Browse Items · NEOMED Bibliography Database

Reflection in/and writing: pedagogy and practice in medical education.

During the past decade, "reflection" and "reflective writing" have become familiar terms and practices in medical education. The authors of this article argue that the use of the terms requires more thoughtfulness and precision, particularly because…

Tags: *Learning, *Professional Competence, *Writing, 2012, Academic medicine : journal of the Association of American Medical Colleges, Curriculum/*standards, Department of Family & Community Medicine, Department of Internal Medicine, Education, Garden Rebecca, Humans, Jones Therese, Medical/*methods, Medical/*psychology, NEOMED College of Medicine, Students, Teaching/*methods, Wear Delese, Zarconi Joseph

Cultural competency 2.0: exploring the concept of "difference" in engagement with the other.

Cultural competency efforts have received much attention in medical education. Most efforts focus on the acquisition of knowledge and skills about various groups based on race and ethnic identity, national origins, religion, and the like. The authors…

The scope and variety of combined baccalaureate-MD programs in the United States.

The landscape of combined baccalaureate-MD programs has changed substantially in the last two decades but has not been documented in detail. The authors review the current state of these programs and discuss opportunities for future study of their…

The effect of race on outcomes of surgical or nonsurgical treatment of patients in the Spine Patient Outcomes Research Trial (SPORT).

STUDY DESIGN: Retrospective review of the data collected prospectively through the Spine Patient Outcomes Research Trial (SPORT). OBJECTIVE: To determine the effect that race or ethnicity had on outcomes after spine surgery in the 3 arms of SPORT.…

Incidence and epidemiology of cervical radiculopathy in the United States military: 2000 to 2009.

STUDY DESIGN: Epidemiological review of a prospectively collected military database. OBJECTIVE: This investigation sought to determine the incidence of cervical radiculopathy and risk factors for its development within the population of the United…

Characterization of the incidence and risk factors for the development of lumbar radiculopathy.

STUDY DESIGN: Epidemiological study of a prospectively collected database. OBJECTIVES: This investigation sought to evaluate the incidence of symptomatic lumbar radiculopathy, and identify risk factors for its development, among individuals serving…

Benzodiazepine-associated atrioventricular block.

Dysrhythmias, although common in overdose situations, are not often seen after benzodiazepine exposures. We report two cases of transient atrioventricular block after benzodiazepine misuse. Case 1 is a 4-year-old boy who was found unresponsive after…

Tinnitus and underlying brain mechanisms.

PURPOSE OF REVIEW: Tinnitus is the sensation of hearing a sound when no external auditory stimulus is present. Most individuals experience tinnitus for brief, unobtrusive periods. However, chronic sensation of tinnitus affects approximately 17% (44…

Cell transplantation as an initiator of endogenous stem cell-based tissue repair.

PURPOSE OF REVIEW: The aim of this review is to summarize recent findings of endogenous cell-based tissue repair triggered by a multitude of approaches, especially stem cell therapy. RECENT FINDINGS: The emerging evidence has demonstrated that an…

Tags: *Regeneration, *Stem Cell Transplantation, *Stem cells, *Wound Healing, 2012, Caplan Arnold I, Cell Transplantation, Current opinion in organ transplantation, Department of Integrative Medical Sciences, Dong Feng, Humans, Mesenchymal Stem Cell Transplantation, NEOMED College of Medicine

Are stem cells the teacher or the student?

PURPOSE OF REVIEW: Stem cell-based therapies for preventing and treating chronic end-organ dysfunction have captured the imagination of the lay public and spurred scientific and clinical development in multiple disciplines and disease states. The…

Tags: *Stem Cell Transplantation, *Stem cells, 2012, Bone Marrow/physiopathology, Current opinion in organ transplantation, Humans, Penn Marc S, Regeneration, Tissue Engineering, Wounds and Injuries/*physiopathology/*surgery

Cutaneous abscesses in children: epidemiology in the era of methicillin-resistant Staphylococcus aureus in a pediatric emergency department.

OBJECTIVE: Skin and soft tissue infections are a major public health issue. Previous literature suggests a recurrence rate of 4% in children. The purpose of this study was to examine the epidemiology, body location, and history of previous infections…

Shear wave ultrasound elastography of the prostate: initial results.

PURPOSE: This prospective study was to evaluate shear wave elastography (SWE) in the detection of prostate cancer (PC). METHODS: Patients scheduled for a transrectal ultrasound (TRUS) biopsy of the prostate because of elevated prostate-specific…

Benign hyperostotic mass of the frontal bone.

Diagnosis of a slow-growing mass of the cranium can be challenging. We present a rare clinical report of a 19-year-old woman with a unilateral mass of the frontal bone. Pathological diagnosis was hyperostosis, which is extremely rare in this age…

Tags: 2012, Bone Transplantation/methods, Chen Oriana I, Diagnosis, Differential, Female, Frontal Bone/diagnostic imaging/surgery, Humans, Hyperostosis Frontalis Interna/*diagnosis, Murthy Ananth S, Osteotomy/methods, The Journal of craniofacial surgery, Tomography, X-Ray Computed, Young Adult

J-LEAPS peptide and LEAPS dendritic cell vaccines.

The J-LEAPS vaccines contain a peptide from beta-2-microglobulin covalently attached to disease-related peptides of 8-30 amino acids which contain a T cell epitope. The J-LEAPS vaccines can initiate a protective Th1 immune response or modulate an…

Tags: 2012, Antigens/genetics/*immunology, Autoimmune Diseases/therapy, beta 2-Microglobulin/genetics/*immunology, Communicable Disease Control/methods, Dendritic Cells/*immunology, Humans, Immunotherapy/*methods, Microbial biotechnology, Neoplasms/therapy, Recombinant Fusion Proteins/genetics/immunology, Rosenthal Ken S, Taylor Patricia, Zimmerman Daniel H

Two GABAA responses with distinct kinetics in a sound localization circuit.

The temporal characteristics and functional diversity of GABAergic inhibition are determined by the spatiotemporal neurotransmitter profile, intrinsic properties of GABAA receptors, and other factors. Here, we report two distinct GABAA responses and…

Tags: *Sound, 2012, Animals, Chick Embryo, Chickens, Department of Anatomy & Neurobiology, Female, GABA-A/*physiology, gamma-Aminobutyric Acid/metabolism, Lu Yong, Male, NEOMED College of Medicine, Neurons/*metabolism, Pitch Discrimination, Receptors, Sound Localization/*physiology, Synapses/physiology, Tang Zheng-Quan, The Journal of physiology

Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways.

Hyperleptinemia, characteristic of diabetes and a hallmark feature of human obesity, contributes to the increased risk of atherosclerotic complications. However, molecular mechanisms mediating leptin-induced atherogenesis and gene expression in…

Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels.

We have previously shown transient receptor potential vanilloid subtype 1 (TRPV1) channel-dependent coronary function is compromised in pigs with metabolic syndrome (MetS). However, the mechanisms through which TRPV1 channels couple coronary blood…

Tags: 13-dienoic Acid/pharmacology, 15-Hydroxy-11 alpha, 2012, 9 alpha-(epoxymethano)prosta-5, American journal of physiology. Heart and circulatory physiology, Anilides/pharmacology, Animals, Bratz Ian N, Capsaicin/analogs & derivatives/pharmacology, Cinnamates/pharmacology, Coronary Vessels/drug effects/*metabolism/physiopathology, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Cardiomyopathies/drug therapy/*metabolism, Enzyme Inhibitors/pharmacology, Guarini Giacinta, Inbred C57BL, Kmetz John G, Large-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors/*metabolism, Male, Meszaros J Gary, Mice, Microvessels/drug effects/physiopathology, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Nitric Oxide/*metabolism, Ohanyan Vahagn A, Peptides/pharmacology, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/agonists/antagonists & inhibitors/biosynthesis/*metabolism, Type 2/drug therapy/*metabolism, Vasoconstrictor Agents/pharmacology, Vasodilation/drug effects

The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats.

There is a significant unmet need for treatments of patients with acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). The primary mechanism that leads to resolution of alveolar and pulmonary edema is active vectorial Na(+) and…

Tags: 2012, Acute Lung Injury/*drug therapy/metabolism/pathology, Adenosine A2A/*chemistry, Adenosine/*analogs & derivatives/therapeutic use, American journal of physiology. Lung cellular and molecular physiology, Amiloride/pharmacology, Animals, Biological Transport, Bronchoalveolar Lavage, Cystic Fibrosis Transmembrane Conductance Regulator/metabolism, Endotoxemia/*drug therapy/metabolism/microbiology, Epithelial Sodium Channel Blockers, Epithelial Sodium Channels/metabolism, Escherichia coli, Escherichia coli Infections/drug therapy/metabolism/microbiology, Folkesson Hans G, Immunoblotting, Kuzenko Stephanie R, Lipson David A, Male, Matthay Michael A, Pneumonia/*drug therapy/metabolism/microbiology, Pulmonary Alveoli/cytology/*drug effects/metabolism, Pulmonary Edema/*drug therapy/metabolism/pathology, Rats, Receptor, Respiratory Physiological Phenomena, Simmons Mark A, Sodium Channel Blockers/pharmacology, Sprague-Dawley, Triazoles/*therapeutic use

A novel coding mechanism for social vocalizations in the lateral amygdala.

The amygdala plays a central role in evaluating the significance of acoustic signals and coordinating the appropriate behavioral responses. To understand how amygdalar responses modulate auditory processing and drive emotional expression, we assessed…

Bile Acid signaling in liver metabolism and diseases.

Obesity, diabetes, and metabolic syndromes are increasingly recognized as health concerns worldwide. Overnutrition and insulin resistance are the major causes of diabetic hyperglycemia and hyperlipidemia in humans. Studies in the past decade provide…

Tags: 2012, Chiang John Y L, Department of Integrative Medical Sciences, Journal of lipids, Li Tiangang, NEOMED College of Medicine

Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats.

OBJECTIVE: We have previously found abrogated ischemia-induced coronary collateral growth in Zucker obese fatty (ZOF) rats compared with Zucker lean (ZLN) rats. Because ZOF rats have structural abnormalities in their mitochondria suggesting…

Tags: 2012, Animal, Animals, Antioxidants/*pharmacology, Arteriosclerosis, thrombosis, and vascular biology, Chilian William M, Collateral Circulation/*drug effects/physiology, Coronary Vessels/drug effects/*growth & development, Department of Integrative Medical Sciences, Disease Models, Guarini Giacinta, Hafemeister Jennifer, Heart/*drug effects/physiology, Lipid Peroxidation/drug effects/physiology, Lipid Peroxides/metabolism, Male, Metabolic Syndrome/*metabolism/physiopathology, Mitochondria, Mitochondrial Proteins/metabolism, Murphy Michael P, NEOMED College of Medicine, Obesity/*metabolism/physiopathology, Ohanyan Vahagn, Organophosphorus Compounds/pharmacology, Oxidative Stress/*drug effects/physiology, Piperidines/pharmacology, Pung Yuh Fen, Rats, Reactive Oxygen Species/metabolism, Rocic Petra, Smith Robin A J, Ubiquinone/pharmacology, Yin Liya, Zucker

Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth.

RATIONALE: A well-developed coronary collateral circulation improves the morbidity and mortality of patients following an acute coronary occlusion. Although regenerative medicine has great potential in stimulating vascular growth in the heart, to…

Tags: *Collateral Circulation, *Coronary Circulation, 2012, Animal, Animals, Bailey Erin, Biomarkers/metabolism, Cell Differentiation, Cell Lineage, Cells, Chilian William M, Circulation research, Coronary Occlusion/genetics/metabolism/pathology/physiopathology/*surgery, Coronary Vessels/metabolism/pathology/*physiopathology, Cultured, Delucia Angelo, Department of Integrative Medical Sciences, Developmental, Disease Models, Endothelial Cells/metabolism/pathology/*transplantation, Enrick Molly, Epigenesis, Gene Expression Profiling, Gene Expression Regulation, Genetic, Guarini Giacinta, Induced Pluripotent Stem Cells/metabolism/*transplantation, Kolz Christopher L, Mice, Muscle, Myocytes, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Physiologic, Pung Yuh Fen, Rats, Regenerative Medicine/methods, Regional Blood Flow, Reverse Transcriptase Polymerase Chain Reaction, SCID, Smooth, Smooth Muscle/metabolism/pathology/*transplantation, Sprague-Dawley, Stevanov Kelly, Teratoma/metabolism/pathology, Time Factors, Transcription Factors/genetics/metabolism, Transduction, Vascular/metabolism/pathology/*physiopathology, Yin Liya

Absence of type VI collagen paradoxically improves cardiac function, structure, and remodeling after myocardial infarction.

RATIONALE: We previously reported that type VI collagen deposition increases in the infarcted myocardium in vivo. To date, a specific role for this nonfibrillar collagen has not been explored in the setting of myocardial infarction (MI). OBJECTIVE:…

Myocardial CXCR4 expression is required for mesenchymal stem cell mediated repair following acute myocardial infarction.

BACKGROUND: Overexpression of stromal cell-derived factor-1 in injured tissue leads to improved end-organ function. In this study, we quantify the local trophic effects of mesenchymal stem cell (MSC) stromal cell-derived factor-1 release on the…

Antitumor effect of novel gallium compounds and efficacy of nanoparticle-mediated gallium delivery in lung cancer.

The widespread application of gallium (Ga) in cancer therapy has been greatly hampered by lack of specificity resulting in poor tumor accumulation and retention. To address the challenge, two lipophilic gallium (III) compounds (gallium hexanedione;…

Tags: 2012, Antineoplastic Agents/*administration & dosage/chemistry/pharmacokinetics, Biocompatible Materials/administration & dosage/chemistry/pharmacokinetics, Cell Line, Cell Survival/drug effects, Coordination Complexes/*administration & dosage/chemistry/pharmacokinetics, Department of Pharmaceutical Sciences, Drug Carriers/administration & dosage/chemistry, Drug Stability, Endocytosis/drug effects, Gallium/*administration & dosage/chemistry/pharmacokinetics, Hemolysis/drug effects, Humans, Journal of biomedical nanotechnology, Lung Neoplasms/*drug therapy/metabolism, Materials Testing, Membrane Potential, Mitochondrial/drug effects, Nanoparticles/*administration & dosage/chemistry, NEOMED College of Pharmacy, Oyewumi Moses O, Particle Size, Platelet Aggregation/drug effects, Reactive Oxygen Species/metabolism, Transferrin/chemistry/pharmacology, Tumor, Wehrung Daniel

Biocompatibility, efficacy and biodistribution of Gelucire-stabilized nanoparticles engineered for docetaxel delivery.

Docetaxel is a potent anticancer agent that will benefit greatly from alternative delivery systems that can overcome several reported adverse effects due to the drug itself and/or the solvent system in the current clinical formulation. In this…

Tags: *Biocompatible Materials, *Nanoparticles, 2012, Animals, Antineoplastic Agents/*administration & dosage/pharmacokinetics/pharmacology, Bi Lipeng, Department of Pharmaceutical Sciences, Docetaxel, Geldenhuys Werner J, Journal of nanoscience and nanotechnology, Macrophage Activation/drug effects, NEOMED College of Pharmacy, Oyewumi Moses O, Platelet Aggregation/drug effects, Rats, Reactive Oxygen Species/metabolism, Taxoids/*administration & dosage/pharmacokinetics/pharmacology, Tissue Distribution, Wehrung Daniel

Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice.

Farnesoid X receptor (FXR) is known to play important regulatory roles in bile acid, lipid, and carbohydrate metabolism. Aged (\textgreater12 months old) Fxr(-/-) mice also develop spontaneous liver carcinomas. In this report, we used three mouse…

Development of GPCR modulation of GABAergic transmission in chicken nucleus laminaris neurons.

Neurons in the nucleus laminaris (NL) of birds act as coincidence detectors and encode interaural time difference to localize the sound source in the azimuth plane. GABAergic transmission in a number of CNS nuclei including the NL is subject to a…

Tags: *Synaptic Transmission, 2012, Animals, Brain/*cytology, Chickens/*metabolism, Department of Anatomy & Neurobiology, G-Protein-Coupled/*metabolism, GABA-A/metabolism, GABA-B/metabolism, gamma-Aminobutyric Acid/*metabolism, Lu Yong, Metabotropic Glutamate/metabolism, NEOMED College of Medicine, Neurons/*metabolism, Patch-Clamp Techniques, PloS one, Receptors, Synapses/metabolism, Tang Zheng-Quan

Diminished behavioral and neural sensitivity to sound modulation is associated with moderate developmental hearing loss.

The acoustic rearing environment can alter central auditory coding properties, yet altered neural coding is seldom linked with specific deficits to adult perceptual skills. To test whether developmental hearing loss resulted in comparable changes to…

Tags: *Attention, *Behavior, 2012, Afferent/pathology, Animal, Animals, Conductive/pathology/*physiopathology, Department of Anatomy & Neurobiology, Female, Gerbillinae, Hearing Loss, Kelly Jack B, Male, NEOMED College of Medicine, Neurons, PloS one, Rosen Merri J, Sanes Dan H, Sarro Emma C

Social vocalizations of big brown bats vary with behavioral context.

Bats are among the most gregarious and vocal mammals, with some species demonstrating a diverse repertoire of syllables under a variety of behavioral contexts. Despite extensive characterization of big brown bat (Eptesicus fuscus) biosonar signals,…

Tags: *Animal Communication, *Behavior, 2012, Acoustics, Animal, Animals, Chiroptera/*physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Electrocardiography, Faure Paul A, Gadziola Marie A, Grimsley Jasmine M S, NEOMED College of Medicine, PloS one, Wenstrup Jeffrey J

Curcumin and neurodegenerative diseases: a perspective.

INTRODUCTION: Curcumin, a dietary polyphenol found in the curry spice turmeric, possesses potent antioxidant and anti-inflammatory properties and an ability to modulate multiple targets implicated in the pathogenesis of chronic illness. Curcumin has…

Tags: 2012, Animals, Bishayee Anupam, Carroll Richard T, Curcumin/adverse effects/pharmacokinetics/*pharmacology/*therapeutic use, Darvesh Altaf S, Department of Pharmaceutical Sciences, Drug Evaluation, Expert opinion on investigational drugs, Geldenhuys Werner J, Humans, NEOMED College of Pharmacy, Neurodegenerative Diseases/*drug therapy/metabolism, Neuroprotective Agents/adverse effects/pharmacokinetics/*pharmacology/*therapeutic use, Novotny Nicholas A, Oxidative Stress/drug effects, Preclinical, Van der Schyf Cornelis J

Novel models for assessing blood-brain barrier drug permeation.

INTRODUCTION: The blood-brain barrier (BBB) is a selectively permeable micro-vascular unit which prevents many central nervous system (CNS)-targeted compounds from reaching the brain. A significant problem in CNS drug development is the ability to…

Tags: *Capillary Permeability, 2012, Allen David D, Animal, Animals, Blood-Brain Barrier/*metabolism, Bloomquist Jeffrey R, Drosophila melanogaster/metabolism, Expert opinion on drug metabolism & toxicology, Geldenhuys Werner J, Grasshoppers/metabolism, High-Throughput Screening Assays, Humans, Models, Pharmaceutical Preparations/*metabolism, Zebrafish/metabolism

The curious case of Cuba.

As health professionals in the United States consider how to focus health care and coverage to ensure better, more equitable patient and population health outcomes, the experience of Cuba's National Health System over the last 5 decades may provide…

Tags: 2012, American journal of public health, Community Assessment – Utilization, Community Health Services, Community Health Services/standards, COST control, Cuba, Delivery of Health Care, Family Practice/education/standards, Health Care Delivery – History – Cuba, Health Personnel – Education, Health Planning Guidelines, Health Policy, HEALTH risk assessment, Health Services Accessibility, Health Status, Health Status Indicators, Health Status Indicators – Utilization, Humans, Integrated/*organization & administration, Keck C William, MEDICAL care – Cuba, MEDICAL care – History, Medical education, National Health Programs – Trends – Cuba, National Health Programs/economics/*organization & administration/trends, NATIONAL health services – Cuba, NURSE & physician, Nurse-Physician Relations, ORGANIZATIONAL change, Outcome Assessment (Health Care), Preventive Health Care, Preventive Health Services, PUBLIC sector, Quality Assurance, Quality Improvement – Methods, Reed Gail A, State Medicine/organization & administration, United States, Universal Health Insurance/economics/standards

Natural products of dietary origin as lead compounds in virtual screening and drug design.

Natural products have been found to be useful in the treatment of several diseases across the ages. In this article, we review the use of natural products, obtained from dietary sources, as lead compounds in developing novel therapeutic agents. These…

Tags: *Biological Products/pharmacology, *Drug Design, 2012, Animals, Bishayee Anupam, Caffeine/pharmacology, Carroll Richard T, Curcumin/pharmacology, Current pharmaceutical biotechnology, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diet, Geldenhuys Werner J, Genistein/pharmacology, Humans, NEOMED College of Pharmacy, Resveratrol, Stilbenes/pharmacology

Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis.

Hepatocellular carcinoma (HCC), one of the most common cancers in the world, is a leading cause of cancerrelated mortality. HCC develops most frequently in the background of oxidative stress and chronic hepatic inflammation due to viral infections,…

Curcumin and liver cancer: a review.

Primary liver cancer, also known as hepatocellular carcinoma (HCC), is one of the most lethal cancers having worldwide prevalence. Although most HCC cases are reported in the developing countries of Asia and Africa, there has been an alarming…

Tags: 2012, Aggarwal Bharat B, Animals, Anti-Inflammatory Agents/therapeutic use, Anticarcinogenic Agents/*therapeutic use, Antineoplastic Agents, Antioxidants/therapeutic use, Bishayee Anupam, Carcinoma, Curcumin/*therapeutic use, Current pharmaceutical biotechnology, Darvesh Altaf S, Department of Pharmaceutical Sciences, Hepatocellular/*drug therapy/prevention & control, Humans, Liver Neoplasms/*drug therapy/prevention & control, NEOMED College of Pharmacy, Phytogenic/*therapeutic use

Angiogenesis in hepatocellular carcinoma: a potential target for chemoprevention and therapy.

Hepatocellular carcinoma (HCC) remains one of the most lethal cancers in the world. Since current treatment options including surgical resection and liver transplantation offer limited therapeutic benefits, there exists a need to evaluate novel…

Tags: 2012, Angiogenesis Inhibitors/*therapeutic use, Animals, Bishayee Anupam, Carcinoma, Current cancer drug targets, Darvesh Altaf S, Department of Pharmaceutical Sciences, Hepatocellular/blood supply/pathology/*prevention & control, Humans, Liver Neoplasms/blood supply/pathology/*prevention & control, NEOMED College of Pharmacy, Neovascularization, Pathologic/*prevention & control

Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC), considered to be one of the most lethal cancers with almost \textgreater 1 million deaths reported annually worldwide, remains a devastating disease with no known effective cure. Hence, chemopreventive strategies come…

Tags: *Phytotherapy, 2012, Alkylating Agents/toxicity, Animals, Anthocyanins/*therapeutic use, Antioxidants/therapeutic use, Barnes Kendra F, Bhatia Deepak, Bishayee Anupam, Blotting, Carcinoma, Current cancer drug targets, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diet, Diethylnitrosamine/toxicity, Experimental/chemically induced/metabolism/*prevention & control, Glutathione Transferase, Haznagy-Radnai Erzsebet, Hepatocellular/chemically induced/metabolism/*prevention & control, Hohmann Judit, Immunoenzyme Techniques, Lipid Peroxidation/drug effects, Liver Neoplasms, Male, Messenger/genetics, NEOMED College of Pharmacy, NF-E2-Related Factor 2/genetics/*metabolism, Nitric Oxide Synthase Type II/genetics/metabolism, Oxidative Stress/*drug effects, Rats, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Ribes/*chemistry, RNA, Signal Transduction, Sprague-Dawley, Thoppil Roslin J, Tyrosine/analogs & derivatives/metabolism, Western

The blood-brain barrier choline transporter.

Drug delivery to the brain is made difficult by the blood-brain barrier (BBB) which is selectively permeable to organic drug compounds. Several membrane solute and nutrient transporters are expressed in the BBB vasculature, which may be utilized as…

Tags: 2012, Allen David D, Animals, Blood-Brain Barrier/drug effects/*metabolism, Central nervous system agents in medicinal chemistry, Drug Delivery Systems/*methods, Geldenhuys Werner J, Humans, Membrane Transport Proteins/*metabolism, Organic Cation Transport Proteins/metabolism, Organic Cation Transporter 1/metabolism, Organic Cation Transporter 2

A fixed-dose combination of adapalene 0.1%-BPO 2.5% allows an early and sustained improvement in quality of life and patient treatment satisfaction in severe acne.

INTRODUCTION: Acne has a significant negative impact on quality of life (QoL): lack of self-confidence, depressive symptoms and suicidal thoughts. The objective was to assess the impact of an initial and continued therapy in severe acne patients…

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