Browse Items · NEOMED Bibliography Database

CONTINUOUS-INFUSION OF PYRIDOSTIGMINE IN THE MANAGEMENT OF MYASTHENIC CRISIS

Tags: 1993, Bonfiglio M F, cholinergic, cholinesterase inhibitors, compounds, Critical care medicine, edrophonium, General & Internal Medicine, gravis, Injections, Intravenous, Journal Article, Kinetics, Martin B R, myasthenia gravis, neostigmine, neuromuscular diseases, ocular motility disorders, pyridinium, pyridostigmine bromide, Receptors, Saltis L M, Traeger S M, ventilatory weaning

Contribution of NMDA and AMPA receptors to temporal patterning of auditory responses in the inferior colliculus.

Although NMDA receptors (NMDARs) are associated with synaptic plasticity, they form an essential part of responses to sensory stimuli. We compared contributions of glutamatergic NMDARs and AMPA receptors (AMPARs) to auditory responses in the inferior…

Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis.

Cysteinyl leukotrienes (cys-LTs) are proinflammatory mediators that enhance vascular permeability through distinct receptors (CysLTRs). We found that CysLT2R regulates angiogenesis in isolated mouse endothelial cells (ECs) and in Matrigel implants in…

Tags: *angiogenesis, *cysteinyl leukotriene receptors, *endothelial cells, *metastasis, *tumor growth, 2019, Adapala Ravi K, Animals, Austen K Frank, Capillary Permeability/drug effects, Cyclohexanecarboxylic Acids/pharmacology, Department of Integrative Medical Sciences, Duah Ernest, Endothelial Cells/*drug effects, Experimental, Gene Knockout Techniques, Inbred C57BL, Kanaoka Yoshihide, Keshamouni Venkateshwar G, Kondeti Vinay, Leukotriene Antagonists/pharmacology, Leukotriene/drug effects/*metabolism, Lung Neoplasms/drug therapy, Male, Mice, NEOMED College of Medicine, Neoplasm Metastasis/drug therapy, Neoplasm Transplantation, Neoplasms, Neovascularization, Paruchuri Sailaja, Pathologic/*chemically induced/drug therapy, Phthalic Acids/pharmacology, Proceedings of the National Academy of Sciences of the United States of America, Receptors, Teegala Lakshminarayan Reddy, Thodeti Charles K

Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis.

UNLABELLED: Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. TGR5 activation also inhibits nuclear factor kappaB (NF-kappaB)-mediated inflammation. Here we…

Depotentiation of vdccLTP requires NMDAR activation.

Long-term potentiation is an enduring increase in synaptic efficacy following repeated stimulation of afferent fibers that is thought to underlie memory. In area CA1 of the hippocampus at least two forms of synaptic potentiation coexist at the same…

Development and validation of an LC-MS/MS method for determination of the L-type voltage-gated calcium channel/NMDA receptor antagonist NGP1-01 in mouse serum.

NGP1-01 (8-benzylamino-8,11-oxapentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane) is a heterocyclic cage compound with multifunctional calcium channel blocking activity that has been demonstrated to be neuroprotective in several neurodegenerative…

Development of GPCR modulation of GABAergic transmission in chicken nucleus laminaris neurons.

Neurons in the nucleus laminaris (NL) of birds act as coincidence detectors and encode interaural time difference to localize the sound source in the azimuth plane. GABAergic transmission in a number of CNS nuclei including the NL is subject to a…

Tags: *Synaptic Transmission, 2012, Animals, Brain/*cytology, Chickens/*metabolism, Department of Anatomy & Neurobiology, G-Protein-Coupled/*metabolism, GABA-A/metabolism, GABA-B/metabolism, gamma-Aminobutyric Acid/*metabolism, Lu Yong, Metabotropic Glutamate/metabolism, NEOMED College of Medicine, Neurons/*metabolism, Patch-Clamp Techniques, PloS one, Receptors, Synapses/metabolism, Tang Zheng-Quan

DEVELOPMENTAL ALTERATIONS IN N-METHYL-D-ASPARTATE STIMULATED H-3 NOREPINEPHRINE RELEASE IN RAT-BRAIN CORTEX AND HIPPOCAMPUS

Developmental alterations in N-methyl-D-aspartate (NMDA)-stimulated [H-3]norepinephrine release from rat brain cortical and hippocampal slices were studied. NMDA (10-1000 muM) resulted in a concentration-dependent increase in [H-3]norepinephrine…

Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation.

Enduring synaptic potentiation can be induced in area CA1 of hippocampus by tetanic stimulation and by exposure to a medium containing high Ca2+ concentration. Both tetanic stimulation and high Ca2+ induce potentiation through voltage-dependent,…

Tags: 1990, 2-Amino-5-phosphonovalerate/*pharmacology, Action Potentials/drug effects, Animals, Calcium/*pharmacology, Electric Stimulation, Grover L M, Hippocampus/drug effects/*physiology, In Vitro Techniques, N-Methyl-D-Aspartate, Neuronal Plasticity/*drug effects, Neuroscience letters, Neurotransmitter/antagonists & inhibitors/*physiology, Receptors, Teyler T J

Discriminative stimulus effect of phenylephrine.

Rats were trained to discriminate phenylephrine in a two-lever, food-motivated operant task by increasing the i.p. administered training dose from 0.8 to 2 mg/kg. Stable discrimination to 2 mg/kg phenylephrine was established and testing of 0.5-2.5…

Discriminative stimulus properties of CGS 10746B: similarity to dopamine D1 receptor antagonists.

CGS 10746B is an imidazole-derivative related to the atypical antipsychotic clozapine which produces a decrease in dopamine release without altering dopamine metabolism or occupying D2 receptors. Rats were trained on an appetitively-motivated,…

Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex.

Male rats were trained to discriminate the stimulus effects of CGS 9896 (30.0 mg/kg) from its vehicle. Once trained, discriminative performance was observed to be dose-responsive in the 3.75-30.0 mg/kg range and analysis of the dose-response curve…

Early upregulation of myocardial CXCR4 expression is critical for dimethyloxalylglycine-induced cardiac improvement in acute myocardial infarction.

The stromal cell-derived factor-1 (SDF-1):CXCR4 is important in myocardial repair. In this study we tested the hypothesis that early upregulation of cardiomyocyte CXCR4 (CM-CXCR4) at a time of high myocardial SDF-1 expression could be a strategy to…

Tags: 2016, alpha Subunit/metabolism, American journal of physiology. Heart and circulatory physiology, Amino Acids, Animal, Animals, Apoptosis/drug effects, Cardiotonic Agents/*pharmacology, Cell Hypoxia, Cell Line, Chilian William M, CXCR4/deficiency/genetics/*metabolism, Department of Integrative Medical Sciences, Dicarboxylic/*pharmacology, Disease Models, Dong Feng, Enzyme Inhibitors/pharmacology, Forudi Farhad, hypoxia, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor-Proline Dioxygenases/antagonists & inhibitors/metabolism, Inbred C57BL, Kiedrowski Matthew, Knockout, Left/*drug effects, Mayorga Mari, Mice, myocardial infarction, Myocardial Infarction/*drug therapy/genetics/metabolism/pathology/physiopathology, Myocardium/*metabolism/pathology, NEOMED College of Medicine, Penn Marc S, Rats, Receptors, Recovery of Function, Shamhart Patricia, Signal Transduction/drug effects, stem cells, Stem Cells/drug effects/metabolism, Stroke Volume/drug effects, Time Factors, Up-Regulation, Ventricular Function, Weber Kristal

Effect of aging on the substance P receptor, NK-1, in the spinal cord of rats with peripheral nerve injury.

Substance P (SP) levels in the spinal cords of very old rats are less than the levels in younger rats (Bergman et al., 1996). After injury to a peripheral nerve in young rats, immunoreactivity (ir) to the SP receptor, NK-1 (neurokinin-1), increases…

Effect of epinephrine on alveolar liquid clearance in the rat.

Endogenous epinephrine has been found to increase alveolar liquid clearance (ALC) in several pulmonary edema models. In this study, we infused epinephrine intravenously for 1 h in anesthetized rats to produce plasma epinephrine concentrations…

Effect of learned behavior upon conditioned place preference to cathinone.

The purpose of this study was to examine whether first training rats to discriminate the stimulus cues produced by an indirect dopamine agonist, cathinone, would influence a subsequent test of preference. The conditioned place preference (CPP)…

Tags: 1991, Alkaloids/*pharmacology, Animals, Antipsychotic Agents/pharmacology, Conditioning, Cues, Discrimination (Psychology)/drug effects, Discrimination Learning/drug effects, Dopamine/drug effects, Dopamine/physiology, Inbred Strains, Learning/*physiology, Male, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Thiazepines/pharmacology

Effects of aging on spinal opioid-induced antinociception.

Initial experiments were conducted to determine whether or not the aging process alters the ability of young, mature, or aged male Fischer 344 rats (5- to 6-, 15- to 16-, and 25- to 26-months-old, respectively) to respond to thermal nociceptive…

Efficacy and safety of ustekinumab and etanercept for the treatment of psoriasis.

IMPORTANCE OF THE FIELD: TNF-alpha inhibitors such as etanercept have been used for psoriasis for years. A fairly well defined efficacy and safety profile has developed. A new biologic agent, ustekinumab, an IL-12 and IL-23 inhibitor, has recently…

Electrical stimuli patterned after the theta-rhythm induce multiple forms of LTP.

The induction of long-term potentiation (LTP) by high-frequency stimulation is considered an acceptable model for the study of learning and memory. In area CA1 calcium influx through N-methyl-D-aspartate receptors (NMDARs; nmdaLTP) and/or

Endogenous mGluR activity suppresses GABAergic transmission in avian cochlear nucleus magnocellularis neurons.

GABAergic transmission in the avian cochlear nucleus magnocellularis (NM) of the chick is subject to modulation by gamma-aminobutyric acid type B (GABA(B)) autoreceptors. Here, I investigated modulation of GABAergic transmission in NM by metabotropic…

Tags: 2-Amino-5-phosphonovalerate/pharmacology, 2007, Amino Acids/pharmacology, Animals, Chickens/*physiology, Cochlear Nucleus/*cytology/*physiology, Department of Anatomy & Neurobiology, Electric Stimulation, Excitatory Amino Acid Antagonists/pharmacology, Excitatory Postsynaptic Potentials/physiology, GABA-B Receptor Agonists, GABA-B Receptor Antagonists, GABA-B/physiology, gamma-Aminobutyric Acid/*physiology, Glycine/analogs & derivatives/pharmacology, In Vitro Techniques, Journal of neurophysiology, Kinetics, Lu Yong, Membrane Potentials/drug effects, Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism/physiology, Models, NEOMED College of Medicine, Neurological, Neurons/*physiology, Patch-Clamp Techniques, Receptors, Resorcinols/pharmacology, Synapses/physiology, Synaptic Transmission/*physiology, Xanthenes/pharmacology

Enhanced ethanol catabolism in orphan nuclear receptor SHP-null mice.

Deficiency of the orphan nuclear hormone receptor small heterodimer partner (SHP, NR0B2) protects mice from diet-induced hepatic steatosis, in part, via repression of peroxisome proliferator-activated receptor (PPAR)-gamma2 (Pparg2) gene expression.…

Epileptic-like activity induces multiple forms of plasticity in hippocampal area CA1.

Mesial temporal lobe epilepsy is a relatively common form of epilepsy that afflicts many thousands of people. It has been suggested that the development of primary and secondary foci may involve mechanisms similar to long-term potentiation (LTP). In…

Tags: *Neuronal Plasticity, 2001, Animals, Brain research, Calcium Channels, Electrophysiology, Epilepsy/chemically induced/*physiopathology, Hippocampus/*physiopathology, Ion Channels/physiology, L-Type/physiology, Long-Evans, Long-Term Potentiation/physiology, Morgan S L, N-Methyl-D-Aspartate/metabolism, Potassium Chloride, Rats, Receptors, Synapses/physiology, Teyler T J

Estrogen receptor-alpha and -beta coexist in a subpopulation of sensory neurons of female rat dorsal root ganglia.

Immunoreactivities for estrogen receptor-alpha (ER-alpha) and ER-beta are expressed in sensory neurons of the dorsal root ganglia (DRG). It has not been established, however, if the two receptor subtypes coexist in the same neuron. Double-staining…

Estrogen receptor-alpha and beta- immunoreactivity and mRNA in neurons of sensory and autonomic ganglia and spinal cord.

Estrogen receptor-alpha immunoreactivity and mRNAs are present in neurons in locales that innervate genital organs, e.g., parasympathetic pelvic autonomic ganglia, sensory dorsal root and nodose ganglia, and autonomic areas of the lumbosacral spinal…

Estrogen receptor-alpha and neural circuits to the spinal cord during pregnancy.

Estrogen receptor immunoreactivity and mRNAs are present in spinal cord neurons in locations that are associated with sensory and autonomic innervation of female reproductive organs. The present study was undertaken to examine the expression of…

Estrogen receptors in the spinal cord, sensory ganglia, and pelvic autonomic ganglia.

Until relatively recently, most studies of the effects of estradiol in the nervous system focused on hypothalamic, limbic, and other brain centers involved in reproductive hormone output, feedback, and behaviors. Almost no studies addressed estradiol…

Tags: 2003, Animals, Autonomic/cytology/*physiology, Estrogen/*physiology, Estrogens/physiology, Female, Female/*innervation/physiology, Ganglia, Genitalia, Humans, Hypogastric Plexus/cytology/physiology, International review of cytology, Mowa C N, Neurotransmitter Agents/physiology, Papka R E, Pregnancy, Receptors, Sensory/cytology/*physiology, Spinal Cord/cytology/*physiology

Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol.

BACKGROUND: The hepatic endocannabinoid system and cytochrome P450 2E1 (CYP2E1), a key enzyme causing alcohol-induced reactive oxygen species (ROS) generation, are major contributors to the pathogenesis of alcoholic liver disease. The nuclear hormone…

Tags: 2013, Alcohol-Induced Injury, Alcoholic Liver Disease, Alcoholic/genetics/*metabolism/prevention & control, Animals, Cannabinoid, CB1/*physiology, Chiang John Y L, Choi Hueng-Sik, Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 CYP2E1/genetics/*metabolism, Department of Integrative Medical Sciences, Enzyme Inhibitors/pharmacology/therapeutic use, Enzymologic/drug effects/physiology, Estrogen/deficiency/genetics/*physiology, Ethanol/pharmacology, Gene Expression Profiling/methods, Gene Expression Regulation, Gene Regulation, Genetic/physiology, Gut, Inbred C57BL, Jang Hyun-Hee, Jeong Won-Il, Kim Don-Kyu, Kim Jung Ran, Kim Yong-Hoon, Knockout, Koh Minseob, Koo Seung-Hoi, Lee Chul-Ho, Liver, Liver Diseases, Liver Metabolism, Liver/metabolism, Male, Mice, NEOMED College of Medicine, Oxidation-Reduction, Oxidative Stress/physiology, Park Jinyoung, Park Seung Bum, Park Tae-Sik, Receptor, Receptors, Signal Transduction/drug effects/physiology, Tamoxifen/analogs & derivatives/pharmacology/therapeutic use, Transcription, Yun Chul-Ho

Evidence for mu opiate receptors on inhibitory terminals in area CA1 of rat hippocampus.

The mechanism of disinhibition produced by opioid peptides was studied using intracellular recording in area CA1 of rat hippocampal slices. The mu-selective opioid peptide [D-Ala2,N-Me-Phe4,Gly-ol5]-enkephalin (DAGO) reversibly depressed…

Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases.

Cardiovascular diseases remain the number one diseases affecting patients' morbidity and mortality. The adenosine receptors are G-protein coupled receptors which have been of interest for drugs target for the treatment of multiple diseases ranging…

Farnesoid X Receptor Activation by Obeticholic Acid Elevates Liver Low-Density Lipoprotein Receptor Expression by mRNA Stabilization and Reduces Plasma Low-Density Lipoprotein Cholesterol in Mice.

Objective- The objective of this study was to determine whether and how activation of farnesoid X receptor (FXR) by obeticholic acid (OCA), a clinical FXR agonist, modulates liver low-density lipoprotein receptor (LDLR) expression under…

Tags: 2018, Arteriosclerosis, thrombosis, and vascular biology, Dong Bin, Human, Kraemer Fredric B, LDL, LDLR protein, Liu Jingwen, Obeticholic acid, Receptors, RNA Stability, Singh Amar Bahadur, untranslated regions, Xu Yanyong, Zhang Yanqiao

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice.

UNLABELLED: Activation of farnesoid X receptor (FXR) markedly attenuates development of atherosclerosis in animal models. However, the underlying mechanism is not well elucidated. Here, we show that the FXR agonist, obeticholic acid (OCA), increases…

Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner.

Cytochrome P450 2D6 (CYP2D6) is a major drug-metabolizing enzyme responsible for eliminating approximately 20% of marketed drugs. Studies have shown that differential transcriptional regulation of CYP2D6 may contribute to large interindividual…

Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.

The bile acid-activated receptors, nuclear farnesoid X receptor (FXR) and the membrane Takeda G-protein receptor 5 (TGR5), are known to improve glucose and insulin sensitivity in obese and diabetic mice. However, the metabolic roles of these two…

Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.

Cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription is repressed by bile acids. The goal of this study is to elucidate the mechanism of CYP7A1 transcription by bile acid-activated farnesoid X receptor (FXR) in its native promoter and cellular…

Forms of associative synaptic plasticity

Tags: 2 forms, 2001, apical dendrites, area ca1, Book/Monograph, glutamate, hippocampal ca1, in-vivo, Long-Term Potentiation, ltp, nmda receptors, protein-phosphorylation, Receptors, Teyler T J

Functional selectivity of NK1 receptor signaling: peptide agonists can preferentially produce receptor activation or desensitization.

A cascade of events follows binding of an agonist ligand to the tachykinin NK(1) receptor. These events include activation of multiple signal transduction pathways as well as cellular modulation of receptor function by the process of desensitization.…

Tags: 2006, Animals, CHO Cells, Cricetinae, Dose-Response Relationship, Drug, Humans, Neurokinin-1/agonists/drug effects/*physiology, Rana catesbeiana, Rats, Receptors, Signal Transduction/*physiology, Simmons Mark A, Substance P/metabolism/pharmacology, Tachykinins/metabolism/pharmacology, The Journal of pharmacology and experimental therapeutics

Functional selectivity, ligand-directed trafficking, conformation-specific agonism: what's in a name?

Research on the design of compounds to selectively affect specific subsets of signals downstream of receptors has burgeoned lately, and several reports discussed at Experimental Biology 2005 indicate progress is being made in the understanding of…

Tags: 2005, G-Protein-Coupled/*agonists/*chemistry, Humans, Ligands, Molecular Conformation, Molecular interventions, Protein Transport, Receptors, Signal Transduction, Simmons Mark A

G protein coupling profile of mGluR6 and expression of G alpha proteins in retinal ON bipolar cells.

Metabotropic glutamate receptor 6 (mGluR6) is a group III, pertussis toxin (PTX)-sensitive G protein coupled mGluR that plays a specialized role in the retina. Retinal ON bipolar cells, which receive direct glutamatergic input from photoreceptor…

G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice.

Bile acids are signaling molecules that play a critical role in regulation of hepatic metabolic homeostasis by activating nuclear farnesoid X receptor (Fxr) and membrane G-protein-coupled receptor (Takeda G-protein-coupled receptor 5; Tgr5). The role…

GABAa receptor-mediated field potentials are enhanced in area CA1 following prenatal cocaine exposure.

Prenatal cocaine exposure results in several documented changes in neurotransmitter receptor number and structure. Increases have been reported for cortical catecholamine and indoleamine receptor number and binding affinity, in the subunit expression…

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