Browse Items (132 total)
- Tags: Dose-Response Relationship
Testosterone enhances dopamine depletion by methamphetamine in male, but not female, mice.
Tags: *Sex Characteristics, 2008, Animals, Castration/methods, Corpus Striatum/drug effects/metabolism, Dluzen Dean E, Dopamine Uptake Inhibitors/*pharmacology, Dopamine/*metabolism, Dose-Response Relationship, Drug, Female, Lewis Chandani, Male, Methamphetamine/*pharmacology, Mice, Neuroscience letters, Testosterone Propionate/*pharmacology
The effect of gender and the neurotrophin, BDNF, upon methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system in mice.
Tags: 2004, Animals, Brain-Derived Neurotrophic Factor/deficiency/genetics/*metabolism, Central Nervous System Stimulants/poisoning, Corpus Striatum/*drug effects/*metabolism, Dluzen Dean E, Dopamine/*metabolism, Dose-Response Relationship, Drug, Female, Humans, Male, Methamphetamine/*poisoning, Mice, Mutation, Neuroscience letters, Neurotoxicity Syndromes/*etiology/*metabolism, Sex Factors, Structure-Activity Relationship, Substantia Nigra/drug effects/metabolism, Transgenic
The role of the N-terminal and mid-region residues of substance P in regulating functional selectivity at the tachykinin NK1 receptor.
Tags: 2008, Amino Acid Sequence, Animals, Beard Debbie J, Binding, Calcium Signaling/physiology, CHO Cells, Competitive/drug effects, Cricetinae, Cricetulus, Dose-Response Relationship, Drug, European journal of pharmacology, Iodine Radioisotopes, Ligands, Models, Molecular, Molecular Sequence Data, Neurokinin-1/chemistry/drug effects/*metabolism, Perrine Shane A, Rats, Receptors, Simmons Mark A, Substance P/chemistry/drug effects/*physiology, Young John K
Formulation and photoirradiation parameters that influenced photoresponsive drug delivery using alkoxylphenacyl-based polycarbonates.
Tags: 2014, Animals, Biocompatibility, Cardiotoxicity, Cell Line, Chamsaz Elaheh A, Chemistry, Department of Pharmaceutical Sciences, Dose-Response Relationship, Doxorubicin, Drug, Drug Delivery Systems/*methods, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Heart/drug effects, Humans, Inbred BALB C, Joy Abraham, Mice, Nanotechnology, NEOMED College of Pharmacy, Oyewumi Moses O, Pharmaceutical, Photic Stimulation/*methods, Photoresponsive, Photosensitizing Agents/*chemical synthesis/radiation effects/toxicity, Polycarboxylate Cement/*chemical synthesis/radiation effects/toxicity, Polymer chain scission, Stimuli-responsive, Tumor, Wehrung Daniel
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.
Tags: 2009, Animal, Animals, Anticarcinogenic Agents/*antagonists & inhibitors/pharmacology, Antitumor, Apoptosis/*drug effects, Bishayee Anupam, Body Weight/drug effects, Cell Proliferation/drug effects, Chemico-biological interactions, Dhir Neetika, Diethylnitrosamine, Disease Models, Dose-Response Relationship, Drinking/drug effects, Drug, Drug Screening Assays, Eating/drug effects, Experimental/chemically induced/pathology/*prevention & control, Female, Immunohistochemistry, Liver Neoplasms, Organ Size/drug effects, Phenobarbital, Proto-Oncogene Proteins c-bcl-2/biosynthesis, Rats, Resveratrol, Sprague-Dawley, Stilbenes/*pharmacology
Structure-activity and in vivo evaluation of a novel lipoprotein lipase (LPL) activator.
Tags: *Diabetes, *High-fat diet, *Homology modeling, *Hyperlipidemia, *Lipoprotein lipase, *Liver cirrhosis, *Obesity, 2017, Animals, Benzeneacetamides/chemical synthesis/chemistry/*pharmacology, Bioorganic & medicinal chemistry letters, Caporoso Joel, Darvesh Altaf S, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dose-Response Relationship, Drug, Geldenhuys Werner J, Imidazoles/chemical synthesis/chemistry/*pharmacology, Lee Yoon-Kwang, Leeper Thomas C, Lin Li, Lipoprotein Lipase/*metabolism, Mice, Molecular Docking Simulation, Molecular Structure, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED College of Pharmacy, Sadana Prabodh, Structure-Activity Relationship
Screening and identification of novel compounds with potential anti-proliferative effects on gallium-resistant lung cancer through an AXL kinase pathway.
Tags: 2014, Alazizi Adnan, Antineoplastic Agents/chemical synthesis/chemistry/*pharmacology, Antitumor, AXL, Bioorganic & medicinal chemistry letters, Cell Line, Cell Proliferation/drug effects, Cell Survival/drug effects, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Drug Resistance, Drug Screening Assays, Gallium, Gallium-resistance, Gallium/pharmacology, Geldenhuys Werner J, Humans, Lin Li, Liva Sophia, Lung cancer, Lung Neoplasms/drug therapy/*enzymology/*pathology, Molecular Structure, Naphthalenes/chemistry/*pharmacology, NEOMED College of Pharmacy, Neoplasm/drug effects, Oyewumi Moses O, Proto-Oncogene Proteins/*antagonists & inhibitors/metabolism, Pyrazoles/chemistry/*pharmacology, Quinolines/chemistry/*pharmacology, Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors/metabolism, Structure-Activity Relationship, Tetrazoles/chemistry/*pharmacology, Tumor, Virtual screening
A novel binding assay identifies high affinity ligands to the rosiglitazone binding site of mitoNEET.
Tags: 2011, Awale Prabha S, Binding Sites/drug effects, Bioorganic & medicinal chemistry letters, Carroll Richard T, Dose-Response Relationship, Drug, Funk Max O, Geldenhuys Werner J, Ligands, Lin Li, Mitochondrial Proteins/*antagonists & inhibitors/metabolism, Molecular Structure, Recombinant Proteins/antagonists & inhibitors/metabolism, Rosiglitazone, Stereoisomerism, Structure-Activity Relationship, Thiazolidinediones/chemical synthesis/chemistry/*pharmacology
Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET.
Tags: *Drug Design, 2010, Animals, Barnes Kendra F, Binding Sites/drug effects/physiology, Bioorganic & medicinal chemistry letters, Carroll Richard T, Dose-Response Relationship, Drug, Drug Delivery Systems/*methods, Funk Max O, Geldenhuys Werner J, Liver/drug effects/metabolism, Mitochondria, Mitochondrial Proteins/*metabolism, Protein Structure, Rats, Secondary, Structure-Activity Relationship, Thiazolidinediones/administration & dosage/*chemical synthesis/*metabolism
A standardized extract of Butea monosperma (Lam.) flowers suppresses the
Tags: *Butea, 2017, Aged, Ansari Mohammad Y, Autophagy, Autophagy/drug effects/physiology, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Butea monosperma (Lam.), Chondrocytes/drug effects/*metabolism, Department of Anatomy & Neurobiology, Dose-Response Relationship, Drug, Flowers, Gene Expression, Haqqi Tariq M, Humans, Interleukin-1beta/*pharmacology, Interleukin-6/*biosynthesis/genetics, Khan Nazir M, Matrix Metalloproteinase 13/biosynthesis/genetics, Matrix Metalloproteinase 3/biosynthesis/genetics, Matrix Metalloproteinase 9/biosynthesis/genetics, Matrix Metalloproteinases/*biosynthesis/genetics, Middle Aged, mTOR, NEOMED College of Medicine, Nutraceuticals, Osteoarthritis, Osteoarthritis/*metabolism, Plant Extracts/isolation & purification/pharmacology
Resveratrol inhibition of varicella-zoster virus replication in vitro.
Tags: 2006, Antiviral Agents/*pharmacology, Antiviral research, Bailey Erin, Blotting, Booth Tristan, Cell Line, Docherty John J, Dose-Response Relationship, Drug, Faith Seth A, Fibroblasts/virology, Herpesvirus 3, Human/*drug effects/physiology, Humans, Immediate-Early Proteins/biosynthesis, Messenger/biosynthesis, Resveratrol, Reverse Transcriptase Polymerase Chain Reaction, RNA, Stilbenes/*pharmacology, Sweet Thomas J, Trans-Activators/biosynthesis, Viral Envelope Proteins/biosynthesis, Viral Plaque Assay, Viral/biosynthesis, Virus Attachment/drug effects, Virus Inactivation/drug effects, Virus Replication/*drug effects, Western
MDMA (Ecstasy) substitutes for the ethanol discriminative cue in HAD but not LAD rats.
Tags: 1995, 4-methylenedioxyamphetamine/*pharmacology, Alcohol (Fayetteville, N.Y.), Alcohol Drinking/*genetics/psychology, Animals, Central Nervous System Depressants/*pharmacology, Cues, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Generalization, Gordon T L, Male, Meehan S M, N-Methyl-3, Piperazines/pharmacology, Rats, Schechter M D, Serotonin Agents/*pharmacology, Serotonin Receptor Agonists/pharmacology, Stimulus
Cocaethylene-induced lethality in mice is potentiated by alcohol.
Ethanol discrimination in Fawn-Hooded rats is compromised when compared to other strains.
Locomotor activity but not conditioned place preference is differentially affected by a moderate dose of ethanol administered to P and NP rats.
Ethanol-produced interoceptive stimuli are time dependent in selectively bred HAS and LAS rats.
Calcium channel blockade attenuates angiotensin II-induced drinking in rats.
Tags: 1993, Amino Acid Sequence, Angiotensin II/*antagonists & inhibitors/pharmacology, Animals, Brain research bulletin, Calcagnetti D J, Calcium Channel Blockers/administration & dosage/*pharmacology, Dimethyl Sulfoxide/pharmacology, Dose-Response Relationship, Drinking Behavior/*drug effects, Drug, Injections, Intraventricular, Isradipine/pharmacology, Male, Molecular Sequence Data, Rats, Schechter M D, Sprague-Dawley
Attenuation of drinking sweetened water following calcium channel blockade.
Tags: 1992, Animals, Brain research bulletin, Calcagnetti D J, Calcium Channel Blockers/*pharmacology, Cocaine/pharmacology, Dihydropyridines/pharmacology, Dose-Response Relationship, Drinking Behavior/*drug effects, Drug, Female, Inbred Strains, Injections, Intraventricular, Isradipine, Male, Rats, Reward, Schechter M D, Taste/*drug effects
Increases in the locomotor activity of rats after intracerebral administration of cathinone.
Tags: 1992, Alkaloids/administration & dosage/*pharmacology, Animals, Brain research bulletin, Calcagnetti D J, Cerebral Ventricles/drug effects/*physiology, Dose-Response Relationship, Drug, Injections, Intraventricular, Male, Motor Activity/*drug effects, Nucleus Accumbens/drug effects/*physiology, Psychotropic Drugs/administration & dosage/*pharmacology, Rats, Schechter M D, Sprague-Dawley, Stereotaxic Techniques, Substantia Nigra/drug effects/*physiology
Premorbid behaviors produced by cocaine, ethanol and cocaethylene in the mouse.
A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.
Tags: 1995, 5)-, Ala(2)-MePhe(4)-Gly(5)-, Animals, Crisp T, D-Penicillamine (2, Dose-Response Relationship, Drug, Enkephalin, Enkephalins/*pharmacology, General pharmacology, Keck B J, Male, Naltrexone/analogs & derivatives/pharmacology, Narcotic Antagonists/*pharmacology, Opioid/*drug effects, Rats, Receptors, Somatostatin/analogs & derivatives/pharmacology, Species Specificity, Spinal Cord/*drug effects, Sprague-Dawley, Stafinsky J L, Uram M
Scopolamine-physostigmine combination does not substitute for nicotine.
Tags: 1995, Animals, Conditioning, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Injections, Male, Nicotine/administration & dosage/*pharmacology, Nicotinic/drug effects, Operant/*drug effects, Physostigmine/administration & dosage/*pharmacology, Progress in neuro-psychopharmacology & biological psychiatry, Rats, Receptors, Schechter M D, Scopolamine/administration & dosage/*pharmacology, Sprague-Dawley, Subcutaneous, Task Performance and Analysis
Dopaminergic mediation of the stimulant generalization of nicotine.
Tags: 1993, Alkaloids/pharmacology, Animals, Central Nervous System Stimulants/administration & dosage/*pharmacology, Cues, Discrimination (Psychology)/drug effects, Dopamine/*physiology, Dose-Response Relationship, Drug, Generalization (Psychology)/*drug effects, Injections, Intraperitoneal, Male, Meehan S M, Nicotine/administration & dosage/*pharmacology, Progress in neuro-psychopharmacology & biological psychiatry, Rats, Schechter M D, Sprague-Dawley, Thiazepines/pharmacology
Differential training sequence effect upon psychostimulant discrimination.
Tags: 1993, Alkaloids/pharmacology, Animals, Appetite Depressants/pharmacology, Central Nervous System Stimulants/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Food, Male, Phenylpropanolamine/pharmacology, Progress in neuro-psychopharmacology & biological psychiatry, Psychotropic Drugs/pharmacology, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley
Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.
Tags: *Dopamine Antagonists, 1993, Alkaloids/administration & dosage/*pharmacology, Animals, Antipsychotic Agents/pharmacology, Calcagnetti D J, Central Nervous System Stimulants/administration & dosage/*pharmacology, Conditioning, Discrimination (Psychology)/drug effects, Dose-Response Relationship, Drug, Injections, Intraventricular, Male, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Rats, Schechter M D, Sprague-Dawley, Thiazepines/pharmacology
Effects of aging on spinal opioid-induced antinociception.
Tags: 1994, 5)-, Aging/*physiology, Ala(2)-MePhe(4)-Gly(5)-, Analgesics, Animals, Chinrock K M, Crisp T, D-Penicillamine (2, Dayal B, delta/agonists, Dose-Response Relationship, Drug, Enkephalin, Enkephalins/administration & dosage/pharmacology, Hoskins D L, Hot Temperature, Inbred F344, Injections, Male, mu/agonists, Neurobiology of aging, Nociceptors/*drug effects, Opioid, Opioid/administration & dosage/*pharmacology, Pain Measurement/drug effects, Rats, Receptors, Spinal, Spinal Cord/*physiology, Stafinsky J L, Uram M
Discriminative stimulus properties of CGS 10746B: similarity to dopamine D1 receptor antagonists.
Tags: 1996, Amphetamines/pharmacology, Animals, Antipsychotic Agents/*pharmacology, Behavioural brain research, Cholinergic Agents/pharmacology, Clozapine/pharmacology, Cues, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dopamine D1/*antagonists & inhibitors, Dose-Response Relationship, Drug, Generalization, Male, Meehan S M, Rats, Receptors, Response/drug effects, Schechter M D, Serotonin Agents/pharmacology, Serotonin Receptor Agonists/pharmacology, Sprague-Dawley, Thiazepines/*pharmacology
The lethal effects of ethanol and cocaine and their combination in mice: implications for cocaethylene formation.
Tags: 1995, Animals, Central Nervous System Depressants/*toxicity, Cocaine/*analogs & derivatives/metabolism/toxicity, Dopamine Uptake Inhibitors/*toxicity, Dose-Response Relationship, Drug, Drug Interactions, Ethanol/*toxicity, Female, Lethal Dose 50, Male, Meehan S M, Mice, Pharmacology, biochemistry, and behavior, Schechter M D, Sex Characteristics
Cocaethylene produces discriminative stimulus properties in the rat: effect of cocaine and ethanol coadministration.
Tags: 1995, Animals, Cocaine/*analogs & derivatives/pharmacokinetics/*pharmacology, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Ethanol/pharmacokinetics/*pharmacology, Male, Pharmacology, biochemistry, and behavior, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley
Discriminative stimulus properties of isradipine: effect of other calcium channel blockers.
Tags: 1995, Animals, Calcium Channel Blockers/*pharmacology, Conditioning, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Generalization, Isradipine/*pharmacology, Male, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Sprague-Dawley, Stimulus/*drug effects
Cocaine discrimination is attenuated by isradipine and CGS 10746B.
Tags: 1993, Animals, Antipsychotic Agents/*pharmacology, Calcium Channel Blockers/*pharmacology, Cocaine/antagonists & inhibitors/*pharmacology, Conditioning, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Ibogaine/pharmacology, Isradipine/*pharmacology, Male, Operant/drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Serotonin Antagonists/pharmacology, Sprague-Dawley, Thiazepines/*pharmacology, Tropanes/pharmacology
Biphasic effects of ethanol tested with drug discrimination in HAD and LAD rats.
Tags: 1992, Alcohol Drinking/genetics/*psychology, Animals, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Inbred Strains, Krimmer E C, Male, Pentobarbital/pharmacology, Pharmacology, biochemistry, and behavior, Rats, Serotonin Antagonists/pharmacology, Sleep/drug effects, Time Factors, Tropanes/pharmacology
Rats bred for differences in preference to cocaine: other behavioral measurements.
Further evidence for the mechanisms that may mediate nicotine discrimination.
Tags: 1992, Animals, Calcium Channel Blockers/pharmacology, Dihydropyridines/pharmacology, Discrimination Learning, Dopamine/*metabolism, Dose-Response Relationship, Drug, Inbred Strains, Indoles/pharmacology, Isradipine, Male, Meehan S M, Nicotine/administration & dosage/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Thiazepines/pharmacology, Tropisetron
Effect of altering dopamine or serotonin neurotransmitters upon cathinone discrimination.
Tags: 1992, Alkaloids/*pharmacology, Animals, Antipsychotic Agents/pharmacology, Calcium Channel Blockers/pharmacology, Dihydropyridines/pharmacology, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dopamine/*physiology, Dose-Response Relationship, Drug, Inbred Strains, Isradipine, Male, Neurotransmitter Agents/*physiology, Pharmacology, biochemistry, and behavior, Psychotropic Drugs/*pharmacology, Rats, Schechter M D, Serotonin Antagonists/pharmacology, Serotonin/*physiology, Thiazepines/pharmacology, Tropanes/pharmacology
Direct microinjection of cathinone into the rat brain produces discriminative stimuli.
Tags: *Brain/anatomy & histology, 1992, Alkaloids/administration & dosage/*pharmacology, Animals, Calcagnetti D J, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, Inbred Strains, Injections, Intraventricular, Male, Microinjections, Nucleus Accumbens/anatomy & histology, Pharmacology, biochemistry, and behavior, Psychotropic Drugs/*pharmacology, Rats, Schechter J B, Schechter M D
Serotonin contributes to the spinal antinociceptive effects of morphine.
Tags: 1991, Adrenergic alpha-Antagonists/pharmacology, Adrenergic Antagonists, Analgesics/*pharmacology, Animals, Biogenic Monoamines/physiology, Crisp T, Dose-Response Relationship, Drug, Inbred Strains, Injections, Male, Morphine/*pharmacology, Naltrexone/pharmacology, Nerve Endings/drug effects, Opioid/drug effects, Perni V C, Pharmacology, biochemistry, and behavior, Rats, Reaction Time, Receptors, Serotonin Antagonists/pharmacology, Serotonin/*physiology, Spanos L J, Spinal, Spinal Cord/*drug effects, Stafinsky J L, Uram M, Weaver M F
Discriminative effects of cocaethylene in rats trained to discriminate cocaine or ethanol.
Antiepileptics inhibit cortical N-methyl-D-aspartate-evoked [3H]norepinephrine efflux.
Conditioned place aversion produced by dopamine release inhibition.
Tags: 1994, Analysis of Variance, Animal, Animals, Antipsychotic Agents/administration & dosage/*pharmacology, Aversive Therapy, Conditioning (Psychology), Disease Models, Dopamine Antagonists/administration & dosage/*pharmacology, Dose-Response Relationship, Drug, European journal of pharmacology, Injections, Intraperitoneal, Male, Meechan S M, Motor Activity/*drug effects, Random Allocation, Rats, Schechter M D, Sprague-Dawley, Thiazepines/administration & dosage/*pharmacology