Browse Items (328 total)
- Tags: Department of Integrative Medical Sciences
Vascular precursor cells in tissue injury repair.
Tags: *Wound Healing, 2017, Animals, Cell Differentiation, Cell Physiology, Cell Proliferation, Chilian William M, Department of Integrative Medical Sciences, Endothelium, Humans, Krieger Jessica, NEOMED College of Medicine, Neovascularization, Physiologic, Regeneration – Physiology, Regeneration/*physiology, Shi Xin, stem cells, Stem Cells – Physiology, Stem Cells/cytology/*physiology, Translational research : the journal of laboratory and clinical medicine, Vascular/cytology, Wound Healing, Yin Liya, Zhang Ping, Zhang Weihong
Cardiac myofibroblast differentiation is attenuated by alpha(3) integrin blockade: potential role in post-MI remodeling.
Tags: 2009, Animals, Bryant Jennifer E, Cell Differentiation/*physiology, Collagen Type VI/*metabolism/physiology, Costic Donald J, Department of Integrative Medical Sciences, Doane Kathleen J, Dockry Michelle, Fibroblasts/*cytology, Immunoblotting, Integrin alpha3/*metabolism, Journal of molecular and cellular cardiology, Koshy John C, Luther Daniel J, Male, Meszaros J Gary, Mohile Monica V, Myocardial Infarction/*metabolism, Myocardium/*cytology, NEOMED College of Medicine, Olson Erik R, Protein Binding, Rats, Shamhart Patricia E
Non-fibrillar collagens: key mediators of post-infarction cardiac remodeling?
Tags: 2010, Animals, Biological, Department of Integrative Medical Sciences, Humans, Journal of molecular and cellular cardiology, Matrix Metalloproteinases/metabolism, Meszaros J Gary, Models, Myocardial Infarction/*metabolism/physiopathology, Myocardium/metabolism/pathology, NEOMED College of Medicine, Non-Fibrillar Collagens/*metabolism, Shamhart Patricia E, Wound Healing/physiology
Coronary collateral growth–back to the future.
Tags: 2012, Chilian William M, Collateral Circulation/*physiology, Coronary Artery Disease/physiopathology/therapy, Coronary Circulation/physiology, Department of Integrative Medical Sciences, Dong Feng, Humans, Journal of molecular and cellular cardiology, Logan Suzanna, Mayorga Maritza, Myocardial Ischemia/physiopathology/therapy, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Penn Marc S, Physiologic/physiology, Pung Yuh Fen, Yin Liya
TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals.
Tags: *Calcium Signaling, *Cell Differentiation, *Mechanotransduction, 2013, Adapala Ravi K, Animals, Cellular, Chilian William M, Department of Integrative Medical Sciences, Extracellular Matrix/metabolism/physiology, Fibroblasts/*physiology, Gene Knockdown Techniques, Journal of molecular and cellular cardiology, Luther Daniel J, Male, Meszaros J Gary, Monoterpenes/pharmacology, Myocardium/cytology, Myofibroblasts/metabolism, NEOMED College of Medicine, Paruchuri Sailaja, Rats, RNA, Small Interfering/genetics, Sprague-Dawley, Thodeti Charles K, Thoppil Roslin J, Transforming Growth Factor beta1/physiology, TRPM Cation Channels/antagonists & inhibitors/metabolism, TRPV Cation Channels/genetics/*metabolism
Overexpressing superoxide dismutase 2 induces a supernormal cardiac function by enhancing redox-dependent mitochondrial function and metabolic dilation.
Tags: 2015, Adenosine Triphosphate/biosynthesis, Animals, Arterial Pressure/drug effects, Bioenergetics, Blood Flow Velocity/drug effects, Cardiac function, Cardiac/drug effects/*enzymology, Catalase/pharmacology, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Department of Integrative Medical Sciences, Echocardiography, Female, Gene Expression, Heart/drug effects/*enzymology, Hydrogen Peroxide/*metabolism/pharmacology, Injections, Intravenous, Journal of molecular and cellular cardiology, Kang Patrick T, Luther Daniel J, Male, Meszaros J Gary, Metabolic dilation, Mice, Mitochondria, Myocardium/*enzymology, Myocytes, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Ohanyan Vahagn, Oxidation-Reduction, Oxygen Consumption/drug effects, Redox regulation, Signal Transduction, Stroke Volume/drug effects, Superoxide dismutase 2 (SOD2), Superoxide Dismutase/*genetics/metabolism, Transgenic, Transgenic mice, Vasodilation/*drug effects
Mitochondrial complex I in the post-ischemic heart: reperfusion-mediated oxidative injury and protein cysteine sulfonation.
Tags: 2018, Chen Chwen-Lih, Chen Yeong-Renn, Complex I, Department of Family & Community Medicine, Department of Integrative Medical Sciences, Journal of molecular and cellular cardiology, Kang Patrick T, Lin Paul, Mitochondrial dysfunction, Myocardial ischemia and reperfusion, NEOMED College of Medicine, Protein cysteine sulfonation, Protein Structure, Zhang Liwen, Zweier Jay L
Inhibition of human papillomavirus type 16 gene expression by nordihydroguaiaretic acid plant lignan derivatives.
Tags: 2000, Antiviral Agents/*pharmacology, Antiviral research, Callahan M, Craigo J, Cultured, DeLucia A L, Department of Integrative Medical Sciences, Female, Gene Expression Regulation, Genetic/drug effects, HIV Long Terminal Repeat/drug effects, Huang R C, Humans, Lignans/chemistry/pharmacology, Masoprocol/*analogs & derivatives/*pharmacology, NEOMED College of Medicine, Papillomaviridae/*genetics, Promoter Regions, Simian virus 40/genetics, Tumor Cells, Viral/*drug effects
Resveratrol inhibition of herpes simplex virus replication.
Tags: 1999, Animals, Antiviral Agents/*pharmacology/toxicity, Antiviral research, Cell Cycle/drug effects, Cell Line, Cercopithecus aethiops, DeLucia A L, Department of Integrative Medical Sciences, Docherty J J, Fu M M, Herpesvirus 1, Herpesvirus 2, Human/*drug effects/physiology, Humans, Immediate-Early Proteins/antagonists & inhibitors/biosynthesis, Limperos R J, Mice, NEOMED College of Medicine, Pokabla C M, Resveratrol, Stiffler B S, Stilbenes/*pharmacology/toxicity, Vero Cells, Virus Latency/drug effects/physiology, Virus Replication/*drug effects/physiology
Stem cells for myocardial regeneration.
Tags: 2011, Animals, Clinical pharmacology and therapeutics, Clinical Trials as Topic/trends, Department of Integrative Medical Sciences, Dong F, Humans, Klein S, Mayorga M E, Myocardial Infarction/pathology/physiopathology/*surgery, NEOMED College of Medicine, Penn M S, Regeneration/*physiology, Regenerative Medicine/*trends, Stem Cell Transplantation/*trends
A metabolic stress-inducible miR-34a-HNF4alpha pathway regulates lipid and lipoprotein metabolism.
Tags: 2015, Animals, Apolipoproteins E/genetics, Atherosclerosis/genetics/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Experimental/genetics/metabolism, Hep G2 Cells, Hepatocyte Nuclear Factor 4/*genetics/metabolism, Humans, Knockout, LDL/genetics, Li Yuanyuan, Lipid Metabolism/*genetics, Lipoproteins/metabolism, Liver/metabolism, Mice, MicroRNAs/*genetics/metabolism, Middle Aged, Nature communications, NEOMED College of Medicine, Non-alcoholic Fatty Liver Disease/*genetics/metabolism, Physiological/*genetics, Receptors, Stress, Triglycerides/*metabolism, Xu Jiesi, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.
Tags: 2016, Adapala R K, Animals, Calcium Signaling/genetics, Cappelli H C, Carcinoma, Cell Line, Cell Proliferation/drug effects, Chilian W M, Cisplatin/administration & dosage, Department of Integrative Medical Sciences, Dudley A C, Endothelium, Gene Expression Regulation, Ghosh K, Humans, Ingber D E, Keshamouni V, Klagsbrun M, Leucine/administration & dosage/analogs & derivatives, Lewis Lung/drug therapy/*genetics/pathology, Meszaros J G, Mice, NEOMED College of Medicine, Neoplastic/drug effects, Neovascularization, Oncogene, Paruchuri S, Pathologic/drug therapy/*genetics/pathology, Sulfonamides/administration & dosage, Thodeti C K, Thoppil R J, TRPV Cation Channels/agonists/biosynthesis/*genetics, Tumor, Vascular Endothelial Growth Factor A/genetics, Vascular/drug effects/*pathology
Thrombospondin-4 mediates TGF-beta-induced angiogenesis.
Tags: 2017, Angiogenesis Inducing Agents/*metabolism, Animals, Cell Movement/drug effects, Cell Proliferation/drug effects, Cells, Chick Embryo, Cultured, Department of Integrative Medical Sciences, Endothelium, Female, Gene Expression Regulation/drug effects, Habib N, Humans, Inbred C57BL, Krukovets I, Male, Mice, Muppala S, Muscle, NEOMED College of Medicine, Neovascularization, Oncogene, Pathologic/drug therapy/metabolism/*pathology, Plow E, Raman P, Signal Transduction/drug effects, Smooth, Stenina-Adognravi O, Thrombospondins/*physiology, Transforming Growth Factor beta/*pharmacology, Vascular/drug effects/metabolism/*pathology, Verbovetsky D, Xiao R, Yendamuri R
Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr (-/-) mice.
TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation.
Tags: 2015, Adapala Ravi K, Animals, Antineoplastic Agents/pharmacology, Cappelli Holly C, Cell Proliferation/drug effects, Department of Integrative Medical Sciences, Dudley Andrew C, Endothelial Cells/drug effects/metabolism, Kondeti Vinay, Leucine/analogs & derivatives/pharmacology, MAP Kinase Signaling System, Meszaros J Gary, Mice, NEOMED College of Medicine, Neoplasms/drug therapy/*metabolism/pathology, Neovascularization, Paruchuri Sailaja, Pathologic/drug therapy, Scientific reports, Sulfonamides/pharmacology, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/drug effects/genetics/*metabolism, Up-Regulation
Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury.
Tags: 2016, Alcoholic/*pathology, Alcohols/*toxicity, Animals, Carboxylic Ester Hydrolases/*metabolism, Chemical and Drug Induced Liver Injury/*pathology, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diet/*adverse effects, Fatty Liver, Gene Expression Regulation, Genetic, Hepatocyte Nuclear Factor 4/*metabolism, Hepatocytes/metabolism, Humans, Inbred C57BL, Jadhav Kavita, Knockout, Li Yuanyuan, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Promoter Regions, Protein Binding, Scientific reports, Xu Jiesi, Xu Yang, Yin Liya, You Min, Zhang Yanqiao
Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE(-/-) mice.
Tags: 2017, Animals, Aorta/drug effects/metabolism, Apolipoproteins E/*metabolism, Atherosclerosis/*drug therapy/metabolism, Chavez Ronaldo J, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Angiopathies/drug therapy/metabolism, Experimental/chemically induced/drug therapy/metabolism, Ganguly Rituparna, Glucose/metabolism, Glycosylation/drug effects, Haney Rebecca, Hyperglycemia/*drug therapy/metabolism, Inbred C57BL, Knockout, Male, Mice, Myocytes, NEOMED College of Medicine, NEOMED Student Publications, Ohanyan Vahagn, Picolinic Acids/*pharmacology, Raman Priya, Sahu Soumyadip, Scientific reports, Shah Shivani, Smooth Muscle/drug effects, Streptozocin/*pharmacology, Thrombospondin 1/*metabolism, Type 1/chemically induced/*drug therapy/metabolism, Yalamanchili Siri
Anti-atherogenic effect of trivalent chromium-loaded CPMV nanoparticles in human aortic smooth muscle cells under hyperglycemic conditions in vitro.
Tags: *Comovirus, 2016, Aorta/*metabolism, Atherosclerosis/*drug therapy/therapy, Azo Compounds/chemistry, Cell Proliferation, Cells, Chlorides/*chemistry, Chromium Compounds/*chemistry, Cultured, Cytokines/metabolism, Czech Tori, Department of Integrative Medical Sciences, Drug Delivery Systems, Electron, Fluorescence, Ganguly Rituparna, Glucose/chemistry, Humans, Hyperglycemia/*metabolism, Lipids/chemistry, Microscopy, Myer Ashley B, Myocytes, Nanoparticles/chemistry, Nanoscale, NEOMED College of Medicine, NF-kappa B/metabolism, Proliferating Cell Nuclear Antigen/chemistry, Raman Priya, Sahu Soumyadip, Smooth Muscle/*metabolism, Spectrophotometry, Steinmetz Nicole F, Transforming Growth Factor beta/metabolism, Transmission, Ultraviolet, Wen Amy M
Orphan nuclear receptor oestrogen-related receptor gamma (ERRgamma) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression.
Tags: 2015, Animals, bile acid, Bile Acids and Salts/metabolism, Cannabinoid, cannabinoid receptors, CB1/agonists/genetics/*metabolism, Cells, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/genetics, cholesterol 7alpha-hydroxylase (CYP7A1), Cultured, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Drug Inverse Agonism, Estrogen/genetics/*metabolism, Ethanol/pharmacology, Gene Expression, Genetic, Glycerides/pharmacology, GSK5182, HEK293 Cells, Hepatocytes/metabolism, Humans, Inbred C57BL, Jeong Won-Il, Kim Don-Kyu, Kim Seong Heon, Knockout, Lee Chul-Ho, Lee In-Kyu, Lee Ji-Min, Liver/*metabolism, Mice, NEOMED College of Medicine, oestrogen-related receptor gamma (ERRgamma), orphan nuclear receptor, Park Seung Bum, Promoter Regions, Rats, Receptor, Receptors, small heterodimer partner (SHP), Sprague-Dawley, The Biochemical journal, Transcription, Zhang Yaochen
A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene.
Tags: 2007, Bile Acids and Salts/metabolism, Carcinoma, Cell Line, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, Enzyme Inhibitors/pharmacology, Gastroenterology, Genetic/drug effects/*physiology, Hepatocellular/*metabolism/pathology, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/drug effects/*metabolism/pathology, Humans, Hydroxamic Acids/pharmacology, Li Tiangang, Liver Neoplasms/*metabolism/pathology, Messenger/metabolism, NEOMED College of Medicine, RNA, Signal Transduction/physiology, Smad3 Protein/metabolism, Transcription, Transforming Growth Factor beta1/*metabolism, Tumor
Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis.
Tags: *angiogenesis, *cysteinyl leukotriene receptors, *endothelial cells, *metastasis, *tumor growth, 2019, Adapala Ravi K, Austen K Frank, Department of Integrative Medical Sciences, Duah Ernest, Kanaoka Yoshihide, Keshamouni Venkateshwar G, Kondeti Vinay, NEOMED College of Medicine, Paruchuri Sailaja, Proceedings of the National Academy of Sciences of the United States of America, Teegala Lakshminarayan Reddy, Thodeti Charles K
Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.
Tags: *DNA-Binding Proteins, *Transcription, 2001, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/genetics, Cultured, Cytochrome P-450 Enzyme System/*genetics, Cytoplasmic and Nuclear/physiology, Department of Integrative Medical Sciences, Genetic, Genetic/physiology, Hepatocyte Nuclear Factor 4, Humans, Molecular Sequence Data, NEOMED College of Medicine, Phosphoproteins/*physiology, Promoter Regions, Receptors, Repressor Proteins/*pharmacology, Steroid 12-alpha-Hydroxylase, Steroid Hydroxylases/*genetics, The Journal of biological chemistry, Transcription Factors/*physiology, Tumor Cells, Zhang M
Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia.
Tags: 2010, Absorption, Anderson Jody, Animals, Biological, Cell Line, Cholesterol/*metabolism, Class B/*genetics/metabolism, Coronary Disease/metabolism, Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, Edwards Peter A, Glucose/metabolism, Gonzalez Frank J, Hepatocyte Nuclear Factor 4/metabolism, Homeostasis, Humans, Lipoproteins/metabolism, Liver/metabolism, Ma Huiyan, Mice, Models, NEOMED College of Medicine, Receptors, Scavenger Receptors, The Journal of biological chemistry, Willson Timothy M, Yin Liya, Zhang Yanqiao
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity.
Tags: *Gene Expression Regulation, 2012, Animals, Bile Acids and Salts/*biosynthesis, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Dietary Fats/administration & dosage/adverse effects, Enzymologic, Epigenesis, Erickson Sandra K, Experimental/genetics/*metabolism, Fasting/metabolism, Francl Jessica M, Genetic/genetics, Glucose/*metabolism/pharmacology, Insulin/*metabolism, Klaassen Curtis D, Li Tiangang, Mice, NEOMED College of Medicine, Obesity/etiology/genetics/*metabolism, Ochoa Adrian, Postprandial Period/genetics, Receptors, Sweetening Agents/pharmacology, The Journal of biological chemistry, Transgenic, Zhang Youcai
Retinoic acid-related orphan receptor alpha regulates diurnal rhythm and fasting induction of sterol 12alpha-hydroxylase in bile acid synthesis.
Tags: 2013, Animals, Bile Acids and Salts/*biosynthesis, Chiang John Y L, Cholesterol, Cholesterol/*biosynthesis/genetics, Circadian Rhythm/*physiology, Department of Integrative Medical Sciences, Diabetes, Diabetes Mellitus, Enzyme Induction/physiology, Fasting/*metabolism, Fatty Liver/drug therapy/genetics/metabolism/pathology, Group F, Hep G2 Cells, Humans, Li Tiangang, Lipid Metabolism, Member 1/genetics/*metabolism, Mice, NEOMED College of Medicine, Non-alcoholic Fatty Liver Disease, Nuclear Receptor Subfamily 1, Nuclear Receptors, Obesity, Pathak Preeti, Phosphorylation/physiology, Protein Kinases/genetics/metabolism, Response Elements/physiology, Steroid 12-alpha-Hydroxylase/*biosynthesis/genetics, The Journal of biological chemistry, Type 2/drug therapy/genetics/metabolism/pathology
Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.
Tags: *bile acid, *bile acid metabolism, *FXR, *Gene Expression Regulation, *GLP-1, *Lipid Metabolism, *liver metabolism, *Non-alcoholic Fatty Liver Disease, *Obesity, *TGR5, *type 2 diabetes, 2017, Animals, Bile Acids and Salts/*biosynthesis/genetics, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Dietary Fats, G-Protein-Coupled/genetics/*metabolism, Glucagon-Like Peptide 1/genetics/metabolism, Glucose/metabolism, Gonzalez Frank, Knockout, Krausz Kristopher W, Lipid Metabolism, Liu Hailiang, Liver/*metabolism, Mice, NEOMED College of Medicine, Obesity/genetics/*metabolism/pathology, Pathak Preeti, Receptors, The Journal of biological chemistry, Xie Cen
A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene.
Tags: *Gene Expression Regulation, 2006, Aged, Amino Acid Motifs, Bile Acids and Salts/metabolism, Cell Line, Cell Nucleus/metabolism, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*chemistry/*genetics, Cultured/metabolism, Department of Integrative Medical Sciences, Enzymologic, Female, Genes, Genetic, Gluconeogenesis, Glutathione Transferase/metabolism, Hepatocyte Nuclear Factor 4/metabolism/*physiology, Hepatocytes/metabolism, Homeodomain Proteins/metabolism/*physiology, Humans, Immunoprecipitation, Li Tiangang, Liver/metabolism, Luciferases/metabolism, Male, Messenger/metabolism, Middle Aged, NEOMED College of Medicine, Phosphoenolpyruvate Carboxykinase (ATP)/metabolism, Plasmids/metabolism, Protein Structure, Reporter, Response Elements, Reverse Transcriptase Polymerase Chain Reaction, RNA, Small Interfering/metabolism, Song Kwang-Hoon, Tertiary, The Journal of biological chemistry, Time Factors, Transcription, Transcriptional Activation, Transfection, Tumor Suppressor Proteins, Two-Hybrid System Techniques
Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.
Tags: *Gene Expression Regulation, *Transcriptional Activation, 2006, Adolescent, Adult, Animals, Chiang John Y L, Child, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/genetics, Department of Integrative Medical Sciences, Ellis Ewa, Enzymologic, Female, Forkhead Box Protein O1, Forkhead Transcription Factors/*physiology, Hepatocytes/*enzymology, Humans, Insulin/metabolism/*physiology, Kong Xiaoying, Li Tiangang, Male, Middle Aged, NEOMED College of Medicine, Owsley Erika, Preschool, Rats, Sterol Regulatory Element Binding Protein 1/*physiology, Strom Stephen, The Journal of biological chemistry, Transcription Factors/*physiology
Redox-dependent mechanisms in coronary collateral growth: the "redox window" hypothesis.
Tags: 2009, Angiotensin II/physiology, Animals, Antioxidants & redox signaling, Belmadani Souad, Carrao Ana Catarina Ribeiro, Chilian William M, Coronary Vessels/*growth & development/metabolism, Department of Integrative Medical Sciences, Humans, NEOMED College of Medicine, Ohanyan Vahagn, Oxidation-Reduction, Pung Yuh Fen, Reactive Oxygen Species/metabolism, Rocic Petra, Yun June
The coronary circulation in acute myocardial ischaemia/reperfusion injury - a target for cardioprotection.
Mechanosensitive transient receptor potential vanilloid 4 regulates Dermatophagoides farinae-induced airway remodeling via 2 distinct pathways modulating matrix synthesis and degradation.
Tags: *Airway Remodeling, *fibronectin, *myofibroblasts, *PAI-1, *PI3K, *TGF-beta1, 2017, Adult, Al-Azzam Nosayba, Animals, Asthma/etiology/genetics/*metabolism/pathology, Cells, Cultured, Department of Integrative Medical Sciences, Dermatophagoides farinae/immunology, Duah Ernest, Extracellular Matrix/*metabolism/pathology, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Fibroblasts/metabolism, Fibronectins/*metabolism, Gombedza Farai, Hexter Madison, Humans, Inbred C57BL, Kondeti Vinay, Koppes Stephanie, Male, Mice, NEOMED College of Medicine, Paruchuri Sailaja, Patil Prachi, Phillips Daniel, Phosphatidylinositol 3-Kinases/metabolism, Plasminogen Activator Inhibitor 1/metabolism, Thodeti Charles K, Transforming Growth Factor beta/metabolism, TRPV Cation Channels/genetics/*metabolism
Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4.
Tags: 2019, Adapala Ravi K, angiogenesis, Cappelli Holly C, Chilian William M, Department of Integrative Medical Sciences, endothelial cell, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Kanugula Anantha K, Meszaros J Gary, Midha Priya, NEOMED College of Medicine, Paruchuri Sailaja, Phosphorylation, Thodeti Charles K
Bile acids as metabolic regulators.
Tags: 2015, Bile Acids and Salts/*metabolism, Biological Transport, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Current opinion in gastroenterology, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Energy Metabolism, Homeostasis, Humans, Inflammation/*metabolism, Intestine, Li Tiangang, Liver/*metabolism/pathology, NEOMED College of Medicine, Obesity/*metabolism, Receptors, Signal Transduction, Small/*metabolism/pathology, Type 2/*metabolism
Cell transplantation as an initiator of endogenous stem cell-based tissue repair.
Kv1.3 channels facilitate the connection between metabolism and blood flow in the heart.
Tags: *contrast echocardiography, *coronary blood flow, *Coronary Circulation/drug effects, *coronary microcirculation, *Kv 1.3 channels, 2017, Animals, Bardakjian Raffi, Chilian William M, Department of Integrative Medical Sciences, Enrick Molly, Graham Kathleen, Hakobyan Tatevik, Khayata Mohamed, Kmetz John, Kolz Christopher, Kv1.3 Potassium Channel/*physiology, Logan Suzanna, Luli Jordan, Mice, Microcirculation (New York, N.Y. : 1994), Myocardium/*metabolism, NEOMED College of Medicine, Ohanyan Vahagn, Potassium Channel Blockers/pharmacology, Regional Blood Flow/drug effects, Triterpenes/pharmacology, Vasodilation/drug effects, Yin Liya
Coronary microvascular Kv1 channels as regulatory sensors of intracellular pyridine nucleotide redox potential.
Tags: * NADH, *endothelium, *ion channels, *vascular smooth muscle, *vasodilation, 2018, Animals, Coronary Vessels/chemistry, Department of Integrative Medical Sciences, Dwenger Marc M, Humans, Microcirculation, Microcirculation (New York, N.Y. : 1994), Navedo Manuel F, NEOMED College of Medicine, Nystoriak Matthew A, Ohanyan Vahagn, Oxidation-Reduction, Potassium Channels, Pyrimidine Nucleotides/*metabolism, Reactive Nitrogen Species/metabolism, Reactive Oxygen Species/metabolism, Voltage-Gated/*physiology
Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
Tags: 2006, Antibiotics, Antitubercular/*pharmacology, Blotting, Cell Line, Chiang John Y L, Chromatin/metabolism, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System/*biosynthesis, Cytoplasmic and Nuclear/*biosynthesis/*drug effects/genetics, Department of Integrative Medical Sciences, Drug metabolism and disposition: the biological fate of chemicals, Electrophoretic Mobility Shift Assay, Enzyme Induction/drug effects, Glutathione Transferase/metabolism, Hepatocyte Nuclear Factor 4/genetics/*metabolism, Hepatocytes/drug effects/metabolism, Humans, Immunoprecipitation, Li Tiangang, Messenger/biosynthesis, NEOMED College of Medicine, Plasmids/genetics, Pregnane X Receptor, Receptor Cross-Talk/drug effects, Receptors, Reverse Transcriptase Polymerase Chain Reaction, Rifampin/*pharmacology, RNA, Steroid/*drug effects/genetics, Transfection, Tumor, Western
Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: 2009, Base Sequence, Calcitriol/drug effects/genetics/*physiology, Cell Line, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Cultured, Department of Integrative Medical Sciences, DNA Primers, Drug metabolism and disposition: the biological fate of chemicals, Electrophoretic Mobility Shift Assay, Gene Knockdown Techniques, Genetic/*physiology, Han Shuxin, Hepatocytes/*drug effects/enzymology, Humans, Immunoprecipitation, Lithocholic Acid/pharmacology, Messenger/genetics, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, RNA, Small Interfering, Transcription, Tumor, Two-Hybrid System Techniques
Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner.
Tags: 2015, Animals, Cytochrome P-450 CYP2D6/*biosynthesis, Cytochrome P-450 Enzyme Inhibitors/*pharmacology, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Drug metabolism and disposition: the biological fate of chemicals, Enzymologic/drug effects, Gene Expression Regulation, Genetic/drug effects/genetics, HEK293 Cells, Hepatocytes/drug effects/enzymology/metabolism, Humans, Isoxazoles/*pharmacology, Jeong Hyunyoung, Knockout, Lee Yoon-Kwang, Mice, NEOMED College of Medicine, Pan Xian, Receptors, Transcription, Transgenic