Browse Items (332 total)
- Tags: Department of Pharmaceutical Sciences
Pharmacotherapy of Alzheimer's disease: current and future trends.
Tags: 2015, Alzheimer Disease/*drug therapy, Alzheimer's disease, Anti-Inflammatory Agents, Antioxidants, cholinesterase inhibitors, Darvesh Altaf S, dementia, Department of Pharmaceutical Sciences, Drug Therapy/*methods/*trends, Expert review of neurotherapeutics, Geldenhuys Werner J, Humans, immunotherapy, memantine, multi-targeted drugs, natural products, NEOMED College of Pharmacy, Pharmacotherapy
Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion.
Tags: 2012, Animals, Corpus Striatum/*drug effects/metabolism, Darvesh Altaf S, Department of Pharmaceutical Sciences, Dluzen Dean E, Dopamine/*metabolism, Drug Synergism, Geldenhuys Werner J, Inbred C57BL, Indoles/*pharmacology, Methamphetamine/*pharmacology, Mice, NEOMED College of Pharmacy, Neurochemistry international
Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.
Tags: 2010, Bioorganic & medicinal chemistry letters, Carroll Richard T, Darvesh Altaf S, Department of Pharmaceutical Sciences, Funk Max O, Geldenhuys Werner J, Models, Molecular, Monoamine Oxidase Inhibitors/chemistry/*pharmacology, Monoamine Oxidase/*drug effects, NEOMED College of Pharmacy, Structure-Activity Relationship, Van der Schyf Cornelis J
Emerging strategies of targeting lipoprotein lipase for metabolic and cardiovascular diseases.
Tags: 2017, Animals, Cardiovascular Diseases/drug therapy/*enzymology, Darvesh Altaf S, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Drug Discovery Today, Geldenhuys Werner J, Humans, Lin Li, Lipoprotein Lipase/chemistry/*metabolism, Metabolic Diseases/drug therapy/*enzymology, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Sadana Prabodh
Identification of a novel serum and glucocorticoid regulated kinase-1 (SGK1) ligand from virtual screening.
Tags: 2012, Binding Sites, Bioorganic & medicinal chemistry letters, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Drug Discovery, Geldenhuys Werner J, Humans, Immediate-Early Proteins/*antagonists & inhibitors/chemistry/metabolism, Ligands, Molecular Docking Simulation, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Protein Kinase Inhibitors/*chemistry/*pharmacology, Protein-Serine-Threonine Kinases/*antagonists & inhibitors/chemistry/metabolism, Sadana Prabodh, Talasila Phani K
Identification of small molecules that bind to the mitochondrial protein mitoNEET.
Tags: *Bioenergetics, *Glitazones, *Mitochondria, *Small Molecule Libraries, *Type II diabetes, 2016, Bioorganic & medicinal chemistry letters, Darvesh Altaf S, Department of Pharmaceutical Sciences, Geldenhuys Werner J, Hypoglycemic Agents/chemistry/metabolism, Leeper Thomas C, Ligands, Mitochondrial Proteins/*metabolism, Morris Daniel L, NEOMED College of Pharmacy, Protein Binding, Sullivan Patrick G, Thiazolidinediones/chemistry/metabolism, Yonutas Heather M
Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits.
Tags: 2020, August 2020 List, Bernstein AI, Cole-Strauss A, CORN oil, Department of Pharmaceutical Sciences, Fleming SM, Gezer AO, Herman DE, journalArticle, Kemp CJ, Kochmanski J, Kuhn NC, Lipton JW, Luk KC, McIntire A, Miller KM, NEOMED College of Pharmacy, NEOMED College of Pharmacy Student, NEOMED Student Publications, Neurobiology of disease, Neuroinflammation, Neurotoxicity, ORGANOCHLORINE pesticides, Parkinson's, Parkinson's disease, Patterson JR, Pesticide, SALINE injections, Sex differences, Sortwell CE, SUBSTANTIA nigra, Synuclein, VanOeveren SE
Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of alpha-synuclein-preformed fibril-induced toxicity and motor deficits.
Tags: 2020, Bernstein Alison I, Cole-Strauss Allyson, Department of Pharmaceutical Sciences, Fleming Sheila M, Gezer Aysegul O, Herman Danielle E, journalArticle, June 2020 Update II, Kemp Christopher J, Kochmanski Joseph, Kuhn Nathan C, Lipton Jack W, Luk Kelvin C, McIntire Alyssa, Miller Kathryn M, NEOMED College of Pharmacy, NEOMED College of Pharmacy Student, NEOMED Student Publications, Neurobiology of disease, Neuroinflammation, Neurotoxicity, Parkinson's, Patterson Joseph R, Pesticide, Sex differences, Sortwell Caryl E, Synuclein, VanOeveren Sarah E
A new LC-MS/MS technique for separation of gangliosides using a phenyl-hexyl column: Systematic separation according to sialic acid class and ceramide subclass
Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes.
Tags: *Ceruloplasmin, *Deamidation, *Heavy water metabolic labeling, *High resolution mass spectrometry, *Iron metabolism, *LC-MS/MS, *Non-enzymatic glycation, *Oxidative Stress, *Protein Processing, *Proteome dynamics, *Serotransferrin, *Type 2 diabetes mellitus, 2017, Adult, Amino Acid Sequence, Bena James, Case-Control Studies, Ceruloplasmin/genetics/*metabolism, Department of Pharmaceutical Sciences, Deuterium/metabolism, Diabetes Mellitus, Diabetic, Diet, Female, Free radical biology & medicine, Gene Expression Regulation, Glycated Hemoglobin A/genetics/metabolism, Glycosylation, Golizeh Makan, Humans, Ilchenko Serguei, Iron/*metabolism, Isotope Labeling, Kashyap Sangeeta R, Kasumov Takhar, Lee Kwangwon, Male, Middle Aged, NEOMED College of Pharmacy, Osme Abdullah, Oxidation-Reduction, Oxidative Stress, Post-Translational, Proteolysis, Sadygov Rovshan G, Transferrin/genetics/*metabolism, Type 2/diet therapy/genetics/*metabolism/pathology
The health benefits of blackcurrants.
Tags: *Health Promotion, *Ribes/chemistry, 2012, Ahmed Shamima, Anthocyanins/analysis, Anti-Infective Agents, Anti-Inflammatory Agents, Antineoplastic Agents, Antioxidants, Bishayee Anupam, Darvesh Altaf S, Department of Pharmaceutical Sciences, Fatty Acids, Flavonoids/analysis, Food & function, Fruit/chemistry, Gopalan Ashwin, Hohmann Judit, Humans, NEOMED College of Pharmacy, Phytogenic, Phytotherapy, Plant Extracts/adverse effects/pharmacokinetics/pharmacology, Reuben Sharon C, Unsaturated/analysis
Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson's Disease.
Tags: 2018, Animal Studies, Deglutition – Drug Effects, Deglutition disorders, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Eating – Drug Effects, Feeding Methods, German Rebecca Z, Gould François D H, Gross Andrew, Isoflavones – Administration and Dosage, Isoflavones – Pharmacodynamics, Mastication, NEOMED College of Medicine, NEOMED College of Pharmacy, Oropharynx – Pathology, Parkinson Disease, Parkinson's disease, Phenotype, Rats, Richardson Jason R
Society of Toxicology Develops Learning Framework for Undergraduate Toxicology Courses Following the Vision and Change Core Concepts Model.
Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1.
Tags: 2017, Acetylation/drug effects, Animals, Butyrates/pharmacology, Cell Line, Cell Survival/drug effects, Department of Pharmaceutical Sciences, Dopamine Plasma Membrane Transport Proteins/*metabolism, Dopamine transporter, Dopaminergic Neurons/cytology/drug effects/metabolism, Dose-Response Relationship, Drug, Eid Aseel, Epigenesis, Epigenetics, Genetic, Genetic/drug effects, Green Ashley L, Group A, Guo Grace L, HDAC, Histone deacetylase, Histone Deacetylase Inhibitors/*pharmacology, Histone Deacetylases/metabolism, Histones/*drug effects/metabolism, Homeodomain Proteins/metabolism, Hydroxamic Acids/pharmacology, Member 2/*metabolism, Messenger/metabolism, NEOMED College of Pharmacy, Neuropharmacology, Nuclear Receptor Subfamily 4, Nurr1, Pitx3, Promoter Regions, Rats, Richardson Jason R, RNA, Transcription Factors/metabolism, Valproate, Valproic Acid/*pharmacology, Zarbl Helmut, Zhan Le
Recognition Sites for Cancer-Targeting Durg Delivery Systems
Tags: 2019, Anhui Medical University, Bao Jianwei, Current Drug Metabolism, Czech Tori, Department of Pharmaceutical Sciences, Guan Siyu, Hu Rongfeng, Journal Article, ligand, Nanoparticles, NEOMED College of Pharmacy, NEOMED College of Pharmacy Student, November 2019 Update, Recognition sites, Tang Jihui, targeted drug delivery system, Tumor, Zhang Qianqian
Methods Used by Colleges and Schools of Pharmacy to Prepare Student Pharmacists for Careers in Academia.
Tags: *Career Choice, *Students, 2017, Academia, American journal of pharmaceutical education, Attitude of Health Personnel, Boyle Jaclyn A, Career, Clifford Kalin M, Curriculum, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dy-Boarman Eliza A, Education, Faculty, Graduate, Haines Seena L, Humans, NEOMED College of Pharmacy, Peeters Michael J, Pharmaceutical, Pharmacists, Pharmacy, Pharmacy/*methods, Pharmacy/*organization & administration, Schools, Societies, Student preparation, Summa Maria A, Surveys and Questionnaires, Training, United States, Willson Megan N
Toolkit for US colleges/schools of pharmacy to prepare learners for careers in academia.
Tags: *Academia, *Career, *Student preparation, *Training, 2017, Boyle Jaclyn A, Clifford Kalin M, Currents in pharmacy teaching & learning, Curriculum/trends, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dy-Boarman Eliza A, Education, Faculty, Haines Seena L, Humans, NEOMED College of Pharmacy, Peeters Michael J, Pharmacy/*education/organization & administration, Pharmacy/*methods/organization & administration, Pharmacy/*psychology, Students, Summa Maria A, Universities/organization & administration/trends, Willson Megan N, Workforce
Alpha 2-Adrenergic Receptor Agonist Brimonidine Stimulates ERK1/2 and AKT Signaling via Transactivation of EGF Receptors in the Human MIO-M1 Muller Cell Line.
Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma.
Tags: 2018, AMP-activated protein kinase, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Biological, Calcium Binding Proteins – Metabolism, Calcium-Binding Proteins/metabolism, Cells – Drug Effects, Cells – Pathology, Department of Pharmaceutical Sciences, Diet, Disease Models, Eye Proteins/genetics, Female, G-Protein-Coupled – Metabolism, G-Protein-Coupled/*metabolism, Glaucoma, Glaucoma – Complications, Glaucoma – Pathology, Glaucoma/*complications/pathology, Harun-Or-Rashid Mohammad, Impact of Events Scale, Inbred DBA, Inflammation – Etiology, Inflammation – Prevention and Control, Inflammation hydroxycarboxylic acid receptor, Inflammation/*etiology/*prevention & control, Inman Denise M, Journal of neuroinflammation, Ketogenic diet, Ketogenic/methods, Male, Membrane Glycoproteins, Membrane Glycoproteins/genetics, Mice, Microfilament Proteins – Metabolism, Microfilament Proteins/metabolism, Microglia/drug effects/pathology, Models, Mutation, Mutation/genetics, NEOMED College of Pharmacy, Neuroprotection/drug effects/*physiology, NLR Family, Optic Nerve – Pathology, Optic Nerve/pathology, Phosphotransferases – Metabolism, Proteins, Pyrin Domain-Containing 3 Protein/genetics/metabolism, Receptors, Retina – Drug Effects, Retina – Pathology, Retinal Ganglion Cells/drug effects/*pathology, Transgenic
Structural and Functional Rescue of Chronic Metabolically Stressed Optic Nerves through Respiration.
Tags: 2018, b-hydroxybutyrate, Crish Samuel D, Department of Pharmaceutical Sciences, Gevorgyan Victoria, Harun-Or-Rashid Mohammad, Inman Denise M, Ketogenic diet, NEOMED College of Pharmacy, neural-glial interaction, optic nerve, Palmer Peter G, Pappenhagen Nate, Smith Matthew A, The Journal of neuroscience : the official journal of the Society for Neuroscience, Wilson Gina N
MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma.
Tags: 2020, Coughlin Lucy, Department of Pharmaceutical Sciences, Glaucoma, Harun-Or-Rashid Mohammad, Inman Denise M, Jassim Assraa Hassan, journalArticle, June 2020 Update II, Metabolism, Monocarboxylate transporter, NEOMED College of Pharmacy Student, NEOMED Student Publications, Neurobiology of disease, Ocular Hypertension, Pappenhagen Nathaniel, Retinal ganglion cell, Zubricky Ryan
Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects.
Tags: 2021, angiotensin-converting enzyme (ACE) inhibitors, Bleske Barry E, British Journal Of Clinical Pharmacology, Carboxylesterase1 (CES1), Choi HJ, Department of Pharmaceutical Sciences, enalapril, Her LH, journalArticle, Jung SM, May 2021 List, NEOMED College of Pharmacy, pharmacogenetics, pharmacokinetics, Shi J, Smith LS, Wang X, Wu AH, Zhu H-J
Deltamethrin exposure inhibits adult hippocampal neurogenesis and causes deficits in learning and memory in mice.
Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium Channels.
Tags: *deltamethrin, *intracellular sodium., *Microglia, *neurodegeneration, *Neuroinflammation, *permethrin, *pyrethroids, *tetrodotoxin, *tumor necrosis factor, *Voltage-gated sodium channels, 2017, Animals, Cell Line, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Hossain Muhammad M, Inbred C57BL, Insecticides/*toxicity, Ion Channel Gating/*drug effects, Liu Jason, Mice, Microglia/*drug effects/metabolism, NEOMED College of Pharmacy, Pyrethrins/*toxicity, Richardson Jason R, Sodium Channels/*drug effects, Toxicological sciences : an official journal of the Society of Toxicology, Transformed, Tumor Necrosis Factor-alpha/metabolism
Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to Deltamethrin.
The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6.
Tags: *gp91(phox), *Microglia, *MPTP, *Na(v)1.6, *Neuroinflammation, *Parkinson's disease, *TNF-alpha, *Voltage-gated sodium channels, *Zonisamide, 2018, Department of Pharmaceutical Sciences, Experimental neurology, Gearing Marla, Hossain Muhammad M, NEOMED College of Pharmacy, Reuhl Kenneth, Richardson Jason R, Weig Blair, Wu Long-Jun
MitoNEET Deficiency Alleviates Experimental Alcoholic Steatohepatitis in Mice by Stimulating Endocrine Adiponectin-Fgf15 Axis.
Tags: *adiponectin, *alcohol, *intestine, *iron, *liver injury, *Signal Transduction, 2016, Adiponectin/genetics/*metabolism, Alcoholic/genetics/*metabolism/pathology, Animals, Department of Pharmaceutical Sciences, Fatty Liver, Fibroblast Growth Factors/genetics/*metabolism, Han Yoonhee, Hu Xudong, Humans, Iron-Binding Proteins/metabolism, Jogasuria Alvin, Kim Chunki, Knockout, Male, Membrane Proteins/*deficiency/metabolism, Mice, NEOMED College of Pharmacy, NF-kappa B/genetics/metabolism, Shen Hong, Sirtuin 1/genetics/metabolism, The Journal of biological chemistry, Wang Jiayou, Wu Jiashin, You Min
Controlled Flow Studies In 4 Mm Endothelialized Dacron Grafts
Tags: 1983, Department of Pharmaceutical Sciences, Engineering, Hunter T J, Journal Article or Conference Abstract Publication, Malindzak G S, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Schmidt S P, Sharp W V, Surgery, Transactions American Society for Artificial Internal Organs
Postmortem vitreous bevacizumab levels of an infant treated for retinopathy of prematurity.
Tags: *Retinopathy of Prematurity, 2016, Angiogenesis Inhibitors, Antibodies, Bevacizumab/*analysis, Bouhenni Rachida, Department of Pharmaceutical Sciences, Gestational Age, Hanna Nancy, Hertle Richard W, Humanized, Humans, Hypes Stephen, Infant, Intravitreal Injections, Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, Lawhon William, Monoclonal, Nasser Orwa, NEOMED College of Pharmacy, Newborn, Vascular Endothelial Growth Factor A, Vitreous Body/*chemistry
Calculation of the Protein Turnover Rate Using the Number of Incorporated 2H Atoms and Proteomics Analysis of a Single Labeled Sample
Tags: 2019, Analytical Chemistry, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Haddad Andrew, Ilchenko Serguei, Journal Article, Kasumov Takhar, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, November 2019 Update, Recchia Fabio A, Sadana Prabodh, Sadygov Rovshan G
The Role Of Nrf2 Transcription Factor In Ganglion Cell Survival In Glaucoma
Tags: 2014, 531 ganglion cells, 634 oxidation/oxidative or free radical damage, 740, Coughlin L, Department of Pharmaceutical Sciences, Inman D M, Investigative ophthalmology & visual science, Journal Article or Conference Abstract Publication, NEOMED College of Pharmacy, Ophthalmology, transgenics/knock-outs
Metabolic Vulnerability In The Neurodegenerative Disease Glaucoma
Tags: 2017, amyotrophic-lateral-sclerosis, axon, Axonopathy, Department of Pharmaceutical Sciences, Frontiers in neuroscience, glucose-transporter glut3, glycogen-synthase kinase-3, Harun-Or-Rashid M, Inman D M, Journal Article or Conference Abstract Publication, lactate, Mitochondria, monocarboxylate transporters, mouse white-matter, NEOMED College of Pharmacy, neuron lactate-shuttle, Neuropathy, Neurosciences & Neurology, optic, optic-nerve head, retinal ganglion-cells, self-destruction, slow wallerian degeneration, Wallerian degeneration
Alpha-lipoic Acid Antioxidant Treatment Limits Glaucoma-related Retinal Ganglion Cell Death And Dysfunction
Tags: 2013, Calkins D J, controlled trial aladin, dba/2j mouse model, Department of Pharmaceutical Sciences, glycation end-products, Horner P J, in-vivo, Inman D M, ischemia-reperfusion, Journal Article or Conference Abstract Publication, Lambert W S, NEOMED College of Pharmacy, nitric-oxide, open-angle glaucoma, optic neuropathy, Oxidative Stress, PloS one, Science & Technology - Other Topics, trabecular meshwork
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR.
Tags: *Atherosclerosis, *Farnesoid X receptor, *NAFLD, *Obesity, *TGR5, 2018, Adorini Luciano, Animals, Bile Acids and Salts/pharmacology/*therapeutic use, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diet, G-Protein-Coupled/*agonists, Hep G2 Cells, High-Fat/adverse effects, Humans, Hypercholesterolemia/*drug therapy/etiology/metabolism, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Lee Yoon Kwang, Li Yuanyuan, Male, Mice, Molecular metabolism, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*drug therapy/etiology/metabolism, Obesity/*drug therapy/etiology/metabolism, Receptors, Xu Jiesi, Xu Yang, Xu Yanyong, Yin Liya, Zhang Yanqiao, Zhu Yingdong
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR.
Tags: *Atherosclerosis, *Farnesoid X receptor, *NAFLD, *Obesity, *TGR5, 2018, Adorini Luciano, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Jadhav Kavita, Kasumov Takhar, Lee Yoon-Kwang, Li Yuanyuan, Molecular metabolism, NEOMED College of Medicine, NEOMED College of Pharmacy, Xu Jiesi, Xu Yang, Xu Yanyong, Yin Liya, Zhang Yanqiao, Zhu Yingdong
Novel approaches to mitigating parathion toxicity: targeting cytochrome
Tags: *menadione, *organophosphorus pesticides, *paraoxon, *parathion, *redox cycling, 2016, Animals, Annals of the New York Academy of Sciences, Baker Angela A, Cholinesterase Inhibitors/metabolism/*toxicity, Cytochrome P-450 Enzyme Inhibitors/*administration & dosage/metabolism, Cytochrome P-450 Enzyme System/metabolism, Department of Pharmaceutical Sciences, Drug Delivery Systems/*methods, Heck Diane E, Humans, Insecticides/metabolism/toxicity, Jan Yi-Hua, Laskin Debra L, Laskin Jeffrey D, Mishin Vladimir, NEOMED College of Pharmacy, Organophosphate Poisoning/drug therapy/enzymology, Parathion/metabolism/*toxicity, Richardson Jason R, Vitamin K 3/*administration & dosage/metabolism