Browse Items · NEOMED Bibliography Database

Spatial and temporal variations in extracellular matrix of periocular and corneal regions during corneal stromal development.

The development of the avian corneal stroma occurs in discrete developmental stages. During this sequence of events, the neural crest-derived corneal fibroblast precursor cells are surrounded by distinct extracellular matrices which change both…

Tags: *Extracellular Matrix, 1996, Animals, Birk D E, Cell Differentiation, Chick Embryo, Collagen/biosynthesis, Cornea/chemistry/*embryology/metabolism, Doane K J, Experimental eye research, Eye Proteins/analysis, Fibroblasts/cytology, Glycoproteins/analysis, McLaughlin J S, Neural Crest/cytology, Proteoglycans/biosynthesis, Time Factors, Ting W H

Alterations in nigrostriatal dopaminergic function within BDNF mutant mice.

The influence of brain-derived neurotrophic factor (BDNF) upon the nigrostriatal dopaminergic system was evaluated in weanling and adult mice carrying a targeted inactivated BDNF gene. Regional specificity of this BDNF mutation was assessed by…

The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.

We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion…

Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice.

Deletion of a single copy of the BDNF gene has been shown to affect the nigrostriatal dopaminergic system of young adult BDNF mice. In the present report we evaluated various indices of nigrostriatal dopaminergic function between

The isolation and characterization of the bovine cytochrome b5 gene, and a transcribed pseudogene.

This is the first isolation and characterization of a cytochrome b5(b5) gene. The bovine b5 gene is quite large, spanning about 28 kb and contains six exons. One of these exons appears to code for a reticulocyte-specific sequence similar to that…

The effect of immediate intraperitoneal carboplatinum on wound healing.

The effect of introducing intraperitoneal carboplatinum on wound healing immediately after wound closure was studied using a rat model. All animals were opened through a midline incision. A bowel anastomosis was then performed in a single-or…

Tags: 1993, Animals, Carboplatin/*administration & dosage/pharmacology, Clark T, Dose-Response Relationship, Drug, Gynecologic oncology, Hopkins M P, Injections, Intraperitoneal, Jenison E L, Male, Postoperative Period, Rats, Shellhaas C, Sprague-Dawley, Stakleff K S, Tissue Adhesions/etiology, Wound Healing/*drug effects

New Kohatius (Omomyidae) from the Eocene of Pakistan.

Tags: *Primates, 1997, Animals, Arif M, Department of Anatomy & Neurobiology, Hussain S T, Journal of human evolution, NEOMED College of Medicine, Pakistan, Thewissen J G, Tooth/*ultrastructure

New hominids from the Lake Turkana Basin, Kenya.

New hominid fossils from the Lake Turkana Basin range in age from ca. 3.35 to ca. 1.0 Ma. Those recovered from sediments stratigraphically just above the Tulu Bor Tuff in the Lomekwi Member of the Nachukui Formation are best attributed to…

Tags: *Fossils, 2001, Animals, Brown B, Brown F H, Femur/physiology, Geologic Sediments, Hominidae/*physiology, Humans, Journal of human evolution, Kenya, Mandible/physiology, Tibia/*physiology, Walker A

Aspects of mineral structure in normally calcifying avian tendon.

Structural characteristics of normally calcifying leg tendons of the domestic turkey Meleagris gallopavo have been observed for the first time by tapping mode atomic force microscopy (TMAFM), and phase as well as corresponding topographic images were…

Tags: 2001, Anatomic, Animals, Atomic Force/methods, Calcification, Collagen/chemistry/ultrastructure, Journal of structural biology, Landis W J, Microscopy, Minerals/*chemistry, Models, Molecular, Non-programmatic, Physiologic, Siperko L M, Tendons/*chemistry/*ultrastructure, Turkeys

Use of brain slices to study long-term potentiation and depression as examples of synaptic plasticity.

Brain slices have been responsible for the majority of advances in our understanding of the cellular aspects of altered synaptic strength underlying memory, long-term potentiation (LTP) and long-term depression (LTD), and increases and decreases,…

Tags: *Long-Term Potentiation, *Neuronal Plasticity, 1999, Animals, Brain/*physiology, Electrophysiology/methods, Glutamic Acid/physiology, In Vitro Techniques, Memory/*physiology, Methods (San Diego, Calif.), Models, Neurological, Synapses/*physiology, Synaptic Transmission, Teyler T J

Depotentiation of vdccLTP requires NMDAR activation.

Long-term potentiation is an enduring increase in synaptic efficacy following repeated stimulation of afferent fibers that is thought to underlie memory. In area CA1 of the hippocampus at least two forms of synaptic potentiation coexist at the same…

Neural stem cells as tools for understanding retroviral neuropathogenesis.

The discovery within the past decade that neural stem cells (NSCs) from the developing and adult mammalian brain can be propagated, cloned, and genetically manipulated ex vivo for ultimate transfer back into the CNS has opened the door to a novel…

Tags: 2000, Animals, Humans, Lynch W P, Membrane Fusion/physiology, Microglia/virology, Neurons/*virology, Portis J L, Retroviridae Infections/virology, Retroviridae Proteins/metabolism, Retroviridae/*pathogenicity, Stem Cells/*virology, Viral Envelope Proteins/metabolism, Virology, Virulence

Reexamination of amphotropic murine leukemia virus neurovirulence: neural stem cell-mediated microglial infection fails to induce acute neurodegeneration.

The 4070A amphotropic murine leukemia virus (A-MuLV) has been variably reported to harbor neurovirulence determinants within its env gene. In this report we reexamined this issue by applying two approaches previously demonstrated to amplify murine…

Anterograde Tract Tracing for Assaying Axonopathy and Transport Deficits in Glaucoma.

Whether to stage degeneration or investigate early pathology in glaucoma, examination of axonal structure and function is essential. There are a wide variety of methods available to investigators using animal models of glaucoma, with varying…

Injury models to study cardiac remodeling in the mouse: myocardial infarction and ischemia-reperfusion.

Deep tissue wound healing requires a complex sequence of several factors working in unison to repair the organ at risk. Myocardial infarction (MI) is particularly complex due to several local and systemic factors mediating the repair process within…

Tags: *Ventricular Remodeling, 2013, Animal, Animals, Cardiovascular Surgical Procedures, Coronary Vessels/surgery, Department of Integrative Medical Sciences, Disease Models, Ligation, Luther Daniel J, Meszaros J Gary, Methods in molecular biology (Clifton, N.J.), Mice, Myocardial Infarction/*etiology/*pathology, Myocardial Reperfusion Injury/*etiology/*pathology, NEOMED College of Medicine, Perfusion/methods, Thodeti Charles K, Wound Healing

Immunohistochemical localization of serotonin, leu-enkephalin, tyrosine hydroxylase, and substance P within the visceral sensory area of cartilaginous fish.

We examined the distribution of immunoreactivity to serotonin (5-HT), leu-enkephalin (LENK), tyrosine-hydroxylase (TH), and substance P (SP) within the primary visceral sensory region of cartilaginous fish. Two genera of sharks, Squalus and…

Tags: *Brain Chemistry, 1992, Animals, Antibodies, Brain Stem/cytology, Cell and tissue research, Cruce W L, Enkephalin, Fishes, Immunohistochemistry, Leucine/*analysis, Medulla Oblongata/cytology, Serotonin/*analysis, Stuesse D C, Stuesse S L, Substance P/*analysis, Tyrosine 3-Monooxygenase/*analysis

The human cytochrome b5 gene and two of its pseudogenes are located on chromosomes 18q23, 14q31-32.1 and 20p11.2, respectively.

Using very high stringency hybridization conditions for the Southern blot hybridization analysis of hamster-human cell hybrid DNA, we were able to map the human cytochrome b5 gene and two of its pseudogenes (psgb(5)1 and psgb(5)2) unambiguously to…

Induction of ethanol dependence increases signal peptidase mRNA levels in rat brain.

Differential Northern blot hybridization was used as a screening tool to identify mRNAs that respond quantitatively to the induction of ethanol dependence. Adult male rats were treated with repeated, high doses of ethanol for 4 consecutive days. This…

L-dopa infusion mode differentially affects corpus striatal dopamine efflux in the presence of reserpine.

In the present experiment we tested the effects of L-DOPA upon dopamine (DA) efflux in vitro from superfused corpus striatal tissue fragments in medium containing reserpine. The purposes of this experiment were first, to evaluate the effects of…

Tags: 1992, Amphetamine/pharmacology, Animals, Chromatography, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, High Pressure Liquid, Infusions, Intravenous, Journal of neural transmission. General section, Kratko F T Jr, Levodopa/*pharmacology, Male, Potassium/pharmacology, Rats, Reserpine/*pharmacology, Sprague-Dawley

L-DOPA modulation of corpus striatal dopamine and dihydroxyphenylacetic acid output from intact and 6-OHDA lesioned rats.

In the present report we examined the differences in in vitro dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) efflux from the corpus striatum (CS) of intact versus 6-hydroxydopamine (6-OHDA) lesioned (in substantia nigra) male rats in response…

Tags: *Sympathectomy, 1996, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Animals, Antiparkinson Agents/*pharmacology, Chemical, Corpus Striatum/drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Journal of neural transmission (Vienna, Austria : 1996), Levodopa/*pharmacology, Male, Oxidopamine, Rats, Sprague-Dawley, Substantia Nigra/drug effects/metabolism, Xu K

The effect of reserpine treatment in vivo upon L-dopa and amphetamine evoked dopamine and DOPAC efflux in vitro from the corpus striatum of male rats.

In the present experiment we tested the effects of L-DOPA and amphetamine upon dopamine and DOPAC efflux in vitro from superfused corpus striatal tissue fragments of male rats who had been pretreated with reserpine. Male rats were treated with…

Tags: 1994, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Amphetamine/*pharmacology, Animals, Cell Compartmentation, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Drug Interactions, Journal of neural transmission. General section, Levodopa/*pharmacology, Liu B, Male, Rats, Research Design, Reserpine/*pharmacology, Secretory Rate/drug effects, Sprague-Dawley

A block in glycoprotein processing correlates with small plaque morphology and virion targetting to cell-cell junctions for an oral and an anal strain of herpes simplex virus type-1.

The characteristics of two clinical isolates of HSV-1 obtained from an oral (424) and an anal (490) lesion were compared with the highly passaged KOS strain. In contrast to KOS, the clinical isolates produced small plaques, were more cell-associated…

Differences in response to the aversive properties and activity effects of low dose ethanol in LAS and HAS selectively bred rats.

Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0-3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place…

Tags: 1992, Animals, Avoidance Learning/*drug effects, Conditioning, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Krimmer E C, Motor Activity/drug effects, Operant/drug effects, Psychopharmacology, Rats, Schechter M D, Sleep/drug effects, Species Specificity

The discriminative properties of the D1 dopamine agonist dihydrexidine in the rat.

The objective of this study was to train rats to discriminate the interoceptive stimuli produced by a selective dopamine D1 agonist. Fourteen male Sprague-Dawley rats acquired the discrimination of the fully effective, high potency, D1 agonist…

Tags: 1995, Amphetamine/pharmacology, Animals, Apomorphine/pharmacology, Benzazepines/pharmacology, Cocaine/pharmacology, Discrimination (Psychology), Dopamine Agonists/pharmacology, Dopamine D1/*agonists, Dose-Response Relationship, Drug, Male, Phenanthridines/*pharmacology, Psychopharmacology, Rats, Receptors, Schechter M D, Sprague-Dawley

Mice transgenic for simian immunodeficiency virus nef are immunologically compromised.

An intact nef gene is essential for rapid development of immunodeficiency in human immunodeficiency virus and simian immunodeficiency virus infections. To assess the role of nef in the immune response, mice transgenic for SIV nef were constructed and…

Rotenone produces opposite effects upon mouse striatal dopamine function as a result of environmental temperature.

Rotenone is a commonly used pesticide that can function as an environmental neurotoxin. Rotenone is a known mitochondrial complex I inhibitor which can lead to oxidative stress and results in dopaminergic cell death. Another environmental factor…

Tags: *temperature, 2006, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Analysis of Variance, Animals, Brain Chemistry/drug effects/physiology/radiation effects, Corpus Striatum/*drug effects/metabolism, Crutchfield Karla C, Dluzen Dean E, Dopamine/*metabolism, Dose-Response Relationship, Drug, Insecticides/*pharmacology, Methamphetamine/pharmacology, Mice, Neurotoxicity research, Rotenone/*pharmacology

The effect of estrogen administration in vivo upon catecholamine release in vitro from superfused hypothalamic tissue of ovariectomized pre-pubertal and adult mice.

In the present report we examined the effects of estrogen upon catecholamine release from superfused medial basal hypothalamic tissue fragments of pre-pubertal ovariectomized CD-1 mice. Prepubertal mice treated with estradiol benzoate (EB–5…

Tags: *Ovariectomy, 1994, Aging/*metabolism, Animals, Attaran M, Catecholamines/*metabolism, Dluzen D, Dopamine/metabolism, Estradiol/*pharmacology, Female, Hypothalamus/*drug effects/metabolism, Journal of endocrinological investigation, Liu B, Mice, Norepinephrine/metabolism, Organ Size/drug effects, Potassium/pharmacology, Uterus/drug effects/growth & development

Demethyleneberberine alleviates inflammatory bowel disease in mice through regulating NF-kappaB signaling and T-helper cell homeostasis.

OBJECTIVE: The activation of NF-kappaB signaling and unbalance of T-helper (Th) cells have been reported to play a key role in the pathogenesis of colitis. Cortex Phellodendri Chinensis (CPC) is commonly used to treat inflammation and diarrhea.…

Tags: 2017, Animals, Anti-Inflammatory Agents/*pharmacology/therapeutic use, Berberine/*analogs & derivatives/pharmacology/therapeutic use, Chen Yingying, Colitis, Colon/drug effects/immunology/pathology, Cytokines/immunology, Dextran Sulfate, DMB, Female, Helper-Inducer/*drug effects/immunology, Homeostasis/drug effects, Immunoglobulin G/blood, Inbred C57BL, Inflammation research : official journal of the European Histamine Research Society ... [et al.], Inflammatory Bowel Diseases/blood/chemically induced/drug therapy/*immunology, Li Rui-Yan, Mice, NF-kappa B/*antagonists & inhibitors/immunology, NF-kappaB, RAW 264.7 Cells, Reactive Oxygen Species/metabolism, Shi Mei-Jing, Signal Transduction/drug effects, Spleen/cytology, T-Lymphocytes, Th cell, Xu Xin-Xin, Yan Yan, Zhang Miao, Zhang Yu-Bin, Zhao Xiao-Tong, Zhao Ya-Xing

Epidemiologic study of tumors in dinosaurs.

Occasional reports in isolated fragments of dinosaur bones have suggested that tumors might represent a population phenomenon. Previous study of humans has demonstrated that vertebral radiology is a powerful diagnostic tool for population screening.…

Tags: *Dinosaurs, 2003, Animals, Bone and Bones/diagnostic imaging, Die Naturwissenschaften, Fossils, Helbling M 2nd, Martin L D, Neoplasms/classification/diagnostic imaging/*epidemiology/*veterinary, Rothschild B M, Tanke D H, Tomography, X-Ray Computed

Raman spectroscopic documentation of Oligocene bladder stone.

Discovery of a fossil (30-35 million-year-old) urolith from Early Oligocene deposits in northeastern Colorado provides the earliest evidence for the antiquity of bladder stones. These are spherical objects with a layered phosphatic structure and a…

Tags: *Fossils, 2013, Anderson Brendan, Animals, Die Naturwissenschaften, Marshall Alison Olcott, Marshall Craig P, Martin Larry D, Raman, Rothschild Bruce M, Spectrum Analysis, Urinary Bladder Calculi/*chemistry, X-Ray Diffraction

Neuropathic pain in aged rats: behavioral responses and astrocytic activation.

We used the Bennett and Xie (1988) model of chronic neuropathic pain to study the effect of age on thermal and tactile sensitivity and on astrocytic activation in the dorsal horn of the spinal cord after nerve injury. Fischer 344 FBNF1 hybrid rats in…

Beyond thermoregulation: metabolic function of cetacean blubber in migrating bowhead and beluga whales.

The processes of lipid deposition and utilization, via the gene leptin (Lep), are poorly understood in taxa with varying degrees of adipose storage. This study examines how these systems may have adapted in marine aquatic environments inhabited by…

Novel thiazolidinedione mitoNEET ligand-1 acutely improves cardiac stem cell survival under oxidative stress.

Ischemic heart disease (IHD) is a leading cause of death worldwide, and regenerative therapies through exogenous stem cell delivery hold promising potential. One limitation of such therapies is the vulnerability of stem cells to the oxidative…

Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction.

We demonstrated previously that TRPV1-dependent coupling of coronary blood flow (CBF) to metabolism is disrupted in diabetes. A critical amount of H2O2 contributes to CBF regulation; however, excessive H2O2 impairs responses. We sought to determine…

Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage.

Mitochondrial dysfunction in obesity and diabetes can be caused by excessive production of free radicals, which can damage mitochondrial DNA. Because mitochondrial DNA plays a key role in the production of ATP necessary for cardiac work, we…

Impairment of pH gradient and membrane potential mediates redox dysfunction in the mitochondria of the post-ischemic heart.

The mitochondrial electrochemical gradient (Deltap), which comprises the pH gradient (DeltapH) and the membrane potential (DeltaPsi), is crucial in controlling energy transduction. During myocardial ischemia and reperfusion (IR), mitochondrial…

Alignment of inducible vascular progenitor cells on a micro-bundle scaffold improves cardiac repair following myocardial infarction.

Ischemic heart disease is still the leading cause of death even with the advancement of pharmaceutical therapies and surgical procedures. Early vascularization in the ischemic heart is critical for a better outcome. Although stem cell therapy has…

Tags: *Cardiovascular regeneration, *Ischemic heart diseases, *Micro-bundle scaffold, *Myocardial infarction, *Neovascularization, *Stem cells, *Tissue Scaffolds, *Vascular progenitor cells, 2017, Animal, Animals, Basic research in cardiology, Cell Differentiation, Cell Proliferation, Cell Survival, Cells, Chilian William M, Coculture Techniques, Cultured, Cumpston Devan, Department of Integrative Medical Sciences, Disease Models, Dong Feng, Endothelial Progenitor Cells/metabolism/*transplantation, Enrick Molly, Fibroblast Growth Factor 2/metabolism, Hakobyan Tatev, Jamaiyar Anurag, Janota Danielle, Kolz Christopher L, Lactic Acid/*chemistry, Muscle, Myocardial Infarction/metabolism/pathology/physiopathology/*surgery, Myocardium/metabolism/*pathology, Myocytes, NEOMED College of Medicine, Newby Bi-Min Zhang, Ohanyan Vahagn, Paracrine Communication, Phenotype, Physiologic, Polyglycolic Acid/*chemistry, Polylactic Acid-Polyglycolic Acid Copolymer, Rats, Signal Transduction, Smooth, Smooth Muscle/metabolism/*transplantation, Song Hokyung, Sprague-Dawley, Stevanov Kelly, Time Factors, Tissue Engineering/*methods, Vascular Endothelial Growth Factor A/metabolism, Vascular/metabolism/*transplantation, Ventricular Remodeling, Wan Weiguo, Yin Liya

Tags: 1999, Animals, Berthoud H R, Brain Stem/*anatomy & histology, Cell and tissue research, Cervix Uteri/*innervation, Collins J J, Estrogen/metabolism, Female, Immunohistochemistry, Lin C E, Neurons/cytology/metabolism, Papka R E, Rats, Receptors, Sprague-Dawley, Uterus/*innervation, Vagus Nerve/*anatomy & histology/metabolism

Browse Items (1073 total)