Browse Items · NEOMED Bibliography Database

Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.

Hepatocellular carcinoma (HCC) is one of the most common cancers and lethal diseases. In view of the limited treatment and a grave prognosis of liver cancer, preventive control has been emphasized. Resveratrol, a polyphenol found in grape skins,…

Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.

Hepatocellular carcinoma (HCC), one of the most frequent and deadliest cancers, has been increasing considerably in the United States. In the absence of a proven effective therapy for HCC, novel chemopreventive strategies are urgently needed to lower…

Tags: 2010, Animals, Antioxidants/*pharmacology/therapeutic use, Antitumor, Barnes Kendra F, Bhatia Deepak, Bishayee Anupam, Cancer prevention research (Philadelphia, Pa.), Carcinogens/toxicity, Carroll Richard T, Chemical and Drug Induced Liver Injury/*etiology/metabolism/pathology, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diethylnitrosamine/toxicity, Dose-Response Relationship, Drug, Drug Screening Assays, Enzyme Induction/drug effects, Experimental/chemically induced/metabolism/pathology/*prevention & control, Female, Hyperplasia, Inflammation/*prevention & control, Lipid Peroxidation/drug effects, Liver Neoplasms, Liver/drug effects/metabolism/pathology, Messenger/biosynthesis/genetics, NEOMED College of Pharmacy, NF-E2-Related Factor 2/biosynthesis/genetics, Nitric Oxide Synthase Type II/biosynthesis/genetics, Oxidative Stress/*drug effects, Phenobarbital/toxicity, Precancerous Conditions/*chemically induced/metabolism/pathology, Rats, Resveratrol, RNA, Sprague-Dawley, Stilbenes/*pharmacology/therapeutic use, Tyrosine/analogs & derivatives/analysis

Rats bred for differences in preference to cocaine: other behavioral measurements.

Cocaine has repeatedly been shown to produce conditioned place preference (CPP) in the rat. The present study employed the heterogenous N/Nih rat stock to produce a selectively bred rat line determined by individual place preference to a conditioning…

Tags: 1992, Animal/*drug effects, Animals, Behavior, Choice Behavior/*drug effects, Cocaine/*pharmacology, Dose-Response Relationship, Drug, Female, Inbred Strains, Male, Motor Activity/drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Species Specificity, Sprague-Dawley

Rat alpha1-macroglobulin enhances nerve growth factor-promoted neurite outgrowth, TrkA phosphorylation, and gene expression of pheochromocytoma PC12 cells.

Monoamine-activated human alpha2-macroglobulin (alpha2M) has been previously demonstrated to inhibit TrkA-, TrkB-, and TrkC-mediated signal transduction. Rat alpha1-macroglobulin (alpha1M) and alpha2M are structural homologues of human alpha2M, but…

Rat alpha(2)-macroglobulin inhibits NGF-promoted neurite outgrowth, TrK phosphorylation, and gene expression of pheochromocytoma PC12 cells.

Rat alpha-1-macroglobulin (alpha(1)M) and alpha-2-macroglobulin (alpha(2)M) are murine homologs of human alpha(2)M, and rat alpha(2)M is generally known as an acute-phase protein. Monoamine-activated forms of human alpha(2)M have been shown to…

Tags: 1999, Adrenal Gland Neoplasms/metabolism, alpha-Macroglobulins/*pharmacology, Animals, Gene Expression Regulation, Journal of neuroscience research, Koo P H, Lee P G, Neoplastic/*drug effects, Nerve Growth Factors/*antagonists & inhibitors, Neurites/*drug effects, PC12 Cells, Pheochromocytoma/metabolism, Phosphorylation, Proto-Oncogene Proteins c-jun/genetics, Rats, Receptor, Sprague-Dawley, trkA/*metabolism

Quantifying rat pulmonary intravascular mononuclear phagocytes.

Cells of the mononuclear phagocyte system (MPS) protect the host by clearing effete and foreign particulates from the circulation. The current study was designed to identify, quantify, harvest, and provide a partial functional characterization of the…

Psychostimulant-induced activity is attenuated by two putative dopamine release inhibitors.

Centrally administered amphetamine (AMPH), cathinone, (CATH), or cocaine (COC) have each been shown to produce elevated activity in rats and this effect is dose responsive. The question remains whether these psychostimulants share a common mechanism…

Prolonged isoproterenol infusion impairs the ability of beta(2)-agonists to increase alveolar liquid clearance.

We determined if prolonged isoproterenol (Iso) infusion in rats impaired the ability of the beta(2)-adrenergic agonist terbutaline to increase alveolar liquid clearance (ALC). We infused rats with Iso (at rates of 4, 40, or 400 microg.kg(-1).h(-1))…

Postreceptor defects in alveolar epithelial beta-adrenergic signaling after prolonged isoproterenol infusion.

We previously found that prolonged isoproterenol (Iso) infusion in rats impaired the ability of beta-adrenoceptor (beta-AR) agonists to increase alveolar liquid clearance (ALC). Here, we determined if postreceptor defects in beta-AR signaling…

Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms.

Hepatocellular carcinoma (HCC), one of the most prevalent and lethal cancers, has shown an alarming rise in the USA. Without effective therapy for HCC, novel chemopreventive strategies may effectively circumvent the current morbidity and mortality.…

Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.

Breast cancer is the second leading cause of cancer-related death in women in the United States and discovery and development of safe chemopreventive drugs is urgently needed. The fruit pomegranate (Punica granatum) is gaining importance because of…

Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.

1. The objective of Exp. 1 was to determine whether intracerebroventricular (ICV) injection of cathinone CATH (8.0-32 micrograms) would produce a dose-dependent conditioned place preference (CPP) and/or activation in rats. Results indicate that rats…

PKA delivery to the distal lung air spaces increases alveolar liquid clearance after isoproterenol-induced alveolar epithelial PKA desensitization.

Isoproterenol (Iso) infusion for 48 h in rats decreases the ability of beta-adrenoceptor (beta-AR) agonists to increase alveolar liquid clearance (ALC). An impairment in protein kinase A (PKA) function appears to be critical in producing the…

Physiology laboratory experience for high school students.

Recently, we were charged with providing a learning opportunity for high school students participating in the Upward Bound Regional Math and Science Program, a program designed to stimulate interest in mathematics and science for students from…

Tags: *Laboratories, 1993, Adolescent, Animals, Collins H L, DiCarlo S E, Dissection, Female, Humans, Male, Muscles/physiology, Ohio, Physiology/*education/instrumentation, Rats, Sprague-Dawley, Teaching/methods, The American journal of physiology

Phosphatidylinositide 3-kinase regulates angiotensin II-induced cytosolic phospholipase A2 activity and growth in vascular smooth muscle cells.

Angiotensin (Ang) II via the AT(1) receptor acts as a mitogen in vascular smooth muscle cells (VSMC) through stimulation of multiple signaling mechanisms, including tyrosine kinases and mitogen-activated protein kinase (MAPK). In addition, cytosolic…

Phentermine+fenfluramine produce cocaine-like discriminative cues.

Drug discrimination studies were conducted in six male Sprague-Dawley rats trained to discriminate the interoceptive cues produced by 10 mg/kg cocaine in an effort to investigate if there is stimulus generalization to phentermine or phentermine +…

Tags: *Discrimination (Psychology), 1996, Animals, Cocaine/*pharmacology, Department of Anatomy & Neurobiology, Dose-Response Relationship, Drug, Fenfluramine/administration & dosage/*pharmacology, Life sciences, Male, McBurney D, NEOMED College of Medicine, Phentermine/administration & dosage/*pharmacology, Rats, Schechter M D, Sprague-Dawley

Pentobarbital differentially inhibits N-methyl-D-aspartate and kainate-stimulated [3H]noradrenaline overflow in rat cortical slices.

1. This study examined the ability of pentobarbital to inhibit NMDA and kainate-stimulated [3H]noradrenaline ([3H]NA) overflow in rat brain cortical slices. 2. Pentobarbital inhibited NMDA-evoked [3H]NA overflow at 100 microM and greater and…

Tags: *Excitatory Amino Acid Agonists, 1995, Adrenergic alpha-Agonists/metabolism, Animals, Brown L M, GABA Modulators/*pharmacology, General pharmacology, Kainic Acid/*antagonists & inhibitors, Male, N-Methylaspartate/*antagonists & inhibitors, Norepinephrine/metabolism, Pentobarbital/*pharmacology, Prefrontal Cortex/*drug effects, Rats, Sprague-Dawley

Para-chlorophenylalanine treatment inhibits the expression of vasoactive intestinal peptide messenger RNA in rat anterior pituitary.

Adult male Sprague-Dawley rats were treated with para-chlorophenylalanine (pCPA) or alpha-methyl tyrosine (alpha-MT) to study the effect of serotonin or catecholamine depletion on the expression of vasoactive intestinal peptide (VIP) messenger RNA in…

P2X receptors in the rat uterine cervix, lumbosacral dorsal root ganglia, and spinal cord during pregnancy.

ATP, an intracellular energy source, is released from cells during tissue stress, damage, or inflammation. The P2X subtype of the ATP receptor is expressed in rat dorsal root ganglion (DRG) cells, spinal cord dorsal horn, and axons in peripheral…

Orphan nuclear receptor oestrogen-related receptor gamma (ERRgamma) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression.

Bile acids are primarily synthesized from cholesterol in the liver and have important roles in dietary lipid absorption and cholesterol homoeostasis. Detailed roles of the orphan nuclear receptors regulating cholesterol 7alpha-hydroxylase (CYP7A1),…

Tags: 2015, Animals, bile acid, Bile Acids and Salts/metabolism, Cannabinoid, cannabinoid receptors, CB1/agonists/genetics/*metabolism, Cells, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/genetics, cholesterol 7alpha-hydroxylase (CYP7A1), Cultured, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Drug Inverse Agonism, Estrogen/genetics/*metabolism, Ethanol/pharmacology, Gene Expression, Genetic, Glycerides/pharmacology, GSK5182, HEK293 Cells, Hepatocytes/metabolism, Humans, Inbred C57BL, Jeong Won-Il, Kim Don-Kyu, Kim Seong Heon, Knockout, Lee Chul-Ho, Lee In-Kyu, Lee Ji-Min, Liver/*metabolism, Mice, NEOMED College of Medicine, oestrogen-related receptor gamma (ERRgamma), orphan nuclear receptor, Park Seung Bum, Promoter Regions, Rats, Receptor, Receptors, small heterodimer partner (SHP), Sprague-Dawley, The Biochemical journal, Transcription, Zhang Yaochen

On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha.

The sterol 12alpha-hydroxylase (CYP8B1) is a key enzyme of the bile acid biosynthetic pathway. It regulates the composition of bile acids in bile, i.e. ratio between cholic acid (CA) and chenodeoxycholic acid (CDCA). In similarity with cholesterol…

Olanzapine attenuates the reinforcing effects of cocaine.

The possibility that the atypical neuroleptic olanzapine can antagonize the ability of cocaine to produce both conditioned place preference and self-administration in rats was investigated. Pre-treatment with olanzapine (3.0, 4.5 mg/kg, but not 1.5…

Nicotine place preference using the biased method of conditioning.

1. The objective of the experimentation was to determine whether nicotine (NIC, 0.8 mg/kg subcutaneously administered) would produce a conditioned place preference (CPP) in rats confined for thirty min to their less-preferred side in a three…

Tags: 1994, Animals, Calcagnetti D J, Conditioning, Cues, Injections, Male, Motor Activity/drug effects, Nicotine/*pharmacology, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Rats, Schechter M D, Sprague-Dawley, Subcutaneous

Multiple binding sites for [125I]RTI-121 and other cocaine analogs in rat frontal cerebral cortex.

In an effort to identify novel binding sites for cocaine and its analogs, we carried out binding studies with the high-affinity and selective ligand [125I]RTI-121 in rat frontal cortical tissue. Very low densities of binding sites were found.…

Morphological heterogeneity within the cingulate cortex in rat: a horseradish peroxidase transport study.

We compared the connections of two areas within rat cingulate cortex, the Cg1/Cg2 area vs the Cg3 area, by iontophoresing small quantities of wheatgerm agglutinin-horseradish peroxidase (WGA-HRP) into either of these two divisions and identifying…

Mesenteric vascular responses to vasopressin during development of DOCA-salt hypertension in male and female rats.

Deoxycorticosterone acetate (DOCA)-salt hypertension develops to a greater extent in male (M) than in female (F) rats. To determine the role of the vasculature, reactivity to arginine vasopressin (AVP) and prostanoid output were examined in the…

Mesenchymal stem cells and their secretome partially restore nerve and urethral function in a dual muscle and nerve injury stress urinary incontinence model.

Childbirth injures muscles and nerves responsible for urinary continence. Mesenchymal stem cells (MSCs) or their secretome given systemically could provide therapeutic benefit for this complex multisite injury. We investigated whether MSCs or their…

Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/beta-Catenin Signaling Pathways.

A pomegranate emulsion (PE), containing various bioactive phytochemicals, has recently been found to exert substantial chemopreventive effect against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumorigenesis in rats via antiproliferative…

MDMA-like stimulus effects of hallucinogens in male Fawn-Hooded rats.

A two-lever, food-motivated, operant technique was employed to train the purportedly serotonergically dysfunctional Fawn-Hooded (FH) rat to discriminate 1.5 mg/kg MDMA. Once all 10 male subjects learned the MDMA-vehicle discrimination at criterion…

Local modulation of adrenergic responses in the hindlimb vasculature of the intact conscious rat.

1. Local modulation of adrenergic responses was examined in the hindlimb vasculature of chronically instrumented intact conscious rats. Sprague-Dawley rats (n = 22) were instrumented with a Doppler flow probe around the right common iliac artery, a…

Tags: 1995, Adrenergic Agonists/*pharmacology, Animals, Arginine/analogs & derivatives/pharmacology, Chen C Y, Collins H L, Cyclooxygenase Inhibitors/pharmacology, DiCarlo S E, Female, Hemodynamics/*drug effects/physiology, Hindlimb/*blood supply/drug effects/metabolism, Indomethacin/pharmacology, Male, NG-Nitroarginine Methyl Ester, Nitric Oxide Synthase/antagonists & inhibitors, Patil R D, Rats, Sprague-Dawley, The Journal of physiology

Lesions of the basolateral amygdala abolish the ability of drug associated cues to reinstate responding during withdrawal from self-administered cocaine.

This study investigated the ability of bilateral excitotoxic lesions of the basolateral amygdala (BLA) to disrupt cocaine self-administration, responding during extinction sessions, and stimulus cued recovery of extinguished responding in rats. BLA…

L-dopa reverses castration-induced disruption of dishabituation responses to female chemical cues in male rats.

In the present experiment, habituation/dishabituation behavioral tests were conducted to measure discriminatory olfactory recognition responses to chemical cues among control, castrated, and castrated+L-3,4-dihydroxyphenylalanine (L-DOPA)-treated…

L-DOPA modulation of corpus striatal dopamine and dihydroxyphenylacetic acid output from intact and 6-OHDA lesioned rats.

In the present report we examined the differences in in vitro dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) efflux from the corpus striatum (CS) of intact versus 6-hydroxydopamine (6-OHDA) lesioned (in substantia nigra) male rats in response…

Tags: *Sympathectomy, 1996, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Animals, Antiparkinson Agents/*pharmacology, Chemical, Corpus Striatum/drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Journal of neural transmission (Vienna, Austria : 1996), Levodopa/*pharmacology, Male, Oxidopamine, Rats, Sprague-Dawley, Substantia Nigra/drug effects/metabolism, Xu K

L-dopa infusion mode differentially affects corpus striatal dopamine efflux in the presence of reserpine.

In the present experiment we tested the effects of L-DOPA upon dopamine (DA) efflux in vitro from superfused corpus striatal tissue fragments in medium containing reserpine. The purposes of this experiment were first, to evaluate the effects of…

Tags: 1992, Amphetamine/pharmacology, Animals, Chromatography, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, High Pressure Liquid, Infusions, Intravenous, Journal of neural transmission. General section, Kratko F T Jr, Levodopa/*pharmacology, Male, Potassium/pharmacology, Rats, Reserpine/*pharmacology, Sprague-Dawley

Isradipine produces neither a conditioned place preference nor aversion.

Isradipine (ISR) has been reported to block cocaine-induced conditioned place preference. Using this procedure, the pairing of this L-type calcium blocker, at doses of 2.5, 5.0 and 10 mg/kg, with a preferred (cue-distinct) environment was…

Tags: 1994, Animals, Calcagnetti D J, Cocaine/*pharmacology, Conditioning, Isradipine/administration & dosage/*pharmacology, Life sciences, Male, Operant/*drug effects, Rats, Schechter M D, Sprague-Dawley

Involvement of {alpha}ENaC and Nedd4-2 in the conversion from lung fluid secretion to fluid absorption at birth in the rat as assayed by RNA interference analysis.

To explore interactions between the epithelial Na channel (ENaC) and neural precursor expressed, developmentally downregulated protein 4-2 (Nedd4-2) at the conversion of the rat lung from fluid secretion to absorption at birth, we used…

Intracranial infusion of monoamine-activated alpha 2-macroglobulin decreases dopamine concentrations within the rat caudate putamen.

Monoamine-activated alpha 2-macroglobulin (alpha 2M) has been shown to inhibit choline acetyltransferase in basal forebrain neurons as well as neurotrophin-dependent neuronal functions. The objective of this study was to determine whether…

Tags: *Nerve Degeneration, 1994, alpha-Macroglobulins/*pharmacology/physiology/toxicity, Animals, Caudate Nucleus/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Hu Y Q, Infusion Pumps, Journal of neuroscience research, Koo P H, Male, Putamen/*drug effects/metabolism, Rats, Sprague-Dawley

Inhibition of striatal dopamine transporter activity by 17beta-estradiol.

Striatal synaptosomes from ovariectomized rats were prepared to examine the effect of 17beta-estradiol on [3H]dopamine uptake. Estradiol inhibited [3H]dopamine uptake in a dose-dependent manner, with an IC50 of 7.2 microM. Use of identical…

Tags: *Membrane Glycoproteins, *Membrane Transport Proteins, *Nerve Tissue Proteins, 1998, Animals, Boja J W, Carrier Proteins/*antagonists & inhibitors, Disshon K A, Dluzen D E, Dopamine Plasma Membrane Transport Proteins, Dopamine/metabolism, Estradiol/*pharmacology, European journal of pharmacology, Female, Neostriatum/*drug effects/metabolism, Rats, Sprague-Dawley, Synaptosomes/*drug effects/metabolism

Inhibition of dopamine and choline acetyltransferase concentrations in rat CNS neurons by rat alpha 1- and alpha 2-macroglobulins.

Previous studies have implicated human alpha-2-macroglobulin (alpha2M) as a potential regulator of neuronal development and function. Rat alpha-1-macroglobulin (alpha1M) and acute-phase alpha-2-macroglobulin (alpha2M) are murine homologues of human…

Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol.

Cardiac fibroblasts (CFs) regulate myocardial remodeling by proliferating, differentiating, and secreting extracellular matrix proteins. Prolonged activation of CFs leads to cardiac fibrosis and reduced myocardial contractile function. Resveratrol…

Tags: 2005, 70-kDa/metabolism, American journal of physiology. Heart and circulatory physiology, Angiotensin II/pharmacology, Animals, Antioxidants/*pharmacology, Bomser Joshua A, Cell Differentiation/drug effects, Cell Division/drug effects, Cells, Cultured, Department of Integrative Medical Sciences, Drug Interactions, Epidermal Growth Factor/pharmacology, Fibroblasts/*cytology/*drug effects, Male, Meszaros J Gary, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, Myocardium/*cytology, Naugle Jennifer E, NEOMED College of Medicine, Olson Erik R, Protein-Serine-Threonine Kinases/metabolism, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins/metabolism, Rats, Resveratrol, Ribosomal Protein S6 Kinases, Signal Transduction/drug effects, Sprague-Dawley, Stilbenes/*pharmacology, Vasoconstrictor Agents/pharmacology, Zhang Xiaojin

Browse Items (158 total)