Browse Items (1073 total)
- Tags: Animals
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) disrupts social memory/recognition processes in the male mouse.
Tags: *Social Behavior, 1-Methyl-4-phenyl-1, 1993, 2, 3, 6-tetrahydropyridine/*analogs & derivatives/pharmacology, Animals, Brain Chemistry/drug effects, Brain research, Catecholamines/metabolism, Cognition/*drug effects, Dluzen D E, Dopamine Agents/*pharmacology, Dopamine/metabolism, Habituation, Kreutzberg J D, Levodopa/pharmacology, Male, Memory/*drug effects, Mice, Psychophysiologic/drug effects
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces norepinephrine concentrations in the olfactory bulbs of male mice.
Tags: *Sex Characteristics, 1-Methyl-4-phenyl-1, 1992, 2, 3, 6-tetrahydropyridine/*pharmacology, Animals, Brain research, Dluzen D E, Dopamine/metabolism, Drug Resistance/genetics, Inbred C57BL, Inbred Strains, Male, Mice, Norepinephrine/*metabolism, Olfactory Bulb/*metabolism, Osmolar Concentration
4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling.
Tags: *4-Hydroxynonenal, *Coronary regulation, *Lipid peroxidation, *Post-translational modification, *Protein Processing, *Reactive oxygen species, *Signal Transduction, *TRPV1, 2016, Action Potentials/drug effects, Aldehydes/antagonists & inhibitors/metabolism/*pharmacology, Animal, Animals, Blood Flow Velocity, Bratz Ian N, Calcium Signaling/drug effects, Cappelli Holly C, Capsaicin/*pharmacology, Cardiovascular Agents/*pharmacology, Connell Patrick J, Coronary Circulation/drug effects, Coronary Vessels/metabolism/physiopathology, Cysteine/genetics/metabolism, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/*metabolism/physiopathology, Disease Models, Fahmy Joseph N, Femoral Artery/metabolism/physiopathology, Free radical biology & medicine, Geldenhuys Werner J, HEK293 Cells, Humans, Inbred C57BL, Lipid Peroxidation, Male, Mice, NEOMED College of Medicine, Patch-Clamp Techniques, Post-Translational, Sinharoy Pritam, Thodeti Charles K, TRPV Cation Channels/genetics/*metabolism, Vasodilation/drug effects
A block in glycoprotein processing correlates with small plaque morphology and virion targetting to cell-cell junctions for an oral and an anal strain of herpes simplex virus type-1.
Tags: *Protein Processing, 1995, Anal Canal/virology, Animals, Archives of virology, Cercopithecus aethiops, Dick J W, Electron, Fluorescent Antibody Technique, Genetic Complementation Test, Herpesvirus 1, Human/genetics/isolation & purification/*physiology, Humans, Indirect, Intercellular Junctions/physiology/*virology, Kinetics, Microscopy, Mouth/virology, Post-Translational, Rosenthal K S, Species Specificity, Vero Cells, Viral Envelope Proteins/*biosynthesis/metabolism, Viral Plaque Assay, Virion/*physiology
A bouquet for a broken heart: can flowers repair a damaged heart?
Tags: 2015, angiogenesis, Animals, Circulation research, Coronary Vessels, Coronary Vessels/*physiopathology, Department of Integrative Medical Sciences, Editorials, endocardium, Endocardium/*physiopathology, endothelial cells, Endothelium, myocardial infarction, Myocardial Infarction/*physiopathology, NEOMED College of Medicine, Thodeti Charles K, Vascular/*physiopathology
A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE.
Tags: 1989, 5)-, Ala(2)-MePhe(4)-Gly(5)-, Amines – Physiology, Anesthetics – Pharmacodynamics, Anesthetics/*pharmacology, Animals, Biogenic Monoamines/*physiology, Cell Surface – Drug Effects, Cell Surface – Physiology, Crisp T, D-Penicillamine (2, Dose-Response Relationship, Drug, Enkephalin, Enkephalins, Enkephalins – Pharmacodynamics, Enkephalins/*pharmacology, Inbred Strains, Injections, Intraspinal, Male, Naloxone – Pharmacodynamics, Naloxone/pharmacology, Opioid/drug effects/*physiology, Pain, Pain – Metabolism, Pain/*metabolism, Rats, Receptors, Spanos L J, Spinal, Spinal Cord – Drug Effects, Spinal Cord – Metabolism, Spinal Cord – Physiopathology, Spinal Cord/drug effects/metabolism/*physiopathology, Stafinsky J L
A comparison of awake and sleeping cortical states by analysis of the somatosensory-evoked response of postcentral area 1 in rhesus monkey.
A critical period for long-term potentiation in the developing rat visual cortex.
A dinosaurian facial deformity and the first occurrence of ameloblastoma in the fossil record.
Tags: *Dinosaurs, *Fossils, 2016, Acheson Katharine A, Ameloblastoma/diagnosis/pathology/*veterinary, Andrei Razvan A, Animals, Codrea Vlad A, Csiki-Sava Zoltan, Dumbrava Mihai D, Mandible/*pathology, Mandibular Neoplasms/diagnosis/pathology/*veterinary, Romania, Rothschild Bruce M, Scientific reports, Weishampel David B
A formidable foe: carbapenem-resistant Acinetobacter baumannii and emerging nonantibiotic therapies.
Tags: *Carbapenem-resistant Acinetobacter baumannii, *decolonization, *hospital-acquired infections, *therapies, *vaccination, 2018, Acinetobacter baumannii/drug effects/*isolation & purification, Acinetobacter Infections – Microbiology, Acinetobacter Infections – Therapy, Acinetobacter Infections/microbiology/*therapy, Animals, Anti-Bacterial Agents/pharmacology, Antibiotics – Pharmacodynamics, Bacterial, Carbapenems – Pharmacodynamics, Carbapenems/pharmacology, Department of Internal Medicine, Drug Resistance, Expert review of anti-infective therapy, Gram-Negative Aerobic Bacteria, Gram-Negative Aerobic Bacteria – Drug Effects, Humans, Microbial, Microbial Culture and Sensitivity Tests, Microbial Sensitivity Tests, NEOMED College of Medicine, Watkins Richard R
A function for binaural integration in auditory grouping and segregation in the inferior colliculus.
Tags: *Auditory Perception, 2015, Animals, Auditory, binaural integration, Evoked Potentials, Female, Guinea Pigs, harmonic complex, Inferior Colliculi/cytology/*physiology, inferior colliculus, Journal of neurophysiology, Magezi David A, Male, Nakamoto Kyle T, Neurons/physiology, Palmer Alan R, pitch, Shackleton Trevor M
A L.E.A.P.S. heteroconjugate vaccine containing a T cell epitope from HSV-1 glycoprotein D elicits Th1 responses and protection.
Tags: 2003, Amino Acid Sequence, Animals, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Conjugate/immunology, Delayed/immunology, Enzyme-Linked Immunosorbent Assay, Epitopes/*immunology, Female, Goel N, Herpes Simplex Virus Vaccines/*immunology, Herpes Simplex/pathology/prevention & control, Herpesvirus 1, Human/*immunology, Hypersensitivity, Inbred BALB C, Interferon-gamma/biosynthesis, Lymphocyte Count, Mice, Molecular Sequence Data, Peptides/immunology, Rong Q, Rosenthal K S, Th1 Cells/*immunology, Vaccine, Vaccines, Viral Envelope Proteins/*immunology, Zimmerman D
A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.
Tags: 1995, 5)-, Ala(2)-MePhe(4)-Gly(5)-, Animals, Crisp T, D-Penicillamine (2, Dose-Response Relationship, Drug, Enkephalin, Enkephalins/*pharmacology, General pharmacology, Keck B J, Male, Naltrexone/analogs & derivatives/pharmacology, Narcotic Antagonists/*pharmacology, Opioid/*drug effects, Rats, Receptors, Somatostatin/analogs & derivatives/pharmacology, Species Specificity, Spinal Cord/*drug effects, Sprague-Dawley, Stafinsky J L, Uram M
A metabolic stress-inducible miR-34a-HNF4alpha pathway regulates lipid and lipoprotein metabolism.
Tags: 2015, Animals, Apolipoproteins E/genetics, Atherosclerosis/genetics/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Experimental/genetics/metabolism, Hep G2 Cells, Hepatocyte Nuclear Factor 4/*genetics/metabolism, Humans, Knockout, LDL/genetics, Li Yuanyuan, Lipid Metabolism/*genetics, Lipoproteins/metabolism, Liver/metabolism, Mice, MicroRNAs/*genetics/metabolism, Middle Aged, Nature communications, NEOMED College of Medicine, Non-alcoholic Fatty Liver Disease/*genetics/metabolism, Physiological/*genetics, Receptors, Stress, Triglycerides/*metabolism, Xu Jiesi, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
A method for calculating current source density (CSD) analysis without resorting to recording sites outside the sampling volume.
A modification of the epidermal scarification model of herpes simplex virus infection to achieve a reproducible and uniform progression of disease.
Tags: *Herpesvirus 1, 2002, Animal, Animals, Disease Models, Disease Progression, Docherty John J, Female, Fu Ming Ming, Goel Neena, Herpes Simplex/pathology/physiopathology/*transmission, Human, Humans, Inbred BALB C, Journal of virological methods, Mice, Reproducibility of Results, Rosenthal Kenneth S, Skin/virology, Zimmerman Daniel H
A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis.
Tags: 1990, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Amphetamines/*pharmacology, Animals, Brain research, Corpus Striatum/*metabolism, Dopamine D2, Dopamine/*metabolism, Dopamine/drug effects, Electrochemistry, Inbred Strains, Male, Pehek E A, Rats, Receptors, Sulpiride/*pharmacology, Yamamoto B K
A neurochemical hypothesis for the origin of hominids.
Tags: *Ardipithecus, *basal ganglia, *Biological Evolution, *dopamine, *hominin, *Neurochemistry, *neurotransmitter, *Selection, *Social Behavior, 2018, Altruism, Animals, Corpus Striatum/*physiology, Dogs, Edler Melissa K, Genetic, Hof Patrick R, Holloway Ralph L, Humans, Jacobs Bob, Lovejoy C Owen, Munger Emily L, Personality, Primates, Proceedings of the National Academy of Sciences of the United States of America, Raghanti Mary Ann, Sherwood Chet C, Social Conformity, Stephenson Alexa R
A new zygodactylid species indicates the persistence of stem passerines into the early Oligocene in North America.
Tags: *Paleobiogeography, *Paleogene, *Passeriformes, *Phylogeny, *Zygodactylidae, 2019, Animals, BMC evolutionary biology, Body Size, Clarke Julia A, Department of Anatomy & Neurobiology, Extremities/anatomy & histology, Feathers/anatomy & histology, Fossils, Geography, Hieronymus Tobin L, NEOMED College of Graduate Studies, NEOMED College of Medicine, North America, Passeriformes/*classification, Skull/anatomy & histology, Species Specificity, Spine/anatomy & histology, Time Factors, Waugh David A
A noninflammatory interleukin-1beta fragment stimulates fetal lung fluid absorption in guinea pigs.
Tags: 2007, Absorption, Adrenergic, Adrenocorticotropic Hormone/blood, Animals, Beard LaMonta L, beta/analysis, Body Fluids/drug effects/metabolism, Department of Integrative Medical Sciences, Epithelial Sodium Channels/genetics, Female, Fetus/drug effects, Folkesson Hans G, Guinea Pigs, Hydrocortisone/biosynthesis, Interleukin-1beta/*pharmacology, Li Tianbo, Lung/*drug effects/metabolism, Messenger/analysis, NEOMED College of Medicine, Oxytocin/pharmacology, Peptide Fragments/*pharmacology, Pregnancy, Receptors, RNA, The Journal of pharmacology and experimental therapeutics, Varadarajulu Shilpa, Yun June
A novel coding mechanism for social vocalizations in the lateral amygdala.
Tags: *Social Behavior, 2012, Acoustic Stimulation, Action Potentials/*physiology, Amygdala/*cytology/physiology, Animal/*physiology, Animals, Auditory Pathways/*physiology, Chiroptera, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Dextrans/metabolism, Echolocation/physiology, Female, Gadziola Marie A, Grimsley Jasmine M S, Journal of neurophysiology, Male, NEOMED College of Medicine, Neurons/*physiology, Reaction Time/physiology, Rhodamines/metabolism, Shanbhag Sharad J, Time Factors, Vocalization, Wenstrup Jeffrey J
A novel mechanism of neurokinin-1 receptor resensitization.
Tags: 2002, Animals, Bennett V J, Cell Membrane/drug effects/metabolism, CHO Cells, Concanavalin A/pharmacology, Cricetinae, Monensin/pharmacology, Neurokinin-1/*agonists/*metabolism, Perrine S A, Phosphorylation/drug effects, Rats, Receptors, Simmons M A, The Journal of pharmacology and experimental therapeutics
A novel role for Bcl-2 associated-athanogene-1 (Bag-1) in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes.
Tags: *Gene Expression Regulation, 2007, Animals, Apoptosis, Biological, Carlson Sara G, Cell Proliferation, Chondrocytes/*metabolism/pathology, Collagen Type II/metabolism, Department of Anatomy & Neurobiology, DNA-Binding Proteins/*metabolism/physiology, Endoplasmic Reticulum/metabolism, Horton Walter E Jr, Journal of cellular biochemistry, McBurney Denise, Models, NEOMED College of Medicine, Phenotype, Rats, RNA Interference, Subcellular Fractions/metabolism, Tang Shou-Ching, Time Factors, Transcription Factors/*metabolism/physiology, Transfection, Yang Ling
A preliminary analysis of correlations between chewing motor patterns and mandibular morphology across mammals.
Tags: *Mastication, 2011, Animals, Biological Evolution, Bite Force, Crompton Alfred W, Doherty Alison H, Electromyography, Feeding Behavior/physiology, Hylander William L, Integrative and comparative biology, Jaw/anatomy & histology/*physiology, Mammals/anatomy & histology/physiology, Masseter Muscle/anatomy & histology/*physiology, Phylogeny, Temporal Muscle/anatomy & histology/*physiology, Vinyard Christopher J, Wall Christine E, Williams Susan H
A preliminary analysis of the relationship between jaw-muscle architecture and jaw-muscle electromyography during chewing across primates.
Tags: *Mastication, 2010, Anatomical record (Hoboken, N.J. : 2007), Animals, Electromyography, Jaw/*anatomy & histology/physiology, Masseter Muscle/*anatomy & histology/physiology, Primates/*anatomy & histology/physiology, Taylor Andrea B, Temporal Muscle/*anatomy & histology/physiology, Vinyard Christopher J
A quantitative LC-MS/MS method for determination of thiazolidinedione mitoNEET ligand NL-1 in mouse serum suitable for pharmacokinetic studies.
Tags: %CV, %RE, 1-Methyl-4-phenyl-1, 2, 2014, 3, 3-thiazolidine-2, 4-dione, 5-[3, 5-[4-hydroxy-3, 5-di-tert-butyl-4-hydroxyphenyl)methyl]-1, 5-dimethyl-phenyl)methyl]thiazolidine-2, 6-tetrahydropyridine, Anderson David J, Animals, Carroll Richard T, Carry-over, Chromatography, Department of Internal Medicine, Geldenhuys Werner J, High Pressure Liquid/*methods, internal standard, IS, Jogiraju Harini, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, LC-MS/MS, Limit of Detection, Lin Li, LLOQ, lower limit of quantification, Methanol, Mice, mitoNEET, Mouse serum, MPTP, MRM, multiple reaction monitoring, NEOMED College of Medicine, NL-1, NL-2, Pedada Kiran K, percent coefficient of variation, peroxisome proliferator activated receptor-gamma, pharmacokinetic, PK, PPAR-gamma, QC, Quality Control, relative error, relative matrix effect, RME, SD, standard deviation, Tandem Mass Spectrometry/*methods, thiazolidinedione, Thiazolidinedione (TZD), Thiazolidinediones/*blood, TZD, Zhou Xiang
A rapid and simple HPLC microassay for biogenic amines in discrete brain regions.
Tags: *Brain Chemistry, 1988, Animals, Biogenic Amines/*analysis, Chromatography, Corpus Striatum/analysis, Donzanti B A, High Pressure Liquid/methods, Inbred Strains, Indicators and Reagents, Male, Nucleus Accumbens/analysis, Organ Specificity, Pharmacology, biochemistry, and behavior, Rats, Reference Values, Yamamoto B K
A single restraint stress exposure potentiates analgesia induced by intrathecally administered DAGO.
Tags: 1992, Ala(2)-MePhe(4)-Gly(5)-, Analgesics/*pharmacology, Analysis of Variance, Animals, Brain research, Calcagnetti D J, Crisp T, Drug Synergism, Enkephalin, Enkephalins/*pharmacology, Injections, Male, Pain Measurement, Physical, Physiological/*physiopathology, Rats, Reaction Time, Restraint, Spinal, Sprague-Dawley, Stafinsky J L, Stress
A slice preparation preserving the callosal projection to contralateral visual cortex.
A system for measuring electrophysiological multiple unit activity and extracellular dopamine concentration at single electrodes.
Tags: 1993, 3, 4-Dihydroxyphenylacetic Acid/analysis, Amphetamine/pharmacology, Animals, Ascorbic Acid/analysis, Cerebral Cortex/drug effects/metabolism/*physiology, Dopamine/*analysis/metabolism, Electric Stimulation/instrumentation/methods, Electrochemistry/instrumentation/methods, Electrophysiology/instrumentation/*methods, Extracellular Space/chemistry, Glynn G E, Hydroxyindoleacetic Acid/analysis, Journal of neuroscience methods, Male, Rats, Serotonin/analysis, Sprague-Dawley, Yamamoto B K
A three-dimensional digital neurological atlas of the mustached bat (Pteronotus parnellii).
Tags: *Atlases as Topic, 2018, Animals, Auditory Cortex/anatomy & histology/diagnostic imaging, Brain Stem/anatomy & histology/diagnostic imaging, Brain/*anatomy & histology/diagnostic imaging, Chiroptera/*anatomy & histology, College of Anatomy & Neurobiology, De Groof Geert, Deleye Steven, Department of Anatomy & Neurobiology, Diffusion Tensor Imaging/methods, Hamaide Julie, Huysmans Toon, Imaging, Jeurissen Ben, Kanwal Jagmeet S, Liang Sayuan, Magnetic Resonance Imaging/*methods, Male, NEOMED College of Medicine, NeuroImage, Radtke-Schuller Susanne, Sijbers Jan, Skull/anatomy & histology/diagnostic imaging, Three-Dimensional/*methods, Tomography, Van Audekerke Johan, Van der Linden Annemie, van Steenkiste Gwendolyn, Verhoye Marleen, Washington Stuart D, Wenstrup Jeffrey J, X-Ray Computed/*methods
A TRP to cardiac fibroblast differentiation.
Tags: *Calcium Signaling, *Cell Differentiation, *Cell Transdifferentiation, *Mechanotransduction, *Wound Healing, 2013, Animals, Atrial Fibrillation/*metabolism, cardiac fibroblast, Cellular, Channels (Austin, Tex.), Department of Integrative Medical Sciences, differentiation, ECM stiffness, Female, Fibroblasts/*metabolism/*physiology, Humans, integrin, Male, mechanical signaling, Meszaros J Gary, myofibroblast, Myofibroblasts/*cytology/*metabolism, NEOMED College of Medicine, Paruchuri Sailaja, Rho/ROCK, Thodeti Charles K, TRPC Cation Channels/*metabolism, TRPM Cation Channels/*metabolism, TRPV Cation Channels/*metabolism, TRPV4
A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis.
Tags: *Flux, *Glutathione, *Heavy water, *Mass spectrometer, *NAFLD, *NASH, *Oxidative Stress, *Western Diet, 2016, Animal, Animals, Antioxidants/metabolism, Department of Pharmaceutical Sciences, Diet, Disease Models, Free radical biology & medicine, Glutathione/blood/*metabolism, Humans, Kasumov Takhar, LDL/blood/*genetics/metabolism, Lee Kwangwon, Li Ling, Liver/*metabolism/pathology, Lopez Rocio, McCullough Arthur, Mice, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/blood/*genetics/pathology, Oxidative Stress/genetics, Previs Stephen F, Receptors, Western/adverse effects, Willard Belinda, Zhang Guo-Fang
Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice.
Tags: *Intracellular Signaling Peptides and Proteins, 2001, Alzheimer Disease/*genetics/metabolism/physiopathology, Animals, Apoptosis Regulatory Proteins, Apoptosis/*genetics, Brain research, Carrier Proteins/*genetics/metabolism, Caspases/metabolism, Chang X, Gene Expression Regulation/physiology, Glucose/deficiency, Guo Q, Hippocampus/*metabolism/physiopathology, Membrane Proteins/*genetics, Mice, Mitochondria/metabolism/pathology, Mutation/*genetics, Neurons/*metabolism/pathology, Presenilin-1, Signal Transduction/genetics, Transgenic/genetics/metabolism, Xie J, Zhang X
Ablation of the hypothalamic arcuate-median eminence region reduces the concentration of vasoactive intestinal peptide in the anterior pituitary gland of male rats.
Tags: 1993, Adrenal Glands/anatomy & histology, Animals, Anterior/*physiology, Arcuate Nucleus of Hypothalamus/*physiology, Brain research, Carrillo A J, Dluzen D E, Drinking Behavior, Hypothalamo-Hypophyseal System/*physiology, Male, Median Eminence/*physiology, Organ Size, Pituitary Gland, Pituitary Gland/anatomy & histology, Prolactin/blood/metabolism, Rats, Sprague-Dawley, Testis/anatomy & histology, Time Factors, Vasoactive Intestinal Peptide/*metabolism
Absence of type VI collagen paradoxically improves cardiac function, structure, and remodeling after myocardial infarction.
Tags: 2012, Adapala Ravi K, Animal, Animals, Apoptosis/physiology, Bonaldo Paolo, Cardiac/pathology/physiology, Chilian William M, Circulation research, Collagen Type VI/*genetics/*metabolism, Department of Integrative Medical Sciences, Disease Models, Echocardiography, Extracellular Matrix/metabolism/pathology, Fibrosis/genetics/pathology/physiopathology, Hodnichak Cheryl, Knockout, Luther Daniel J, Male, Meszaros J Gary, Mice, Myocardial Infarction/diagnostic imaging/*genetics/*physiopathology, Myocytes, NEOMED College of Medicine, Shamhart Patricia E, Thodeti Charles K, Ventricular Remodeling/*physiology, Weihrauch Dorothee
Activation and circuitry of uterine-cervix-related neurons in the lumbosacral dorsal root ganglia and spinal cord at parturition.
Tags: 2005, Analysis of Variance, Animals, Blotting, Cell Count/methods, Cervix Uteri/*cytology, Cyclic AMP Response Element-Binding Protein/metabolism, Estrogen Receptor alpha/metabolism, Female, Ganglia, Gene Expression Regulation/physiology, Immunohistochemistry/methods, Journal of neuroscience research, Lumbosacral Region, Models, Nerve Net/cytology/*physiology, Neurological, Neurons/classification/*physiology, Oncogene Proteins v-fos/metabolism, Papka R E, Parturition/*physiology, Pregnancy, Puder B A, Rats, Spinal Cord/*cytology, Spinal/*cytology, Sprague-Dawley, Stilbamidines/metabolism, Time Factors, Western/methods
Activation of heterotrimeric G-proteins independent of a G-protein coupled receptor and the implications for signal processing.
Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.
Tags: 2016, Adapala R K, Animals, Calcium Signaling/genetics, Cappelli H C, Carcinoma, Cell Line, Cell Proliferation/drug effects, Chilian W M, Cisplatin/administration & dosage, Department of Integrative Medical Sciences, Dudley A C, Endothelium, Gene Expression Regulation, Ghosh K, Humans, Ingber D E, Keshamouni V, Klagsbrun M, Leucine/administration & dosage/analogs & derivatives, Lewis Lung/drug therapy/*genetics/pathology, Meszaros J G, Mice, NEOMED College of Medicine, Neoplastic/drug effects, Neovascularization, Oncogene, Paruchuri S, Pathologic/drug therapy/*genetics/pathology, Sulfonamides/administration & dosage, Thodeti C K, Thoppil R J, TRPV Cation Channels/agonists/biosynthesis/*genetics, Tumor, Vascular Endothelial Growth Factor A/genetics, Vascular/drug effects/*pathology