Browse Items · NEOMED Bibliography Database

A novel coding mechanism for social vocalizations in the lateral amygdala.

The amygdala plays a central role in evaluating the significance of acoustic signals and coordinating the appropriate behavioral responses. To understand how amygdalar responses modulate auditory processing and drive emotional expression, we assessed…

Roles of inhibition in creating complex auditory responses in the inferior colliculus: facilitated combination-sensitive neurons.

We studied roles of inhibition on temporally sensitive facilitation in combination-sensitive neurons from the mustached bat's inferior colliculus (IC). In these integrative neurons, excitatory responses to best frequency (BF) tones are enhanced by…

Temporal features of spectral integration in the inferior colliculus: effects of stimulus duration and rise time.

This report examines temporal features of facilitation and suppression that underlie spectrally integrative responses to complex vocal signals. Auditory responses were recorded from 160 neurons in the inferior colliculus (IC) of awake mustached bats.…

Acute exercise attenuates cardiac autonomic regulation in hypertensive rats.

Dynamic exercise may be used as a safe, therapeutic approach to reduce sympathetic nerve activity at rest and thus may be beneficial for individuals with hypertension. Therefore, we tested the hypothesis that a single bout of mild to moderate dynamic…

Isolation of canine coronary sinus musculature from the atria by radiofrequency catheter ablation prevents induction of atrial fibrillation.

BACKGROUND: The junction between the coronary sinus (CS) musculature and both atria contributes to initiation of atrial tachyarrhythmias. The current study investigated the effects of CS isolation from the atria by radiofrequency catheter ablation on…

Thirty-Day Readmissions After Transcatheter Aortic Valve Replacement in the United States: Insights From the Nationwide Readmissions Database.

BACKGROUND: Readmissions after cardiac procedures are common and contribute to increased healthcare utilization and costs. Data on 30-day readmissions after transcatheter aortic valve replacement (TAVR) are limited. METHODS AND RESULTS: Patients…

Tags: *aortic stenosis, *costs and cost analysis, *length of stay, *Patient Readmission/economics, *readmission, *rehospitalization, *transcatheter aortic valve implantation, *transcatheter aortic valve replacement, 2017, 80 and over, Abbott J Dawn, Aged, Aortic Valve Stenosis/diagnosis/economics/*surgery, Aronow Wilbert S, Bhatt Deepak L, Chatterjee Saurav, Circulation. Cardiovascular interventions, Comorbidity, Databases, Department of Internal Medicine, Factual, Female, Fonarow Gregg C, Gheewala Neil, Goldsweig Andrew, Gordon Paul C, Greenbaum Adam B, Gupta Tanush, Hospital Costs, Humans, Khera Sahil, Kolte Dhaval, Length of Stay, Male, NEOMED College of Medicine, Patient Discharge, Postoperative Complications/etiology, Risk Factors, Sardar M Rizwan, Sharaf Barry, Skilled Nursing Facilities, Time Factors, Transcatheter Aortic Valve Replacement/*adverse effects/economics, Treatment Outcome, United States

Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth.

RATIONALE: A well-developed coronary collateral circulation improves the morbidity and mortality of patients following an acute coronary occlusion. Although regenerative medicine has great potential in stimulating vascular growth in the heart, to…

Tags: *Collateral Circulation, *Coronary Circulation, 2012, Animal, Animals, Bailey Erin, Biomarkers/metabolism, Cell Differentiation, Cell Lineage, Cells, Chilian William M, Circulation research, Coronary Occlusion/genetics/metabolism/pathology/physiopathology/*surgery, Coronary Vessels/metabolism/pathology/*physiopathology, Cultured, Delucia Angelo, Department of Integrative Medical Sciences, Developmental, Disease Models, Endothelial Cells/metabolism/pathology/*transplantation, Enrick Molly, Epigenesis, Gene Expression Profiling, Gene Expression Regulation, Genetic, Guarini Giacinta, Induced Pluripotent Stem Cells/metabolism/*transplantation, Kolz Christopher L, Mice, Muscle, Myocytes, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Physiologic, Pung Yuh Fen, Rats, Regenerative Medicine/methods, Regional Blood Flow, Reverse Transcriptase Polymerase Chain Reaction, SCID, Smooth, Smooth Muscle/metabolism/pathology/*transplantation, Sprague-Dawley, Stevanov Kelly, Teratoma/metabolism/pathology, Time Factors, Transcription Factors/genetics/metabolism, Transduction, Vascular/metabolism/pathology/*physiopathology, Yin Liya

Left ventricular pseudoaneurysm presenting twenty-eight months after myocardial infarction. A case report.

Tags: 1997, Angiology, Coronary Aneurysm/diagnosis/*etiology, Department of Internal Medicine, Female, Heart Ventricles, Humans, Magnetic Resonance Imaging/methods, Martin R, Middle Aged, Myocardial Infarction/*complications, NEOMED College of Medicine, Ognibene A, Smith A S, Tegtmeier T, Time Factors

Impact of reirradiation of painful osseous metastases on quality of life and function: a secondary analysis of the NCIC CTG SC.20 randomized trial.

PURPOSE: We previously demonstrated that 48% of patients with pain at sites of previously irradiated bone metastases benefit from reirradiation. It is unknown whether alleviating pain also improves patient perception of quality of life (QOL).…

Association of parathyroid hormone with 20-year cognitive decline: The ARIC study.

OBJECTIVE: We hypothesized that elevated parathyroid hormone (PTH) levels will be independently associated with 20-year cognitive decline in a large population-based cohort. METHODS: We studied 12,964 middle-aged white and black ARIC participants…

Growth hormone injections improve bone quality in a mouse model of osteogenesis imperfecta.

UNLABELLED: Systemic growth hormone injections increased spine and femur length in a mouse model of OI. Femur BMC, cross-sectional area, and BMD were increased. Smaller gains were produced in vertebral BMC and cross-sectional area. Biomechanical…

Circuitry underlying spectrotemporal integration in the auditory midbrain.

Combination sensitivity in central auditory neurons is a form of spectrotemporal integration in which excitatory responses to sounds at one frequency are facilitated by sounds within a distinctly different frequency band. Combination-sensitive…

Tags: 2011, Acoustic Stimulation/*methods, Animals, Auditory Pathways/*physiology, Chiroptera, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Female, Male, Mesencephalon/*physiology, NEOMED College of Medicine, Nerve Net/*physiology, Schofield Brett R, The Journal of neuroscience : the official journal of the Society for Neuroscience, Time Factors, Wenstrup Jeffrey J, Yavuzoglu Asuman

The anabolic effects of vitamin D-binding protein-macrophage activating factor (DBP-MAF) and a novel small peptide on bone.

Vitamin D-binding protein-macrophage activating factor (DBP-MAF) has previously been shown to stimulate bone resorption and correct the skeletal defects associated with osteopetrosis in two nonallelic mutations in rats. This same protein and a small…

Evaluation and use of a rapid Staphylococcus aureus assay by an antimicrobial stewardship program.

PURPOSE: The performance of a rapid test for methicillin-resistant Staphylococcus aureus (MRSA) in a large community hospital was investigated. METHODS: A prospective observational study was conducted to evaluate an immunochromatographic assay (Alere…

Tags: 2013, Affinity, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, Anti-Bacterial Agents/administration & dosage/*pharmacology, Bacteriological Techniques, Barrett Heather L, Biological Assay – Methods, Cell Culture Techniques, Chromatography, Community, Department of Internal Medicine, DiPersio Joseph R, False Negative Reactions, File Thomas M Jr, Funding Source, Hospitals, Human, Humans, Methicillin-Resistant Staphylococcus Aureus – Analysis, Methicillin-Resistant Staphylococcus aureus/*isolation & purification, Microbial Sensitivity Tests, NEOMED College of Medicine, Observational Methods, Pasquale Timothy R, Prospective Studies, Sensitivity and Specificity, Staphylococcal Infections/*diagnosis/microbiology, Staphylococcus aureus/*isolation & purification, Time Factors, Trienski Tamara L

Lung fluid absorption is induced in preterm guinea pigs ventilated with low tidal volumes.

The objective of this study was to determine if low tidal volume (V(t)) ventilation was beneficial when ventilating preterm fetuses. The authors ventilated preterm guinea pig fetuses at gestation day (GD) 67, 3 days before birth, newborn, and…

Thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor

The purpose of this study is to investigate a thermoreversible gel using Pluronic

Tags: *Drug Delivery Systems, 2013, Animal, Animals, Benzodioxoles/*administration & dosage/pharmacokinetics/toxicity, Bhatia Deepak, Body Temperature, Delayed-Action Preparations, Disease Models, Drug Carriers/chemistry/toxicity, Fibroblasts/drug effects/metabolism, Filtering Surgery/*methods, Geldenhuys Werner, Gels, Glaucoma/*surgery, Imidazoles/*administration & dosage/pharmacokinetics/toxicity, Miladore Nicholas, Nakamura Hiroshi, Pharmaceutical development and technology, Poloxamer/chemistry/toxicity, Protein-Serine-Threonine Kinases/antagonists & inhibitors, Pyridines/*administration & dosage/pharmacokinetics/toxicity, Rabbits, Receptor, Receptors, Sutariya Vijaykumar, Temperature, Time Factors, Transforming Growth Factor beta/antagonists & inhibitors, Transforming Growth Factor-beta Type I, Viscosity, Wehrung Daniel

Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells.

CONTEXT: Phytochemicals are produced by desert plants to protect themselves against stressful environments. They have been shown to be useful in preventing and fighting adverse pathophysiological conditions and complex diseases, including cancer.…

Uncovering tinea incognito. Topical corticosteroids can mask typical features of ringworm.

Neoadjuvant chemotherapy for operable breast cancer: is this the future?

The idea of using preoperative or neoadjuvant chemotherapy in patients with operable breast cancer originated from experimental and clinical observations as well as theoretical hypotheses on tumor cell growth and dissemination. Initially,…

Mechanical Ventilation Antioxidant Trial.

BACKGROUND: Many patients each year require prolonged mechanical ventilation. Inflammatory processes may prevent successful weaning, and evidence indicates that mechanical ventilation induces oxidative stress in the diaphragm, resulting in atrophy…

Tags: 2015, 80 and over, Acetylcysteine, Adult, Aged, American journal of critical care : an official publication, American Association of Critical-Care Nurses, Antioxidants, Antioxidants/*therapeutic use, Artificial, Artificial/*adverse effects, Ascorbic Acid – Administration and Dosage, Ascorbic Acid/therapeutic use, Chi Square Test, Clochesy John M, Critical Care/*methods, Critical Illness, Critically Ill Patients, Cystine/analogs & derivatives/therapeutic use, Data Analysis Software, Department of Internal Medicine, Dietary Supplementation, Double-Blind Method, Double-Blind Studies, Female, Funding Source, Goldstein Lawrence S, Howe Kimberly P, Human, Humans, Inflammation/*drug therapy/*etiology, Intensive Care Units, Length of Stay, Log-Rank Test, Male, Mantel-Haenszel Test, Middle Age, Middle Aged, NEOMED College of Medicine, Owen Hugh, Oxidative Stress, Oxidative Stress/*drug effects, Prospective Studies, RANDOMIZED controlled trials, Respiration, T-Tests, Time Factors, Treatment Outcome, Ventilator Weaning, Vitamin E, Vitamin E/therapeutic use, Vitamins/therapeutic use

Comparative antiplatelet activity of COX1 NSAIDS versus aspirin, encompassing regimen simplification and gastroprotection: a call for a controlled study.

This study was conducted to assess the feasibility of COX1 NSAID substitution for aspirin for preventative therapy related to circulating anticoagulants, as manifest by inhibition of platelet aggregation. There was no difference in platelet…

Use of Fine-scale Geospatial Units and Population Data to Evaluate Access to Emergency Care.

Introduction: Time to facility is a crucial element in emergency medicine (EM). Fine-scale geospatial units such as census block groups (CBG) and publicly available population datasets offer a low-cost and accurate approach to modeling geographic…

Functional outcome after anal sphincter injury and treatment with mesenchymal stem cells.

This research demonstrates the regenerative effects of mesenchymal stem cells (MSCs) on the injured anal sphincter by comparing anal sphincter pressures following intramuscular and serial intravascular MSC infusion in a rat model of anal sphincter…

Understanding residents' work: moving beyond counting hours to assessing educational value.

PURPOSE: To begin to understand how residents' work affects their own educations and the hospitals in which most of their training takes place, the authors undertook a systematic review of the literature analyzing residents' activities. This review…

Tags: *Workload, 2003, Academic medicine : journal of the Association of American Medical Colleges, Boex James R, Department of Family & Community Medicine, Education, Graduate/*statistics & numerical data, Humans, Internship and Residency/*statistics & numerical data, Leahy Peter J, Medical, Medicine/statistics & numerical data, NEOMED College of Medicine, Specialization, Time Factors

Behavioral effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE; "EVE").

Eight male rats were trained to discriminate 2.0 mg/kg

Tags: 1987, 3, 4-methylenedioxyamphetamine, 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology, Amphetamines/*pharmacology, Animals, Boja J W, Discrimination (Psychology), Dose-Response Relationship, Drug, Inbred Strains, Legislation, Male, N-Methyl-3, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Time Factors, United States

Norfenfluramine, the fenfluramine metabolite, provides stimulus control: evidence for serotonergic mediation.

Nine male rats were trained to discriminate 1.4 mg/kg norfenfluramine (NF) from its vehicle using a two-lever, food-motivated, operant discrimination task. Once trained, the rats showed a dose-dependent decrease in responding on the

Tags: 1988, Animal/*drug effects, Animals, Behavior, Boja J W, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Fenfluramine/*analogs & derivatives/*pharmacology, Inbred Strains, Male, Norfenfluramine/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Serotonin/pharmacology, Serotonin/physiology, Time Factors

Characterization of the early events in vitamin C and K3-induced death of human bladder tumor cells.

Aspartame exposure and in vitro hippocampal slice excitability and plasticity.

Aspartame (APM) is a low-calorie sweetener recently approved and released for widespread use in the United States. However, concerns still exist that APM consumption may be responsible for adverse neurological and psychological effects in some…

Tags: 1988, Animals, Aspartame/*toxicity, Dipeptides/*toxicity, Electric Stimulation, Electrophysiology, Female, Fountain S B, Fundamental and applied toxicology : official journal of the Society of Toxicology, Hennes S K, Hippocampus/*drug effects/physiopathology, Neuronal Plasticity/*drug effects, Neurons/drug effects, Rats, Teyler T J, Time Factors

A reappraisal of appendicitis in the elderly.

Historically, appendicitis in the elderly is associated with higher morbidity and mortality. Ninety-six patients over 60 years of age with appendicitis treated over a 10-year period were reviewed. Only 20% presented classically with anorexia, fever,…

Tags: 1990, 80 and over, Aged, American journal of surgery, Appendicitis/complications/*diagnosis/mortality/surgery, Diagnosis, Differential, Female, Guyton D P, Horattas M C, Humans, Male, Middle Aged, Postoperative Complications, Retrospective Studies, Time Factors, Wu D

Tromantadine inhibits a late step in herpes simplex virus type 1 replication and syncytium formation.

Addition of tromantadine after virus penetration inhibited HSV-1 induced syncytium formation and virus production in HEp-2 and VERO cells and acted additively with neutralizing antibody in blocking virus spread and cytopathology. Inhibition of…

Gallstones induced by sex steroids in the female Syrian hamster: duration effects.

Scanning (SEM), and transmission (TEM) electron microscopy were used and correlated to morphologically characterize changes induced in the gallbladder epithelium of female Syrian hamster in response to treatments with estradiol (E) alone, and…

Tags: 1995, Animals, Body Weight, Cholelithiasis/*chemically induced, Cricetinae, Electron, Epithelium/drug effects/ultrastructure, Estradiol/*toxicity, Female, Gallbladder/*drug effects/pathology, Gilloteaux J, Journal of submicroscopic cytology and pathology, Karkare S, Lipids/blood, Medroxyprogesterone/*toxicity, Mesocricetus, Microscopy, Organ Size, Time Factors

Gallstone pancreatitis: a prospective randomized trial of the timing of surgery.

The correct timing of surgery in cases of gallstone pancreatitis is debatable. To delineate more clearly the influence of the timing of surgery in the treatment of the disease, a prospective randomized clinical study of early surgery (less than 48…

Possible leukopenia associated with long-term use of echinacea.

Tags: 2002, Echinacea/*adverse effects, Female, Franco Kathleen N, Humans, Kemp David Eric, Leukopenia/*chemically induced, Middle Aged, Phytotherapy/*adverse effects, The Journal of the American Board of Family Practice, Time Factors

Ethanol interoceptive cue and sleep-time duration in HAS and LAS selectively bred rats.

The drug discrimination paradigm was used to evaluate the effects of selective breeding for differential sensitivity to the hypnotic effects of ethanol. Tenth generation high alcohol sensitive (HAS) and low alcohol sensitive (LAS) rats were trained…

Tags: *Cues, *Discrimination Learning, *Hypnotics and Sedatives, 1990, Animals, Breeding, Ethanol/*pharmacology, Krimmer E C, Male, Pharmacology, biochemistry, and behavior, Phenotype, Rats, Sleep/*drug effects, Species Specificity, Time Factors

Elapsed time from symptom onset and acute myocardial infarction in a community hospital.

STUDY OBJECTIVE: Previous reports have emphasized that thrombolytic therapy for acute myocardial infarction should be initiated within three or four hours of symptom onset to obtain the best clinical outcomes. However, our clinical impression was…

Delays in immunizations of high-risk infants during the first two years of life: special care for the high-risk infant should not mean special immunization schedules.

Because experience in our newborn intensive care unit follow-up clinic since 1982 suggested that immunizations of newborn intensive care unit graduates in the first 2 years of life were inappropriately delayed, questionnaires were sent to families…

Effect of digital rectal examination (and ejaculation) on serum prostate-specific antigen after twenty-four hours. A randomized, prospective study.

The purpose of this randomized, controlled, clinical trial was to determine the effect of the digital rectal examination (DRE) on the prostate-specific antigen (PSA) serum levels in view of conflicting literature reports and screening methods and…

Tags: *Palpation, 1993, 80 and over, Adult, Aged, Ejaculation, Geller L, Gerson L W, Humans, Male, McAleer J K, McMahon D, Middle Aged, Prospective Studies, Prostate-Specific Antigen/*blood, Rectum, Time Factors, Urology

The modulation of long-term potentiation by delta-9-tetrahydrocannabinol in the rat hippocampus, in vitro.

The duration of long-term potentiation (LTP) of the CA1 evoked field potential in rat hippocampal slices was significantly modulated by pre-treatment of slices with delta-9-tetrahydrocannabinol (THC) added to the incubation media. The three THC doses…

Tags: 1987, Animals, Brain research bulletin, Dronabinol/*pharmacology, Evoked Potentials/drug effects, Hippocampus/*drug effects/physiology, In Vitro Techniques, Kinetics, Male, Nowicky A V, Pyramidal Tracts/drug effects/physiology, Rats, Teyler T J, Time Factors, Vardaris R M

Delayed presentation of an inflammatory polyp following colonic ischemia.

Inflammatory polyps are usually associated with inflammatory bowel disease. The majority of these lesions are asymptomatic, however, they may be a source of obstruction or hemorrhage. These polyps represent re-epithelialization of the damaged colonic…

Tags: 1993, Aged, Colitis/*etiology/pathology/surgery, Colon/*blood supply, Colonic Polyps/diagnosis/*etiology/pathology/surgery, Colonoscopy, Female, Hlivko T J, Humans, Ischemia/*complications, Pidala M J, Slezak F A, The American surgeon, Time Factors

Trauma attending in the resuscitation room: does it affect outcome?

Although there are no Class I data supporting the regionalization of trauma care the consensus is that trauma centers decrease morbidity and mortality. However, the controversy continues over whether trauma surgeons should be in-house or take call…

Browse Items (137 total)