Browse Items · NEOMED Bibliography Database

Why adult mammalian intrafusal and extrafusal fibers contain different myosin heavy-chain isoforms.

Multiple isoforms of the contractile protein myosin are present in mammalian skeletal muscles. The diversity of the heavy-chain subunits of myosin (MyHCs) in intrafusal fibers is thought to reflect a pathway of differentiation that is unique to…

VDCCs and NMDARs underlie two forms of LTP in CA1 hippocampus in vivo.

N-methyl-D-aspartate receptor/channel (NMDAR) and voltage-dependent calcium channel (VDCC) antagonists applied independently reduce the magnitude of long-term potentiation (LTP) in area CA1 of the hippocampal slice preparation. When used in…

Tags: 1999, Animals, Calcium Channel Blockers/*pharmacology, Dizocilpine Maleate/pharmacology, Excitatory Amino Acid Antagonists/*pharmacology, Excitatory Postsynaptic Potentials/drug effects, Hippocampus/*drug effects, Journal of neurophysiology, Long-Evans, Long-Term Potentiation/*drug effects, Male, Membrane Potentials/physiology, Morgan S L, N-Methyl-D-Aspartate/*antagonists & inhibitors, Rats, Receptors, Teyler T J, Verapamil/pharmacology

Vanadium in the detection, prevention and treatment of cancer: the in vivo evidence.

Vanadium, a dietary micronutrient, is yet to be established as an essential part of the human diet. Over the past century, several biological effects of vanadium, such as insulin-mimetic action as well as amelioration of hyperlipidemia and…

Tags: 10-Dimethyl-1, 2-benzanthracene, 2010, 9, Animal, Animals, Biological, Bishayee Anupam, Breast Neoplasms – Chemically Induced, Breast Neoplasms – Diagnosis, Breast Neoplasms – Drug Therapy, Cancer letters, Cell Division – Drug Effects, Cell Division/drug effects, Chatterjee Malay, Disease Models, Experimental/chemically induced/diagnosis/drug therapy, Experimental/drug therapy/pathology, Female, Glioblastoma/drug therapy, Glioma – Drug Therapy, Heterologous, Humans, Hydrocarbons, Male, Mammary Neoplasms, Metals, Metals – Diagnostic Use, Metals – Therapeutic Use, Models, Neoplasm Staging, Neoplasm Transplantation, Neoplasms, Neoplasms – Diagnosis, Neoplasms – Drug Therapy, Neoplasms – Pathology, Neoplasms – Prevention and Control, Neoplasms/*diagnosis/drug therapy/prevention & control, Organometallic Compounds – Therapeutic Use, Organometallic Compounds/therapeutic use, Patel Mehool A, Rats, Trace Elements – Diagnostic Use, Trace Elements – Therapeutic Use, Trace Elements/therapeutic use, Transplantation, Vanadium Compounds, Vanadium Compounds – Therapeutic Use, Vanadium Compounds/therapeutic use/toxicity, Vanadium/*therapeutic use/toxicity, Waghray Abhijeet, Xenografts

Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1.

The dopamine transporter (DAT) is the key regulator of dopaminergic transmission and is a target of several xenobiotics, including pesticides and pharmacological agents. Previously, we identified a prominent role for histone deacetylases in the…

Tags: 2017, Acetylation/drug effects, Animals, Butyrates/pharmacology, Cell Line, Cell Survival/drug effects, Department of Pharmaceutical Sciences, Dopamine Plasma Membrane Transport Proteins/*metabolism, Dopamine transporter, Dopaminergic Neurons/cytology/drug effects/metabolism, Dose-Response Relationship, Drug, Eid Aseel, Epigenesis, Epigenetics, Genetic, Genetic/drug effects, Green Ashley L, Group A, Guo Grace L, HDAC, Histone deacetylase, Histone Deacetylase Inhibitors/*pharmacology, Histone Deacetylases/metabolism, Histones/*drug effects/metabolism, Homeodomain Proteins/metabolism, Hydroxamic Acids/pharmacology, Member 2/*metabolism, Messenger/metabolism, NEOMED College of Pharmacy, Neuropharmacology, Nuclear Receptor Subfamily 4, Nurr1, Pitx3, Promoter Regions, Rats, Richardson Jason R, RNA, Transcription Factors/metabolism, Valproate, Valproic Acid/*pharmacology, Zarbl Helmut, Zhan Le

Vagal afferents reflexly inhibit exercise in conscious rats.

Activation of vagal afferents reflexly inhibited locomotion induced by stimulation of the mesencephalic locomotor region in decerebrate cats. However, this reflex has not been tested in intact mammals. Therefore, the purpose of this study was to test…

Vagal afferents from the uterus and cervix provide direct connections to the brainstem.

Previous anatomical studies demonstrated vagal innervation to the ovary and distal colon and suggested the vagus nerve has uterine inputs. Recent behavioral and physiological evidence indicated that the vagus nerves conduct sensory information from…

Tags: 1999, Animals, Berthoud H R, Brain Stem/*anatomy & histology, Cell and tissue research, Cervix Uteri/*innervation, Collins J J, Estrogen/metabolism, Female, Immunohistochemistry, Lin C E, Neurons/cytology/metabolism, Papka R E, Rats, Receptors, Sprague-Dawley, Uterus/*innervation, Vagus Nerve/*anatomy & histology/metabolism

Use of TFMPP stimulus properties as a model of 5-HT1B receptor activation.

Recent evidence indicates that when 1-(3-trifluoromethylphenyl)piperazine (TFMPP) is used as a training drug in the drug discrimination paradigm it produces a stimulus effect that is site-selective at the 5-HT1B receptor. The present study sought to…

Tags: 1988, Animals, Biological, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Male, Models, Norfenfluramine/pharmacology, Pharmaceutical Vehicles, Pharmacology, biochemistry, and behavior, Piperazines/*pharmacology, Rats, Receptors, Schechter M D, Serotonin/*drug effects/physiology, Serotonin/pharmacology

Use of in vitro superfusion to assess the dynamics of striatal dopamine clearance: influence of estrogen.

To determine the feasibility of assessing dopamine uptake using in vitro superfusion, striatal tissue from ovariectomized female rats was infused with dopamine (1 microM), nomifensine (1 mM), or a combination of dopamine and nomifensine. Treatment…

Tags: 1999, Animals, Brain research, Corpus Striatum/drug effects/*physiology, Disshon K A, Dluzen D E, Dopamine/*metabolism/pharmacology, Estradiol/*pharmacology, Female, Kinetics, Nomifensine/*pharmacology, Ovariectomy, Rats, Sprague-Dawley

Type VI collagen induces cardiac myofibroblast differentiation: implications for postinfarction remodeling.

Cardiac fibroblast (CF) proliferation and differentiation into hypersecretory myofibroblasts can lead to excessive extracellular matrix (ECM) production and cardiac fibrosis. In turn, the ECM produced can potentially activate CFs via distinct…

Two forms of long-term potentiation in area CA1 activate different signal transduction cascades.

1. The effects of protein kinase inhibitors on N-methyl-D-aspartate (NMDA)-receptor-mediated, voltage-dependent calcium channel (VDCC)-mediated, and

Tags: 1996, Animals, Cavus I, Hippocampus/drug effects/*physiology, Journal of neurophysiology, Long-Term Potentiation/drug effects/*physiology, Nifedipine/pharmacology, Rats, Signal Transduction/drug effects/*physiology, Teyler T

Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure.

BACKGROUND: Alcohol consumption during pregnancy is a significant public health problem and can result in a continuum of adverse outcomes to the fetus known as fetal alcohol spectrum disorders (FASD). Subjects with FASD show significant neurological…

TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals.

The phenotypic switch underlying the differentiation of cardiac fibroblasts into hypersecretory myofibroblasts is critical for cardiac remodeling following myocardial infarction. Myofibroblasts facilitate wound repair in the myocardium by secreting…

Triethyltin exposure suppresses synaptic transmission in area CA1 of the rat hippocampal slice.

To examine the effects of TET on the electrophysiology of area CA1 of hippocampus, hippocampal slices were obtained from adult hooded rats and were maintained in vitro using standard techniques. Stimulating and recording electrodes were placed in the…

Tags: 1988, Animals, Evoked Potentials/drug effects, Female, Fountain S B, Hennes S K, Hippocampus/drug effects/*pathology/physiology, In Vitro Techniques, Neurotoxicology and teratology, Pyramidal Tracts/drug effects/*pathology/physiology, Rats, Synapses/drug effects/*physiology, Synaptic Transmission/*drug effects, Teyler T J, Ting Y L, Trialkyltin Compounds/*toxicity, Triethyltin Compounds/*toxicity

Trianthema portulacastrum Linn. exerts chemoprevention of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats.

Due to limited treatment options for advanced-stage metastatic breast cancer, a high priority should be given to develop non-toxic chemopreventive drugs. The value of various natural and dietary agents to reduce the risk of developing breast cancer…

Trianthema portulacastrum Linn. displays anti-inflammatory responses during chemically induced rat mammary tumorigenesis through simultaneous and differential regulation of NF-kappaB and Nrf2 signaling pathways.

Trianthema portulacastrum, a medicinal and dietary plant, has gained substantial importance due to its various pharmacological properties, including anti-inflammatory and anticarcinogenic activities. We have recently reported that a characterized T.…

TRENDS IN PLACE PREFERENCE CONDITIONING WITH A CROSS-INDEXED BIBLIOGRAPHY, 1957-1991

The purpose of this work is to present a perspective of the conditioned place preference (CPP) test by offering an overview of the empirical research from 1957-1991. The intent is not to extensively analyze the controversies inherent to any…

Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.

The gene encoding cholesterol 7alpha-hydroxylase (CYP7A), the rate-limiting enzyme in bile acid synthesis, is transcriptionally regulated by bile acids and hormones. Previously, we have identified two bile acid response elements (BARE) in the…

Tags: *Receptors, *Transcriptional Activation, 1998, Animals, Base Sequence, Bile Acids and Salts/biosynthesis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, DNA/metabolism, Galli G, Genes, Genetic, Hepatocyte Nuclear Factor 4, Hormones/*physiology, Journal of lipid research, Luciferases/genetics, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid, Oligonucleotide Probes/metabolism, Phosphoproteins/metabolism, Promoter Regions, Rats, Receptors, Repetitive Sequences, Reporter, Retinoic Acid/metabolism, Retinoid X Receptors, Sadeghpour A, Site-Directed, Steroid, Stroup D, Transcription Factors/metabolism, Tumor Cells

Topographic organization of efferent projections of medial frontal cortex.

By using fluorescent retrograde tracers, we compared efferent projections of the medial frontal cortex to two subcortical areas: the superior colliculus, a somatic motor area, and the laterodorsal tegmental nucleus, a visceral motor area. Neurons…

Tags: 1993, Animals, Brain Mapping/*methods, Brain research bulletin, Efferent Pathways/physiology, Female, Fluorescent Dyes, Frontal Lobe/*physiology, Male, Microinjections, Rats, Sprague-Dawley, Stuesse S L, Superior Colliculi/physiology, Tegmentum Mesencephali/physiology, Zeng D

Time-dependent effect of ethanol upon discrimination behavior.

The discriminative stimulus properties produced by ethanol were employed to demonstrate differences in discriminative performance over time in rats trained at different postinjection times. Thus, one group of rats was trained to discriminate between…

Tags: 1989, Alcohol (Fayetteville, N.Y.), Animals, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Inbred Strains, Male, Rats, Schechter M D, Time Factors

Time and dose dependency of the suppression of pulmonary metastases of rat mammary cancer by amiloride.

Amiloride is an inhibitor of urokinase plasminogen activator (uPA), an essential component of the plasminogen/plasmin enzyme system. Inhibition of uPA prevents the conversion of plasminogen to tumor cell surface bound plasmin which is required for…

Therapeutic Strategies To Hasten The Resolution Of Pulmonary Edema

The role of the N-terminal and mid-region residues of substance P in regulating functional selectivity at the tachykinin NK1 receptor.

Previous studies have shown that tachykinin peptide ligands of the tachykinin NK1 receptor exhibit functional selectivity with respect to signal activation and desensitization. The differences are most dramatic between the naturally occurring…

The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex.

The purpose of the present study was to improve our understanding of the role of NMDA receptors in neocortical synaptic plasticity. In slices of rat visual cortex the field potential elicited in layer III in response to white matter stimulation…

The role of dopamine and serotonin receptors in the mediation of the ethanol interoceptive cue.

The drug discrimination paradigm was used to evaluate the contribution of dopamine or serotonin receptors in the mediation of the stimulus properties of ethanol. Briefly, rats were trained to discriminate between ethanol (600 mg/kg, IP) and water…

Tags: 1988, Animals, Conditioning, Cues, Discrimination (Psychology)/*physiology, Dopamine/drug effects/*physiology, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Inbred Strains, Male, Operant/physiology, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Serotonin/drug effects/*physiology, Signs S A

The re-expression of two myosin heavy chains in regenerated rat muscle spindles.

The vascular supply and tendons of the extensor digitorum longus (EDL) muscles of two adult rats were unilaterally severed and the muscles were allowed to regenerate for 40 days. Serial frozen sections of muscle grafts were cut and stained for…

Tags: *Gene Expression Regulation, *Regeneration, 1989, Afferent/*physiology, Animals, Fei C, Female, Immunohistochemistry, Inbred F344, Muscle Denervation, Muscles/innervation/*metabolism, Myosins/*metabolism, Neurons, Neuroscience letters, Rats, Walro J M

The opposing effects of retinoic acid and phorbol esters converge to a common response element in the promoter of the rat cholesterol 7 alpha-hydroxylase gene (CYP7A).

The activity of the rat CYP7A/luciferase reporter gene was increased five-fold by all-trans retinoic acid (atRA) or 9-cis retinoic acid (9cRA) in transient transfection assay in HepG2 cells. Cotransfection with retinoid X receptor (RXR) stimulated…

The noradrenergic component contributing to spinal fentanyl-induced antinociception is supraspinally mediated.

1. Male Sprague-Dawley rats were fitted with intrathecal (i.t.) and intracerebroventricular (i.c.v.) catheters. Fentanyl was injected either i.t. or i.c.v., and the antinociceptive efficacy of fentanyl was evaluated using the tail-flick…

The NMDA receptor antagonist MK-801 produces ethanol-like discrimination in the rat.

Two groups of rats, one derived from N/Nih stock and the second from the (putatively) serotonin-compromised Fawn-Hooded line, were trained to discriminate ethanol from its vehicle in a drug discrimination paradigm. Once each of the two groups…

Tags: 1993, Alcohol (Fayetteville, N.Y.), Animals, Department of Anatomy & Neurobiology, Discrimination Learning/*drug effects, Dizocilpine Maleate/*pharmacology, Ethanol/*pharmacology, Gordon T L, McBurney D M, Meehan S M, N-Methyl-D-Aspartate/physiology, NEOMED College of Medicine, Rats, Receptors, Schechter M D

The modulation of long-term potentiation by delta-9-tetrahydrocannabinol in the rat hippocampus, in vitro.

The duration of long-term potentiation (LTP) of the CA1 evoked field potential in rat hippocampal slices was significantly modulated by pre-treatment of slices with delta-9-tetrahydrocannabinol (THC) added to the incubation media. The three THC doses…

Tags: 1987, Animals, Brain research bulletin, Dronabinol/*pharmacology, Evoked Potentials/drug effects, Hippocampus/*drug effects/physiology, In Vitro Techniques, Kinetics, Male, Nowicky A V, Pyramidal Tracts/drug effects/physiology, Rats, Teyler T J, Time Factors, Vardaris R M

The mechanistic basis for the disparate effects of angiotensin II on coronary collateral growth.

OBJECTIVE: We hypothesize that controversial effects of angiotensin II (Ang II) are attributable to its regulation of reactive oxygen species (ROS) and

The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis.

Although there are multiple rodent models of the metabolic syndrome, very few develop vascular complications. In contrast, the JCR:LA-cp rat develops both metabolic syndrome and early atherosclerosis in predisposed areas. However, the pathology of…

The effects of pregnancy and estrogen on the expression of calcitonin gene-related peptide (CGRP) in the uterine cervix, dorsal root ganglia and spinal cord.

Before parturition the uterine cervix undergoes a ripening process ("softens" and dilates) to allow passage of the fetus at term. The exact mechanism(s) responsible for cervical ripening are unknown, though a role for peptidergic sensory neurons is…

The effects of nicotine on dopamine and DOPAC output from rat striatal tissue.

The effects of varying doses of nicotine infusion upon spontaneous (basal) and subsequent potassium chloride-stimulated dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) output from superfused corpus striatal tissue fragments of male rats were…

Tags: 1998, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Amphetamine/pharmacology, Anderson L I, Animals, Central Nervous System Stimulants/pharmacology, Corpus Striatum/*drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Dose-Response Relationship, Drug, European journal of pharmacology, Ganglionic Stimulants/administration & dosage/*pharmacology, Male, Nicotine/administration & dosage/*pharmacology, Potassium Chloride/pharmacology, Rats, Sprague-Dawley

The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats.

In the present report, the peptides arginine vasopressin (AVP), oxytocin (OXT) or their respective antagonists were infused bilaterally into the olfactory bulb to assess their effects upon recognition responses. Recognition responses were determined…

Tags: *Social Behavior, 1998, Aging, Animals, Arginine Vasopressin/*pharmacology, Discrimination Learning/*drug effects, Dluzen D E, Engelmann M, Landgraf R, Male, Memory/drug effects, Muraoka S, Olfactory Bulb/*drug effects, Oxytocin/*pharmacology, Peptides, Rats

The Effects Of Carbon Dioxide Pneumoperitoneum On Seeding Of Tumor In Port Sites In A Rat Model

OBJECTIVES: The use of laparoscopic surgical techniques for the resection of intraperitoneal malignancies has been rapidly increasing in recent years; concomitantly, tumor recurrences at trocar sites have also been reported. These reports bring into…

Tags: 1999, American journal of obstetrics and gynecology, colon cancer, Dulai R M, Holda S, Hopkins M P, implantation, Journal Article or Conference Abstract Publication, Laparoscopy, Obstetrics & Gynecology, Occhino A, Ovarian cancer, Rats, Recurrence, tumor implantation

The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus.

The effects of phenobarbital, phenytoin, and valproic acid on pharmacologically isolated NMDA-EPSP, AMPA-EPSP, and GABA-IPSPs were examined in rat hippocampal slices. Phenobarbital (0.05 mg/ml) had no effect on the NMDA-EPSP, but decreased the slope…

Tags: 1997, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/*pharmacology, Animals, Anticonvulsants/*pharmacology, Brain research bulletin, Brown-Croyts L M, Electrophysiology, gamma-Aminobutyric Acid/*pharmacology, Hippocampus/*drug effects/physiology, Inbred Strains, Ko G Y, Male, N-Methylaspartate/*pharmacology, Phenobarbital/pharmacology, Phenytoin/pharmacology, Rats, Teyler T J, Valproic Acid/pharmacology

The effects of anticonvulsant drugs on long-term potentiation (LTP) in the rat hippocampus.

In hippocampal CA1 area, there are at least two forms of long-term potentiation (LTP): one is N-methyl-D-aspartate (NMDA) receptor-dependent LTP (NMDA LTP), which is induced with a 25 Hz tetanus and blocked by 50 microM

The effects of aging on spinal neurochemistry in the rat.

The purpose of this study was to investigate how the aging process alters the basal levels of serotonin, norepinephrine, dopamine, and their respective metabolites in the spinal cord using high-performance liquid chromatography and electrochemical…

Tags: 1997, Aging/*metabolism, Animals, Brain research bulletin, Chromatography, Crisp T, Dopamine/metabolism, Electrochemistry/methods, Gordon T L, High Pressure Liquid, Inbred F344, King M A, Ko M L, Male, Norepinephrine/metabolism, Rats, Serotonin/metabolism, Spinal Cord/*metabolism

The effects of aging on mu and delta opioid receptors in the spinal cord of Fischer-344 rats.

Previous research has demonstrated that the antinociceptive efficacy of opioids decreases with advancing age. This study utilized radioligand binding techniques to determine if this decline is due to a change in the receptor density (Bmax) and/or…

The effect of various insufflation gases on tumor implantation in an animal model.

OBJECTIVE: The expanded use of laparoscopy has led to reports of tumor dissemination and spread to laparoscopic port sites. We previously showed that carbon dioxide insufflation produced tumor dissemination compared with laparotomy. It is unknown…

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