Browse Items (75 total)
- Tags: Chiang John Y L
Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.
Tags: 2005, American journal of physiology. Gastrointestinal and liver physiology, Bile Acids and Salts/pharmacology, Chiang John Y L, Cholestasis/*physiopathology, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/pharmacology, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/pharmacology, Enzyme Inhibitors/*pharmacology, Genetic, Glucocorticoid, Hepatoblastoma/pathology, Hepatocyte Nuclear Factor 4, Humans, Li Tiangang, Liver Neoplasms/pathology, Messenger/analysis/biosynthesis, NEOMED College of Medicine, Phosphoproteins/pharmacology, Pregnane X Receptor, Receptors, Rifampin/*pharmacology, RNA, Steroid/*physiology, Transcription, Transcription Factors/pharmacology, Tumor Cells, Up-Regulation
Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors.
Tags: 2003, American journal of physiology. Gastrointestinal and liver physiology, Animals, Bile Acids and Salts/biosynthesis/genetics/*physiology, Bile/*physiology, Cardiovascular Diseases/genetics/physiopathology, Chiang John Y L, Cholesterol/physiology, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Feedback/physiology, Gene Expression Regulation/physiology, Humans, Liver Diseases/genetics/physiopathology, Liver/*physiology, NEOMED College of Medicine, Receptors
Regulation of bile acid and cholesterol metabolism by PPARs.
Bile Acid signaling in liver metabolism and diseases.
Intestinal Farnesoid X Receptor and Takeda G Protein Couple Receptor 5 Signaling in Metabolic Regulation.
Tags: *Signal Transduction, 2017, Animals, Bile Acids and Salts/biosynthesis/metabolism, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, Digestive diseases (Basel, Switzerland), Donepudi Ajay, Ferrell Jessica, G-Protein-Coupled/*metabolism, Humans, Intestinal Mucosa/*metabolism, Liu Hailiang, Liver/metabolism, NEOMED College of Medicine, Pathak Preeti, Receptors
Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: *Gene Expression Regulation, 2010, Acetylation, AMP-Activated Protein Kinases/metabolism, ATP Citrate (pro-S)-Lyase/genetics/metabolism, Bile Acids and Salts/metabolism, Cells, Chanda Dipanjan, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Epigenesis, Genes, Genetic, Glucose/*administration & dosage, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*enzymology/metabolism, Histones/metabolism, Humans, Hyperglycemia/enzymology/*metabolism, Journal of lipid research, Li Tiangang, Messenger/metabolism, Methylation, NEOMED College of Medicine, Reporter, RNA, RNA Interference, Zhang Yanqiao
A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.
Tags: 2010, 3' Untranslated Regions/genetics, Base Sequence, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Department of Integrative Medical Sciences, Enzymologic/drug effects/*genetics, Fibroblast Growth Factors/pharmacology, Gene Expression Regulation, Genetic/drug effects/genetics, Hep G2 Cells, Hepatocytes/drug effects/enzymology/*metabolism, Humans, Isoxazoles/pharmacology, Journal of lipid research, Li Tiangang, MicroRNAs/*genetics/*metabolism, NEOMED College of Medicine, Oligonucleotide Array Sequence Analysis, Owsley Erika, Post-Transcriptional/drug effects/genetics, RNA Processing, Song Kwang-Hoon, Transcription
Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis.
Tags: *Aldehyde Reductase/genetics/metabolism, 2011, Adenoviridae, Animal, Animals, Blood Glucose/*metabolism, Chiang John Y L, Cholesterol/analysis, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism/physiopathology, Disease Models, Fatty Liver/genetics/*metabolism/physiopathology, Ge Xuemei, Gene Expression, Genetic Vectors, Gluconeogenesis/genetics, Homeostasis, Humans, Journal of lipid research, Li Tiangang, Liver/*metabolism/physiopathology, Ma Huiyan, Malondialdehyde/blood, Mice, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, Transfection, Transgenic, Triglycerides/analysis, Yin Liya, Zhang Yanqiao
Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.
Tags: *bile acids and salt/metabolism, *cholesterol/diet, *Lipids, *Liver, 2016, Animal, Animals, Bile Acids and Salts/genetics/metabolism, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Diet, Disease Models, Exhalation/genetics, Ferrell Jessica M, Glucose/metabolism, High-Fat, Homeostasis, Humans, Journal of lipid research, Li Feng, Lipid Metabolism/genetics, Liver/enzymology/pathology, Metabolic Diseases/*genetics/metabolism, Mice, NEOMED College of Medicine
Cholesterol 7alpha-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.
Tags: *bile acid, *Cholesterol 7-alpha-Hydroxylase/genetics/metabolism, *Farnesoid X receptor, *Homeostasis, *Liver Cirrhosis/chemically induced/enzymology/genetics/prevention & control, *Liver/enzymology/pathology, *nuclear receptor, *Takeda G protein-coupled receptor 5, 2016, Animals, Boehme Shannon, Chiang John Y L, Cholesterol/genetics/*metabolism, Department of Integrative Medical Sciences, G-Protein-Coupled/genetics/metabolism, Hep G2 Cells, Humans, Journal of lipid research, Knockout, Liu Hailiang, Mice, NEOMED College of Medicine, NF-kappa B/genetics/metabolism, Oxidative Stress, Pathak Preeti, Receptors, Tumor Necrosis Factor-alpha/genetics/metabolism
PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine.
Tags: *Lipid Metabolism, 2007, ATP Binding Cassette Transporter, ATP Binding Cassette Transporter 1, ATP-Binding Cassette Transporters/genetics, Base Sequence, Cell Line, Chen Wenling, Chiang John Y L, Cholestanetriol 26-Monooxygenase/*metabolism, Cholesterol, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Fluorinated, Genes, Genetic/drug effects, Genetic/genetics, HDL/metabolism, Hepatocytes/drug effects/enzymology/metabolism, Humans, Hydrocarbons, Hydroxycholesterols/metabolism/pharmacology, Intestinal Mucosa/metabolism, Intestines/cytology/drug effects/enzymology, Journal of lipid research, Li Tiangang, Member 1, Messenger/genetics/metabolism, Molecular Sequence Data, NEOMED College of Medicine, Pregnane X Receptor, Promoter Regions, Receptors, Reporter, Response Elements/genetics, Rifampin/pharmacology, RNA, Steroid/*metabolism, Subfamily G, Sulfonamides/pharmacology, Transcription, Up-Regulation/drug effects
TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression.
Tags: *Gene Expression Regulation, 2008, Animals, Cell Line, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Department of Integrative Medical Sciences, Enzymologic, Forkhead Transcription Factors/physiology, Humans, Insulin/*physiology, Journal of lipid research, Li Tiangang, Ma Huiyan, Male, NEOMED College of Medicine, Nerve Tissue Proteins/physiology, Rats, Signal Transduction, Smad3 Protein/antagonists & inhibitors/pharmacology, Sprague-Dawley, Transforming Growth Factor beta1/*physiology, Tumor, Tumor Necrosis Factor-alpha/*physiology
Bile acids: regulation of synthesis.
Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Biological, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Humans, Journal of lipid research, Models, NEOMED College of Medicine, Receptors, Signal Transduction/physiology
Bile acid regulation of gene expression: roles of nuclear hormone receptors.
A novel bile acid-activated vitamin D receptor signaling in human hepatocytes.
Tags: 2010, Calcitriol/*metabolism, Calcitriol/pharmacology, Cell Membrane/drug effects/metabolism, Cell Nucleus/drug effects/metabolism, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors/genetics, Department of Integrative Medical Sciences, Ellis Ewa, Enzyme Activation/drug effects, Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors, Genetic/genetics, Han Shuxin, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*drug effects/enzymology/*metabolism, Humans, Intracellular Space/drug effects/metabolism, Li Tiangang, Ligands, Lithocholic Acid/*pharmacology, Mitogen-Activated Protein Kinase Kinases/metabolism, Molecular endocrinology (Baltimore, Md.), NEOMED College of Medicine, Phosphorylation/drug effects, Phosphotyrosine/metabolism, Promoter Regions, Protein Kinase Inhibitors/pharmacology, Protein Transport/drug effects, Proto-Oncogene Proteins c-raf/metabolism, Receptors, Retinoid X Receptor alpha/metabolism, Signal Transduction/*drug effects, src-Family Kinases/metabolism, Steroid Hydroxylases/genetics/metabolism, Strom Stephen, Vitamin D3 24-Hydroxylase
Recent advances in understanding bile acid homeostasis.
Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism.
Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Chiang John Y L, Department of Integrative Medical Sciences, Expert opinion on drug metabolism & toxicology, Gene Expression Regulation, Genetic Predisposition to Disease, Hepatocyte Nuclear Factor 4/genetics/*metabolism, Humans, Lipid Metabolism, Liver/metabolism, Mutation, NEOMED College of Medicine, Pharmaceutical Preparations/*metabolism, Signal Transduction/physiology
Nuclear receptors in bile acid metabolism.
Tags: 2013, Animals, Bile Acids and Salts/*metabolism, Biological Transport, Chiang John Y L, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Drug metabolism reviews, Humans, Inactivation, Li Tiangang, Metabolic, NEOMED College of Medicine, Receptors, Xenobiotics/metabolism/pharmacology
Bile Acid Metabolism in Liver Pathobiology.
Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).
Tags: *DNA-Binding Proteins, 2003, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites/genetics, Cell Line, Chen Wenling, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholestanetriol 26-Monooxygenase, Cloning, Cultured, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, DNA, DNA/chemistry/genetics, Dose-Response Relationship, Drug, gene, Gene Expression Regulation/drug effects, Genetic/*genetics, Hepatocyte Nuclear Factor 4, Humans, Luciferases/genetics/metabolism, Molecular, Molecular Sequence Data, Mutagenesis, Mutation, NEOMED College of Medicine, Phosphoproteins/genetics/*metabolism, Promoter Regions, Receptors, Recombinant Fusion Proteins/genetics/metabolism, Response Elements/genetics, Sequence Analysis, Site-Directed, Steroid Hydroxylases/*genetics, Transcription Factors/genetics/*metabolism, Transfection, Tumor Cells
Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases.
Tags: *Lipid Metabolism, 2005, Animals, Chiang John Y L, Chronic Disease, Current opinion in investigational drugs (London, England : 2000), Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/metabolism, Dyslipidemias/drug therapy/metabolism, Heart Diseases/*drug therapy/metabolism, Humans, Hypoglycemic Agents/therapeutic use, Hypolipidemic Agents/therapeutic use, Liver Diseases/*drug therapy/metabolism, Metabolic Diseases/*drug therapy/metabolism, NEOMED College of Medicine, Receptors
Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.
Tags: 2003, ATP Binding Cassette Transporter, ATP-Binding Cassette Transporters/*genetics, Biochemical and biophysical research communications, Cell Line, Chenodeoxycholic Acid/antagonists & inhibitors, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, DNA-Binding Proteins/*antagonists & inhibitors/metabolism, Dose-Response Relationship, Drug, Gene Expression Regulation/drug effects, Humans, Member 11, NEOMED College of Medicine, Owsley Erika, Pregnane X Receptor, Pregnenediones/*pharmacology, Receptors, Steroid/*metabolism, Subfamily B, Transcription Factors/*antagonists & inhibitors/metabolism, Transcriptional Activation/drug effects
On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha.
Tags: *DNA-Binding Proteins, 2002, alpha-Fetoproteins/genetics/*physiology, Animals, Base Sequence, Bile Acids and Salts/*pharmacology, Biochimica et biophysica acta, Cattle, Chiang John Y L, Cytochrome P-450 Enzyme System/*genetics, Department of Integrative Medical Sciences, DNA, Eggertsen Gosta, Enzymologic/*drug effects/physiology, Gene Expression Regulation, Genetic, Genetic/*drug effects, Hepatocyte Nuclear Factor 4, Messenger/genetics, NEOMED College of Medicine, Phosphoproteins/genetics/*physiology, Promoter Regions, Rats, RNA, Sprague-Dawley, Steroid 12-alpha-Hydroxylase, Steroid Hydroxylases/*genetics, Transcription, Transcription Factors/genetics/*physiology, Yang Yizeng, Zhang Ming
Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.
Tags: *Signal Transduction, 2018, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/*antagonists & inhibitors/pharmacology, Department of Integrative Medical Sciences, Disease Models, Ferrell Jessica M, G-Protein-Coupled/*metabolism, Gastrointestinal Microbiome/*drug effects, Glucagon-Like Peptide 1/metabolism, Gonzalez Frank J, GTP-Binding Proteins/*metabolism, Hepatology (Baltimore, Md.), Inbred C57BL, Krausz Kristopher W, Lipid Metabolism, Male, Mice, NEOMED College of Medicine, Nichols Robert G, Pathak Preeti, Patterson Andrew D, Random Allocation, Receptors, Sensitivity and Specificity, Xie Cen
Sterol 12alpha-hydroxylase Aggravates Dyslipidemia by Activating the Ceramide/mTORC1/SREBP1C Pathway via FGF21 and FGF15.
Bile Acids as Metabolic Regulators and Nutrient Sensors
Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets
Tags: 2019, Bile Acids and Salts, Chiang John Y L, Cytoplasmic and Nuclear, Department of Integrative Medical Sciences, Diabetes & Metabolism Journal, Ferrell Jessica M, G-protein-coupled, Gastrointestinal Microbiome, June 2019 Update, NEOMED College of Medicine, Non-alcoholic Fatty Liver Disease, Receptors
Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets.
Tags: 2019, BILE acids, Bile Acids and Salts, Chiang John Y L, cholesterol 7-alpha-hydroxylase, Cytoplasmic and Nuclear, Department of Integrative Medical Sciences, Diabetes & Metabolism Journal, Endocrinology & Metabolism, Farnesoid X receptor, farnesoid-x-receptor, Fatty Liver, fatty liver-disease, Ferrell Jessica M, G protein coupled receptors, G-protein-coupled, Gastrointestinal Microbiome, growth-factor 19, gut microbiota, hepatic steatosis, improves insulin sensitivity, Liver disease, Metabolic, NEOMED College of Medicine, Non-alcoholic fatty, Non-alcoholic Fatty Liver Disease, nuclear, Receptor, Receptors, September 2019 Update, serum fgf21 levels, Syndrome
Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy.
Tags: 2020, alcoholic and nonalcoholic fatty, American journal of physiology. Gastrointestinal and liver physiology, Bile acid metabolism, bile acid therapies, Chiang John Y L, Department of Integrative Medical Sciences, Farnesoid X receptor, Ferrell Jessica M, Liver Diseases, NEOMED College of Graduate Studies, NEOMED College of Medicine, Takeda G protein-coupled receptor 5
Bile Acid Biology, Pathophysiology, and Therapeutics.
Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease.
Tags: 2020, alcoholic liver disease (ALD), Bacterial Translocation, bile acid, binding protein, Chiang John Y L, Department of Integrative Medical Sciences, farnesoid X receptor (FXR), farnesoid-x-receptor, Fatty Liver, glucagon-like peptide-1, growth-factor 19, gut microbiota, Hepatobiliary surgery and nutrition, Journal Article, journalArticle, June 2020 Update I, Li Tiangang, Microbiota, molecular-cloning, NEOMED College of Medicine, non-alcoholic steatohepatitis (NASH), Nuclear Receptor, solute transporter-alpha