Browse Items (51 total)
- Tags: Genetic
In situ hybridization study of obesity-associated alteration in growth hormone mRNA levels.
Tags: *Gene Expression Regulation, 1992, Ahmad I, Animals, Autoradiography, Blotting, Finkelstein J A, Genetic, Growth Hormone/*genetics/metabolism, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, Male, Messenger/*analysis, Northern, Nucleic Acid Hybridization, Obesity/*etiology/physiopathology, Pituitary Gland/*chemistry/metabolism, Rats, RNA, Steggles A W, Transcription, Zucker
A plant lignan, 3'-O-methyl-nordihydroguaiaretic acid, suppresses papillomavirus E6 protein function, stabilizes p53 protein, and induces apoptosis in cervical tumor cells.
Tags: 2007, Allen Kristi L, Apoptosis Regulatory Proteins/metabolism, Apoptosis/*drug effects, Awad Keytam S, bcl-2-Associated X Protein/metabolism, Caspase 3/metabolism, Caspase 9/metabolism, Cultured/drug effects, DeLucia Angelo L, Department of Integrative Medical Sciences, Enzyme Activation/drug effects, Female, Genetic, Humans, Luciferases, Lynch William P, Masoprocol/*analogs & derivatives/therapeutic use, Molecular carcinogenesis, NEOMED College of Medicine, Oncogene Proteins, Plants/chemistry, Proto-Oncogene Proteins/metabolism, Repressor Proteins/*metabolism, Transcription, Tschantz Deidra R, Tumor Cells, Tumor Suppressor Protein p53/genetics/*metabolism, Uterine Cervical Neoplasms/*drug therapy/metabolism/pathology, Viral/*metabolism
Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids.
Tags: *Hydroxysteroid Dehydrogenases, *Membrane Glycoproteins, 2001, Animals, Bile Acids and Salts/*pharmacology, Caco-2 Cells, Carrier Proteins/genetics/physiology, Cell Line, Chen W, Chiang J Y, CHO Cells, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear/genetics/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/drug effects/genetics/physiology, DNA/metabolism, Embryo, Gene Expression/*drug effects, Genetic, Genetic/drug effects, Humans, Journal of lipid research, Kidney, Liver/metabolism, Luciferases/genetics, Mammalian, Messenger/analysis, NEOMED College of Medicine, Owsley E, Promoter Regions, Rats, Receptors, Recombinant Fusion Proteins/metabolism, Retinoic Acid/genetics/physiology, Retinoid X Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Stroup D, Taurocholic Acid/pharmacology, Transcription, Transcription Factors/drug effects/genetics/physiology, Transfection, Tumor Cells, Yang Y
Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
Tags: 2001, Animals, Binding Sites, Cells, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/drug effects/*genetics/metabolism, Cricetinae, Cultured, Department of Integrative Medical Sciences, gene, Gene Expression Regulation/drug effects, Genetic, Humans, Hydroxycholesterols, Kimmel R, Liver/physiology, Lovastatin/pharmacology, Luciferases/genetics/metabolism, Mevalonic Acid/metabolism/pharmacology, NEOMED College of Medicine, Nicotinic Acids/pharmacology, Organ Specificity, Polyisoprenyl Phosphates/pharmacology, Rats, Receptors, Response Elements, Retinoic Acid/genetics/metabolism, Retinoid X Receptors, Species Specificity, Steroid/genetics/*metabolism, Stroup D, Tetrahydronaphthalenes/pharmacology, Transcription, Transcription Factors/genetics/metabolism, Transfection
Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *Transcription, 2000, Animals, Bile Acids and Salts/*pharmacology, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear, Department of Integrative Medical Sciences, DNA-Binding Proteins/*physiology, Genetic, Humans, Kimmel R, NEOMED College of Medicine, Promoter Regions, Receptors, Repressor Proteins/*physiology, Response Elements, Retinoic Acid/genetics, Retinoid X Receptors, Stroup D, The Journal of biological chemistry, Transcription Factors/genetics/*physiology, Tumor Cells, Weinberger C
Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter.
Tags: *Promoter Regions, 1994, Animals, Antigens, Base Sequence, Bile Acids and Salts/*metabolism, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cloning, Deoxyribonuclease I, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Gene Expression Regulation, Genetic, Humans, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Nuclear Proteins/metabolism, Oligodeoxyribonucleotides, Polyomavirus Transforming/genetics, Rats, Recombinant Fusion Proteins/genetics/metabolism, Sprague-Dawley, Stroup D, The Journal of biological chemistry, Thyroid Hormones/genetics
Cloning and 5'-flanking sequence of a rat cholesterol 7 alpha-hydroxylase gene.
Tags: *Promoter Regions, 1992, Amino Acid Sequence, Animals, Base Sequence, Biochimica et biophysica acta, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Department of Integrative Medical Sciences, DNA, Genetic, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Rats, Restriction Mapping, Wang D P, Yang T P
Impact of circadian nuclear receptor REV-ERBalpha on midbrain dopamine production and mood regulation.
Tags: *Affect, *Circadian Rhythm, 2014, Animals, Bipolar Disorder/genetics, Cell, Choe Han Kyoung, Chung Sooyoung, CLOCK Proteins/genetics/metabolism, Cytoplasmic and Nuclear/genetics/*metabolism, Dluzen Dean E, Dopamine/*metabolism, Genetic, Group A, Histones/metabolism, Humans, Hwang Onyou, Inbred C57BL, Kim Kwang-Soo, Kim Kyungjin, Knockout, Lee Eun Jeong, Lee Inah, Male, Member 2/metabolism, Mesencephalon/*metabolism, Mice, Mood Disorders/genetics/metabolism, Nuclear Receptor Subfamily 4, Park Seong-Beom, Rats, Receptors, Repressor Proteins/genetics/*metabolism, Son Gi Hoon, Son Hyo Jin, Transcription, Tyrosine 3-Monooxygenase/genetics, Yun Seongsik
Sensory nerves and neuropeptides in uterine cervical ripening.
Tags: 2002, Animal, Animals, Calcitonin Gene-Related Peptide/biosynthesis, Capsaicin/pharmacology, Cervical Ripening/*metabolism, Cervix Uteri/*innervation/*metabolism, Collins J J, Complementary/metabolism, Department of Anatomy & Neurobiology, Female, Genetic, Immunohistochemistry, Labor, McCarson K E, Messenger/metabolism, NEOMED College of Medicine, Neurokinin-1/biosynthesis, Neurons/metabolism, Neuropeptides/*biosynthesis, Nitric Oxide Synthase/biosynthesis, Obstetric, Papka R E, Peptides, Plasmids/metabolism, Postpartum Period, Pregnancy, Rats, Receptors, RNA, Secretogranin II, Sprague-Dawley, Substance P/biosynthesis, Transcription, Usip S
Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells.
Tags: 1994, Animals, Bile Acids and Salts/*pharmacology, Biochemical and biophysical research communications, Cells, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Crestani M, Cultured, Department of Integrative Medical Sciences, Enzymologic/*drug effects, Gene Expression Regulation, Genetic, Genetic/genetics, Humans, Karam W G, Luciferases/biosynthesis/genetics, Messenger/*biosynthesis, NEOMED College of Medicine, Promoter Regions, Rats, Recombinant Fusion Proteins/biosynthesis, RNA, Steroids/*pharmacology, Thyroid Hormones/*pharmacology, Transcription, Transfection
The opposing effects of retinoic acid and phorbol esters converge to a common response element in the promoter of the rat cholesterol 7 alpha-hydroxylase gene (CYP7A).
Tags: *Promoter Regions, 1996, Animals, Base Sequence, Biochemical and biophysical research communications, Cell Line, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Crestani M, Department of Integrative Medical Sciences, DNA Primers, Galli G, Genetic, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Rats, Sadeghpour A, Signal Transduction, Stroup D, Tetradecanoylphorbol Acetate/*pharmacology, Tretinoin/*pharmacology
Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.
Tags: *Receptors, *Transcriptional Activation, 1998, Animals, Base Sequence, Bile Acids and Salts/biosynthesis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, DNA/metabolism, Galli G, Genes, Genetic, Hepatocyte Nuclear Factor 4, Hormones/*physiology, Journal of lipid research, Luciferases/genetics, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid, Oligonucleotide Probes/metabolism, Phosphoproteins/metabolism, Promoter Regions, Rats, Receptors, Repetitive Sequences, Reporter, Retinoic Acid/metabolism, Retinoid X Receptors, Sadeghpour A, Site-Directed, Steroid, Stroup D, Transcription Factors/metabolism, Tumor Cells
Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7).
Tags: *Promoter Regions, *Transcription, 1995, Animals, Base Sequence, Cell Count, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Crestani M, Cultured, Cyclic AMP/pharmacology, Department of Integrative Medical Sciences, Enzymologic/*physiology, Gene Expression Regulation, Genetic, Hormones/*pharmacology, Journal of lipid research, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Phorbol Esters/pharmacology, Rats, Second Messenger Systems/physiology, Stroup D, Transfection, Tumor Cells
The isolation and characterization of the bovine cytochrome b5 gene, and a transcribed pseudogene.
Tags: *Pseudogenes, 1993, Amino Acid Sequence, Animals, Base Sequence, Blotting, Cattle/*genetics, Cristiano R J, Cytochromes b5/*genetics, DNA/genetics/isolation & purification, Exons, Gene Expression, Genetic, Genomic Library, Genomics, Giordano S J, Humans, Introns, Messenger/biosynthesis/metabolism, Molecular Sequence Data, Nucleic Acid, Nucleic Acid Conformation, Oligodeoxyribonucleotides, Rabbits, Restriction Mapping, Reticulocytes/metabolism, RNA, RNA Precursors/chemistry/metabolism, Sequence Homology, Southern, Steggles A W, Transcription
Basic transcription element binding protein (BTEB) transactivates the cholesterol 7 alpha-hydroxylase gene (CYP7A).
Tags: *Gene Expression Regulation, 1998, Animals, Bile Acids and Salts/genetics, Binding Sites/genetics, Biochemical and biophysical research communications, Carcinoma, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Complementary/analysis, Cultured, Department of Integrative Medical Sciences, DNA, DNA-Binding Proteins/metabolism/*physiology, Electrophoresis, Enzyme Activation/genetics, Foti D, Genetic, Hepatocellular, Humans, Kruppel-Like Transcription Factors, Liver/enzymology, NEOMED College of Medicine, Podophyllin/analogs & derivatives/metabolism, Podophyllotoxin/analogs & derivatives, Polyacrylamide Gel, Promoter Regions, Protein Binding/genetics, Rats, Stroup D, Transcription Factors/metabolism/*physiology, Tumor Cells
The human liver and reticulocyte cytochrome b5 mRNAs are products from a single gene.
Tags: *Genes, 1991, Amino Acid Sequence, Base Sequence, Biochemical and biophysical research communications, Cytochromes b5/blood/*genetics, Gene Library, Genetic, Giordano S J, Humans, Liver/*metabolism, Molecular Sequence Data, Polymerase Chain Reaction, Polymorphism, Reticulocytes/*metabolism, RNA/blood/genetics/isolation & purification, Steggles A W
Curated compendium of human transcriptional biomarker data.
Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1.
Tags: 2017, Acetylation/drug effects, Animals, Butyrates/pharmacology, Cell Line, Cell Survival/drug effects, Department of Pharmaceutical Sciences, Dopamine Plasma Membrane Transport Proteins/*metabolism, Dopamine transporter, Dopaminergic Neurons/cytology/drug effects/metabolism, Dose-Response Relationship, Drug, Eid Aseel, Epigenesis, Epigenetics, Genetic, Genetic/drug effects, Green Ashley L, Group A, Guo Grace L, HDAC, Histone deacetylase, Histone Deacetylase Inhibitors/*pharmacology, Histone Deacetylases/metabolism, Histones/*drug effects/metabolism, Homeodomain Proteins/metabolism, Hydroxamic Acids/pharmacology, Member 2/*metabolism, Messenger/metabolism, NEOMED College of Pharmacy, Neuropharmacology, Nuclear Receptor Subfamily 4, Nurr1, Pitx3, Promoter Regions, Rats, Richardson Jason R, RNA, Transcription Factors/metabolism, Valproate, Valproic Acid/*pharmacology, Zarbl Helmut, Zhan Le
Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, alpha-Ketoglutarate (alpha-KG), and DNA hydroxymethylation levels by interleukin-1beta in primary human chondrocytes.
Tags: *DNA methylation, *Epigenesis, 2014, 5-hmC, 5-Methylcytosine/analogs & derivatives, Chondrocytes, Chondrocytes/chemistry/*metabolism, Cytokine, Cytosine/*analogs & derivatives/analysis/metabolism, Department of Anatomy & Neurobiology, Dioxygenase, DNA Methylation, DNA-Binding Proteins/*biosynthesis/genetics, Epigenetics, Genetic, Haqqi Tariq M, Haseeb Abdul, Humans, IL-1, Interleukin-1beta/pharmacology/*physiology, Isocitrate Dehydrogenase/*biosynthesis/genetics, Ketoglutaric Acids/*metabolism, Makki Mohammad Shahidul, Messenger/biosynthesis/genetics, Mixed Function Oxygenases, NEOMED College of Medicine, Primary Cell Culture, Proto-Oncogene Proteins/*biosynthesis/genetics, RNA, The Journal of biological chemistry, TNF-alpha, Tumor Necrosis Factor-alpha/pharmacology/physiology
Polymorphisms of human cholesterol 7 alpha-hydroxylase.
Tags: 1992, Amino Acid Sequence, Base Sequence, Biochemical and biophysical research communications, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Department of Integrative Medical Sciences, DNA/genetics, Genetic, Humans, Karam W G, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Oligodeoxyribonucleotides/chemistry, Polymerase Chain Reaction, Polymorphism, Restriction Mapping
Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics.
Tags: *DNA methylation, *Epigenetics, *HDACs, *lncRNA, *miRNA, *OSTEOARTHRITIS, 2018, Animals, Department of Anatomy & Neurobiology, Epigenesis, Genetic, Haqqi Tariq M, Histone Deacetylase Inhibitors/*therapeutic use, Humans, Khan Nazir M, NEOMED College of Medicine, Osteoarthritis/*drug therapy/*genetics, Pharmacological research
All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade.
Tags: 2014, Animals, Axe David, Basic Helix-Loop-Helix Transcription Factors/genetics, Blood Glucose/analysis, Chiang John Y L, Cook Aaron, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Fatty Liver/*drug therapy/metabolism, Gene Expression Regulation, Genetic, Hardwick James P, Hepatology (Baltimore, Md.), Inbred C57BL, Kim Chun-Ki, Kim Seong-Chul, Lee Mikang, Lee Yoon-Kwang, Li Tiangang, Lipid Metabolism, Liver/metabolism, Male, Mice, Moore David D, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease, PPAR gamma/*genetics, Receptors, Repressor Proteins/genetics, Retinoic Acid Receptor alpha, Retinoic Acid/physiology, Smallwood Nicole, Transcription, Tretinoin/pharmacology/*therapeutic use
Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: *Gene Expression Regulation, 2010, Acetylation, AMP-Activated Protein Kinases/metabolism, ATP Citrate (pro-S)-Lyase/genetics/metabolism, Bile Acids and Salts/metabolism, Cells, Chanda Dipanjan, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Epigenesis, Genes, Genetic, Glucose/*administration & dosage, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*enzymology/metabolism, Histones/metabolism, Humans, Hyperglycemia/enzymology/*metabolism, Journal of lipid research, Li Tiangang, Messenger/metabolism, Methylation, NEOMED College of Medicine, Reporter, RNA, RNA Interference, Zhang Yanqiao
Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.
Tags: 2005, American journal of physiology. Gastrointestinal and liver physiology, Bile Acids and Salts/pharmacology, Chiang John Y L, Cholestasis/*physiopathology, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/pharmacology, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/pharmacology, Enzyme Inhibitors/*pharmacology, Genetic, Glucocorticoid, Hepatoblastoma/pathology, Hepatocyte Nuclear Factor 4, Humans, Li Tiangang, Liver Neoplasms/pathology, Messenger/analysis/biosynthesis, NEOMED College of Medicine, Phosphoproteins/pharmacology, Pregnane X Receptor, Receptors, Rifampin/*pharmacology, RNA, Steroid/*physiology, Transcription, Transcription Factors/pharmacology, Tumor Cells, Up-Regulation
Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells.
Tags: 2006, Bile Acids and Salts/*metabolism, Cells, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cultured, Cytokines/*metabolism, Department of Integrative Medical Sciences, Gene Expression Regulation, Genetic, Hepatocytes/*cytology/drug effects, Hepatology (Baltimore, Md.), Humans, Immunoblotting, In Vitro Techniques, Interleukin-1/pharmacology, Jahan Asmeen, Li Tiangang, Messenger/analysis, NEOMED College of Medicine, Probability, Proto-Oncogene Proteins c-jun/*metabolism, Reverse Transcriptase Polymerase Chain Reaction, RNA, Sensitivity and Specificity, Signal Transduction/genetics, Transcription
The isolation and characterization of the human cytochrome b5 gene.
Tags: 1995, Animals, Base Sequence, Biochemical and biophysical research communications, Cattle, Cell Line, Cloning, Cosmids, Cultured, Cytochromes b5/biosynthesis/*genetics, DNA Primers, DNA/genetics/isolation & purification, Gene Library, Genetic, Giordano S J, Hominidae/*genetics, Humans, Introns, Li X R, Luciferases/biosynthesis, Messenger/analysis/biosynthesis, Molecular, Molecular Sequence Data, Polymerase Chain Reaction, Promoter Regions, Rabbits, RNA, Steggles A W, Transfection, Tumor Cells, Yoo M
Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes.
Tags: *IL-6, *MCPIP1, *miRNA, *OSTEOARTHRITIS, *Vorinostat, 2017, Adult, Aged, CCAAT-Enhancer-Binding Proteins/genetics/metabolism, Cells, Chondrocytes/*metabolism/pathology, Connective tissue research, Cultured, Department of Anatomy & Neurobiology, Female, Gene Expression Regulation/*drug effects, Genetic, Haqqi Tariq M, Humans, Hydroxamic Acids/*pharmacology, Interleukin-1beta/genetics/*metabolism, Interleukin-6/genetics/*metabolism, Makki Mohammad S, Male, MicroRNAs/genetics/*metabolism, Middle Aged, NEOMED College of Medicine, Osteoarthritis/drug therapy/genetics/*metabolism/pathology, Promoter Regions, Ribonucleases/*biosynthesis/genetics, Transcription Factors/*biosynthesis/genetics, Vorinostat
Synthesis of radioactive single-stranded DNA probes using asymmetrical PCR and oligonucleotide random priming.
Tags: *DNA, *Oligonucleotides, *Phosphorus Radioisotopes, 1999, Animals, BioTechniques, Blotting, Cercopithecus aethiops, Deoxyribonuclease EcoRI, DNA, DNA Probes/*chemical synthesis, Genetic, Herpesvirus 1, Human/genetics, Isotope Labeling, Mao H, Messenger/analysis, Northern, Nucleic Acid Denaturation, Polymerase Chain Reaction/*methods, RNA, Rosenthal K S, Single-Stranded, Templates, Vero Cells, Viral/analysis
Strain-dependent structural variants of herpes simplex virus type 1 ICP34.5 determine viral plaque size, efficiency of glycoprotein processing, and viral release and neuroinvasive disease potential.
Tags: *Genetic Variation, 2003, Animals, Cercopithecus aethiops, Cultured, Encephalitis, Genetic, Herpes Simplex/*physiopathology/virology, Herpesvirus 1, Human/*classification/genetics/*pathogenicity, Inbred BALB C, Journal of virology, Male, Mao Hanwen, Mice, Recombination, Rosenthal Ken S, Transfection, Tumor Cells, Vero Cells, Viral Envelope Proteins/metabolism, Viral Plaque Assay, Viral Proteins/*chemistry/*genetics/metabolism
Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *DNA-Binding Proteins, *Regulatory Sequences, 2000, Animals, Anticholesteremic Agents/pharmacology, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Clofibric Acid/pharmacology, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Enzymologic, Gene Expression Regulation, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Marrapodi M, Models, NEOMED College of Medicine, Nucleic Acid, Peroxisome Proliferators/pharmacology, Phosphoproteins/metabolism, Promoter Regions, Protein Binding, Pyrimidines/pharmacology, Rats, Receptors, Reporter, Response Elements, Retinoic Acid/metabolism, Retinoid X Receptors, Species Specificity, Transcription, Transcription Factors/*agonists/metabolism, Transcriptional Activation
Cardiovascular Effects of Exposure to Cigarette Smoke and Electronic Cigarettes: Clinical Perspectives From the Prevention of Cardiovascular Disease Section Leadership Council and Early Career Councils of the American College of Cardiology.
Tags: 2015, Al-Mallah Mouaz H, atherogenesis, Bahrami Hossein, Benowitz Neal L, Bhakta Shyam, Cardiovascular Diseases – Etiology, Cardiovascular Diseases/*etiology, Deedwania Prakash, Department of Internal Medicine, El-Chami Mikhael F, Electronic Cigarettes – Adverse Effects, Electronic Nicotine Delivery Systems/*adverse effects, Epigenesis, Feldman Dmitriy N, Ference Brian A, Genes, Genetic, genetic and epigenetic effects, Humans, Impact of Events Scale, Jahangir Eiman, Journal of the American College of Cardiology, Mehta Laxmi S, Morris Pamela B, NEOMED College of Medicine, Phan Binh An P, Ryan John J, Sanchez Shields Monica, Scales, smoke-free legislation, Smoking – Complications, Smoking – Legislation and Jurisprudence – United States, Smoking Cessation, Smoking/*adverse effects/legislation & jurisprudence, Thrombosis, tobacco cessation, United States, Winchester David E
Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration.
Tags: *Astrocyte, *DNA methylation, *Epigenesis, *Epigenetic, *Histone, *neurodegeneration, *Neuroinflammation, 2018, Acetylation, Alzheimer Disease/genetics/pathology, Animals, Astrocytes/*cytology/immunology, Biochimica et biophysica acta. Molecular basis of disease, Cell Differentiation, Department of Pharmaceutical Sciences, DNA Methylation, Genetic, Histones/metabolism, Humans, Inflammation/*pathology, Methylation, MicroRNAs/metabolism, Neal Matthew, NEOMED College of Pharmacy, Neurodegenerative Diseases/genetics/*pathology, Neuroglia/metabolism, Neurons/immunology, Parkinson Disease/genetics/pathology, Richardson Jason R
Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein.
Tags: *Transcription Factors, 2004, Base Sequence, Biochemical and biophysical research communications, CCAAT-Enhancer-Binding Proteins/*metabolism, Chiang John Y L, Cytochrome P-450 Enzyme System/*genetics/physiology, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA-Binding Proteins/*metabolism, Enzyme Repression, Genetic, Humans, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Norlin Maria, Promoter Regions, Response Elements, Sp1 Transcription Factor/antagonists & inhibitors, Steroid Hydroxylases/*genetics/physiology, Sterol Regulatory Element Binding Protein 1, Sterols/metabolism, Transcription
Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure.
Tags: *2H2O-labeling, *Brain, *Genetic Variation, *Histone, *Mass spectrometry, *Post-translational modifications, *Postnatal alcohol exposure, *Turnover, 2017, Acetylation, Animal, Animals, Cell Proliferation, Clinical epigenetics, Department of Pharmaceutical Sciences, Disease Models, DNA Damage, Epigenesis, Female, Fetal Alcohol Spectrum Disorders/genetics/*metabolism, Genetic, Histones/*genetics/*metabolism, Humans, Kasumov Takhar, Li Ling, NEOMED College of Pharmacy, Post-Translational, Pregnancy, Previs Stephen, Protein Processing, Proteomics/*methods, Rachdaoui Nadia, Rats, Sarkar Dipak, Sprague-Dawley, Willard Belinda
A neurochemical hypothesis for the origin of hominids.
Tags: *Ardipithecus, *basal ganglia, *Biological Evolution, *dopamine, *hominin, *Neurochemistry, *neurotransmitter, *Selection, *Social Behavior, 2018, Altruism, Animals, Corpus Striatum/*physiology, Dogs, Edler Melissa K, Genetic, Hof Patrick R, Holloway Ralph L, Humans, Jacobs Bob, Lovejoy C Owen, Munger Emily L, Personality, Primates, Proceedings of the National Academy of Sciences of the United States of America, Raghanti Mary Ann, Sherwood Chet C, Social Conformity, Stephenson Alexa R
Sequential activation of Elk-1/Egr-1/GADD45alpha by arsenic.
Tags: 2014, Arsenic/*pharmacology, Bhatia Deepak, Bishayee Anupam, Bronchi/cytology/drug effects/metabolism, Cell Cycle Proteins/biosynthesis/genetics/*metabolism, Cell Line, Early Growth Response Protein 1/biosynthesis/genetics/*metabolism, Epithelial Cells/drug effects/metabolism, ets-Domain Protein Elk-1/biosynthesis/genetics/*metabolism, Genetic, Humans, MAP Kinase Signaling System, Messenger/biosynthesis/genetics, Nuclear Proteins/biosynthesis/genetics/*metabolism, Oncotarget, Promoter Regions, Proto-Oncogene Proteins c-akt/metabolism, RNA, Shi Qiwen, Sutariya Vijaykumar
Serotonergic involvement in the regulation of prolactin and vasoactive intestinal peptide mRNA expression in the rat anterior pituitary.
Tags: 1994, 5-Hydroxytryptophan/pharmacology, alpha-Methyltyrosine, Animals, Anterior/*chemistry/drug effects/metabolism, Blotting, Bromocriptine/pharmacology, Carrillo A J, Gene Expression Regulation/drug effects/physiology, Genetic, Haloperidol/pharmacology, Ketanserin/pharmacology, Liu B, Male, Messenger/*analysis/genetics, Methiothepin/pharmacology, Methoxydimethyltryptamines/pharmacology, Methyltyrosines/pharmacology, Molecular and cellular endocrinology, Northern, Pituitary Gland, Prolactin/analysis/*genetics/metabolism, Quipazine/pharmacology, Rats, RNA, Serotonin/*physiology, Signs S A, Sprague-Dawley, Time Factors, Transcription, Vasoactive Intestinal Peptide/analysis/*genetics/metabolism, Wolford J
A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene.
Tags: *Gene Expression Regulation, 2006, Aged, Amino Acid Motifs, Bile Acids and Salts/metabolism, Cell Line, Cell Nucleus/metabolism, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*chemistry/*genetics, Cultured/metabolism, Department of Integrative Medical Sciences, Enzymologic, Female, Genes, Genetic, Gluconeogenesis, Glutathione Transferase/metabolism, Hepatocyte Nuclear Factor 4/metabolism/*physiology, Hepatocytes/metabolism, Homeodomain Proteins/metabolism/*physiology, Humans, Immunoprecipitation, Li Tiangang, Liver/metabolism, Luciferases/metabolism, Male, Messenger/metabolism, Middle Aged, NEOMED College of Medicine, Phosphoenolpyruvate Carboxykinase (ATP)/metabolism, Plasmids/metabolism, Protein Structure, Reporter, Response Elements, Reverse Transcriptase Polymerase Chain Reaction, RNA, Small Interfering/metabolism, Song Kwang-Hoon, Tertiary, The Journal of biological chemistry, Time Factors, Transcription, Transcriptional Activation, Transfection, Tumor Suppressor Proteins, Two-Hybrid System Techniques
HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).
Tags: *Receptors, *Transcription, 2000, Animals, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Cultured, Department of Integrative Medical Sciences, DNA Primers, DNA-Binding Proteins/*metabolism, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Luciferases/genetics, Mutation, NEOMED College of Medicine, Phosphoproteins/*metabolism, Promoter Regions, Rats, Recombinant Proteins/metabolism, Reporter, Sprague-Dawley, Steroid, Stroup D, Transcription Factors/*metabolism, Tumor Cells
Orphan receptors chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor (RXR) activate and bind the rat cholesterol 7alpha-hydroxylase gene (CYP7A).
Tags: *Gene Expression Regulation, *Receptors, 1997, Animals, Chiang J Y, Chickens, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Circadian Rhythm, COUP Transcription Factor I, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Department of Integrative Medical Sciences, DNA-Binding Proteins/*metabolism, Electrophoresis, Enzymologic, Genetic, Glucocorticoid/*genetics, Models, Molecular, NEOMED College of Medicine, Nuclear Proteins/*metabolism, Polyacrylamide Gel, Promoter Regions, Rats, Receptors, Recombinant Proteins/genetics/metabolism, Retinoic Acid/*metabolism, Retinoid X Receptors, Steroid, Stroup D, The Journal of biological chemistry, Transcription Factors/*metabolism