Browse Items (84 total)
- Tags: Inbred C57BL
PKCalpha mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells.
Tags: 2011, Acetylcholine/*pharmacology, Adapala Ravi K, American journal of physiology. Heart and circulatory physiology, Animals, Bratz Ian N, Calcium Signaling/*drug effects, Carbazoles/pharmacology, Cells, Cultured, Department of Integrative Medical Sciences, Endothelial Cells/*drug effects/enzymology, Enzyme Activation, Inbred C57BL, Knockout, Male, Mesenteric Arteries/drug effects/enzymology, Meszaros J Gary, Mice, Mutation, NEOMED College of Medicine, Nitric Oxide Synthase Type III/metabolism, Phosphorylation, Protein Kinase C-alpha/genetics/*metabolism, Protein Kinase Inhibitors/pharmacology, Suzuki Makoto, Talasila Phani K, Tetradecanoylphorbol Acetate/pharmacology, Thodeti Charles K, Time Factors, Transfection, TRPV Cation Channels/*agonists/deficiency/genetics/metabolism, Vasodilation/*drug effects, Vasodilator Agents/*pharmacology, Zhang David X
Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss.
Tags: 1-Methyl-4-phenyl-1, 2, 2017, 3, 6-tetrahydropyridine/*administration & dosage, Alam Gelareh, Animals, Burchfield Shelbie L, Catecholamines/metabolism, Cell Count, Corpus Striatum/*drug effects/metabolism, Department of Pharmaceutical Sciences, Dopamine, Dopamine transporter, Dopaminergic Neurons/*drug effects/metabolism, Edler Melissa, Inbred C57BL, Male, Mice, MPTP, MPTP Poisoning, NEOMED College of Pharmacy, Neurotoxicology, Parkinsonian Disorders/*metabolism/*pathology, Richardson Jason R, Stereology, Substantia Nigra/*drug effects/metabolism, Tyrosine 3-Monooxygenase/*metabolism, Tyrosine hydroxylase, Vesicular monoamine transporter
TRPA1 ion channel stimulation enhances cardiomyocyte contractile function via a CaMKII-dependent pathway.
Tags: [Ca2+]i, *Myocardial Contraction, 2017, Andrei Spencer R, Animals, Bratz Ian N, Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism, CaMKII, Cardiac/*metabolism, cardiomyocytes, Channels (Austin, Tex.), contractility, Damron Derek S, Dey Souvik, Ghosh Monica, Inbred C57BL, Knockout, Mice, Myocytes, Sinharoy Pritam, TRPA1, TRPA1 Cation Channel/deficiency/*metabolism
TRPA1 is functionally co-expressed with TRPV1 in cardiac muscle: Co-localization at z-discs, costameres and intercalated discs.
Tags: 2016, Andrei Spencer R, Animals, Bratz Ian N, Ca2+, Calcium/physiology, Cardiac/*physiology, cardiomyocytes, Channels (Austin, Tex.), Damron Derek S, Inbred C57BL, Male, Mice, Myocytes, Sinharoy Pritam, Transient Receptor Potential Channels/genetics/*physiology, TRPA1, TRPA1 Cation Channel, TRPV Cation Channels/genetics/*physiology, TRPV1, Z-disc
Beyond thermoregulation: metabolic function of cetacean blubber in migrating bowhead and beluga whales.
Tags: *Lipid Metabolism, 2017, Adipose Tissue/*metabolism, Aging/metabolism, Amino Acid Sequence, Animals, Ball H C, Base Sequence, Beluga Whale/*physiology, Blubber, Body Temperature Regulation, bowhead whale, Bowhead Whale/*physiology, Department of Anatomy & Neurobiology, Department of Family & Community Medicine, development, Duff R J, Female, George John C, Humans, Inbred C57BL, Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, leptin, Leptin/genetics, Leptin/genetics/metabolism, Lipase/genetics, Londraville R L, Long-Evans, Male, Metabolic activity, Mice, NEOMED College of Medicine, Prokop J W, Rats, Receptors, Seasons, Suydam R S, Thewissen J G M, Vinyard C
Methods and insights from the characterization of osteoprogenitor cells of bats (Mammalia: Chiroptera).
Tags: 2016, Animals, Ball H C, Bone Marrow Cells/cytology, Cell Differentiation/genetics, Cell Proliferation, Cells, Cellular Reprogramming, Chiroptera, Cooper L N, Core Binding Factor Alpha 1 Subunit/genetics/metabolism, Cultured, Department of Anatomy & Neurobiology, Inbred C57BL, Mbimba T, Mice, Moussa F M, NEOMED College of Medicine, Orman R, Osteoblasts/cytology/*metabolism, Osteocalcin/genetics/metabolism, Osteogenesis/*genetics, Real-Time Polymerase Chain Reaction, Safadi F F, Stem cell research, Stem Cells/*cytology/metabolism, Transcription Factors/genetics/metabolism
Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide.
Tags: 2017, Alam Gelerah, Animals, Astrocytes/immunology/pathology, Beier Eric E, Cell Death/physiology, Corpus Striatum/immunology/pathology, Cytokines/metabolism, Department of Pharmaceutical Sciences, Disease Progression, Dopaminergic Neurons/*immunology/pathology, Edler Melissa, Inbred C57BL, Inflammation/pathology/physiopathology, Lipopolysaccharides/*toxicity, Male, Messenger/metabolism, Mice, Microglia/*immunology/pathology, Neal Matthew, NEOMED College of Pharmacy, Nerve Degeneration/*immunology/pathology, Neurobiology of disease, Neurodegenerative Diseases/immunology/pathology, Neuroimmunomodulation/physiology, Random Allocation, Richardson Jason R, RNA, Time Factors, Wu Long-Jun
Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling.
Tags: 2017, Adenosine Triphosphate – Metabolism, Adenosine Triphosphate/*metabolism, Ammi Azzdine Y, Animal Studies, Animals, Belcik J Todd, Chilian William M, Chon Chae Ryung, Circulation, contrast echocardiography, Davidson Brian P, Department of Integrative Medical Sciences, Equipment and Supplies, Field Joshua, Harmann Leanne, Hemodynamics, Humans, Inbred C57BL, Liang Sherry, Linden Joel, Lindner Jonathan R, Male, Mice, Microbubbles, Microcirculation, Muscle, NEOMED College of Medicine, Neurotransmitter Agents – Metabolism, Perfusion, Purinergic Agents/*metabolism, Qi Yue, Signal Transduction, Skeletal – Blood Supply, Skeletal/*blood supply, Ultrasonography – Methods, Ultrasonography/*methods, Wu Melinda D, Xie Aris, Yadava Mrinal
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.
Tags: *Alzheimers disease, *Immunity, *Inflammation, *Tauopathy, *TREM2, 2017, Allan Kevin, Animal, Animals, Bemiller Shane M, Crish Samuel D, Department of Pharmaceutical Sciences, Disease Models, Formica Shane V, Humans, Immunologic/*deficiency, Inbred C57BL, Kokiko-Cochran Olga N, Lamb Bruce T, Landreth Gary E, Lasagna-Reeves Cristian A, McCray Tyler J, Membrane Glycoproteins/*deficiency, Mice, Microglia/metabolism, Molecular neurodegeneration, NEOMED College of Pharmacy, Protein Kinases/*metabolism, Ransohoff Richard M, Receptors, Signal Transduction/physiology, tau Proteins/*metabolism, Tauopathies/metabolism/*pathology, Transgenic, Wilson Gina, Xu Guixiang
The Detrimental Role Played by Lipocalin-2 in Alcoholic Fatty Liver in Mice.
Tags: 2016, Alcoholic/*metabolism, Animal, Animals, Blotting, Cai Yan, Department of Pharmaceutical Sciences, Disease Models, Fatty Liver, Gao Bin, Hu Xudong, Humans, Inbred C57BL, Jogasuria Alvin, Kim Chunki, Knockout, Lee Kwangwon, Lipocalin-2/*metabolism, Mice, NEOMED College of Pharmacy, Polymerase Chain Reaction, The American journal of pathology, Wang Jiayou, Western, Wu Jiashin, Xu Ming-Jiang, Yin Huquan, You Min
Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.
Tags: 2011, Animals, Awale Prabha S, Bioorganic & medicinal chemistry letters, Carroll Richard T, Dluzen Dean E, Funk Max O, Geldenhuys Werner J, Humans, Inbred C57BL, Male, Mice, Models, Molecular, Molecular Structure, Monoamine Oxidase Inhibitors/chemical synthesis/chemistry/*pharmacology, Monoamine Oxidase/*metabolism, Stereoisomerism, Stinnett Hilary, Structure-Activity Relationship, Thiazolidinediones/chemical synthesis/chemistry/*pharmacology
Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways.
Tags: 2012, Adapala Ravi K, American journal of physiology. Cell physiology, Animals, Cell Movement/physiology, Cells, Chavez Ronaldo J, Cuadra Rene H, Cultured, Department of Integrative Medical Sciences, Ganguly Rituparna, Gene Expression Regulation/physiology, Haney Rebecca M, Humans, Inbred C57BL, Janus Kinase 2/*biosynthesis, Knockout, Leptin/*physiology, Male, MAP Kinase Signaling System/*physiology, Mice, Muscle, Myocytes, NEOMED College of Medicine, Raman Priya, Smooth, Smooth Muscle/enzymology/metabolism, Thodeti Charles K, Thrombospondin 1/*biosynthesis, Up-Regulation/*physiology, Vascular/enzymology/*metabolism
Demethyleneberberine alleviates inflammatory bowel disease in mice through regulating NF-kappaB signaling and T-helper cell homeostasis.
Tags: 2017, Animals, Anti-Inflammatory Agents/*pharmacology/therapeutic use, Berberine/*analogs & derivatives/pharmacology/therapeutic use, Chen Yingying, Colitis, Colon/drug effects/immunology/pathology, Cytokines/immunology, Dextran Sulfate, DMB, Female, Helper-Inducer/*drug effects/immunology, Homeostasis/drug effects, Immunoglobulin G/blood, Inbred C57BL, Inflammation research : official journal of the European Histamine Research Society ... [et al.], Inflammatory Bowel Diseases/blood/chemically induced/drug therapy/*immunology, Li Rui-Yan, Mice, NF-kappa B/*antagonists & inhibitors/immunology, NF-kappaB, RAW 264.7 Cells, Reactive Oxygen Species/metabolism, Shi Mei-Jing, Signal Transduction/drug effects, Spleen/cytology, T-Lymphocytes, Th cell, Xu Xin-Xin, Yan Yan, Zhang Miao, Zhang Yu-Bin, Zhao Xiao-Tong, Zhao Ya-Xing
Impact of circadian nuclear receptor REV-ERBalpha on midbrain dopamine production and mood regulation.
Tags: *Affect, *Circadian Rhythm, 2014, Animals, Bipolar Disorder/genetics, Cell, Choe Han Kyoung, Chung Sooyoung, CLOCK Proteins/genetics/metabolism, Cytoplasmic and Nuclear/genetics/*metabolism, Dluzen Dean E, Dopamine/*metabolism, Genetic, Group A, Histones/metabolism, Humans, Hwang Onyou, Inbred C57BL, Kim Kwang-Soo, Kim Kyungjin, Knockout, Lee Eun Jeong, Lee Inah, Male, Member 2/metabolism, Mesencephalon/*metabolism, Mice, Mood Disorders/genetics/metabolism, Nuclear Receptor Subfamily 4, Park Seong-Beom, Rats, Receptors, Repressor Proteins/genetics/*metabolism, Son Gi Hoon, Son Hyo Jin, Transcription, Tyrosine 3-Monooxygenase/genetics, Yun Seongsik
Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction.
Tags: *Coronary Circulation, *Microcirculation, 2016, Animals, Basic research in cardiology, Bratz Ian N, Capsaicin, Chen Yeong-Renn, Connell Patrick J, Coronary blood flow, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetic Angiopathies/*metabolism, Dick Gregory M, Fahmy Joseph N, Fancher Ibra S, HEK293 Cells, Humans, Hydrogen peroxide, Hydrogen Peroxide/*metabolism, Inbred C57BL, Kang Patrick T, Klarich Brittany, Knockout, Male, Mice, NEOMED College of Medicine, reactive oxygen species, Thodeti Charles K, TRPV Cation Channels/*metabolism, TRPV1
4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling.
Tags: *4-Hydroxynonenal, *Coronary regulation, *Lipid peroxidation, *Post-translational modification, *Protein Processing, *Reactive oxygen species, *Signal Transduction, *TRPV1, 2016, Action Potentials/drug effects, Aldehydes/antagonists & inhibitors/metabolism/*pharmacology, Animal, Animals, Blood Flow Velocity, Bratz Ian N, Calcium Signaling/drug effects, Cappelli Holly C, Capsaicin/*pharmacology, Cardiovascular Agents/*pharmacology, Connell Patrick J, Coronary Circulation/drug effects, Coronary Vessels/metabolism/physiopathology, Cysteine/genetics/metabolism, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/*metabolism/physiopathology, Disease Models, Fahmy Joseph N, Femoral Artery/metabolism/physiopathology, Free radical biology & medicine, Geldenhuys Werner J, HEK293 Cells, Humans, Inbred C57BL, Lipid Peroxidation, Male, Mice, NEOMED College of Medicine, Patch-Clamp Techniques, Post-Translational, Sinharoy Pritam, Thodeti Charles K, TRPV Cation Channels/genetics/*metabolism, Vasodilation/drug effects
Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease.
Tags: *Alzheimer Disease/complications/genetics/pathology, *Alzheimer's disease, *bone density, *microtubule-associated protein, *serotonin, *tau proteins, *tauopathies, 2017, Age Factors, Alzheimer's disease, Alzheimer's Disease – Complications, Alzheimer's Disease – Pathology, Animal, Animal Studies, Animals, Biological, Body Composition, Body Composition/genetics, Body Weight, Body Weight/genetics, Bone Density – Physiology, Bone Density/*physiology, Bone Diseases – Etiology, Bone Diseases/*etiology, Brain Stem – Pathology, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Disease Models, Dorsal Raphe Nucleus/*pathology, Female, Inbred C57BL, Journal of Alzheimer's disease : JAD, Male, Mice, Models, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurons – Metabolism, Neurons – Pathology, Neurons/metabolism/pathology, Oxidoreductases – Metabolism, Phosphorylation, Serotonin – Metabolism, Serotonin/*metabolism, Smith Matthew A, tau Proteins/*genetics/metabolism, Tauopathies/complications/genetics, Transgenic, Tryptophan Hydroxylase/metabolism, Wilson Gina N
Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein.
Tags: *Alpha-synuclein, *ATP13A2, *Mice, *Phenotype, *Sensorimotor, 2018, Adenosine Triphosphatases/*deficiency/genetics, alpha-Synuclein/genetics/*metabolism, Animal, Animals, Behavioural brain research, Blackwood Rachel, Body Temperature, Body Weight, Department of Pharmaceutical Sciences, Dirr Emily R, Disease Models, Ekhator Osunde R, Female, Fleming Sheila M, Gait Disorders, Holden John G, Humans, Inbred C57BL, Male, Masliah Eliezer, Membrane Proteins/*deficiency/genetics, Mice, Motor Skills/physiology, NEOMED College of Pharmacy, Neurologic/*metabolism, Phenotype, Schultheis Patrick J, Severity of Illness Index, Sex Characteristics, Transgenic
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces norepinephrine concentrations in the olfactory bulbs of male mice.
Tags: *Sex Characteristics, 1-Methyl-4-phenyl-1, 1992, 2, 3, 6-tetrahydropyridine/*pharmacology, Animals, Brain research, Dluzen D E, Dopamine/metabolism, Drug Resistance/genetics, Inbred C57BL, Inbred Strains, Male, Mice, Norepinephrine/*metabolism, Olfactory Bulb/*metabolism, Osmolar Concentration
Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice.
Tags: *MPTP Poisoning, 1-Methyl-4-phenyl-1, 1996, 2, 3, 4-Dihydroxyphenylacetic Acid/metabolism, 6-tetrahydropyridine/*antagonists & inhibitors, Animals, Brain research, Catecholamines/metabolism, Dluzen D E, Dopamine Agents/*toxicity, Dopamine/metabolism/*physiology, Female, Inbred C57BL, Male, Mice, Neostriatum/drug effects/metabolism/*pathology, Nervous System Diseases/chemically induced/*pathology/*prevention & control, Olfactory Bulb/drug effects/metabolism, Orchiectomy, Substantia Nigra/drug effects/metabolism/*pathology, Testosterone/*pharmacology
The effects of intranasal infusion of
Tags: 1-Methyl-4-phenyl-1, 1996, 2, 3, 6-tetrahydropyridine/administration & dosage/*pharmacology, Administration, Animals, Brain research, Catecholamines/*metabolism, Corpus Striatum/drug effects/*metabolism, Department of Internal Medicine, Dluzen D E, Dopamine Agents/administration & dosage/*pharmacology, Dopamine/metabolism, Inbred C57BL, Injections, Intranasal, Intraperitoneal, Kefalas G, Male, Mice, NEOMED College of Medicine, Norepinephrine/metabolism, Olfactory Bulb/drug effects/*metabolism
Estrogen as a neuroprotectant against MPTP-induced neurotoxicity in C57/B1 mice.
Tags: *MPTP Poisoning, 1996, Animals, Corpus Striatum/drug effects/*metabolism/pathology, Dluzen D E, Dopamine/*metabolism, Drug Implants, Estradiol/administration & dosage/*pharmacology, Female, Inbred C57BL, Liu B, Male, McDermott J L, Mice, Neuroprotective Agents/administration & dosage/*pharmacology, Neurotoxicology and teratology, Neurotoxins, Olfactory Pathways/drug effects/*metabolism/pathology, Orchiectomy, Ovariectomy, Sex Characteristics
Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release.
Tags: *MPTP Poisoning, 1996, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Animals, Corpus Striatum/*drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Estradiol/*pharmacology, Female, Inbred C57BL, Inbred Strains, Journal of neurochemistry, Levodopa/pharmacology, Liu B, McDermott J L, Mice, Osmolar Concentration, Ovariectomy
Modulatory effects of testosterone on
Tags: *MPTP Poisoning, 1-Methyl-4-phenyl-1, 1994, 2, 3, 6-tetrahydropyridine/antagonists & inhibitors, Animals, Corpus Striatum/drug effects/*metabolism, Dluzen D, Dopamine/*metabolism, Drug Implants, Inbred C57BL, Inbred Strains, Jain R, Journal of neurochemistry, Levodopa/pharmacology, Liu B, Male, Mice, Neurotoxins/antagonists & inhibitors/*toxicity, Orchiectomy, Parkinson Disease, Reference Values, Secondary/chemically induced/*physiopathology, Species Specificity, Testosterone/administration & dosage/*pharmacology
Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice.
Tags: 2010, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Aging/*physiology, Animals, Corpus Striatum/*metabolism, Dluzen Dean E, Dopamine Plasma Membrane Transport Proteins/*genetics, Dopamine/*metabolism, Heterozygote, Inbred C57BL, Ji Jing, Knockout, Male, McDermott Janet L, Mice, Motor Activity, Mutation, Neuroscience letters, Substantia Nigra/*metabolism
G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice.
Tags: *Gene Expression Regulation, 2017, Analysis of Variance, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Department of Integrative Medical Sciences, Disease Models, Donepudi Ajay C, Energy Metabolism/physiology, Fasting, Fatty Liver/*metabolism/pathology, G-Protein-Coupled/*genetics, Hepatology (Baltimore, Md.), Homeostasis/genetics, Inbred C57BL, Li Feng, Lipid Metabolism/genetics, Male, Mice, NEOMED College of Medicine, Oxygen Consumption/physiology, Random Allocation, Receptors, RNA-Binding Proteins/*metabolism, Signal Transduction
Myocardial CXCR4 expression is required for mesenchymal stem cell mediated repair following acute myocardial infarction.
Tags: 2012, Agarwal Udit, Animals, Apoptosis/physiology, Cardiac/cytology/physiology, Cell Movement/physiology, Chemokine CXCL12/*metabolism, Circulation, Coronary Circulation/physiology, CXCR4/*genetics/metabolism, Department of Integrative Medical Sciences, Dong Feng, Finan Amanda, Gene Expression/physiology, Green Fluorescent Proteins/genetics, Harvey James, Inbred C57BL, Knockout, Mesenchymal Stem Cell Transplantation/*methods, Mesenchymal Stem Cells/*metabolism, Mice, Myocardial Infarction/genetics/pathology/*therapy, Myocardium/cytology, Myocytes, NEOMED College of Medicine, Paracrine Communication/physiology, Penn Marc S, Receptors, Ventricular Remodeling/physiology, Weber Kristal
Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis.
Tags: *angiogenesis, *cysteinyl leukotriene receptors, *endothelial cells, *metastasis, *tumor growth, 2019, Adapala Ravi K, Animals, Austen K Frank, Capillary Permeability/drug effects, Cyclohexanecarboxylic Acids/pharmacology, Department of Integrative Medical Sciences, Duah Ernest, Endothelial Cells/*drug effects, Experimental, Gene Knockout Techniques, Inbred C57BL, Kanaoka Yoshihide, Keshamouni Venkateshwar G, Kondeti Vinay, Leukotriene Antagonists/pharmacology, Leukotriene/drug effects/*metabolism, Lung Neoplasms/drug therapy, Male, Mice, NEOMED College of Medicine, Neoplasm Metastasis/drug therapy, Neoplasm Transplantation, Neoplasms, Neovascularization, Paruchuri Sailaja, Pathologic/*chemically induced/drug therapy, Phthalic Acids/pharmacology, Proceedings of the National Academy of Sciences of the United States of America, Receptors, Teegala Lakshminarayan Reddy, Thodeti Charles K
The effect of manganese exposure in Atp13a2-deficient mice.
Tags: *Alpha-synuclein, *Lipofuscin, *Manganese, *Parkinson's disease, *Sensorimotor function, 2018, Adenosine Triphosphatases/genetics/*metabolism, Aga Diana S, alpha-Synuclein/metabolism, Animal, Animals, Behavior, Brain/*drug effects/*metabolism, Department of Pharmaceutical Sciences, Ekhator Osunde R, Female, Fleming Sheila M, Holden John G, Inbred C57BL, Karkare Swagata, Knockout, Lemkuhl Andrew, Linn Stephen C, Liou Benjamin, Male, Manganese/metabolism/*toxicity, Membrane Proteins/genetics/*metabolism, Mice, Motor Activity, Mullin Elizabeth J, NEOMED College of Pharmacy, Neurotoxicology, Pamphile Shanta, Roth Jerome A, Santiago Nicholas A, Schultheis Patrick J, Shull Gary E, Sun Ying
Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE(-/-) mice.
Tags: 2017, Animals, Aorta/drug effects/metabolism, Apolipoproteins E/*metabolism, Atherosclerosis/*drug therapy/metabolism, Chavez Ronaldo J, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Angiopathies/drug therapy/metabolism, Experimental/chemically induced/drug therapy/metabolism, Ganguly Rituparna, Glucose/metabolism, Glycosylation/drug effects, Haney Rebecca, Hyperglycemia/*drug therapy/metabolism, Inbred C57BL, Knockout, Male, Mice, Myocytes, NEOMED College of Medicine, NEOMED Student Publications, Ohanyan Vahagn, Picolinic Acids/*pharmacology, Raman Priya, Sahu Soumyadip, Scientific reports, Shah Shivani, Smooth Muscle/drug effects, Streptozocin/*pharmacology, Thrombospondin 1/*metabolism, Type 1/chemically induced/*drug therapy/metabolism, Yalamanchili Siri
MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
Tags: *Aging, *Disease Models, *drug discovery, *mitochondrial dysfunction, *mitoNEET, 2017, ACS chemical neuroscience, Animal, Animals, Benkovic Stanley A, Brown Candice M, Corpus Striatum/*metabolism/*pathology, Crish Samuel D, Darvesh Altaf S, Department of Pharmaceutical Sciences, Geldenhuys Werner J, Inbred C57BL, Iron-Binding Proteins/genetics/*metabolism, Knockout, Lin Li, Male, Membrane Proteins/genetics/*metabolism, Mice, Mitochondria/*metabolism/*pathology, NEOMED College of Pharmacy, Parkinson Disease/*metabolism/pathology, Richardson Jason R, Sullivan Patrick G, Yonutas Heather M
Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion.
Tags: 2012, Animals, Corpus Striatum/*drug effects/metabolism, Darvesh Altaf S, Department of Pharmaceutical Sciences, Dluzen Dean E, Dopamine/*metabolism, Drug Synergism, Geldenhuys Werner J, Inbred C57BL, Indoles/*pharmacology, Methamphetamine/*pharmacology, Mice, NEOMED College of Pharmacy, Neurochemistry international
Brain-targeted delivery of paclitaxel using glutathione-coated nanoparticles for brain cancers.
Tags: *Drug Delivery Systems, 2011, Adenosine Triphosphatases/metabolism, Animals, Antineoplastic Agents, ATP Binding Cassette Transporter, Blood-Brain Barrier/metabolism, Brain Neoplasms/drug therapy, Bui Thong, Cell Death/drug effects, Cell Line, Coumarins/administration & dosage/pharmacokinetics, Delayed-Action Preparations, Geldenhuys Werner, Glioma/drug therapy/pathology, Glutathione/*chemistry, Harrison Kimberly, Humans, Inbred C57BL, Journal of drug targeting, Male, Mbimba Thomas, Member 1/metabolism, Mice, Microtubules/metabolism, Nanoparticles, Paclitaxel/administration & dosage/*pharmacokinetics/pharmacology, Particle Size, Permeability, Phytogenic/administration & dosage/*pharmacokinetics/pharmacology, Rats, Subfamily B, Sutariya Vijaykumar, Thiazoles/administration & dosage/pharmacokinetics, Tubulin/metabolism, Tumor
Mechanosensitive transient receptor potential vanilloid 4 regulates Dermatophagoides farinae-induced airway remodeling via 2 distinct pathways modulating matrix synthesis and degradation.
Tags: *Airway Remodeling, *fibronectin, *myofibroblasts, *PAI-1, *PI3K, *TGF-beta1, 2017, Adult, Al-Azzam Nosayba, Animals, Asthma/etiology/genetics/*metabolism/pathology, Cells, Cultured, Department of Integrative Medical Sciences, Dermatophagoides farinae/immunology, Duah Ernest, Extracellular Matrix/*metabolism/pathology, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Fibroblasts/metabolism, Fibronectins/*metabolism, Gombedza Farai, Hexter Madison, Humans, Inbred C57BL, Kondeti Vinay, Koppes Stephanie, Male, Mice, NEOMED College of Medicine, Paruchuri Sailaja, Patil Prachi, Phillips Daniel, Phosphatidylinositol 3-Kinases/metabolism, Plasminogen Activator Inhibitor 1/metabolism, Thodeti Charles K, Transforming Growth Factor beta/metabolism, TRPV Cation Channels/genetics/*metabolism
Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels.
Tags: 13-dienoic Acid/pharmacology, 15-Hydroxy-11 alpha, 2012, 9 alpha-(epoxymethano)prosta-5, American journal of physiology. Heart and circulatory physiology, Anilides/pharmacology, Animals, Bratz Ian N, Capsaicin/analogs & derivatives/pharmacology, Cinnamates/pharmacology, Coronary Vessels/drug effects/*metabolism/physiopathology, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Cardiomyopathies/drug therapy/*metabolism, Enzyme Inhibitors/pharmacology, Guarini Giacinta, Inbred C57BL, Kmetz John G, Large-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors/*metabolism, Male, Meszaros J Gary, Mice, Microvessels/drug effects/physiopathology, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Nitric Oxide/*metabolism, Ohanyan Vahagn A, Peptides/pharmacology, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/agonists/antagonists & inhibitors/biosynthesis/*metabolism, Type 2/drug therapy/*metabolism, Vasoconstrictor Agents/pharmacology, Vasodilation/drug effects
Par-4 is a synaptic protein that regulates neurite outgrowth by altering calcium homeostasis and transcription factor AP-1 activation.
Tags: *Intracellular Signaling Peptides and Proteins, 2001, Animals, Antibodies, Apoptosis Regulatory Proteins, Brain research, Calcium Signaling/*physiology, Calcium/*metabolism, Carrier Proteins/genetics/immunology/*metabolism, Cell Compartmentation/physiology, Cerebral Cortex/cytology, Chang X, Du H, Gene Expression/physiology, Guo Q, Hippocampus/cytology, Homeostasis/physiology, Inbred C57BL, Mice, Nerve Growth Factor/pharmacology, Neurites/*metabolism, Neurons/metabolism/ultrastructure, PC12 Cells, Rats, Synaptosomes/metabolism, Transcription Factor AP-1/*metabolism, Transcriptional Activation/drug effects/physiology, Transfection, Xie J, Zhang X
Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium Channels.
Tags: *deltamethrin, *intracellular sodium., *Microglia, *neurodegeneration, *Neuroinflammation, *permethrin, *pyrethroids, *tetrodotoxin, *tumor necrosis factor, *Voltage-gated sodium channels, 2017, Animals, Cell Line, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Hossain Muhammad M, Inbred C57BL, Insecticides/*toxicity, Ion Channel Gating/*drug effects, Liu Jason, Mice, Microglia/*drug effects/metabolism, NEOMED College of Pharmacy, Pyrethrins/*toxicity, Richardson Jason R, Sodium Channels/*drug effects, Toxicological sciences : an official journal of the Society of Toxicology, Transformed, Tumor Necrosis Factor-alpha/metabolism
The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6.
Tags: *gp91(phox), *Microglia, *MPTP, *Na(v)1.6, *Neuroinflammation, *Parkinson's disease, *TNF-alpha, *Voltage-gated sodium channels, *Zonisamide, 2018, Aged, Animals, Antiparkinson Agents/*pharmacology, Experimental neurology, Female, Gearing Marla, Hossain Muhammad M, Humans, Inbred C57BL, Inflammation/metabolism, Male, Mice, Microglia/drug effects/*metabolism, NAV1.6 Voltage-Gated Sodium Channel/*biosynthesis, Neuroprotective Agents/pharmacology, Parkinsonian Disorders/*metabolism/pathology, Reuhl Kenneth, Richardson Jason R, Weig Blair, Wu Long-Jun, Zonisamide/*pharmacology
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR.
Tags: *Atherosclerosis, *Farnesoid X receptor, *NAFLD, *Obesity, *TGR5, 2018, Adorini Luciano, Animals, Bile Acids and Salts/pharmacology/*therapeutic use, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diet, G-Protein-Coupled/*agonists, Hep G2 Cells, High-Fat/adverse effects, Humans, Hypercholesterolemia/*drug therapy/etiology/metabolism, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Lee Yoon Kwang, Li Yuanyuan, Male, Mice, Molecular metabolism, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*drug therapy/etiology/metabolism, Obesity/*drug therapy/etiology/metabolism, Receptors, Xu Jiesi, Xu Yang, Xu Yanyong, Yin Liya, Zhang Yanqiao, Zhu Yingdong
Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol.
Tags: 2013, Alcohol-Induced Injury, Alcoholic Liver Disease, Alcoholic/genetics/*metabolism/prevention & control, Animals, Cannabinoid, CB1/*physiology, Chiang John Y L, Choi Hueng-Sik, Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 CYP2E1/genetics/*metabolism, Department of Integrative Medical Sciences, Enzyme Inhibitors/pharmacology/therapeutic use, Enzymologic/drug effects/physiology, Estrogen/deficiency/genetics/*physiology, Ethanol/pharmacology, Gene Expression Profiling/methods, Gene Expression Regulation, Gene Regulation, Genetic/physiology, Gut, Inbred C57BL, Jang Hyun-Hee, Jeong Won-Il, Kim Don-Kyu, Kim Jung Ran, Kim Yong-Hoon, Knockout, Koh Minseob, Koo Seung-Hoi, Lee Chul-Ho, Liver, Liver Diseases, Liver Metabolism, Liver/metabolism, Male, Mice, NEOMED College of Medicine, Oxidation-Reduction, Oxidative Stress/physiology, Park Jinyoung, Park Seung Bum, Park Tae-Sik, Receptor, Receptors, Signal Transduction/drug effects/physiology, Tamoxifen/analogs & derivatives/pharmacology/therapeutic use, Transcription, Yun Chul-Ho