Browse Items · NEOMED Bibliography Database

Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).

Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyses sterol side-chain oxidation of bile acid synthesis from cholesterol, and the first reaction of the acidic bile acid biosynthetic pathway. Hydrophobic bile acids suppress human CYP27A1 gene…

Tags: *DNA-Binding Proteins, 2003, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites/genetics, Cell Line, Chen Wenling, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholestanetriol 26-Monooxygenase, Cloning, Cultured, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, DNA, DNA/chemistry/genetics, Dose-Response Relationship, Drug, gene, Gene Expression Regulation/drug effects, Genetic/*genetics, Hepatocyte Nuclear Factor 4, Humans, Luciferases/genetics/metabolism, Molecular, Molecular Sequence Data, Mutagenesis, Mutation, NEOMED College of Medicine, Phosphoproteins/genetics/*metabolism, Promoter Regions, Receptors, Recombinant Fusion Proteins/genetics/metabolism, Response Elements/genetics, Sequence Analysis, Site-Directed, Steroid Hydroxylases/*genetics, Transcription Factors/genetics/*metabolism, Transfection, Tumor Cells

Reexamining interstitial radiotherapy for PCa.

Tags: *Brachytherapy/adverse effects/instrumentation/methods/trends, *Radioisotopes/adverse effects, 1994, Contemporary urology, Dose-Response Relationship, Forecasting, Humans, Male, Prostatectomy, Prostatic Neoplasms/diagnostic imaging/*radiotherapy, Radiation, Summers J L, Treatment Outcome, Ultrasonography

Reduced vascular responsiveness after a single bout of dynamic exercise in the conscious rabbit.

We measured agonist-induced changes in the iliac artery blood flow velocity (IFV) independent of baroreflex-mediated compensatory mechanisms in chronically instrumented New Zealand White rabbits (n = 8). Animals were instrumented with a Doppler flow…

Rats bred for differences in preference to cocaine: other behavioral measurements.

Cocaine has repeatedly been shown to produce conditioned place preference (CPP) in the rat. The present study employed the heterogenous N/Nih rat stock to produce a selectively bred rat line determined by individual place preference to a conditioning…

Tags: 1992, Animal/*drug effects, Animals, Behavior, Choice Behavior/*drug effects, Cocaine/*pharmacology, Dose-Response Relationship, Drug, Female, Inbred Strains, Male, Motor Activity/drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Species Specificity, Sprague-Dawley

Rats become acutely tolerant to cathine after amphetamine or cathinone administration.

The drug discrimination paradigm was used to evaluate in rats the ability of the discriminate response to either 0.8 mg/kg d-amphetamine or 0.8 mg/kg l-cathinone to generalize to 2.4-6.0 mg/kg of the active cathinone metabolite d-norpseudoephedrine,…

Tags: 1990, Alkaloids/*pharmacology, Amphetamine/*pharmacology, Animals, Antipsychotic Agents/pharmacology, Discrimination (Psychology)/drug effects, Dose-Response Relationship, Drug, Drug Tolerance, Inbred Strains, Male, Phenylpropanolamine/*pharmacology, Psychopharmacology, Psychotropic Drugs/*pharmacology, Rats, Schechter M D, Thiazepines/pharmacology

Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium Channels.

Microglia are considered to be the resident immune cells of the central nervous system and contribute significantly to ongoing neuroinflammation in a variety of neurodegenerative diseases. Recently, we and others identified that voltage-gated sodium…

Premorbid behaviors produced by cocaine, ethanol and cocaethylene in the mouse.

1. The premorbid behaviors produced by the administration of cocaine, ethanol, their combination, as well as a metabolite produced by their co-administration, viz. cocaethylene, were defined, determined and quantified in the HS strain of mice. 2. The…

Tags: 1995, Animal/*drug effects, Animals, Behavior, Cocaine/*analogs & derivatives/*toxicity, Dose-Response Relationship, Drug, Ethanol/*toxicity, Female, General pharmacology, Lethal Dose 50, Male, Meehan S M, Mice, Schechter M D

Preferential increase in pituitary prolactin versus vasoactive intestinal peptide as a function of estradiol benzoate dose in the ovariectomized rat.

Vasoactive intestinal peptide (VIP) is synthesized in various tissues, including the anterior pituitary gland, where it may stimulate the release of PRL. Because estrogen plays a central role in the regulation of PRL, it becomes important to…

Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.

1. The objective of Exp. 1 was to determine whether intracerebroventricular (ICV) injection of cathinone CATH (8.0-32 micrograms) would produce a dose-dependent conditioned place preference (CPP) and/or activation in rats. Results indicate that rats…

Phentermine+fenfluramine produce cocaine-like discriminative cues.

Drug discrimination studies were conducted in six male Sprague-Dawley rats trained to discriminate the interoceptive cues produced by 10 mg/kg cocaine in an effort to investigate if there is stimulus generalization to phentermine or phentermine +…

Tags: *Discrimination (Psychology), 1996, Animals, Cocaine/*pharmacology, Department of Anatomy & Neurobiology, Dose-Response Relationship, Drug, Fenfluramine/administration & dosage/*pharmacology, Life sciences, Male, McBurney D, NEOMED College of Medicine, Phentermine/administration & dosage/*pharmacology, Rats, Schechter M D, Sprague-Dawley

Phase II study of gefitinib in patients with advanced salivary gland cancers.

BACKGROUND: The purpose of this study was to determine the antitumor activity of the epidermal growth factor receptor (EGFR) inhibitor gefitinib in patients with recurrent/metastatic salivary gland cancer. METHODS: We conducted a phase II study in…

Tags: 2015, 80 and over, Adenocarcinoma/drug therapy/mortality/pathology, adenoid cystic carcinoma, Adenoid Cystic/*drug therapy/mortality/pathology, Adult, Aged, Antineoplastic Agents/*therapeutic use, Blumenschein George R Jr, Carcinoma, Department of Internal Medicine, Disease-Free Survival, Dose-Response Relationship, Drug, Drug Administration Schedule, El-Naggar Adel K, Female, Gefitinib, Glisson Bonnie S, Gonzalez-Angulo Ana M, Head & neck, Humans, Jakob John A, Kies Merrill S, Kupferman Michael E, Lee J Jack, Liu Diane D, Local/*drug therapy/mortality/pathology, Male, Maximum Tolerated Dose, Middle Aged, NEOMED College of Medicine, Neoplasm Invasiveness/pathology, Neoplasm Recurrence, Neoplasm Staging, non-adenoid cystic carcinoma, Prognosis, Quinazolines/*therapeutic use, Remission Induction, response to therapy, salivary gland cancer, Salivary Gland Neoplasms/*drug therapy/mortality/pathology, Survival Analysis, Treatment Outcome

Pertubation of beta1 integrin function using anti-sense or function-blocking antibodies on corneal cells grown on fibronectin and tenascin.

During corneal development, neural crest derivatives from the periocular mesenchyme migrate into the cornea and differentiate into corneal fibroblasts. During this time, these cells interact with a variety of extracellular matrices for proper…

Persistent left ventricular dysfunction after cocaine treatment in rabbits.

The present study was undertaken to determine whether the diminished cardiac performance associated with cocaine administration persists after the drug has been eliminated from the body. Cocaine (5 or 10 mg/kg iv) was administered to conscious (n =…

Olanzapine attenuates the reinforcing effects of cocaine.

The possibility that the atypical neuroleptic olanzapine can antagonize the ability of cocaine to produce both conditioned place preference and self-administration in rats was investigated. Pre-treatment with olanzapine (3.0, 4.5 mg/kg, but not 1.5…

Norfenfluramine, the fenfluramine metabolite, provides stimulus control: evidence for serotonergic mediation.

Nine male rats were trained to discriminate 1.4 mg/kg norfenfluramine (NF) from its vehicle using a two-lever, food-motivated, operant discrimination task. Once trained, the rats showed a dose-dependent decrease in responding on the

Tags: 1988, Animal/*drug effects, Animals, Behavior, Boja J W, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Fenfluramine/*analogs & derivatives/*pharmacology, Inbred Strains, Male, Norfenfluramine/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Serotonin/pharmacology, Serotonin/physiology, Time Factors

Myocardial work load is a major determinant of norepinephrine-induced left ventricular dysfunction.

This study was conducted to determine whether increased myocardial energy demand plays a role in norepinephrine (NE)-induced left ventricular (LV) dysfunction. A range of arterial pressure-heart rate (P-R) products (myocardial energy demand) was…

Mesenteric vascular responses to vasopressin during development of DOCA-salt hypertension in male and female rats.

Deoxycorticosterone acetate (DOCA)-salt hypertension develops to a greater extent in male (M) than in female (F) rats. To determine the role of the vasculature, reactivity to arginine vasopressin (AVP) and prostanoid output were examined in the…

MDMA-like stimulus effects of hallucinogens in male Fawn-Hooded rats.

A two-lever, food-motivated, operant technique was employed to train the purportedly serotonergically dysfunctional Fawn-Hooded (FH) rat to discriminate 1.5 mg/kg MDMA. Once all 10 male subjects learned the MDMA-vehicle discrimination at criterion…

MDMA (Ecstasy) substitutes for the ethanol discriminative cue in HAD but not LAD rats.

Selectively bred high- and low-alcohol-drinking (HAD/LAD) rats were trained to discriminate the interoceptive stimuli produced by IP-administered 600 mg/kg ethanol (10% w/v in a two-lever, food-motivated operant task. Once criterion discrimination…

Locomotor activity but not conditioned place preference is differentially affected by a moderate dose of ethanol administered to P and NP rats.

The conditioned place preference (CPP) test and spontaneous motor activity were used in order to determine if ethanol-preferring (P) rats differ from ethanol nonpreferring (NP) rats after the administration of a moderate (1.0 g/kg) dose of ethanol.…

Tags: *Alcohol Drinking, *Environment, 1992, Alcohol (Fayetteville, N.Y.), Animals, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Male, Motor Activity/*drug effects, Mutant Strains, Rats, Reinforcement (Psychology), Schechter M D

Localization and function of NK(3) subtype tachykinin receptors of layer V pyramidal neurons of the guinea-pig medial prefrontal cortex.

The NK(3) subtype of tachykinin receptor has been implicated as a modulator of synaptic transmission in several brain regions, including the cerebral cortex. The localization and expression of NK(3) receptors within the brain vary from species to…

Tags: 2008, Animals, Autoradiography/methods, Dose-Response Relationship, Drug, Drug Interactions, Excitatory Amino Acid Antagonists/pharmacology, Excitatory Postsynaptic Potentials/drug effects/radiation effects, Guinea Pigs, In Vitro Techniques, Iodine Isotopes/pharmacokinetics, Male, Medd A M, Membrane Potentials/drug effects/physiology/radiation effects, Neurokinin B/analogs & derivatives/pharmacokinetics, Neurokinin-3/agonists/antagonists & inhibitors/*metabolism, Neuroscience, Patch-Clamp Techniques, Peptide Fragments/pharmacology, Prefrontal Cortex/*cytology, Protein Binding/drug effects, Pyramidal Cells/drug effects/*metabolism, Quinolines/pharmacology, Quinoxalines/pharmacology, Receptors, Simmons M A, Sobotka-Briner C D, Substance P/analogs & derivatives/pharmacology, Valine/analogs & derivatives/pharmacology

Leading inhibition to neural oscillation is important for time-domain processing in the auditory midbrain.

A number of central auditory neurons exhibit paradoxical latency shift (PLS), a response characterized by longer response latencies at higher sound levels. PLS neurons are known to play a role in target ranging for echolocating bats that emit…

Lack of generalization of nisoxetine with amphetamine in the rat.

Rats were trained to discriminate between the stimulus properties of intraperitoneally administered d-amphetamine (0.8 mg/kg) and its vehicle in a two-lever, food-motivated operant task. Once trained, doses of the norepinephrine reuptake inhibiting…

Tags: *Discrimination (Psychology), 1988, Animals, Boja J W, Conditioning, Dextroamphetamine/*pharmacology, Dose-Response Relationship, Drug, Fluoxetine/*analogs & derivatives/pharmacology, Inbred Strains, Male, Norepinephrine/antagonists & inhibitors, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Reference Values, Schechter M D

Inverse agonist properties of the THBC discriminative stimulus: asymmetrical generalization with FG 7142.

Male rats were trained to discriminate the stimulus properties of the beta-carbolines 1,2,3,4-tetrahydro-beta-carboline (THBC) (15.0 mg/kg) or FG 7142 (5.0 mg/kg) from vehicle in a two-lever, food-motivated operant task. Consistent with the…

Tags: 1991, Animals, Avoidance Learning/drug effects, Carbolines/antagonists & inhibitors/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, GABA-A/*drug effects, Generalization, Inbred Strains, Leidenheimer N J, Male, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Stimulus/*drug effects

Inverse agonist properties of the FG 7142 discriminative stimulus.

A two-lever, food-motivated discrimination was established between the benzodiazepine receptor partial inverse agonist FG 7142 (5.0 mg/kg) and its vehicle. The FG 7142 discriminative stimulus was pharmacologically characterized by testing trained…

Tags: 1991, Animals, Appetite Depressants/*pharmacology, Carbolines/antagonists & inhibitors/*pharmacology, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, GABA-A/drug effects, Generalization, Inbred Strains, Leidenheimer N J, Male, Pharmacology, biochemistry, and behavior, Rats, Receptors, Reinforcement Schedule, Schechter M D, Stimulus/drug effects

Interaction of ethanol and tetrahydro-beta-carboline (THBC) in a discriminative task.

Rats (n = 10) were trained to discriminate between ethanol (600 mg/kg, IP) and its vehicle, or between THBC (20 mg/kg) and its vehicle in a two-lever food-motivated operant task. Once the discriminative training criterion was attained, rats in each…

Tags: 1988, Alcohol (Fayetteville, N.Y.), Animal/drug effects, Animals, Behavior, Carbolines/*pharmacology, Conditioning (Psychology)/drug effects, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Interactions, Ethanol/*pharmacology, Inbred Strains, Male, Rats, Schechter M D, Signs S A

Increases in the locomotor activity of rats after intracerebral administration of cathinone.

There is a widespread practice among people living in Eastern Africa and Southern Arabia of chewing the leaves of the Khat shrub so as to produce pharmacological effects that are practically indistinguishable from those produced by amphetamine…

Tags: 1992, Alkaloids/administration & dosage/*pharmacology, Animals, Brain research bulletin, Calcagnetti D J, Cerebral Ventricles/drug effects/*physiology, Dose-Response Relationship, Drug, Injections, Intraventricular, Male, Motor Activity/*drug effects, Nucleus Accumbens/drug effects/*physiology, Psychotropic Drugs/administration & dosage/*pharmacology, Rats, Schechter M D, Sprague-Dawley, Stereotaxic Techniques, Substantia Nigra/drug effects/*physiology

Increased drug sensitivity in the drug discrimination procedure afforded by drug versus drug training.

Rats were trained to discriminate norfenfluramine (NF) 1.4 mg/kg from its vehicle or amphetamine (AMPH) 0.8 mg/kg or pentobarbital (PB) 6.0 mg/kg in order to determine the role that drug combination training plays in the rate of learning and…

Tags: 1990, Amphetamine/pharmacology, Animals, Boja J W, Discrimination (Psychology)/*drug effects, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Inbred Strains, Male, Norfenfluramine/pharmacology, Pentobarbital/pharmacology, Psychopharmacology, Rats, Reinforcement Schedule, Schechter M D

High-Dose Flu Vaccine has Increased Immunogenicity in HIV Patients.

Tags: 2013, Department of Internal Medicine, Dose-Response Relationship, Double-Blind Studies, Human, Human Immunodeficiency Virus, Infectious Disease Alert, Influenza Vaccine, NEOMED College of Medicine, Ohio, RANDOMIZED controlled trials, Watkins Richard R

Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.

Bile acids activate a nuclear receptor, farnesoid X receptor (FXR), that induces bile salt export pump (BSEP) but inhibits cholesterol 7alpha-hydroxylase (CYP7A1) gene transcription in the liver. Guggulsterone, a plant sterol that lowers serum…

Glycinergic "inhibition" mediates selective excitatory responses to combinations of sounds.

In the mustached bat's inferior colliculus (IC), combination-sensitive neurons display time-sensitive facilitatory interactions between inputs tuned to distinct spectral elements in sonar or social vocalizations. Here we compare roles of ionotropic…

Tags: *Sound, 2008, Acoustic Stimulation/methods, Action Potentials/drug effects/physiology, Animals, Auditory Pathways/*physiology, Chiroptera/physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Dose-Response Relationship, Drug Interactions, Excitatory Amino Acid Antagonists/pharmacology, GABA Agents/pharmacology, GABA/physiology, Gans Donald, Glycine Agents/pharmacology, Glycine/*physiology, Inferior Colliculi/cytology/drug effects/*physiology, Iontophoresis/methods, N-Methyl-D-Aspartate/antagonists & inhibitors/physiology, NEOMED College of Medicine, Neural Inhibition/drug effects/*physiology, Neurons/drug effects/physiology/radiation effects, Piperazines/pharmacology, Radiation, Receptors, Sanchez Jason Tait, The Journal of neuroscience : the official journal of the Society for Neuroscience, Wenstrup Jeffrey J

Further evidence for the mechanisms that may mediate nicotine discrimination.

Rats were trained to discriminate the interoceptive stimuli produced by subcutaneously administered 0.4 mg/kg nicotine in a two-lever, food-motivated, operant task. Once criterion performance was attained, dose-response experiments indicated an ED50…

Tags: 1992, Animals, Calcium Channel Blockers/pharmacology, Dihydropyridines/pharmacology, Discrimination Learning, Dopamine/*metabolism, Dose-Response Relationship, Drug, Inbred Strains, Indoles/pharmacology, Isradipine, Male, Meehan S M, Nicotine/administration & dosage/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Thiazepines/pharmacology, Tropisetron

Functional selectivity of NK1 receptor signaling: peptide agonists can preferentially produce receptor activation or desensitization.

A cascade of events follows binding of an agonist ligand to the tachykinin NK(1) receptor. These events include activation of multiple signal transduction pathways as well as cellular modulation of receptor function by the process of desensitization.…

Tags: 2006, Animals, CHO Cells, Cricetinae, Dose-Response Relationship, Drug, Humans, Neurokinin-1/agonists/drug effects/*physiology, Rana catesbeiana, Rats, Receptors, Signal Transduction/*physiology, Simmons Mark A, Substance P/metabolism/pharmacology, Tachykinins/metabolism/pharmacology, The Journal of pharmacology and experimental therapeutics

Functional consequences of fenfluramine neurotoxicity.

Male Sprague-Dawley rats were trained to discriminate the anorectic drug d,l-fenfluramine (2.0 mg/kg intraperitoneally administered) from its vehicle using a food-motivated (fixed-ratio 10 schedule) two-lever operant task. Once trained, doses of 0.5,…

Tags: 1990, Animals, Conditioning, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, Fenfluramine/*toxicity, Inbred Strains, Male, Nervous System Diseases/*chemically induced/psychology, Operant/drug effects, Pharmacology, biochemistry, and behavior, Rats, Reinforcement Schedule, Schechter M D

Formulation and photoirradiation parameters that influenced photoresponsive drug delivery using alkoxylphenacyl-based polycarbonates.

Recently, we reported the synthesis and biocompatibility of alkoxylphenacyl-based polycarbonates (APP); a promising new class of polymers that undergo photo-induced chain scission. In the current study, nanoparticles (NPs) were prepared from the APP…

Evaluation of factors associated with achieving glycemic control in a pharmacist-managed diabetes clinic.

The aim of this study was to identify factors that are associated with patients achieving goal A1c after 6 months in a pharmacist-managed diabetes clinic. This study is a descriptive, retrospective chart review of patients with type 2 diabetes…

Tags: 2014, Ambulatory Care, Ambulatory Care/organization & administration, American journal of therapeutics, Blood Glucose – Drug Effects, Blood Glucose/drug effects, Boros Melanie L, Department of Internal Medicine, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Diabetes Mellitus, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Frazee Lawrence A, Glycated Hemoglobin A/metabolism, Glycosylated – Metabolism, Hemoglobin A, Human, Humans, Hypoglycemic Agents – Administration and Dosage, Hypoglycemic Agents – Therapeutic Use, Hypoglycemic Agents/administration & dosage/*therapeutic use, Insulin – Administration and Dosage, Insulin – Therapeutic Use, Insulin/administration & dosage/therapeutic use, Kostoff Matthew D, Male, Middle Age, Middle Aged, Moorman John M, NEOMED College of Medicine, NEOMED College of Pharmacy, Pharmaceutical Services/*organization & administration, Pharmacists – Administration, Pharmacists/*organization & administration, Pharmacy Service – Administration, Prospective Studies, Retrospective Design, Retrospective Studies, Social Work – Statistics and Numerical Data, Social Work/statistics & numerical data, Treatment Outcome, Treatment Outcomes, Type 2 – Drug Therapy, Type 2/*drug therapy

Efficacy of Higher-dose Oseltamivir in Adults with Influenza A and B.

Tags: 2014, Department of Internal Medicine, Dose-Response Relationship, Infectious Disease Alert, Influenza – Drug Therapy, Influenza A Virus, Influenza B Virus, Multicenter Studies, NEOMED College of Medicine, Oseltamivir – Adverse Effects, Oseltamivir – Therapeutic Use, Prospective Studies, Treatment Outcomes, Watkins Richard R

Browse Items (132 total)