Browse Items (39 total)
- Tags: Department of Pharmaceutical Sciences, 2016
A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis.
Tags: *Flux, *Glutathione, *Heavy water, *Mass spectrometer, *NAFLD, *NASH, *Oxidative Stress, *Western Diet, 2016, Animal, Animals, Antioxidants/metabolism, Department of Pharmaceutical Sciences, Diet, Disease Models, Free radical biology & medicine, Glutathione/blood/*metabolism, Humans, Kasumov Takhar, LDL/blood/*genetics/metabolism, Lee Kwangwon, Li Ling, Liver/*metabolism/pathology, Lopez Rocio, McCullough Arthur, Mice, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/blood/*genetics/pathology, Oxidative Stress/genetics, Previs Stephen F, Receptors, Western/adverse effects, Willard Belinda, Zhang Guo-Fang
Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease.
Tags: 2016, Alzheimer Disease/etiology/*metabolism/pathology, Alzheimer's disease, Amyloid beta-Peptides/*metabolism, Animal, Animal/physiology, Animals, Behavior, Bemiller Shane M, Bhaskar Kiran, Blotting, Brain Injuries, Brain/*metabolism/pathology, Crish Samuel, Department of Pharmaceutical Sciences, Disease Models, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Immunohistochemistry, Inbred C57BL, Inflammation/*metabolism/pathology, Journal of neurotrauma, Kokiko-Cochran Olga N, Lamb Bruce T, Lee Sungho, Lee Yu-Shang, macrophage, Mice, NEOMED College of Pharmacy, Neuroinflammation, Ransohoff Lena, Ransohoff Richard M, Saber Maha, Sikora Matt, Teknipp Ryan, Transgenic, Traumatic brain injury, Traumatic/complications/*metabolism/*pathology, Veenstra Mike, Western, Wilson Gina, Xu Guixiang
Assessment of alkoxylphenacyl-based polycarbonates as a potential platform for controlled delivery of a model anti-glaucoma drug.
Tags: *Models, 2016, Animals, Bouhenni Rachida, Brimonidine tartrate, Chamsaz Elaheh A, Crish Samuel D, Department of Pharmaceutical Sciences, Drug delivery, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Glaucoma/*drug therapy, Humans, Joy Abraham, Manickavasagam Dharani, Nanoparticles, NEOMED College of Pharmacy, Ocular microfilms, Oyewumi Moses O, Polycarboxylate Cement/*therapeutic use, Rats, Sanders Matthew, Sustained release, Theoretical, Wehrung Daniel
Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury.
Tags: 2016, Alcoholic/*pathology, Alcohols/*toxicity, Animals, Carboxylic Ester Hydrolases/*metabolism, Chemical and Drug Induced Liver Injury/*pathology, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diet/*adverse effects, Fatty Liver, Gene Expression Regulation, Genetic, Hepatocyte Nuclear Factor 4/*metabolism, Hepatocytes/metabolism, Humans, Inbred C57BL, Jadhav Kavita, Knockout, Li Yuanyuan, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Promoter Regions, Protein Binding, Scientific reports, Xu Jiesi, Xu Yang, Yin Liya, You Min, Zhang Yanqiao
Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice.
Tags: *Lipid Metabolism, 2016, Adiposity, Animals, Carboxylesterase/*metabolism, Carboxylic Ester Hydrolases/genetics/*metabolism, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Endoplasmic Reticulum Stress, Energy Metabolism, Experimental/enzymology, Gene Knockdown Techniques, Glucose Tolerance Test, Glucose/metabolism, Hepatocyte Nuclear Factor 4/*metabolism, Hepatology (Baltimore, Md.), High-Fat/adverse effects, Homeostasis, Humans, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Li Yuanyuan, Lipogenesis, Lipolysis, Liver/enzymology, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*etiology/metabolism, Obesity/enzymology/etiology, Sterol Regulatory Element Binding Protein 1/metabolism, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Tags: *Career Mobility, *Faculty, 2016, American journal of pharmaceutical education, Asbill Scott, debate, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Education, Humans, Moultry Aisha Morris, NEOMED College of Pharmacy, Pharmacy, pharmacy education, Pharmacy/*methods/trends, Policastri Anne, promotion, Sincak Carrie A, Smith Lisa S, tenure, Texas, Ulbrich Timothy R
Tags: *Cost of Illness, 2016, Adams Richard, Adult, Assisted Living, Baughman Kristin R, Bonfine Natalie, Chronic Disease/*epidemiology, Chronic pain, Co-morbid illness, College of Graduate Studies, Community mental health journal, Comorbidity, Department of Family & Community Medicine, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Department of Psychiatry, Dugan Sara E, Female, Gallagher Mary, Headache, Health Status, Human, Humans, Male, Mental Disorders, Mental Disorders/complications/*epidemiology, Middle Aged, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED College of Pharmacy, Olds R Scott, Piatt Elizabeth, Prevalence, Ritter Christian, Self Report, Severe mental illness, Young Adult
Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma.
Tags: *Astrocyte, *Axonopathy, *Glaucoma, *Gliosis, *neurodegeneration, *Retinal ganglion cell, 2016, Animal, Animals, Astrocytes/*pathology, Axons/pathology, Calkins David J, Cooper Melissa L, Crish Samuel D, Department of Pharmaceutical Sciences, Disease Models, Experimental eye research, Glaucoma, Horner Philip J, Imaging, Inbred DBA, Inman Denise M, Mice, NEOMED College of Pharmacy, Nerve Degeneration/etiology/*pathology, Open-Angle/*pathology, Optic Nerve Diseases/etiology/*pathology, Optic Nerve/*pathology, Photomicrography, Retinal Ganglion Cells/*pathology, Three-Dimensional, Time Factors
Early Cytoskeletal Protein Modifications Precede Overt Structural Degeneration in the DBA/2J Mouse Model of Glaucoma.
Tags: *Brain Chemistry, *dynamic proteome, *Gaussian process, *Mass spectrometry, *Ornstein-Uhlenbeck process, *protein degradation rate constant, *protein turnover rate constant, *stable isotope labeling, *stochastic differential equation for protein turnover rate constant, 2016, Animals, Chromatography, Data Interpretation, Department of Pharmaceutical Sciences, Isotope Labeling, Journal of proteome research, Kasumov Takhar, Kinetics, Liquid, Liver/*chemistry, Mass spectrometry, Mice, NEOMED College of Pharmacy, Normal Distribution, Previs Stephen F, Proteins/*metabolism, Proteome/*metabolism, Proteomics/methods, Rahman Mahbubur, Sadygov Rovshan G, Statistical, Stochastic Processes
Tags: *Gene Transfer Techniques, 2016, Animals, Cationic lipids, Cell Line, Cell Survival/drug effects/physiology, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, DNA/*administration & dosage/chemistry, gene therapy, Hep G2 Cells, Humans, macrophage activation, Macrophages/drug effects/physiology, Mice, Nanoparticles, Nanoparticles/*administration & dosage/chemistry, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Oyewumi Moses O, Pharmaceutical development and technology, Polyethylene Glycols/*administration & dosage/chemistry, Sadana Prabodh, Transfection, Wehrung Daniel
Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress.
Tags: *ammonia, *ATP, *cellular respiration, *cirrhosis, *Mitochondria, *Oxidative Stress, *portacaval anastamosis, *Reactive oxygen species, *skeletal muscle, 2016, Adenosine Triphosphate/metabolism, Aged, Allawy Allawy, Animals, Cell Line, Cell Respiration, Creatine Kinase/metabolism, Dasarathy Srinivasan, Davuluri Gangarao, Department of Pharmaceutical Sciences, Female, Flask Chris A, Hoppel Charles, Humans, Hyperammonemia/*metabolism, Kasumov Takhar, Kumar Avinash, Liver Cirrhosis/metabolism, Male, Middle Aged, Mitochondria, Muscle, Muscle/*metabolism, Myosin Heavy Chains/metabolism, NAD/metabolism, NEOMED College of Pharmacy, Rats, Reactive Oxygen Species/metabolism, Rennison Julie H, Sandlers Yana, Singh Dharmvir, Skeletal/*metabolism, Sprague-Dawley, Thapaliya Samjhana, The Journal of physiology, Thiobarbituric Acid Reactive Substances/metabolism, Van Wagoner David R
Tags: *Bioenergetics, *Glitazones, *Mitochondria, *Small Molecule Libraries, *Type II diabetes, 2016, Bioorganic & medicinal chemistry letters, Darvesh Altaf S, Department of Pharmaceutical Sciences, Geldenhuys Werner J, Hypoglycemic Agents/chemistry/metabolism, Leeper Thomas C, Ligands, Mitochondrial Proteins/*metabolism, Morris Daniel L, NEOMED College of Pharmacy, Protein Binding, Sullivan Patrick G, Thiazolidinediones/chemistry/metabolism, Yonutas Heather M
Tags: 2016, Affo Silvia, Alcoholic/*immunology, Altamirano Jose, Animals, Arroyo Vicente, Bataller Ramon, Caballeria Juan, Cell Proliferation, Cells, Chen Jiegen, Collagen/genetics/metabolism, Common/*pathology, Crews Fulton, Cultured, Department of Pharmaceutical Sciences, Dumitru Raluca, Female, Gene Expression Profiling, Gene Expression Regulation, Gines Pere, Hepatic Duct, Hepatitis, Hepatocytes/*metabolism/pathology, Humans, Inbred BALB C, Keratins, Knockout, Lipopolysaccharides/metabolism, Lozano Juan Jose, Male, Matsushita Hiroshi, Mice, Middle Aged, Morales-Ibanez Oriol, NEOMED College of Pharmacy, Odena Gemma, Rautou Pierre-Emmanuel, Rodrigo-Torres Daniel, Sancho-Bru Pau, Scientific reports, Seki Ekihiro, Signal Transduction, Toll-Like Receptor 4/genetics/*metabolism, Type I/genetics/*metabolism, Valla Dominique, You Min, Zou Jian
MitoNEET Deficiency Alleviates Experimental Alcoholic Steatohepatitis in Mice by Stimulating Endocrine Adiponectin-Fgf15 Axis.
Tags: *adiponectin, *alcohol, *intestine, *iron, *liver injury, *Signal Transduction, 2016, Adiponectin/genetics/*metabolism, Alcoholic/genetics/*metabolism/pathology, Animals, Department of Pharmaceutical Sciences, Fatty Liver, Fibroblast Growth Factors/genetics/*metabolism, Han Yoonhee, Hu Xudong, Humans, Iron-Binding Proteins/metabolism, Jogasuria Alvin, Kim Chunki, Knockout, Male, Membrane Proteins/*deficiency/metabolism, Mice, NEOMED College of Pharmacy, NF-kappa B/genetics/metabolism, Shen Hong, Sirtuin 1/genetics/metabolism, The Journal of biological chemistry, Wang Jiayou, Wu Jiashin, You Min
Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice.
Tags: 2016, Animal, Animals, Blackwood Rachel, Calcium Signaling/genetics, Dantrolene/*administration & dosage, Dasgupta Nupur, Department of Pharmaceutical Sciences, Disease Models, Fleming Sheila, Gaucher Disease/*drug therapy/genetics/physiopathology, Grabowski Gregory A, Human molecular genetics, Humans, Inskeep Venette, Li Ronghua, Liou Benjamin, Marshall John, Mice, Mitochondria/*drug effects/genetics/pathology, NEOMED College of Pharmacy, Neurons/drug effects/pathology, Neuroprotective Agents/administration & dosage, Peng Yanyan, Quinn Brian, Ryanodine Receptor Calcium Release Channel/*genetics/metabolism, Setchell Kenneth D R, Sun Ying, Zhang Wujuan
Tags: 2016, biosynthesis, Department of Pharmaceutical Sciences, Deuterium Oxide/chemistry, deuterium water, flux analysis, Kasumov Takhar, Kinetics, Macromolecular Substances/*chemistry/*metabolism, Mass spectrometry, Mass Spectrometry/*methods, Metabolomics, Miyagi Masaru, NEOMED College of Pharmacy, Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, proteomics
Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.
Tags: 2016, Adiponectin/*blood, Alcoholic/blood/*genetics/metabolism, Animal, Animals, Chrast Roman, Department of Pharmaceutical Sciences, Disease Models, Fatty Liver, Fibroblast Growth Factors/*blood, Finck Brian N, Gene Knockout Techniques, Han Yoonhee, Hu Xudong, Jogasuria Alvin, Kim Chunki, Lipid Metabolism, Male, Mice, Myeloid Cells/*metabolism, NEOMED College of Pharmacy, NF-kappa B/metabolism, Nuclear Proteins/*deficiency, Organ Specificity, Phosphatidate Phosphatase/*deficiency, Scientific reports, Shen Hong, Signal Transduction, Wang Jiayou, Wu Jiashin, You Min
Tags: *menadione, *organophosphorus pesticides, *paraoxon, *parathion, *redox cycling, 2016, Animals, Annals of the New York Academy of Sciences, Baker Angela A, Cholinesterase Inhibitors/metabolism/*toxicity, Cytochrome P-450 Enzyme Inhibitors/*administration & dosage/metabolism, Cytochrome P-450 Enzyme System/metabolism, Department of Pharmaceutical Sciences, Drug Delivery Systems/*methods, Heck Diane E, Humans, Insecticides/metabolism/toxicity, Jan Yi-Hua, Laskin Debra L, Laskin Jeffrey D, Mishin Vladimir, NEOMED College of Pharmacy, Organophosphate Poisoning/drug therapy/enzymology, Parathion/metabolism/*toxicity, Richardson Jason R, Vitamin K 3/*administration & dosage/metabolism
Tags: *AUY922, *Electroretinography, *Histopathology, *HSP90 inhibitor, *Ocular toxicity, *Rodents, 2016, Akimov Mikhail, Animals, Department of Pharmaceutical Sciences, Electroretinography, Eye/*drug effects/physiopathology, Isoxazoles/toxicity, Kluwe William, Lu Hong, Miller Paul E, NEOMED College of Pharmacy, Rats, Resorcinols/toxicity, Richardson Terrilyn A, Roman Danielle, Schadt Heiko, Toxicology and applied pharmacology, Turner Oliver, VerHoeve James, Vicart Axel, Walker Ursula Junker, Wistar, Wolford Suzanne T, Zhou Wei
Osteoactivin (GPNMB) ectodomain protein promotes growth and invasive behavior of human lung cancer cells.
Tags: *Cell Movement, *Cell Proliferation, 2016, Animals, Apoptosis, Biomarkers, Carcinoma, Cell Adhesion, Cultured, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Female, GPNMB, Humans, integrin, Lung cancer, Lung Neoplasms/metabolism/*pathology, Manickavasagam Dharani, Membrane Glycoproteins/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, NEOMED College of Pharmacy, Neoplasm Invasiveness, Non-Small-Cell Lung/metabolism/*pathology, Novak Kimberly, NSCLC, Nude, Oncotarget, Oyewumi Moses O, Paulic Nikola, Protein Domains, Safadi Fayez F, Sondag Gregory R, Tumor Cells, Tumor/*metabolism, Wehrung Daniel, Xenograft Model Antitumor Assays
Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucoma.
Tags: *Axonal Transport/physiology, *bouton, *Mitochondria, *neurodegeneration, *retinal, *RRID:IMSRJAX:000671, *RRID:IMSRJAX:007048, *RRID:SCR002716, *RRID:SCR002865, *superior colliculus, *synapse, 2016, Animal, Animals, Crish Samuel D, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Disease Models, Electron, Fening Kelly M, Glaucoma/metabolism/*pathology, Imaging, Inbred DBA, Inman Denise M, Mice, Microscopy, Mitochondria/pathology, NEOMED College of Medicine, NEOMED College of Pharmacy, Neuroanatomical Tract-Tracing Techniques, Regression Analysis, Retinal Ganglion Cells/metabolism/*pathology, Scanning, Schofield Brett R, Smith Matthew A, Superior Colliculi/metabolism/*pathology, Synapses/metabolism/*pathology, The Journal of comparative neurology, Three-Dimensional, Visual Pathways/metabolism/pathology, Xia Christina Z
Tags: *Retinopathy of Prematurity, 2016, Angiogenesis Inhibitors, Antibodies, Bevacizumab/*analysis, Bouhenni Rachida, Department of Pharmaceutical Sciences, Gestational Age, Hanna Nancy, Hertle Richard W, Humanized, Humans, Hypes Stephen, Infant, Intravitreal Injections, Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, Lawhon William, Monoclonal, Nasser Orwa, NEOMED College of Pharmacy, Newborn, Vascular Endothelial Growth Factor A, Vitreous Body/*chemistry
Prevalence and Predictors of Metformin Prescribing in Adults with Type 2 Diabetes Mellitus: A National Cross-Sectional Study.
Tags: *evidence-based medicine, *metformin, *predictors, *prescribing, 2016, Adolescent, Adult, Aged, Boyle Jaclyn A, Cross-Sectional Studies, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Diabetes Mellitus, Female, Humans, Hypoglycemic Agents/*therapeutic use, Logistic Models, Male, Metformin/*therapeutic use, Middle Aged, Moorman John M, NEOMED College of Pharmacy, Pharmacotherapy, Prevalence, Soric Mate M, Type 2/*drug therapy
Tags: 2016, antiinflammatory properties, Atherosclerosis, Bebek G, Biochemistry & Molecular Biology, Department of Pharmaceutical Sciences, fatty liver-disease, gene-expression, HDL, Heavy water, high-density-lipoprotein, Journal Article or Conference Abstract Publication, Journal of proteome research, Kasumov T, Li L, Mass-spectrometry, McCullough A J, NAFLD, NEOMED College of Pharmacy, oxidized phospholipids, PPAR-alpha, Previs S F, Proteome dynamics, proteomics, rapid method, Sadygov R G, shotgun, Smith J D, statistical-model, Willard B
Tags: 2016, Cober M Petrea, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Drug Packaging – Methods, Drug Packaging/*methods, Fat Emulsions, Humans, Infant, Intravenous – Administration and Dosage, intravenous fat emulsions, Intravenous/*administration & dosage, Medication Errors – Prevention and Control, Medication Errors/*prevention & control, NEOMED College of Pharmacy, neonates, Newborn, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, parenteral nutrition, Parenteral Nutrition – Methods, parenteral nutrition solutions, Parenteral Nutrition/*methods, Pediatrics
Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium.
Tags: *cytochrome P450, *flavoenzymes, *heme, *nitric oxide synthase, *Reactive oxygen species, 2016, Aleksunes Lauren M, Animals, Cytochrome P-450 Enzyme Inhibitors/*pharmacology, Cytochrome P-450 Enzyme System/*metabolism, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Heck Diane E, Heindel Ned D, Heme/*antagonists & inhibitors/metabolism, Humans, Jan Yi-Hua, Laskin Debra L, Laskin Jeffrey D, Liver/drug effects/enzymology, Mice, Microsomes, Mishin Vladimir, NEOMED College of Pharmacy, Nitric Oxide Synthase Type II/*antagonists & inhibitors/metabolism, Nitric Oxide/metabolism, Onium Compounds/*pharmacology, Rats, Recombinant Proteins/metabolism, Richardson Jason R, Sprague-Dawley, Szilagyi John T, Time Factors, Toxicological sciences : an official journal of the Society of Toxicology
Tags: 2016, Alcoholic/*metabolism, Animal, Animals, Blotting, Cai Yan, Department of Pharmaceutical Sciences, Disease Models, Fatty Liver, Gao Bin, Hu Xudong, Humans, Inbred C57BL, Jogasuria Alvin, Kim Chunki, Knockout, Lee Kwangwon, Lipocalin-2/*metabolism, Mice, NEOMED College of Pharmacy, Polymerase Chain Reaction, The American journal of pathology, Wang Jiayou, Western, Wu Jiashin, Xu Ming-Jiang, Yin Huquan, You Min
The therapeutic efficacy of intensive medical therapy in ameliorating high-density lipoprotein dysfunction in subjects with type two diabetes.
Tags: *Diet, *Exercise Therapy, *Intensive medical therapy, *Myeloperoxidase, *Paraoxonase one, *Pro-inflammatory high-density lipoproteins, 2016, Adult, Apolipoprotein A-I/blood/drug effects, Bena James, Biguanides/pharmacology/therapeutic use, Combined Modality Therapy, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diabetic, Female, HDL/blood/*drug effects, Humans, Hypoalphalipoproteinemias/complications/diet therapy/drug therapy/therapy, Hypoglycemic Agents/*pharmacology/therapeutic use, Insulin/analogs & derivatives/pharmacology/therapeutic use, Kashyap Sangeeta, Kasumov Takhar, Kheniser Karim, Li Ling, Lipids in health and disease, Lipoproteins, Male, Middle Aged, NEOMED College of Pharmacy, Retrospective Studies, Treatment Outcome, Type 2/blood/complications/*therapy
Trimethyltin intoxication induces the migration of ventricular/subventricular zone cells to the injured murine hippocampus.
Tags: *Brain injury, *Hippocampus, *Neural stem cells, *Neurogenesis, *Subventricular stem cells, *Trimethyltin, 2016, Amino Acids/metabolism, Animals, Brain Injuries/*pathology, Bromodeoxyuridine/metabolism, Cell Movement/*drug effects, Department of Pharmaceutical Sciences, Functional Laterality, Glial Fibrillary Acidic Protein/metabolism, Hippocampus/*pathology, Inbred C3H, Lateral Ventricles/drug effects/*pathology, Lowndes Herbert E, Male, Mice, NEOMED College of Pharmacy, Neurogenesis/drug effects/physiology, Neurotoxicology, Reuhl Kenneth R, Richardson Jason R, Trimethyltin Compounds/*toxicity, Weig Blair C