Browse Items (51 total)
- Tags: Genetic
Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1.
Tags: 2017, Acetylation/drug effects, Animals, Butyrates/pharmacology, Cell Line, Cell Survival/drug effects, Department of Pharmaceutical Sciences, Dopamine Plasma Membrane Transport Proteins/*metabolism, Dopamine transporter, Dopaminergic Neurons/cytology/drug effects/metabolism, Dose-Response Relationship, Drug, Eid Aseel, Epigenesis, Epigenetics, Genetic, Genetic/drug effects, Green Ashley L, Group A, Guo Grace L, HDAC, Histone deacetylase, Histone Deacetylase Inhibitors/*pharmacology, Histone Deacetylases/metabolism, Histones/*drug effects/metabolism, Homeodomain Proteins/metabolism, Hydroxamic Acids/pharmacology, Member 2/*metabolism, Messenger/metabolism, NEOMED College of Pharmacy, Neuropharmacology, Nuclear Receptor Subfamily 4, Nurr1, Pitx3, Promoter Regions, Rats, Richardson Jason R, RNA, Transcription Factors/metabolism, Valproate, Valproic Acid/*pharmacology, Zarbl Helmut, Zhan Le
Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure.
Tags: *2H2O-labeling, *Brain, *Genetic Variation, *Histone, *Mass spectrometry, *Post-translational modifications, *Postnatal alcohol exposure, *Turnover, 2017, Acetylation, Animal, Animals, Cell Proliferation, Clinical epigenetics, Department of Pharmaceutical Sciences, Disease Models, DNA Damage, Epigenesis, Female, Fetal Alcohol Spectrum Disorders/genetics/*metabolism, Genetic, Histones/*genetics/*metabolism, Humans, Kasumov Takhar, Li Ling, NEOMED College of Pharmacy, Post-Translational, Pregnancy, Previs Stephen, Protein Processing, Proteomics/*methods, Rachdaoui Nadia, Rats, Sarkar Dipak, Sprague-Dawley, Willard Belinda
Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.
Tags: *DNA-Binding Proteins, *Transcription, 2001, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/genetics, Cultured, Cytochrome P-450 Enzyme System/*genetics, Cytoplasmic and Nuclear/physiology, Department of Integrative Medical Sciences, Genetic, Genetic/physiology, Hepatocyte Nuclear Factor 4, Humans, Molecular Sequence Data, NEOMED College of Medicine, Phosphoproteins/*physiology, Promoter Regions, Receptors, Repressor Proteins/*pharmacology, Steroid 12-alpha-Hydroxylase, Steroid Hydroxylases/*genetics, The Journal of biological chemistry, Transcription Factors/*physiology, Tumor Cells, Zhang M
Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells.
Tags: *Promoter Regions, *Transcription, *Transcription Factors, 1996, Base Sequence, Binding Sites, Cell Line, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Consensus Sequence, Crestani M, Department of Integrative Medical Sciences, DNA-Binding Proteins/genetics/metabolism, Enzyme Repression, Enzymologic/*drug effects, Galli G, Gene Expression Regulation, Genes, Genetic, Glucocorticoid/genetics/metabolism, Glucocorticoids/pharmacology, Hepatocyte Nuclear Factor 3-alpha, Humans, Insulin/pharmacology, Journal of lipid research, Marrapodi M, Molecular Sequence Data, NEOMED College of Medicine, Nuclear Proteins/genetics/metabolism, Phorbol Esters/pharmacology, Receptors, Recombinant Fusion Proteins/biosynthesis, Reporter, Stroup D, Thyroid Hormones/pharmacology, Transfection, Wang D P
Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein.
Tags: *Transcription Factors, 2004, Base Sequence, Biochemical and biophysical research communications, CCAAT-Enhancer-Binding Proteins/*metabolism, Chiang John Y L, Cytochrome P-450 Enzyme System/*genetics/physiology, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA-Binding Proteins/*metabolism, Enzyme Repression, Genetic, Humans, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Norlin Maria, Promoter Regions, Response Elements, Sp1 Transcription Factor/antagonists & inhibitors, Steroid Hydroxylases/*genetics/physiology, Sterol Regulatory Element Binding Protein 1, Sterols/metabolism, Transcription
Transcriptional regulation of human oxysterol 7 alpha-hydroxylase gene (CYP7B1) by Sp1.
Tags: 2001, Base Sequence, Binding, Binding Sites/genetics, Cell Line, Chiang J Y, Competitive, CpG Islands/genetics, Cultured, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA/genetics, Enzymologic, gene, Gene Expression Regulation, Genetic, Humans, Luciferases/genetics/metabolism, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid/genetics, Protein Binding, Recombinant Fusion Proteins/genetics/metabolism, Regulatory Sequences, Sequence Deletion, Site-Directed, Sp1 Transcription Factor/metabolism/*physiology, Steroid Hydroxylases/*genetics/metabolism, Transcription, Transfection, Tumor Cells, Wu Z
Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.
Tags: *Receptors, *Transcriptional Activation, 1998, Animals, Base Sequence, Bile Acids and Salts/biosynthesis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, DNA/metabolism, Galli G, Genes, Genetic, Hepatocyte Nuclear Factor 4, Hormones/*physiology, Journal of lipid research, Luciferases/genetics, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid, Oligonucleotide Probes/metabolism, Phosphoproteins/metabolism, Promoter Regions, Rats, Receptors, Repetitive Sequences, Reporter, Retinoic Acid/metabolism, Retinoid X Receptors, Sadeghpour A, Site-Directed, Steroid, Stroup D, Transcription Factors/metabolism, Tumor Cells
The opposing effects of retinoic acid and phorbol esters converge to a common response element in the promoter of the rat cholesterol 7 alpha-hydroxylase gene (CYP7A).
Tags: *Promoter Regions, 1996, Animals, Base Sequence, Biochemical and biophysical research communications, Cell Line, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Crestani M, Department of Integrative Medical Sciences, DNA Primers, Galli G, Genetic, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Rats, Sadeghpour A, Signal Transduction, Stroup D, Tetradecanoylphorbol Acetate/*pharmacology, Tretinoin/*pharmacology
The isolation and characterization of the human cytochrome b5 gene.
Tags: 1995, Animals, Base Sequence, Biochemical and biophysical research communications, Cattle, Cell Line, Cloning, Cosmids, Cultured, Cytochromes b5/biosynthesis/*genetics, DNA Primers, DNA/genetics/isolation & purification, Gene Library, Genetic, Giordano S J, Hominidae/*genetics, Humans, Introns, Li X R, Luciferases/biosynthesis, Messenger/analysis/biosynthesis, Molecular, Molecular Sequence Data, Polymerase Chain Reaction, Promoter Regions, Rabbits, RNA, Steggles A W, Transfection, Tumor Cells, Yoo M
The isolation and characterization of the bovine cytochrome b5 gene, and a transcribed pseudogene.
Tags: *Pseudogenes, 1993, Amino Acid Sequence, Animals, Base Sequence, Blotting, Cattle/*genetics, Cristiano R J, Cytochromes b5/*genetics, DNA/genetics/isolation & purification, Exons, Gene Expression, Genetic, Genomic Library, Genomics, Giordano S J, Humans, Introns, Messenger/biosynthesis/metabolism, Molecular Sequence Data, Nucleic Acid, Nucleic Acid Conformation, Oligodeoxyribonucleotides, Rabbits, Restriction Mapping, Reticulocytes/metabolism, RNA, RNA Precursors/chemistry/metabolism, Sequence Homology, Southern, Steggles A W, Transcription
The human liver and reticulocyte cytochrome b5 mRNAs are products from a single gene.
Tags: *Genes, 1991, Amino Acid Sequence, Base Sequence, Biochemical and biophysical research communications, Cytochromes b5/blood/*genetics, Gene Library, Genetic, Giordano S J, Humans, Liver/*metabolism, Molecular Sequence Data, Polymerase Chain Reaction, Polymorphism, Reticulocytes/*metabolism, RNA/blood/genetics/isolation & purification, Steggles A W
Synthesis of radioactive single-stranded DNA probes using asymmetrical PCR and oligonucleotide random priming.
Tags: *DNA, *Oligonucleotides, *Phosphorus Radioisotopes, 1999, Animals, BioTechniques, Blotting, Cercopithecus aethiops, Deoxyribonuclease EcoRI, DNA, DNA Probes/*chemical synthesis, Genetic, Herpesvirus 1, Human/genetics, Isotope Labeling, Mao H, Messenger/analysis, Northern, Nucleic Acid Denaturation, Polymerase Chain Reaction/*methods, RNA, Rosenthal K S, Single-Stranded, Templates, Vero Cells, Viral/analysis
Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1.
Tags: 1999, Animals, Base Sequence, Blotting, Cell Line, Chiang J Y, Chromosome Mapping, Cloning, Codon, Complementary/biosynthesis/*isolation & purification, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA, Genetic, Genetic/genetics, Humans, Hydroxycholesterols/metabolism, Initiator, Javitt N B, Journal of lipid research, Luciferases/genetics, Martin K O, Mice, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Northern, Nucleic Acid, Promoter Regions, Regulatory Sequences, Steroid Hydroxylases/*genetics/metabolism, Transcription, Transfection, Wu Z
Strain-dependent structural variants of herpes simplex virus type 1 ICP34.5 determine viral plaque size, efficiency of glycoprotein processing, and viral release and neuroinvasive disease potential.
Tags: *Genetic Variation, 2003, Animals, Cercopithecus aethiops, Cultured, Encephalitis, Genetic, Herpes Simplex/*physiopathology/virology, Herpesvirus 1, Human/*classification/genetics/*pathogenicity, Inbred BALB C, Journal of virology, Male, Mao Hanwen, Mice, Recombination, Rosenthal Ken S, Transfection, Tumor Cells, Vero Cells, Viral Envelope Proteins/metabolism, Viral Plaque Assay, Viral Proteins/*chemistry/*genetics/metabolism
Serotonergic involvement in the regulation of prolactin and vasoactive intestinal peptide mRNA expression in the rat anterior pituitary.
Tags: 1994, 5-Hydroxytryptophan/pharmacology, alpha-Methyltyrosine, Animals, Anterior/*chemistry/drug effects/metabolism, Blotting, Bromocriptine/pharmacology, Carrillo A J, Gene Expression Regulation/drug effects/physiology, Genetic, Haloperidol/pharmacology, Ketanserin/pharmacology, Liu B, Male, Messenger/*analysis/genetics, Methiothepin/pharmacology, Methoxydimethyltryptamines/pharmacology, Methyltyrosines/pharmacology, Molecular and cellular endocrinology, Northern, Pituitary Gland, Prolactin/analysis/*genetics/metabolism, Quipazine/pharmacology, Rats, RNA, Serotonin/*physiology, Signs S A, Sprague-Dawley, Time Factors, Transcription, Vasoactive Intestinal Peptide/analysis/*genetics/metabolism, Wolford J
Sequential activation of Elk-1/Egr-1/GADD45alpha by arsenic.
Tags: 2014, Arsenic/*pharmacology, Bhatia Deepak, Bishayee Anupam, Bronchi/cytology/drug effects/metabolism, Cell Cycle Proteins/biosynthesis/genetics/*metabolism, Cell Line, Early Growth Response Protein 1/biosynthesis/genetics/*metabolism, Epithelial Cells/drug effects/metabolism, ets-Domain Protein Elk-1/biosynthesis/genetics/*metabolism, Genetic, Humans, MAP Kinase Signaling System, Messenger/biosynthesis/genetics, Nuclear Proteins/biosynthesis/genetics/*metabolism, Oncotarget, Promoter Regions, Proto-Oncogene Proteins c-akt/metabolism, RNA, Shi Qiwen, Sutariya Vijaykumar
Sensory nerves and neuropeptides in uterine cervical ripening.
Tags: 2002, Animal, Animals, Calcitonin Gene-Related Peptide/biosynthesis, Capsaicin/pharmacology, Cervical Ripening/*metabolism, Cervix Uteri/*innervation/*metabolism, Collins J J, Complementary/metabolism, Department of Anatomy & Neurobiology, Female, Genetic, Immunohistochemistry, Labor, McCarson K E, Messenger/metabolism, NEOMED College of Medicine, Neurokinin-1/biosynthesis, Neurons/metabolism, Neuropeptides/*biosynthesis, Nitric Oxide Synthase/biosynthesis, Obstetric, Papka R E, Peptides, Plasmids/metabolism, Postpartum Period, Pregnancy, Rats, Receptors, RNA, Secretogranin II, Sprague-Dawley, Substance P/biosynthesis, Transcription, Usip S
Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
Tags: 2001, Animals, Binding Sites, Cells, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/drug effects/*genetics/metabolism, Cricetinae, Cultured, Department of Integrative Medical Sciences, gene, Gene Expression Regulation/drug effects, Genetic, Humans, Hydroxycholesterols, Kimmel R, Liver/physiology, Lovastatin/pharmacology, Luciferases/genetics/metabolism, Mevalonic Acid/metabolism/pharmacology, NEOMED College of Medicine, Nicotinic Acids/pharmacology, Organ Specificity, Polyisoprenyl Phosphates/pharmacology, Rats, Receptors, Response Elements, Retinoic Acid/genetics/metabolism, Retinoid X Receptors, Species Specificity, Steroid/genetics/*metabolism, Stroup D, Tetrahydronaphthalenes/pharmacology, Transcription, Transcription Factors/genetics/metabolism, Transfection
Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells.
Tags: *Gene Expression Regulation, *Promoter Regions, 2000, Amino Acid Sequence, Archives of biochemistry and biophysics, Base Sequence, Cell Line, Chen L, Cloning, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 4, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, DNA, DNA Footprinting, Enzymologic, Exons, Genes, Genetic, Genetic/drug effects, Hardwick J P, Humans, Introns, Leukotriene B4/metabolism, Mixed Function Oxygenases/metabolism, Models, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Peroxisome Proliferators/*metabolism, Receptors, Reporter, Retinoic Acid Receptor alpha, Retinoic Acid/metabolism, Sequence Analysis, Transcription, Transcription Factors/metabolism, Transfection, Tretinoin/*metabolism, Zhang X
Polymorphisms of human cholesterol 7 alpha-hydroxylase.
Tags: 1992, Amino Acid Sequence, Base Sequence, Biochemical and biophysical research communications, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Department of Integrative Medical Sciences, DNA/genetics, Genetic, Humans, Karam W G, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Oligodeoxyribonucleotides/chemistry, Polymerase Chain Reaction, Polymorphism, Restriction Mapping
Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *DNA-Binding Proteins, *Regulatory Sequences, 2000, Animals, Anticholesteremic Agents/pharmacology, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Clofibric Acid/pharmacology, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Enzymologic, Gene Expression Regulation, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Marrapodi M, Models, NEOMED College of Medicine, Nucleic Acid, Peroxisome Proliferators/pharmacology, Phosphoproteins/metabolism, Promoter Regions, Protein Binding, Pyrimidines/pharmacology, Rats, Receptors, Reporter, Response Elements, Retinoic Acid/metabolism, Retinoid X Receptors, Species Specificity, Transcription, Transcription Factors/*agonists/metabolism, Transcriptional Activation
Orphan receptors chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor (RXR) activate and bind the rat cholesterol 7alpha-hydroxylase gene (CYP7A).
Tags: *Gene Expression Regulation, *Receptors, 1997, Animals, Chiang J Y, Chickens, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Circadian Rhythm, COUP Transcription Factor I, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Department of Integrative Medical Sciences, DNA-Binding Proteins/*metabolism, Electrophoresis, Enzymologic, Genetic, Glucocorticoid/*genetics, Models, Molecular, NEOMED College of Medicine, Nuclear Proteins/*metabolism, Polyacrylamide Gel, Promoter Regions, Rats, Receptors, Recombinant Proteins/genetics/metabolism, Retinoic Acid/*metabolism, Retinoid X Receptors, Steroid, Stroup D, The Journal of biological chemistry, Transcription Factors/*metabolism
Orphan nuclear receptor oestrogen-related receptor gamma (ERRgamma) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression.
Tags: 2015, Animals, bile acid, Bile Acids and Salts/metabolism, Cannabinoid, cannabinoid receptors, CB1/agonists/genetics/*metabolism, Cells, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/genetics, cholesterol 7alpha-hydroxylase (CYP7A1), Cultured, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Drug Inverse Agonism, Estrogen/genetics/*metabolism, Ethanol/pharmacology, Gene Expression, Genetic, Glycerides/pharmacology, GSK5182, HEK293 Cells, Hepatocytes/metabolism, Humans, Inbred C57BL, Jeong Won-Il, Kim Don-Kyu, Kim Seong Heon, Knockout, Lee Chul-Ho, Lee In-Kyu, Lee Ji-Min, Liver/*metabolism, Mice, NEOMED College of Medicine, oestrogen-related receptor gamma (ERRgamma), orphan nuclear receptor, Park Seung Bum, Promoter Regions, Rats, Receptor, Receptors, small heterodimer partner (SHP), Sprague-Dawley, The Biochemical journal, Transcription, Zhang Yaochen
On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha.
Tags: *DNA-Binding Proteins, 2002, alpha-Fetoproteins/genetics/*physiology, Animals, Base Sequence, Bile Acids and Salts/*pharmacology, Biochimica et biophysica acta, Cattle, Chiang John Y L, Cytochrome P-450 Enzyme System/*genetics, Department of Integrative Medical Sciences, DNA, Eggertsen Gosta, Enzymologic/*drug effects/physiology, Gene Expression Regulation, Genetic, Genetic/*drug effects, Hepatocyte Nuclear Factor 4, Messenger/genetics, NEOMED College of Medicine, Phosphoproteins/genetics/*physiology, Promoter Regions, Rats, RNA, Sprague-Dawley, Steroid 12-alpha-Hydroxylase, Steroid Hydroxylases/*genetics, Transcription, Transcription Factors/genetics/*physiology, Yang Yizeng, Zhang Ming
Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids.
Tags: *Hydroxysteroid Dehydrogenases, *Membrane Glycoproteins, 2001, Animals, Bile Acids and Salts/*pharmacology, Caco-2 Cells, Carrier Proteins/genetics/physiology, Cell Line, Chen W, Chiang J Y, CHO Cells, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear/genetics/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/drug effects/genetics/physiology, DNA/metabolism, Embryo, Gene Expression/*drug effects, Genetic, Genetic/drug effects, Humans, Journal of lipid research, Kidney, Liver/metabolism, Luciferases/genetics, Mammalian, Messenger/analysis, NEOMED College of Medicine, Owsley E, Promoter Regions, Rats, Receptors, Recombinant Fusion Proteins/metabolism, Retinoic Acid/genetics/physiology, Retinoid X Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Stroup D, Taurocholic Acid/pharmacology, Transcription, Transcription Factors/drug effects/genetics/physiology, Transfection, Tumor Cells, Yang Y
Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, alpha-Ketoglutarate (alpha-KG), and DNA hydroxymethylation levels by interleukin-1beta in primary human chondrocytes.
Tags: *DNA methylation, *Epigenesis, 2014, 5-hmC, 5-Methylcytosine/analogs & derivatives, Chondrocytes, Chondrocytes/chemistry/*metabolism, Cytokine, Cytosine/*analogs & derivatives/analysis/metabolism, Department of Anatomy & Neurobiology, Dioxygenase, DNA Methylation, DNA-Binding Proteins/*biosynthesis/genetics, Epigenetics, Genetic, Haqqi Tariq M, Haseeb Abdul, Humans, IL-1, Interleukin-1beta/pharmacology/*physiology, Isocitrate Dehydrogenase/*biosynthesis/genetics, Ketoglutaric Acids/*metabolism, Makki Mohammad Shahidul, Messenger/biosynthesis/genetics, Mixed Function Oxygenases, NEOMED College of Medicine, Primary Cell Culture, Proto-Oncogene Proteins/*biosynthesis/genetics, RNA, The Journal of biological chemistry, TNF-alpha, Tumor Necrosis Factor-alpha/pharmacology/physiology
Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.
Tags: 2005, American journal of physiology. Gastrointestinal and liver physiology, Bile Acids and Salts/pharmacology, Chiang John Y L, Cholestasis/*physiopathology, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/pharmacology, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/pharmacology, Enzyme Inhibitors/*pharmacology, Genetic, Glucocorticoid, Hepatoblastoma/pathology, Hepatocyte Nuclear Factor 4, Humans, Li Tiangang, Liver Neoplasms/pathology, Messenger/analysis/biosynthesis, NEOMED College of Medicine, Phosphoproteins/pharmacology, Pregnane X Receptor, Receptors, Rifampin/*pharmacology, RNA, Steroid/*physiology, Transcription, Transcription Factors/pharmacology, Tumor Cells, Up-Regulation
Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth.
Tags: *Collateral Circulation, *Coronary Circulation, 2012, Animal, Animals, Bailey Erin, Biomarkers/metabolism, Cell Differentiation, Cell Lineage, Cells, Chilian William M, Circulation research, Coronary Occlusion/genetics/metabolism/pathology/physiopathology/*surgery, Coronary Vessels/metabolism/pathology/*physiopathology, Cultured, Delucia Angelo, Department of Integrative Medical Sciences, Developmental, Disease Models, Endothelial Cells/metabolism/pathology/*transplantation, Enrick Molly, Epigenesis, Gene Expression Profiling, Gene Expression Regulation, Genetic, Guarini Giacinta, Induced Pluripotent Stem Cells/metabolism/*transplantation, Kolz Christopher L, Mice, Muscle, Myocytes, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Physiologic, Pung Yuh Fen, Rats, Regenerative Medicine/methods, Regional Blood Flow, Reverse Transcriptase Polymerase Chain Reaction, SCID, Smooth, Smooth Muscle/metabolism/pathology/*transplantation, Sprague-Dawley, Stevanov Kelly, Teratoma/metabolism/pathology, Time Factors, Transcription Factors/genetics/metabolism, Transduction, Vascular/metabolism/pathology/*physiopathology, Yin Liya
In situ hybridization study of obesity-associated alteration in growth hormone mRNA levels.
Tags: *Gene Expression Regulation, 1992, Ahmad I, Animals, Autoradiography, Blotting, Finkelstein J A, Genetic, Growth Hormone/*genetics/metabolism, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, Male, Messenger/*analysis, Northern, Nucleic Acid Hybridization, Obesity/*etiology/physiopathology, Pituitary Gland/*chemistry/metabolism, Rats, RNA, Steggles A W, Transcription, Zucker
Impact of circadian nuclear receptor REV-ERBalpha on midbrain dopamine production and mood regulation.
Tags: *Affect, *Circadian Rhythm, 2014, Animals, Bipolar Disorder/genetics, Cell, Choe Han Kyoung, Chung Sooyoung, CLOCK Proteins/genetics/metabolism, Cytoplasmic and Nuclear/genetics/*metabolism, Dluzen Dean E, Dopamine/*metabolism, Genetic, Group A, Histones/metabolism, Humans, Hwang Onyou, Inbred C57BL, Kim Kwang-Soo, Kim Kyungjin, Knockout, Lee Eun Jeong, Lee Inah, Male, Member 2/metabolism, Mesencephalon/*metabolism, Mice, Mood Disorders/genetics/metabolism, Nuclear Receptor Subfamily 4, Park Seong-Beom, Rats, Receptors, Repressor Proteins/genetics/*metabolism, Son Gi Hoon, Son Hyo Jin, Transcription, Tyrosine 3-Monooxygenase/genetics, Yun Seongsik
Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter.
Tags: *Promoter Regions, 1994, Animals, Antigens, Base Sequence, Bile Acids and Salts/*metabolism, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cloning, Deoxyribonuclease I, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Gene Expression Regulation, Genetic, Humans, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Nuclear Proteins/metabolism, Oligodeoxyribonucleotides, Polyomavirus Transforming/genetics, Rats, Recombinant Fusion Proteins/genetics/metabolism, Sprague-Dawley, Stroup D, The Journal of biological chemistry, Thyroid Hormones/genetics
Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7).
Tags: *Promoter Regions, *Transcription, 1995, Animals, Base Sequence, Cell Count, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Crestani M, Cultured, Cyclic AMP/pharmacology, Department of Integrative Medical Sciences, Enzymologic/*physiology, Gene Expression Regulation, Genetic, Hormones/*pharmacology, Journal of lipid research, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Phorbol Esters/pharmacology, Rats, Second Messenger Systems/physiology, Stroup D, Transfection, Tumor Cells
HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).
Tags: *Receptors, *Transcription, 2000, Animals, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Cultured, Department of Integrative Medical Sciences, DNA Primers, DNA-Binding Proteins/*metabolism, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Luciferases/genetics, Mutation, NEOMED College of Medicine, Phosphoproteins/*metabolism, Promoter Regions, Rats, Recombinant Proteins/metabolism, Reporter, Sprague-Dawley, Steroid, Stroup D, Transcription Factors/*metabolism, Tumor Cells
Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes.
Tags: *IL-6, *MCPIP1, *miRNA, *OSTEOARTHRITIS, *Vorinostat, 2017, Adult, Aged, CCAAT-Enhancer-Binding Proteins/genetics/metabolism, Cells, Chondrocytes/*metabolism/pathology, Connective tissue research, Cultured, Department of Anatomy & Neurobiology, Female, Gene Expression Regulation/*drug effects, Genetic, Haqqi Tariq M, Humans, Hydroxamic Acids/*pharmacology, Interleukin-1beta/genetics/*metabolism, Interleukin-6/genetics/*metabolism, Makki Mohammad S, Male, MicroRNAs/genetics/*metabolism, Middle Aged, NEOMED College of Medicine, Osteoarthritis/drug therapy/genetics/*metabolism/pathology, Promoter Regions, Ribonucleases/*biosynthesis/genetics, Transcription Factors/*biosynthesis/genetics, Vorinostat
Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: *Gene Expression Regulation, 2010, Acetylation, AMP-Activated Protein Kinases/metabolism, ATP Citrate (pro-S)-Lyase/genetics/metabolism, Bile Acids and Salts/metabolism, Cells, Chanda Dipanjan, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Epigenesis, Genes, Genetic, Glucose/*administration & dosage, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*enzymology/metabolism, Histones/metabolism, Humans, Hyperglycemia/enzymology/*metabolism, Journal of lipid research, Li Tiangang, Messenger/metabolism, Methylation, NEOMED College of Medicine, Reporter, RNA, RNA Interference, Zhang Yanqiao
Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *Transcription, 2000, Animals, Bile Acids and Salts/*pharmacology, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear, Department of Integrative Medical Sciences, DNA-Binding Proteins/*physiology, Genetic, Humans, Kimmel R, NEOMED College of Medicine, Promoter Regions, Receptors, Repressor Proteins/*physiology, Response Elements, Retinoic Acid/genetics, Retinoid X Receptors, Stroup D, The Journal of biological chemistry, Transcription Factors/genetics/*physiology, Tumor Cells, Weinberger C
Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics.
Tags: *DNA methylation, *Epigenetics, *HDACs, *lncRNA, *miRNA, *OSTEOARTHRITIS, 2018, Animals, Department of Anatomy & Neurobiology, Epigenesis, Genetic, Haqqi Tariq M, Histone Deacetylase Inhibitors/*therapeutic use, Humans, Khan Nazir M, NEOMED College of Medicine, Osteoarthritis/*drug therapy/*genetics, Pharmacological research
Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration.
Tags: *Astrocyte, *DNA methylation, *Epigenesis, *Epigenetic, *Histone, *neurodegeneration, *Neuroinflammation, 2018, Acetylation, Alzheimer Disease/genetics/pathology, Animals, Astrocytes/*cytology/immunology, Biochimica et biophysica acta. Molecular basis of disease, Cell Differentiation, Department of Pharmaceutical Sciences, DNA Methylation, Genetic, Histones/metabolism, Humans, Inflammation/*pathology, Methylation, MicroRNAs/metabolism, Neal Matthew, NEOMED College of Pharmacy, Neurodegenerative Diseases/genetics/*pathology, Neuroglia/metabolism, Neurons/immunology, Parkinson Disease/genetics/pathology, Richardson Jason R
Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells.
Tags: 1994, Animals, Bile Acids and Salts/*pharmacology, Biochemical and biophysical research communications, Cells, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Crestani M, Cultured, Department of Integrative Medical Sciences, Enzymologic/*drug effects, Gene Expression Regulation, Genetic, Genetic/genetics, Humans, Karam W G, Luciferases/biosynthesis/genetics, Messenger/*biosynthesis, NEOMED College of Medicine, Promoter Regions, Rats, Recombinant Fusion Proteins/biosynthesis, RNA, Steroids/*pharmacology, Thyroid Hormones/*pharmacology, Transcription, Transfection