Browse Items · NEOMED Bibliography Database

Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.

Tumor vessels are characterized by abnormal morphology and hyperpermeability that together cause inefficient delivery of chemotherapeutic agents. Although vascular endothelial growth factor has been established as a critical regulator of tumor…

Resveratrol inhibition of herpes simplex virus replication.

Resveratrol, a phytoalexin, was found to inhibit herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) replication in a dose-dependent, reversible manner. The observed reduction in virus yield was not caused by the direct inactivation of HSV by…

Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1.

The dopamine transporter (DAT) is the key regulator of dopaminergic transmission and is a target of several xenobiotics, including pesticides and pharmacological agents. Previously, we identified a prominent role for histone deacetylases in the…

Tags: 2017, Acetylation/drug effects, Animals, Butyrates/pharmacology, Cell Line, Cell Survival/drug effects, Department of Pharmaceutical Sciences, Dopamine Plasma Membrane Transport Proteins/*metabolism, Dopamine transporter, Dopaminergic Neurons/cytology/drug effects/metabolism, Dose-Response Relationship, Drug, Eid Aseel, Epigenesis, Epigenetics, Genetic, Genetic/drug effects, Green Ashley L, Group A, Guo Grace L, HDAC, Histone deacetylase, Histone Deacetylase Inhibitors/*pharmacology, Histone Deacetylases/metabolism, Histones/*drug effects/metabolism, Homeodomain Proteins/metabolism, Hydroxamic Acids/pharmacology, Member 2/*metabolism, Messenger/metabolism, NEOMED College of Pharmacy, Neuropharmacology, Nuclear Receptor Subfamily 4, Nurr1, Pitx3, Promoter Regions, Rats, Richardson Jason R, RNA, Transcription Factors/metabolism, Valproate, Valproic Acid/*pharmacology, Zarbl Helmut, Zhan Le

Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3.

BACKGROUND: Although arachidonic acid metabolites, cysteinyl leukotrienes (cys-LTs; leukotriene [LT] C4, LTD4, and LTE4), and prostaglandin (PG) E2 are generated at the site of inflammation, it is not known whether crosstalk exists between these 2…

Protein thiyl radical mediates S-glutathionylation of complex I.

Complex I is a critical site of O(2)(*-) production and the major host of reactive protein thiols in mitochondria. In response to oxidative stress, complex I protein thiols at the 51- and 75-kDa subunits are reversibly

Tags: *Oxidative Stress, 2012, Amino Acid Motifs, Amino Acid Sequence, Animals, Binding Sites, Cattle, Cell Line, Chen Chwen-Lih, Chen Jingfeng, Chen Yeong-Renn, Cyclic N-Oxides/chemistry/pharmacology, Cysteine/chemistry/*metabolism, Department of Integrative Medical Sciences, Electron Transport Complex I/chemistry/*metabolism, Free radical biology & medicine, Free Radical Scavengers/chemistry/pharmacology, Free Radicals/chemistry/*metabolism, Glutathione/chemistry/*metabolism, Green Kari B, Heart/enzymology/metabolism, Kang Patrick T, Mice, Mitochondria, Models, Molecular, Molecular Sequence Data, Muscle Cells/drug effects/metabolism, NEOMED College of Medicine, Onium Compounds/pharmacology, Peptide Fragments/chemistry, Peptide Mapping, Protein, Rats, Rotenone/pharmacology, Structural Homology, Superoxides/metabolism, Zhang Liwen

Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells.

Superoxide (O(2)(*-)) is implicated in inflammatory states including arteriosclerosis and ischemia-reperfusion injury. Cobalamin (Cbl) supplementation is beneficial for treating many inflammatory diseases and also provides protection in…

Formulation and photoirradiation parameters that influenced photoresponsive drug delivery using alkoxylphenacyl-based polycarbonates.

Recently, we reported the synthesis and biocompatibility of alkoxylphenacyl-based polycarbonates (APP); a promising new class of polymers that undergo photo-induced chain scission. In the current study, nanoparticles (NPs) were prepared from the APP…

Lipopolysaccharide supports maintaining the stemness of CD133(+) hepatoma cells through activation of the NF-kappaB/HIF-1alpha pathway.

Due to the existence of cancer stem cells (CSCs), persistence and relapse of human hepatocellular carcinoma (HCC) are common after treatment with existing anti-cancer therapies. Emerging evidence indicates that lipopolysaccharide (LPS) plays a…

Tags: *Cancer stem cells, *Lipopolysaccharide, *Plasticity, *Stemness maintenance, *Tumor microenvironment, 2016, AC133 Antigen/genetics/*metabolism, alpha Subunit/genetics/*metabolism, Animals, Antineoplastic Agents – Pharmacodynamics, Antineoplastic Agents/pharmacology, Body Weights and Measures, Cancer letters, Carcinoma, Cell Line, Cell Movement – Drug Effects, Cell Movement/drug effects, Cell Physiology, Cell Physiology – Drug Effects, Cell Proliferation/drug effects, Department of Integrative Medical Sciences, Drug Resistance, Gene Expression Regulation, Genes, Genetic Techniques, Han Zhi-Peng, Hepatocellular, Hepatocellular – Drug Therapy, Hepatocellular – Metabolism, Hepatocellular – Pathology, Hepatocellular/drug therapy/genetics/*metabolism/pathology, Humans, Hypoxia-Inducible Factor 1, Inbred BALB C, Jing Ying-Ying, Lai Fo-Bao, Li Rong, Li Xiao-Yong, Lipopolysaccharides – Pharmacodynamics, Lipopolysaccharides/*pharmacology, Liu Jing-Feng, Liu Wen-Ting, Liver Neoplasms, Liver Neoplasms – Drug Therapy, Liver Neoplasms – Metabolism, Liver Neoplasms – Pathology, Liver Neoplasms/drug therapy/genetics/*metabolism/pathology, Male, Mice, NEOMED College of Medicine, Neoplasm, Neoplasm Invasiveness, Neoplastic, Neoplastic Stem Cells/*drug effects/metabolism/pathology, NF-kappa B – Metabolism, NF-kappa B/*metabolism, Nude, Pan Xiao-Rong, Phenotype, Proteins, Proteins – Metabolism, RNA Interference, Shi Rong-Yu, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Stem Cells – Drug Effects, Stem Cells – Metabolism, Stem Cells – Pathology, Time Factors, Transfection, Tumor Burden, Tumor Microenvironment, Wei Li-Xin, Wu Meng-Chao, Yang Xue, Yu Guo-Feng, Zeng Jian-Xing, Zhang Hang-Jie, Zhang Ping, Zhao Qiu-Dong

Novel compounds that target lipoprotein lipase and mediate growth arrest in acute lymphoblastic leukemia.

Over the past decade, the therapeutic strategies employed to treat B-precursor acute lymphoblastic leukemia (ALL) have been progressively successful in treating the disease. Unfortunately, the treatment associated dyslipidemia, either acute or…

Tags: *Acute lymphoblastic leukemia, *Cancer, *Co-culture model, *Lipids, *Lipoprotein lipase, *Metabolism, 2018, Amides/chemistry/metabolism/pharmacology, Antineoplastic Agents/*chemistry/metabolism/pharmacology, Binding Sites, Bioorganic & medicinal chemistry letters, Cell Line, Cell Proliferation/drug effects, Coculture Techniques, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dyslipidemias/complications/metabolism/pathology, Geldenhuys Werner J, Gibson Laura F, Humans, Lipoprotein Lipase/antagonists & inhibitors/*metabolism, Mesenchymal Stem Cells/cytology/metabolism, Molecular Docking Simulation, Nair Rajesh R, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Piktel Debbie, Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications/metabolism/pathology, Protein Binding, Protein Structure, Sadana Prabodh, Serum Albumin/chemistry/metabolism, Tertiary, Tumor

Screening and identification of novel compounds with potential anti-proliferative effects on gallium-resistant lung cancer through an AXL kinase pathway.

The clinical application of gallium compounds as anticancer agents is hampered by development of resistance. As a potential strategy to overcome the limitation, eight series of compounds were identified through virtual screening of AXL kinase…

Tags: 2014, Alazizi Adnan, Antineoplastic Agents/chemical synthesis/chemistry/*pharmacology, Antitumor, AXL, Bioorganic & medicinal chemistry letters, Cell Line, Cell Proliferation/drug effects, Cell Survival/drug effects, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Drug Resistance, Drug Screening Assays, Gallium, Gallium-resistance, Gallium/pharmacology, Geldenhuys Werner J, Humans, Lin Li, Liva Sophia, Lung cancer, Lung Neoplasms/drug therapy/*enzymology/*pathology, Molecular Structure, Naphthalenes/chemistry/*pharmacology, NEOMED College of Pharmacy, Neoplasm/drug effects, Oyewumi Moses O, Proto-Oncogene Proteins/*antagonists & inhibitors/metabolism, Pyrazoles/chemistry/*pharmacology, Quinolines/chemistry/*pharmacology, Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors/metabolism, Structure-Activity Relationship, Tetrazoles/chemistry/*pharmacology, Tumor, Virtual screening

BCNU-induced gR2 defect mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium.

A deficiency of mitochondrial glutathione reductase (or GR2) is capable of adversely affecting the reduction of GSSG and increasing mitochondrial oxidative stress. BCNU [1,3-bis (2-chloroethyl)-1-nitrosourea] is an anticancer agent and known…

Tags: 2014, Alkylating/*adverse effects/pharmacology, Animals, Antineoplastic Agents, Biochemical pharmacology, Cardiotoxins/adverse effects/pharmacology, Carmustine/*adverse effects/pharmacology, Cattle, Cell Line, Chen Chwen-Lih, Chen Yeong-Renn, Complex I, Department of Integrative Medical Sciences, Electron Transport Complex I/chemistry/*metabolism, Fatty Acids, Glutathione reductase, Glutathione Reductase/*antagonists & inhibitors/metabolism, Glutathione/*metabolism, Guarini Giacinta, Heart Ventricles/drug effects/metabolism/physiopathology, Heart/*drug effects/metabolism, Ion Channels/metabolism, Kang Patrick T, Left/*chemically induced/metabolism/physiopathology, Male, Mice, Mitochondria, Mitochondrial Proteins/metabolism, NEOMED College of Medicine, Nonesterified/metabolism, Oxidative Stress, Oxidative Stress/drug effects, Post-Translational/drug effects, Protein Processing, Rats, Ren Pei, S-Glutathionylation, Sprague-Dawley, Superoxide Dismutase/genetics/metabolism, Systolic dysfunction, Transgenic, Uncoupling Protein 3, Ventricular Dysfunction

Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.

The conversion of cholesterol to bile acids is the major pathway for cholesterol catabolism. Bile acids are metabolic regulators of triglycerides and glucose metabolism in the liver. This study investigated the roles of FoxO1 in the regulation of…

Tags: 2009, Adenoviridae/genetics, Animals, Bile Acids and Salts/biosynthesis, Biochimica et biophysica acta, Cell Line, Cell Nucleus/drug effects/metabolism, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*antagonists & inhibitors/genetics/metabolism, Department of Integrative Medical Sciences, Dietary Fats/*administration & dosage/*pharmacology, Down-Regulation/drug effects, Enzymologic/drug effects, Feeding Behavior/*drug effects, Forkhead Box Protein O1, Forkhead Transcription Factors/genetics/*metabolism, Gene Expression Regulation, Gene Knockdown Techniques, Gene Transfer Techniques, Hepatocytes/drug effects/*enzymology, Humans, Inbred C57BL, Insulin Resistance, Insulin/metabolism, Lee Yoon-Kwang, Li Tiangang, Ma Huiyan, Male, Messenger/genetics/metabolism, Mice, Moore David D, NEOMED College of Medicine, Park Young Joo, RNA, RNA Interference/drug effects, Strom Stephen, Tumor

Resveratrol inhibition of varicella-zoster virus replication in vitro.

Resveratrol was found to inhibit varicella-zoster virus (VZV) replication in a dose-dependent and reversible manner. This decrease in virus production in the presence of resveratrol was not caused by direct inactivation of VZV or inhibition of virus…

Genomic structure and regulation of the rat hepatic CYP4F1 gene by peroxisome proliferators.

The rat hepatic gene CYP4F1 encodes a fatty acid omega hydroxylase P450 that metabolizes proinflammatory eicosanoids and long-chain fatty acids. We have completely sequenced the CYP4F1 gene (Accession Nos. AF200361 and AF181083), identified multiple…

Impairment of pH gradient and membrane potential mediates redox dysfunction in the mitochondria of the post-ischemic heart.

The mitochondrial electrochemical gradient (Deltap), which comprises the pH gradient (DeltapH) and the membrane potential (DeltaPsi), is crucial in controlling energy transduction. During myocardial ischemia and reperfusion (IR), mitochondrial…

The human cytochrome b5 gene and two of its pseudogenes are located on chromosomes 18q23, 14q31-32.1 and 20p11.2, respectively.

Using very high stringency hybridization conditions for the Southern blot hybridization analysis of hamster-human cell hybrid DNA, we were able to map the human cytochrome b5 gene and two of its pseudogenes (psgb(5)1 and psgb(5)2) unambiguously to…

Reexamination of amphotropic murine leukemia virus neurovirulence: neural stem cell-mediated microglial infection fails to induce acute neurodegeneration.

The 4070A amphotropic murine leukemia virus (A-MuLV) has been variably reported to harbor neurovirulence determinants within its env gene. In this report we reexamined this issue by applying two approaches previously demonstrated to amplify murine…

The opposing effects of retinoic acid and phorbol esters converge to a common response element in the promoter of the rat cholesterol 7 alpha-hydroxylase gene (CYP7A).

The activity of the rat CYP7A/luciferase reporter gene was increased five-fold by all-trans retinoic acid (atRA) or 9-cis retinoic acid (9cRA) in transient transfection assay in HepG2 cells. Cotransfection with retinoid X receptor (RXR) stimulated…

Inhibition of the G2/M transition of the cell cycle by methyl-2,5-dihydroxycinnamate in human lymphoid cells.

Immortalized human lymphoid cells treated with Methyl-2,5-dihydroxycinnamate (MDHC), a stable analog of erbstatin, inhibited the G2/M transition of the cell cycle. The MDHC inhibition of the cell cycle was observed at concentrations well below the…

Tags: 1996, Biochemical and biophysical research communications, Cell Line, Cinnamates/*pharmacology, Cultured, G2 Phase/*drug effects, Humans, Jamison J M, Koch J A, Lymphocytes/cytology/*drug effects, Mitosis/*drug effects, Monocytes/cytology/drug effects, Rosenthal K S, Summers J L, Transformed, Tumor Cells

The isolation and characterization of the human cytochrome b5 gene.

From a series of lambda and cosmid libraries, we isolated DNA sequences corresponding to the complete coding region for the human cytochrome b5 (CYB5) gene. The overall gene organization was the same as the bovine and rabbit CYB5 genes. One cosmid…

Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells.

The human liver CYP4F2 gene (Accession No. AF221943) encodes a leukotriene B(4) omega-hydroxylase that metabolizes leukotriene B(4) (LTB(4)) to a less potent proinflammatory eicosanoid, 20-OH-LTB(4). We sequenced a 6.7-kb genomic fragment of the…

Biocompatibility and in vivo tolerability of a new class of photoresponsive alkoxylphenacyl-based polycarbonates.

Potential toxicities of chromophoric or polymeric units of most photoresponsive delivery systems have impacted clinical relevance. Herein, we evaluated the biocompatibility and tolerability of alkoxylphenacyl-based polycarbonates (APPs) as a new…

Osteoactivin regulates head and neck squamous cell carcinoma invasion by modulating matrix metalloproteases.

Nearly 60% of patients with head and neck squamous cell carcinoma (HNSCC) die of metastases or locoregional recurrence. Metastasis is mediated by cancer cell migration and invasion, which are in part dependent on extracellular matrix degradation by…

Osteoactivin Promotes Migration of Oral Squamous Cell Carcinomas.

Nearly 50% of patients with oral squamous cell carcinoma (OSCC) die of metastases or locoregional recurrence. Metastasis is mediated by cancer cell adhesion, migration, and invasion. Osteoactivin (OA) overexpression plays a role in metastases in…

Osteoactivin induces transdifferentiation of C2C12 myoblasts into osteoblasts.

Osteoactivin (OA) is a novel osteogenic factor important for osteoblast differentiation and function. Previous studies showed that OA stimulates matrix mineralization and transcription of osteoblast specific genes required for differentiation. OA…

Osteoactivin promotes osteoblast adhesion through HSPG and alphavbeta1 integrin.

Osteoactivin (OA), also known as glycoprotein nmb (gpnmb) plays an important role in the regulation of osteoblast differentiation and function. OA induced osteoblast differentiation and function in vitro by stimulating alkaline phosphatase (ALP)…

Tags: 2014, 3T3 Cells, Abdelmagid Samir M, Actin Cytoskeleton/physiology, ADHESION, Alkaline Phosphatase/biosynthesis, Animals, Antibodies/immunology, Cell Adhesion, Cell Differentiation, Cell Line, Cell Proliferation, Chlorates/pharmacology, Department of Anatomy & Neurobiology, Extracellular Signal-Regulated MAP Kinases/biosynthesis, Eye Proteins/genetics/immunology/*metabolism, Focal Adhesion Kinase 1/biosynthesis, Focal Adhesions, Frara Nagat, Heparan Sulfate Proteoglycans/*metabolism, Heparin/pharmacology, Hisijara Israel Arango, Inbred C57BL, integrin, Journal of cellular biochemistry, Membrane Glycoproteins/genetics/immunology/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, OSTEOACTIVIN, OSTEOBLAST, OSTEOBLAST DIFFERENTIATION, Osteoblasts/*physiology, Osteogenesis/physiology, Protein Binding, Rats, Receptors, Recombinant Proteins, Safadi Fayez F, Scott Ethan M, Sondag Gregory R, Vitronectin/immunology/*metabolism

Coordinate down-regulation of cartilage matrix gene expression in Bcl-2 deficient chondrocytes is associated with decreased SOX9 expression and decreased mRNA stability.

The anti-apoptotic protein Bcl-2 has been shown to function in roles unrelated to apoptosis in a variety of cell types. We have previously reported that loss of Bcl-2 expression alters chondrocyte morphology and modulates aggrecan expression via an…

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.

UNLABELLED: Mouse fibroblast growth factor 15 (FGF15) and human ortholog FGF19 have been identified as the bile acid-induced intestinal factors that mediate bile acid feedback inhibition of cholesterol 7alpha-hydroxylase gene (C YP7A1) transcription…

Tags: 2009, Butadienes/pharmacology, Carcinoma, Cell Line, Chenodeoxycholic Acid/*pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*biosynthesis, Cytoplasmic and Nuclear/metabolism/physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Fibroblast Growth Factor, Fibroblast Growth Factors/drug effects/*physiology, Gene Expression/drug effects, Hepatocellular/metabolism, Hepatocytes/metabolism, Hepatology (Baltimore, Md.), Humans, Isoxazoles/pharmacology, Li Tiangang, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, NEOMED College of Medicine, Nitriles/pharmacology, Owsley Erika, Receptor, Receptors, Signal Transduction/drug effects, Song Kwang-Hoon, Strom Stephen, Transcription Factors/metabolism, Tumor, Type 4/antagonists & inhibitors

Browse Items (68 total)