Browse Items · NEOMED Bibliography Database

Role of the adjacent stroma cells in prostate cancer development and progression: synergy between TGF-beta and IGF signaling.

This review postulates the role of transforming growth factor-beta (TGF-beta) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal…

Weighted Lin-Wang tests for crossing hazards.

Lin and Wang have introduced a quadratic version of the logrank test, appropriate for situations in which the underlying survival distributions may cross. In this note, we generalize the Lin-Wang procedure to incorporate weights and investigate the…

Tags: *Survival Analysis, 2014, Algorithms, Animal, Animals, Computational and mathematical methods in medicine, Computer Simulation, Data Interpretation, Disease Models, Humans, Jia Zhenyu, Kaplan-Meier Estimate, Koziol James A, Leukemia/drug therapy, Mice, Models, Reproducibility of Results, Statistical

Molecular, phenotypic aspects and therapeutic horizons of rare genetic bone disorders.

A rare disease afflicts less than 200,000 individuals, according to the National Organization for Rare Diseases (NORD) of the United States. Over 6,000 rare disorders affect approximately 1 in 10 Americans. Rare genetic bone disorders remain the…

Tags: 2014, Abdelmagid Samir M, Bahl Jaya, BioMed research international, Bone and Bones/*physiopathology, Bone Diseases/*epidemiology/genetics, Dhawan Naveen, Faruqi Taha, Gupta Vineet, Humans, Osteogenesis/genetics, Rare Diseases/*epidemiology/genetics, Tu Khin, Vohra Shivani

Establishing reliable miRNA-cancer association network based on text-mining method.

Associating microRNAs (miRNAs) with cancers is an important step of understanding the mechanisms of cancer pathogenesis and finding novel biomarkers for cancer therapies. In this study, we constructed a miRNA-cancer association network (miCancerna)…

Apocynum Tablet Protects against Cardiac Hypertrophy via Inhibiting AKT and ERK1/2 Phosphorylation after Pressure Overload.

Background. Cardiac hypertrophy occurs in many cardiovascular diseases. Apocynum tablet (AT), a traditional Chinese medicine, has been widely used in China to treat patients with hypertension. However, the underlying molecular mechanisms of AT on the…

Tags: 2014, Evidence-based complementary and alternative medicine : eCAM, Gong Kaizheng, Guo Liheng, Liu Qin, Qi Jianyong, Wang Lei, Wu Jiashin, Yu Juan, Zhang Minzhou, Zhou Miao

A note regarding problems with interaction and varying block sizes in a comparison of endotracheal tubes.

A randomized clinical experiment to compare two types of endotracheal tubes utilized a block design where each of the six participating anesthesiologists performed tube insertions for an equal number of patients for each type of tube. Five…

Tags: *Randomized Controlled Trials as Topic, *Research Design, 2014, Algorithms, Anesthesiology/*methods, Computational and mathematical methods in medicine, Data Interpretation, Einsporn Richard L, Humans, Intratracheal/*instrumentation, Intubation, Jia Zhenyu, Models, Sample Size, Statistical, Treatment Outcome

A brief etymology of the collateral circulation.

It is well known that the protective capacity of the collateral circulation falls short in many individuals with ischemic disease of the heart, brain, and lower extremities. In the past 15 years, opportunities created by molecular and genetic tools,…

Isolation of canine coronary sinus musculature from the atria by radiofrequency catheter ablation prevents induction of atrial fibrillation.

BACKGROUND: The junction between the coronary sinus (CS) musculature and both atria contributes to initiation of atrial tachyarrhythmias. The current study investigated the effects of CS isolation from the atria by radiofrequency catheter ablation on…

Cardiac mitochondria and reactive oxygen species generation.

Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cardiovascular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by the…

Tags: 2014, Animals, Cardiac/*metabolism, Cardiovascular Diseases/*metabolism, Chen Yeong-Renn, Circulation research, Department of Integrative Medical Sciences, electron transport chain complex proteins, Heart/*metabolism, Humans, Membrane Potentials/physiology, Mitochondria, myocardial infarction, Myocytes, NEOMED College of Medicine, reactive oxygen species, Reactive Oxygen Species/*metabolism, Signal Transduction/physiology, Zweier Jay L

Narrative analysis of the ethics in providing advance care planning.

Our objective was to better understand the values and ethical dilemmas surrounding advance care planning through stories told by registered nurses and licensed social workers, who were employed as care managers within Area Agencies on Aging. We…

Cardiac arrest is a predictor of difficult tracheal intubation independent of operator experience in hospitalized patients.

BACKGROUND: Placement of advanced airways has been associated with worsened neurologic outcome in survivors of out-of-hospital cardiac arrest. These findings have been attributed to factors such as inexperienced operators, prolonged intubation times…

Veno-venous ECMO: a synopsis of nine key potential challenges, considerations, and controversies.

BACKGROUND: Following the 2009 H1N1 Influenza pandemic, extracorporeal membrane oxygenation (ECMO) emerged as a viable alternative in selected, severe cases of ARDS. Acute Respiratory Distress Syndrome (ARDS) is a major public health problem. Average…

Age effects on tinnitus and hearing loss in CBA/CaJ mice following sound exposure.

Tinnitus is a maladaptive neuropathic condition that develops in humans and laboratory animals following auditory insult. In our previous study we demonstrated that sound exposure leads to development of behavioral evidence of tinnitus in a sample of…

Tags: 2014, Acoustic trauma, Age-related hearing loss, Chonko Kurt T, Department of Anatomy & Neurobiology, Galazyuk Alexander V, Gap-induced suppression of the acoustic startle reflex, Longenecker Ryan J, Maricich Steve M, NEOMED College of Medicine, SpringerPlus, Tinnitus development

Impact of reirradiation of painful osseous metastases on quality of life and function: a secondary analysis of the NCIC CTG SC.20 randomized trial.

PURPOSE: We previously demonstrated that 48% of patients with pain at sites of previously irradiated bone metastases benefit from reirradiation. It is unknown whether alleviating pain also improves patient perception of quality of life (QOL).…

Generation of "virtual" control groups for single arm prostate cancer adjuvant trials.

It is difficult to construct a control group for trials of adjuvant therapy (Rx) of prostate cancer after radical prostatectomy (RP) due to ethical issues and patient acceptance. We utilized 8 curve-fitting models to estimate the time to 60%, 65%,…

Human quadrupeds, primate quadrupedalism, and Uner Tan Syndrome.

Since 2005, an extensive literature documents individuals from several families afflicted with "Uner Tan Syndrome (UTS)," a condition that in its most extreme form is characterized by cerebellar hypoplasia, loss of balance and coordination, impaired…

Interleukin-1/toll-like receptor-induced nuclear factor kappa B signaling participates in intima hyperplasia after carotid artery balloon injury in goto-kakizaki rats: a potential target therapy pathway.

The value of restenosis after percutaneous coronary intervention (PCI) is recognized worldwide, especially for diabetic patients. Interleukin-1/Toll-like receptor (IL-1/TLR) signaling is involved in innate and adaptive immune responses, but whether…

Alterations in gene array patterns in dendritic cells from aged humans.

Dendritic cells (DCs) are major antigen-presenting cells that play a key role in initiating and regulating innate and adaptive immune responses. DCs are critical mediators of tolerance and immunity. The functional properties of DCs decline with age.…

Anthracobunids from the middle eocene of India and pakistan are stem perissodactyls.

Anthracobunidae is an Eocene family of large mammals from south Asia that is commonly considered to be part of the radiation that gave rise to elephants (proboscideans) and sea cows (sirenians). We describe a new collection of anthracobunid fossils…

Tags: *Fossils, 2014, Animals, Bajpai Sunil, Clementz Mark, Cooper Lisa Noelle, Department of Anatomy & Neurobiology, Dugong, Elephants, Hussain S Taseer, India, Madar Sandra I, NEOMED College of Medicine, Pakistan, PloS one, Seiffert Erik R, Thewissen J G M

Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels.

Metabolic syndrome, characterized by obesity, hyperglycemia, dyslipidemia and hypertension, increases the risks for cardiovascular disease, diabetes and stroke. Carboxylesterase 1 (CES1) is an enzyme that hydrolyzes triglycerides and cholesterol…

Mediastinal mass in a 25-year-old man.

A 25-year-old black man presented with left-sided chest pain and cough for 3 days. His pain was pressure-like and nonradiating and was aggravated with movement and relieved when the patient lay at a 45 degrees angle. The patient denied fevers,…

Parkinson's disease biomarker: a patent evaluation of WO2013153386.

INTRODUCTION: Parkinson's disease (PD) is a neurodegenerative movement disorder resultant from the loss of dopaminergic neurons in the brain. There is an urgent need for effective biomarkers that can be used in the early diagnosis of PD.…

Developing competencies for pediatric hospice and palliative medicine.

In 2006, hospice and palliative medicine (HPM) became an officially recognized subspecialty. This designation helped initiate the Accreditation Council of Graduate Medical Education Outcomes Project in HPM. As part of this process, a group of expert…

Sequential activation of Elk-1/Egr-1/GADD45alpha by arsenic.

Long-term exposure to arsenic, an environmental contaminant, leads to increased risks of cancers. In the present study, we investigated the sequential regulation of Elk-1 and Egr-1 on As3+-induced GADD45alpha, an effector of G2/M checkpoint. We found…

Sequential advanced pharmacy practice experiences at one institution for students from three pharmacy schools.

PURPOSE: The structure and implementation of an advanced pharmacy practice experience (APPE) that was sequential in nature are described. SUMMARY: In early 2008, the pharmacy department of the Cleveland Clinic began conversations with three partner…

Teaching and learning curriculum programs: recommendations for postgraduate pharmacy experiences in education.

PURPOSE: Recommendations for the development and support of teaching and learning curriculum (TLC) experiences within postgraduate pharmacy training programs are discussed. SUMMARY: Recent attention has turned toward meeting teaching- and…

Tags: *Curriculum, *Learning, *Teaching, 2014, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, Bradley-Baker Lynette R, Brown Bonnie, Certification – Education, Curriculum Development – Standards, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Education, Faculty – Education, Gettig Jacob, Graduate – Standards, Graduate/*organization & administration/standards, Hospital, Humans, Internship, Martello Jay L, McClendon Katie S, NEOMED College of Pharmacy, Nonmedical, Organizational Objectives, Outcomes of Education, Pharmacists, Pharmacy, Pharmacy – History, Pharmacy – Organizations, Pharmacy Service, Portfolio, Quality Improvement, Smith Kelly M, Students, Teaching Methods, Teeters Janet, Ulbrich Timothy R, Wegrzyn Nicole, Wright Eric A

Falls and cognitive decline in Mexican Americans 75 years and older.

BACKGROUND: Little is known about long-term emotional and cognitive consequences of falls. We examined the association between falls and subsequent cognitive decline, and tested the hypothesis that depression would mediate any falls-cognition…

Congenital anomaly of the inferior vena cava and factor V Leiden mutation predisposing to deep vein thrombosis.

A previously healthy 21-year-old man presented with back pain, bilateral extremity pain, and right lower extremity weakness, paresthesias, and swelling. Sonographic examination revealed diffuse deep vein thrombosis (DVT) in the femoral and popliteal…

Tags: *Mutation, 2014, Activated Protein C Resistance/*complications/diagnosis/drug therapy/genetics, Anticoagulants – Therapeutic Use, Anticoagulants/therapeutic use, Blood Coagulation Factors, deep vein thrombosis (DVT), Disease Susceptibility, DNA Mutational Analysis, Erickson Cameron R, Factor V/*genetics, Genetic Predisposition to Disease, Hematologic Diseases, Hematologic Diseases – Complications, Hematologic Diseases – Diagnosis, Hematologic Diseases – Drug Therapy, Human, Humans, Inferior – Abnormalities, Inferior – Radiography, Inferior – Ultrasonography, inferior vena cava (IVC), Inferior/*abnormalities/diagnostic imaging, Kulthia Arun, Lamparello Brooke M, lower extremities, Male, Mutation, Phlebography – Methods, Phlebography/methods, Predictive Value of Tests, Risk Factors, Sequence Analysis, Thet Zeyar, thrombophilic, Tomography, Ultrasonography, Vascular Health and Risk Management, Vascular Malformations – Complications, Vascular Malformations – Diagnosis, Vascular Malformations/*complications/diagnosis, Vena Cava, venography, Venous Thrombosis, Venous Thrombosis – Diagnosis, Venous Thrombosis – Drug Therapy, Venous Thrombosis – Etiology, Venous Thrombosis/diagnosis/drug therapy/*etiology/genetics, Virparia Vasudev, X-Ray Computed, Young Adult

Concurrent treatment of chronic psoriasis and asthma with ustekinumab.

A 56-year-old woman with a 40-year history of guttate flares of psoriasis associated with stress and infection as well as chronic asthma was treated with subcutaneous injections of ustekinumab, repeated after 1 month and then every 3 months. Her…

Hand hygiene and face touching in family medicine offices: a Cincinnati Area Research and Improvement Group (CARInG) network study.

BACKGROUND: Family medicine offices may play an important role in the transmission of common illnesses such as upper respiratory tract infections (URTIs). There has, however, been little study of whether physicians teach patients about URTI…

An institutional series and contemporary review of bacterial spinal epidural abscess: current status and future directions.

OBJECT: Over the past decade, the incidence of bacterial spinal epidural abscess (SEA) has been increasing. In recent years, studies on this condition have been rampant in the literature. The authors present an 11-year institutional experience with…

Perineuronal nets and GABAergic cells in the inferior colliculus of guinea pigs.

Perineuronal nets (PNs) are aggregates of extracellular matrix that have been associated with neuronal plasticity, critical periods, fast-spiking cells and protection from oxidative stress. Although PNs have been reported in the auditory system in…

Tags: 2014, Auditory, Department of Anatomy & Neurobiology, Extracellular Matrix, Foster Nichole L, Frontiers in neuroanatomy, GABA, inhibition, Mellott Jeffrey G, midbrain, NEOMED College of Medicine, plasticity, Schofield Brett R

Projections from the dorsal and ventral cochlear nuclei to the medial geniculate body.

Direct projections from the cochlear nucleus (CN) to the medial geniculate body (MG) mediate a high-speed transfer of acoustic information to the auditory thalamus. Anderson etal. (2006) used anterograde tracers to label the projection from the…

Tags: 2014, collateral projections, Department of Anatomy & Neurobiology, fear conditioning, Foster Nichole L, Frontiers in neuroanatomy, lemniscal pathway, magnocellular pathway, Mellott Jeffrey G, Motts Susan D, multimodal processing, multipolar cells, NEOMED College of Medicine, Schofield Brett R, T-stellate, thalamus

Distribution of GABAergic cells in the inferior colliculus that project to the thalamus.

A GABAergic component has been identified in the projection from the inferior colliculus (IC) to the medial geniculate body (MG) in cats and rats. We sought to determine if this GABAergic pathway exists in guinea pig, a species widely used in…

Tags: 2014, Auditory system, Department of Anatomy & Neurobiology, Foster Nichole L, Frontiers in neuroanatomy, GAD, inhibition, medial geniculate, Mellott Jeffrey G, Motts Susan D, Nakamoto Kyle T, NEOMED College of Medicine, Schofield Brett R, tectothalamic

Subcollicular projections to the auditory thalamus and collateral projections to the inferior colliculus.

Experiments in several species have identified direct projections to the medial geniculate nucleus (MG) from cells in subcollicular auditory nuclei. Moreover, many cochlear nucleus cells that project to the MG send collateral projections to the…

Tags: 2014, binaural, brain evolution, Department of Anatomy & Neurobiology, Frontiers in neuroanatomy, lateral lemniscus, medial geniculate nucleus, Mellott Jeffrey G, Motts Susan D, NEOMED College of Medicine, paralemniscal area, parallel pathways, reticular formation, Schofield Brett R, superior olive

Ultrastructural characterization of GABAergic and excitatory synapses in the inferior colliculus.

In the inferior colliculus (IC) cells integrate inhibitory input from the brainstem and excitatory input from both the brainstem and auditory cortex. In order to understand how these inputs are integrated by IC cells identification of their synaptic…

Tags: 2014, Auditory, circuit, Department of Anatomy & Neurobiology, Frontiers in neuroanatomy, gamma-aminobutyric acid, inhibition, Killius Jeanette, Mellott Jeffrey G, Nakamoto Kyle T, NEOMED College of Medicine, Schofield Brett R, Sowick Colleen S, Storey-Workley Megan E, ultrastructure

Excitatory and inhibitory projections in parallel pathways from the inferior colliculus to the auditory thalamus.

Individual subdivisions of the medial geniculate body (MG) receive a majority of their ascending inputs from 1 or 2 subdivisions of the inferior colliculus (IC). This establishes parallel pathways that provide a model for understanding auditory…

Tags: 2014, Auditory system, Department of Anatomy & Neurobiology, Foster Nichole L, Frontiers in neuroanatomy, GABA, GAD, lemniscal, medial geniculate, Mellott Jeffrey G, NEOMED College of Medicine, non-lemniscal, Ohl Andrew P, Schofield Brett R, tectothalamic

Interplay between low threshold voltage-gated K(+) channels and synaptic inhibition in neurons of the chicken nucleus laminaris along its frequency axis.

Central auditory neurons that localize sound in horizontal space have specialized intrinsic and synaptic cellular mechanisms to tightly control the threshold and timing for action potential generation. However, the critical interplay between…

Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma.

Axonal transport deficits have been reported as an early pathology in several neurodegenerative disorders, including glaucoma. However, the progression and mechanisms of these deficits are poorly understood. Previous work suggests that anterograde…

Developmental hearing loss impairs signal detection in noise: putative central mechanisms.

Listeners with hearing loss have difficulty processing sounds in noisy environments. This is most noticeable for speech perception, but is reflected in a basic auditory processing task: detecting a tonal signal in a noise background, i.e.,…

Tags: 2014, auditory cortex, conductive hearing loss, Department of Anatomy & Neurobiology, Electrophysiology, Frontiers in systems neuroscience, Galazyuk Alexander V, Gay Jennifer D, gerbil, intracellular, masking, NEOMED College of Medicine, Noise, Rosen Merri J, signal detection, Voytenko Sergiy V

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