Browse Items · NEOMED Bibliography Database

A multi-level modeling approach examining PTSD symptom reduction during prolonged exposure therapy: moderating effects of number of trauma types experienced, having an HIV-related index trauma, and years since HIV diagnosis among

People living with HIV (PLWH) have extensive interpersonal trauma histories and higher rates of posttraumatic stress disorder (PTSD) than the general population. Prolonged exposure (PE) therapy is efficacious in reducing PTSD across a variety of…

Tags: *HIV/AIDS, *prolonged exposure therapy, *PTSD, *trauma history, 2017, Adult, AIDS care, Boarts Jessica M, Ciesla Jeffrey A, Coleman Jennifer A, Delahanty Douglas L, Descriptive Statistics, Feeny Norah C, Female, HIV Infections/*psychology, HIV-Infected Patients – Psychosocial Factors, Human, Humans, Implosive Therapy/*methods, Jones Tracy, Junglen Angela G, LONGITUDINAL method, Male, Middle Aged, Pacella Maria L, Post-Traumatic – Symptoms, Post-Traumatic – Therapy, POST-traumatic stress disorder, Post-Traumatic/diagnosis/*psychology/*therapy, Prospective Studies, Psychological/*psychology/therapy, PSYCHOLOGY of HIV-positive people, Smith Brian C, Stress, Stress Disorders, Time, Time Factors, Trauma – Classification, Trauma – History, TREATMENT effectiveness, TREATMENT of post-traumatic stress disorder, Treatment Outcome, Treatment Outcomes – Evaluation, United States, WOUNDS & injuries – Classification, WOUNDS & injuries – History

Use of Fine-scale Geospatial Units and Population Data to Evaluate Access to Emergency Care.

Introduction: Time to facility is a crucial element in emergency medicine (EM). Fine-scale geospatial units such as census block groups (CBG) and publicly available population datasets offer a low-cost and accurate approach to modeling geographic…

Alignment of inducible vascular progenitor cells on a micro-bundle scaffold improves cardiac repair following myocardial infarction.

Ischemic heart disease is still the leading cause of death even with the advancement of pharmaceutical therapies and surgical procedures. Early vascularization in the ischemic heart is critical for a better outcome. Although stem cell therapy has…

Tags: *Cardiovascular regeneration, *Ischemic heart diseases, *Micro-bundle scaffold, *Myocardial infarction, *Neovascularization, *Stem cells, *Tissue Scaffolds, *Vascular progenitor cells, 2017, Animal, Animals, Basic research in cardiology, Cell Differentiation, Cell Proliferation, Cell Survival, Cells, Chilian William M, Coculture Techniques, Cultured, Cumpston Devan, Department of Integrative Medical Sciences, Disease Models, Dong Feng, Endothelial Progenitor Cells/metabolism/*transplantation, Enrick Molly, Fibroblast Growth Factor 2/metabolism, Hakobyan Tatev, Jamaiyar Anurag, Janota Danielle, Kolz Christopher L, Lactic Acid/*chemistry, Muscle, Myocardial Infarction/metabolism/pathology/physiopathology/*surgery, Myocardium/metabolism/*pathology, Myocytes, NEOMED College of Medicine, Newby Bi-Min Zhang, Ohanyan Vahagn, Paracrine Communication, Phenotype, Physiologic, Polyglycolic Acid/*chemistry, Polylactic Acid-Polyglycolic Acid Copolymer, Rats, Signal Transduction, Smooth, Smooth Muscle/metabolism/*transplantation, Song Hokyung, Sprague-Dawley, Stevanov Kelly, Time Factors, Tissue Engineering/*methods, Vascular Endothelial Growth Factor A/metabolism, Vascular/metabolism/*transplantation, Ventricular Remodeling, Wan Weiguo, Yin Liya

Tromantadine inhibits a late step in herpes simplex virus type 1 replication and syncytium formation.

Addition of tromantadine after virus penetration inhibited HSV-1 induced syncytium formation and virus production in HEp-2 and VERO cells and acted additively with neutralizing antibody in blocking virus spread and cytopathology. Inhibition of…

Short-term and long-term outcomes of patients undergoing urgent transcatheter aortic valve replacement under a minimalist strategy.

OBJECTIVES: Urgent transcatheter aortic valve replacement (TAVR) is associated with worse short-term outcomes compared with elective TAVR; however, little is known about long-term outcomes or the safety of the minimalist strategy in this setting. …

Tags: 2019, Aged 80 and over, Aortic Valve Stenosis/diagnosis/mortality/surgery, Aortic Valve/diagnostic imaging/surgery, Attizzani GF, Bezerra HG, Cardiac Catheterization/methods, Cleveland Clinic Akron General Hospital, Costa MA, Davis A, Department of Internal Medicine, Echocardiography Transesophageal, Elective Surgical Procedures/methods, Female, Femoral Artery, Follow-Up Studies, Hospital Mortality/trends, Humans, Ichibori Y, journalArticle, June2020SubmittedList, Kalra A, Kobe D, Ladas T, Length of Stay, Li J, Lipinski J, Male, Markowitz AH, minimalist approach, NEOMED College of Medicine, Patel S, Patel T, Peters M, Retrospective Studies, Risk Factors, Saric P, severe aortic stenosis, Severity of Illness Index, The Journal of invasive cardiology, Time Factors, transcatheter aortic valve replacement, Transcatheter Aortic Valve Replacement/methods, Treatment Outcome, Tsushima T, United States/epidemiology, urgent procedure

Feasibility and safety of adopting next-day discharge as first-line option after transfemoral transcatheter aortic valve replacement.

OBJECTIVES: Data on next-day discharge (NDD) after transcatheter aortic valve replacement (TAVR) are limited. This study investigated the feasibility and safety of NDD as a first-line option (the very-early discharge [VED] strategy) compared with…

Tags: 2019, Academic Medical Centers, Aged, Aged 80 and over, aortic stenosis, Aortic Valve Stenosis/diagnosis/surgery, Attizzani GF, Bezerra HG, Cleveland Clinic Akron General Hospital, Cohort Studies, Costa MA, Davis A, Department of Internal Medicine, early discharge, Feasibility Studies, Female, Follow-Up Studies, Humans, Ichibori Y, journalArticle, June2020SubmittedList, Kalra A, Length of Stay, Li J, Lipinski J, Male, Markowitz AH, minimalist approach, NEOMED College of Medicine, next-day discharge, Ohio, Panhwar M, Patel SM, Patel TM, Patient Discharge, Patient Readmission/statistics & numerical data, Patient Safety, Propensity Score, Qureshi G, Retrospective Studies, Risk Assessment, Sareyyupoglu B, Saric P, Severity of Illness Index, Survival Analysis, The Journal of invasive cardiology, Time Factors, transcatheter aortic valve replacement, Transcatheter Aortic Valve Replacement/methods/mortality, United States, Zidar DA

Mechanical Ventilation Antioxidant Trial.

BACKGROUND: Many patients each year require prolonged mechanical ventilation. Inflammatory processes may prevent successful weaning, and evidence indicates that mechanical ventilation induces oxidative stress in the diaphragm, resulting in atrophy…

Tags: 2015, 80 and over, Acetylcysteine, Adult, Aged, American journal of critical care : an official publication, American Association of Critical-Care Nurses, Antioxidants, Antioxidants/*therapeutic use, Artificial, Artificial/*adverse effects, Ascorbic Acid – Administration and Dosage, Ascorbic Acid/therapeutic use, Chi Square Test, Clochesy John M, Critical Care/*methods, Critical Illness, Critically Ill Patients, Cystine/analogs & derivatives/therapeutic use, Data Analysis Software, Department of Internal Medicine, Dietary Supplementation, Double-Blind Method, Double-Blind Studies, Female, Funding Source, Goldstein Lawrence S, Howe Kimberly P, Human, Humans, Inflammation/*drug therapy/*etiology, Intensive Care Units, Length of Stay, Log-Rank Test, Male, Mantel-Haenszel Test, Middle Age, Middle Aged, NEOMED College of Medicine, Owen Hugh, Oxidative Stress, Oxidative Stress/*drug effects, Prospective Studies, RANDOMIZED controlled trials, Respiration, T-Tests, Time Factors, Treatment Outcome, Ventilator Weaning, Vitamin E, Vitamin E/therapeutic use, Vitamins/therapeutic use

A reappraisal of appendicitis in the elderly.

Historically, appendicitis in the elderly is associated with higher morbidity and mortality. Ninety-six patients over 60 years of age with appendicitis treated over a 10-year period were reviewed. Only 20% presented classically with anorexia, fever,…

Tags: 1990, 80 and over, Aged, American journal of surgery, Appendicitis/complications/*diagnosis/mortality/surgery, Diagnosis, Differential, Female, Guyton D P, Horattas M C, Humans, Male, Middle Aged, Postoperative Complications, Retrospective Studies, Time Factors, Wu D

Panniculectomy at the time of gynecologic surgery in morbidly obese patients.

OBJECTIVE: Our goal was to demonstrate that panniculectomy performed at the time of gynecologic surgery aids in reducing the operative time and exposure and does not increase the wound infection rate in morbidly obese patients. STUDY DESIGN: A…

A new zygodactylid species indicates the persistence of stem passerines into the early Oligocene in North America.

BACKGROUND: The lake deposits of the informal Ruby Paper Shale unit, part of the Renova Formation of Montana, have yielded abundant plant fossils that document Late Eocene - Early Oligocene global cooling in western North America. A nearly complete…

Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway.

Prostate apoptosis response-4 (Par-4) is a leucine zipper protein that promotes neuronal cell death in Alzheimer's disease (AD). Neuronal degeneration in AD may result from extracellular accumulation of amyloid beta peptide (Abeta) 1-42. To examine…

Two components of long-term potentiation induced by different patterns of afferent activation.

Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in…

Tags: 1990, 2-Amino-5-phosphonovalerate/*pharmacology, Afferent Pathways/physiology, Animals, Calcium/*physiology, Grover L M, Hippocampus/*physiology, In Vitro Techniques, Membrane Potentials, Memory/*physiology, N-Methyl-D-Aspartate/*physiology, Nature, Neuronal Plasticity, Receptors, Synaptic Transmission, Teyler T J, Time Factors

N-methyl-D-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus: input-specific induction and preclusion in a non-tetanized pathway.

We previously reported that an N-methyl-D-aspartate receptor-independent component of long-term potentiation with an apparent delayed onset can be induced in area CA1 of the hippocampus. Here we show that some but not all of this delay in onset can…

Tags: 1992, 2-Amino-5-phosphonovalerate/*pharmacology, Animals, Electron, Evoked Potentials/drug effects, Grover L M, Hippocampus/*physiology, In Vitro Techniques, Microscopy, N-Methyl-D-Aspartate/*physiology, N-Methylaspartate/*pharmacology, Neuroscience, Pyramidal Tracts/drug effects/*physiology, Rats, Receptors, Teyler T J, Time Factors

An improved approach to separating startle data from noise.

BACKGROUND: The acoustic startle reflex (ASR) is a rapid, involuntary movement to sound, found in many species. The ASR can be modulated by external stimuli and internal state, making it a useful tool in many disciplines. ASR data collection and…

The ability of an HSV strain to initiate zosteriform spread correlates with its neuroinvasive disease potential.

The requirements for disease development in the mouse epidermal scarification-zosteriform model of HSV infection are likely to parallel those required for primary HSV disease of humans. HSV-1 strains, which are neuroinvasive in the mouse footpad…

A comparison of the National Ambulatory Medical Care Survey (NAMCS) measurement approach with direct observation of outpatient visits.

BACKGROUND: The National Ambulatory Medical Care Survey (NAMCS) informs a wide range of important policy and clinical decisions by providing nationally representative data about outpatient practice. However, the validity of the NAMCS methods has not…

Early development of intrinsic and synaptic properties of chicken nucleus laminaris neurons.

Onset of auditory brainstem responses in chickens takes place at about embryonic day 11/12 (E11/12). We investigated early development of neuronal properties of chicken nucleus laminaris neurons, the third-order auditory neurons critically involved…

Temporal features of spectral integration in the inferior colliculus: effects of stimulus duration and rise time.

This report examines temporal features of facilitation and suppression that underlie spectrally integrative responses to complex vocal signals. Auditory responses were recorded from 160 neurons in the inferior colliculus (IC) of awake mustached bats.…

Leading inhibition to neural oscillation is important for time-domain processing in the auditory midbrain.

A number of central auditory neurons exhibit paradoxical latency shift (PLS), a response characterized by longer response latencies at higher sound levels. PLS neurons are known to play a role in target ranging for echolocating bats that emit…

A novel coding mechanism for social vocalizations in the lateral amygdala.

The amygdala plays a central role in evaluating the significance of acoustic signals and coordinating the appropriate behavioral responses. To understand how amygdalar responses modulate auditory processing and drive emotional expression, we assessed…

Aspartame exposure and in vitro hippocampal slice excitability and plasticity.

Aspartame (APM) is a low-calorie sweetener recently approved and released for widespread use in the United States. However, concerns still exist that APM consumption may be responsible for adverse neurological and psychological effects in some…

Tags: 1988, Animals, Aspartame/*toxicity, Dipeptides/*toxicity, Electric Stimulation, Electrophysiology, Female, Fountain S B, Fundamental and applied toxicology : official journal of the Society of Toxicology, Hennes S K, Hippocampus/*drug effects/physiopathology, Neuronal Plasticity/*drug effects, Neurons/drug effects, Rats, Teyler T J, Time Factors

A comparison of implanted cardioverter/defibrillator interrogation protocol effectiveness between 2 patients in the ED.

Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines.

Knowledge about the conversion of the epithelium in the distal air spaces of the lung from secretion to absorption is imperative to the understanding of postnatal lung development; little such information is available in rats. Distal air space fluid…

What can we learn from the time course of untreated and partially treated community-onset Streptococcus pneumoniae pneumonia? A clinical perspective on superiority and noninferiority trial designs for mild community-acquired pneumonia.

There are no well-designed placebo-controlled clinical trials in the recent era that precisely define the magnitude of the drug effect of antimicrobial therapy for mild community-acquired pneumonia (CAP). However, there is evidence that ineffective…

Tags: *Research Design, 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Community-Acquired Infections/*drug therapy/microbiology, Department of Internal Medicine, Disease Progression, File Thomas M Jr, Humans, NEOMED College of Medicine, Pneumococcal/*drug therapy/microbiology, Pneumonia, Randomized Controlled Trials as Topic/*methods, Schentag Jerome J, Streptococcus pneumoniae/*isolation & purification, Time Factors, Treatment Outcome

Macrolide therapy for community-acquired pneumonia due to atypical pathogens: outcome assessment at an early time point.

BACKGROUND: Therapy directed against atypical pathogens in patients with community-acquired pneumonia (CAP) is often recommended. This post-hoc analysis evaluated the effect of addition of a macrolide to ceftaroline fosamil or ceftriaxone treatment…

Tags: 2017, 80 and over, Adult, Aged, Anti-Bacterial Agents/adverse effects/*therapeutic use, Atypical pathogen, Bacterial/*drug therapy, Ceftaroline fosamil, Ceftriaxone/adverse effects/*therapeutic use, Cephalosporins/adverse effects/*therapeutic use, Chlamydial Pneumonia, Chlamydophila pneumoniae, Clinical Trials, Combination/adverse effects/methods, Community-Acquired Infections/*drug therapy, Community-acquired pneumonia, Department of Internal Medicine, Double-Blind Method, Drug Therapy, Eckburg Paul B, Female, File Thomas M Jr, Friedland H David, Humans, International journal of antimicrobial agents, Legionella pneumophila, Llorens Lily, Macrolide, Macrolides/adverse effects/*therapeutic use, Male, Middle Aged, Mycoplasma, Mycoplasma pneumoniae, NEOMED College of Medicine, Phase III as Topic, Pneumonia, Randomized Controlled Trials as Topic, Talbot George H, Time Factors, Treatment Outcome

Recommendations for treatment of hospital-acquired and ventilator-associated pneumonia: review of recent international guidelines.

Recently published guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia are reviewed for recommendations regarding diagnosis and antimicrobial therapy to assess the implications for development of future…

Tags: *Practice Guidelines as Topic, 2010, Anti-Bacterial Agents/*therapeutic use, Bacteria/drug effects/isolation & purification, Bacterial/diagnosis/*drug therapy, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Clinical Trials as Topic, Cross Infection/diagnosis/*drug therapy, Department of Internal Medicine, File Thomas M Jr, Hospitals, Humans, Microbial Sensitivity Tests, NEOMED College of Medicine, Pneumonia, Time Factors, Ventilator-Associated/diagnosis/*drug therapy

A new dosing paradigm: high-dose, short-course fluoroquinolone therapy for community-acquired pneumonia.

The goals of optimal antimicrobial therapy are to treat infection effectively, to improve the clinical condition of the patient, and to prevent the emergence of resistant bacterial strains. For ideal drug usage the World Health Organization…

Tags: 2003, Clinical cornerstone, Community-Acquired Infections/*drug therapy, Department of Internal Medicine, File Thomas M Jr, Fluoroquinolones/*administration & dosage/pharmacology/therapeutic use, Humans, NEOMED College of Medicine, Ofloxacin/administration & dosage/pharmacology/therapeutic use, Pneumococcal/*drug therapy, Pneumonia, Safety, Time Factors, Treatment Outcome

Timing and type of surgical treatment of Clostridium difficile-associated disease: a practice management guideline from the Eastern Association for the Surgery of Trauma.

BACKGROUND: Clostridium difficile infection is the leading cause of nosocomial diarrhea in the United States; however, few patients will develop fulminant C. difficile-associated disease (CDAD), necessitating an urgent operative intervention.…

Tags: *Clostridium difficile, *Practice Guidelines as Topic, *Societies, *Traumatology, 2014, Bosarge Patrick, Clostridium difficile, Clostridium Infections – Epidemiology, Clostridium Infections – Microbiology, Clostridium Infections – Surgery, Clostridium Infections/epidemiology/microbiology/*surgery, Cross Infection – Epidemiology, Cross Infection – Microbiology, Cross Infection – Surgery, Cross Infection/epidemiology/microbiology/*surgery, Dorion Heath, Duane Therese M, Enniss Toby, Ferrada Paula, Haut Elliott R, Human, Humans, Incidence, Johnson Emily, Martin Niels D, Medical, Medical Organizations, Meta Analysis, Operative Time, Praba-Egge Anita, Practice Guidelines, Rushing Amy, Sultan Shahnaz, Survival – Trends, Survival Rate/trends, systematic review, The journal of trauma and acute care surgery, Time Factors, Traumatology, United States, United States/epidemiology, Velopulos Catherine G

Characterization of the early events in vitamin C and K3-induced death of human bladder tumor cells.

Spatial and temporal variations in extracellular matrix of periocular and corneal regions during corneal stromal development.

The development of the avian corneal stroma occurs in discrete developmental stages. During this sequence of events, the neural crest-derived corneal fibroblast precursor cells are surrounded by distinct extracellular matrices which change both…

Tags: *Extracellular Matrix, 1996, Animals, Birk D E, Cell Differentiation, Chick Embryo, Collagen/biosynthesis, Cornea/chemistry/*embryology/metabolism, Doane K J, Experimental eye research, Eye Proteins/analysis, Fibroblasts/cytology, Glycoproteins/analysis, McLaughlin J S, Neural Crest/cytology, Proteoglycans/biosynthesis, Time Factors, Ting W H

The effect of freezing and extraction upon striatal dopaminergic function.

Determinations of striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were compared under conditions where tissue was either frozen followed by extraction (FE) or extracted followed by freezing (EF). In Experiment 1,…

Tags: *Freezing, 2011, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Analysis of Variance, Animals, Chemical Fractionation/methods, Corpus Striatum/*metabolism, Cryopreservation/methods, Dluzen Dean E, Dopamine/*metabolism, Journal of neuroscience methods, Male, Mice, Time Factors

Olfactory bulb norepinephrine depletion abolishes vasopressin and oxytocin preservation of social recognition responses in rats.

Male rats were implanted bilaterally with cannulae directed at the olfactory bulbs and infused with either vehicle or 6-OHDA to selectively deplete norepinephrine concentrations at this site. At 5-7 days following this treatment, these animals…

Tags: *Social Behavior, 1998, Animals, Arginine Vasopressin/administration & dosage/*pharmacology, Dluzen D E, Infusions, Landgraf R, Male, Muraoka S, Neuroscience letters, Norepinephrine/*physiology, Olfactory Bulb/drug effects/*physiology, Oxidopamine/administration & dosage/pharmacology, Oxytocin/administration & dosage/*pharmacology, Parenteral, Rats, Time Factors, Wistar

Relationships among gender, age, time, and temperature in methamphetamine-induced striatal dopaminergic neurotoxicity.

A neurotoxic regimen of methamphetamine (MA-40 mg/kg ip) administered at 0 (control-MA vehicle), 0.5 and 72 h prior to determinations of striatal dopamine (DA) and DOPAC (3,4-dihydroxyphenylacetic acid)/DA ratios were compared among juvenile and…

Neuroprotective role of estrogen upon methamphetamine and related neurotoxins within the nigrostriatal dopaminergic system.

In this report we describe some of the data on the capacity for estrogen to function as a neuroprotectant of the nigrostriatal dopaminergic (NSDA) system. The data show that estrogen (E) can alter two different response characteristics to NSDA…

Tags: 2000, Animals, Annals of the New York Academy of Sciences, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Drug Interactions, Estrogens/*administration & dosage, McDermott J L, Methamphetamine/antagonists & inhibitors/*toxicity, Neurotoxins/antagonists & inhibitors/*toxicity, Substantia Nigra/*drug effects/metabolism, Time Factors

Final Two-Year Outcomes for the Sentry Bioconvertible Inferior Vena Cava Filter in Patients Requiring Temporary Protection from Pulmonary Embolism.

PURPOSE: To report final 2-year outcomes with the Sentry bioconvertible inferior vena cava (IVC) filter in patients requiring temporary protection against pulmonary embolism (PE). MATERIALS AND METHODS: In a prospective multicenter trial, the…

Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma.

Glaucoma challenges the survival of retinal ganglion cell axons in the optic nerve through processes dependent on both aging and ocular pressure. Relevant stressors likely include complex interplay between axons and astrocytes, both in the retina and…

Lifestyle factors and primary care specialty selection: comparing 2012-2013 graduating and matriculating medical students' thoughts on specialty lifestyle.

PURPOSE: To compare how first-year (MS1) and fourth-year students (MS4) ascribe importance to lifestyle domains and specialty characteristics in specialty selection, and compare students' ratings with their primary care (PC) interest. METHOD: In…

Temperature-sensitive Medications in Interfacility Transport: The Ice Pack Myth.

INTRODUCTION: Critical Care Transport teams use various strategies to maintain temperature sensitive drugs and equipment at optimal temperature. The purpose of this study was to examine the effectiveness of current passive refrigeration of…

Single versus multiple fractions of repeat radiation for painful bone metastases: a randomised, controlled, non-inferiority trial.

BACKGROUND: Although repeat radiation treatment has been shown to palliate pain in patients with bone metastases from multiple primary origin sites, data for the best possible dose fractionation schedules are lacking. We aimed to assess two dose…

Tags: *Dose Fractionation, *Radiotherapy, 2014, Aged, Analgesics – Therapeutic Use, Analgesics/therapeutic use, Australia, Babington Scott, Bone Neoplasms, Bone Neoplasms – Complications, Bone Neoplasms – Radiotherapy, Bone Neoplasms/complications/*radiotherapy/*secondary, Brief pain inventory, Brundage Michael D, Canada, Cauda Equina, Chen Bingshu E, Chi Square Test, Chi-Square Distribution, Chow Edward, Clinical Assessment Tools, Clinical Trials, Computer-Assisted, Computer-Assisted – Adverse Effects, Computer-Assisted/adverse effects, Demas William F, Europe, Female, Fractures, Funding Source, Hartsell William F, Hoskin Peter, Human, Humans, Intention to Treat Analysis, Israel, Logistic Models, Logistic Regression, Male, Meyer Ralph M, Middle Age, Middle Aged, Nabid Abdenour, New Zealand, Odds Ratio, Oei Bing, Pain – Diagnosis, Pain – Drug Therapy, Pain – Etiology, Pain – Radiotherapy, Pain Measurement, Pain/diagnosis/drug therapy/*etiology/*radiotherapy, Questionnaires, Radiation, Radiation Dosage, Radiotherapy, Radiotherapy Planning, Risk Factors, Roos Daniel, Scales, Spinal Cord Compression – Etiology, Spinal Cord Compression/etiology, Spontaneous – Etiology, Spontaneous/etiology, Surveys and Questionnaires, The Lancet. Oncology, Time Factors, Tissing-Tan Caroline J A, Treatment Outcome, Treatment Outcomes, van der Linden Yvette M, Wilson Carolyn F, Wong Rebecca K S, Wu Jackson S Y

Impact of reirradiation of painful osseous metastases on quality of life and function: a secondary analysis of the NCIC CTG SC.20 randomized trial.

PURPOSE: We previously demonstrated that 48% of patients with pain at sites of previously irradiated bone metastases benefit from reirradiation. It is unknown whether alleviating pain also improves patient perception of quality of life (QOL).…

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