, Body Weight/drug effects, Buletko A Blake, Corpus Striatum/*drug effects/metabolism, Darvesh Altaf S, Department of Pharmaceutical Sciences, Dluzen Dean E, Dopamine Plasma Membrane Transport Proteins/metabolism, Dopamine/*metabolism, Drug Synergism, Geldenhuys Werner J, HSP70 Heat-Shock Proteins/metabolism, Inbred Strains, Male, McDermott Janet L, Methamphetamine/*toxicity, Mice, NEOMED College of Pharmacy, Neurotoxicity Syndromes/*etiology/metabolism, Neurotoxicology and teratology, Oxidative Stress/drug effects, Testosterone Propionate/*pharmacology, Vesicular Monoamine Transport Proteins/metabolism, Western