Browse Items · NEOMED Bibliography Database

Weighted Lin-Wang tests for crossing hazards.

Lin and Wang have introduced a quadratic version of the logrank test, appropriate for situations in which the underlying survival distributions may cross. In this note, we generalize the Lin-Wang procedure to incorporate weights and investigate the…

Tags: *Survival Analysis, 2014, Algorithms, Animal, Animals, Computational and mathematical methods in medicine, Computer Simulation, Data Interpretation, Disease Models, Humans, Jia Zhenyu, Kaplan-Meier Estimate, Koziol James A, Leukemia/drug therapy, Mice, Models, Reproducibility of Results, Statistical

Vanadium in the detection, prevention and treatment of cancer: the in vivo evidence.

Vanadium, a dietary micronutrient, is yet to be established as an essential part of the human diet. Over the past century, several biological effects of vanadium, such as insulin-mimetic action as well as amelioration of hyperlipidemia and…

Tags: 10-Dimethyl-1, 2-benzanthracene, 2010, 9, Animal, Animals, Biological, Bishayee Anupam, Breast Neoplasms – Chemically Induced, Breast Neoplasms – Diagnosis, Breast Neoplasms – Drug Therapy, Cancer letters, Cell Division – Drug Effects, Cell Division/drug effects, Chatterjee Malay, Disease Models, Experimental/chemically induced/diagnosis/drug therapy, Experimental/drug therapy/pathology, Female, Glioblastoma/drug therapy, Glioma – Drug Therapy, Heterologous, Humans, Hydrocarbons, Male, Mammary Neoplasms, Metals, Metals – Diagnostic Use, Metals – Therapeutic Use, Models, Neoplasm Staging, Neoplasm Transplantation, Neoplasms, Neoplasms – Diagnosis, Neoplasms – Drug Therapy, Neoplasms – Pathology, Neoplasms – Prevention and Control, Neoplasms/*diagnosis/drug therapy/prevention & control, Organometallic Compounds – Therapeutic Use, Organometallic Compounds/therapeutic use, Patel Mehool A, Rats, Trace Elements – Diagnostic Use, Trace Elements – Therapeutic Use, Trace Elements/therapeutic use, Transplantation, Vanadium Compounds, Vanadium Compounds – Therapeutic Use, Vanadium Compounds/therapeutic use/toxicity, Vanadium/*therapeutic use/toxicity, Waghray Abhijeet, Xenografts

Two distinct representations of social vocalizations in the basolateral amygdala.

Acoustic communication signals carry information related to the types of social interactions by means of their "acoustic context," the sequencing and temporal emission pattern of vocalizations. Here we describe responses to natural vocal sequences in…

Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure.

BACKGROUND: Alcohol consumption during pregnancy is a significant public health problem and can result in a continuum of adverse outcomes to the fetus known as fetal alcohol spectrum disorders (FASD). Subjects with FASD show significant neurological…

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.

BACKGROUND: Genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) confer increased risk of developing late-onset Alzheimer's Disease (LOAD) and other neurodegenerative disorders. Recent studies provided insight into the…

Thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor

The purpose of this study is to investigate a thermoreversible gel using Pluronic

Tags: *Drug Delivery Systems, 2013, Animal, Animals, Benzodioxoles/*administration & dosage/pharmacokinetics/toxicity, Bhatia Deepak, Body Temperature, Delayed-Action Preparations, Disease Models, Drug Carriers/chemistry/toxicity, Fibroblasts/drug effects/metabolism, Filtering Surgery/*methods, Geldenhuys Werner, Gels, Glaucoma/*surgery, Imidazoles/*administration & dosage/pharmacokinetics/toxicity, Miladore Nicholas, Nakamura Hiroshi, Pharmaceutical development and technology, Poloxamer/chemistry/toxicity, Protein-Serine-Threonine Kinases/antagonists & inhibitors, Pyridines/*administration & dosage/pharmacokinetics/toxicity, Rabbits, Receptor, Receptors, Sutariya Vijaykumar, Temperature, Time Factors, Transforming Growth Factor beta/antagonists & inhibitors, Transforming Growth Factor-beta Type I, Viscosity, Wehrung Daniel

The Physiologic Impact of Unilateral Recurrent Laryngeal Nerve (RLN) Lesion on Infant Oropharyngeal and Esophageal Performance.

Recurrent laryngeal nerve (RLN) injury in neonates, a complication of patent ductus arteriosus corrective surgery, leads to aspiration and swallowing complications. Severity of symptoms and prognosis for recovery are variable. We transected the RLN…

Tags: 2015, Animal, Animals, Aspiration, Ballester Ashley, Biological, Deglutition, Deglutition – Physiology, Deglutition disorders, Deglutition Disorders – Etiology, Deglutition Disorders – Physiopathology, Deglutition Disorders/*etiology/physiopathology, Deglutition/*physiology, Department of Anatomy & Neurobiology, Disease Models, Dysphagia, Esophagus, Esophagus – Physiopathology, Esophagus/*physiopathology, Fraley Luke, German Rebecca Z, Gould François D H, Gross Andrew, Human, Infant, Lammers Andrew R, Laryngeal Nerves – Injuries, Laryngeal Nerves – Physiopathology, Models, NEOMED College of Medicine, Ohlemacher Jocelyn, Oropharynx – Physiopathology, Oropharynx/*physiopathology, Recurrent laryngeal nerve, Recurrent Laryngeal Nerve Injuries/*complications/physiopathology, Recurrent Laryngeal Nerve/*physiopathology, Swine

The mechanistic basis for the disparate effects of angiotensin II on coronary collateral growth.

OBJECTIVE: We hypothesize that controversial effects of angiotensin II (Ang II) are attributable to its regulation of reactive oxygen species (ROS) and

The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis.

Although there are multiple rodent models of the metabolic syndrome, very few develop vascular complications. In contrast, the JCR:LA-cp rat develops both metabolic syndrome and early atherosclerosis in predisposed areas. However, the pathology of…

The effect of manganese exposure in Atp13a2-deficient mice.

Loss of function mutations in the P5-ATPase ATP13A2 are associated with Kufor-Rakeb Syndrome and Neuronal Ceroid Lipofuscinosis. While the function of ATP13A2 is unclear, in vitro studies suggest it is a lysosomal protein that interacts with the…

The Detrimental Role Played by Lipocalin-2 in Alcoholic Fatty Liver in Mice.

We have previously shown that the ethanol-mediated elevation of lipocaline-2 (LCN2) is closely associated with the development of alcoholic fatty liver disease (AFLD) in mice. Herein, we aimed to understand the functional significance of LCN2…

The ability of an HSV strain to initiate zosteriform spread correlates with its neuroinvasive disease potential.

The requirements for disease development in the mouse epidermal scarification-zosteriform model of HSV infection are likely to parallel those required for primary HSV disease of humans. HSV-1 strains, which are neuroinvasive in the mouse footpad…

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.

BACKGROUND: Traumatic brain injury (TBI) with its associated morbidity is a major area of unmet medical need that lacks effective therapies. TBI initiates a neuroinflammatory cascade characterized by activation of astrocytes and microglia, and…

Social vocalizations of big brown bats vary with behavioral context.

Bats are among the most gregarious and vocal mammals, with some species demonstrating a diverse repertoire of syllables under a variety of behavioral contexts. Despite extensive characterization of big brown bat (Eptesicus fuscus) biosonar signals,…

Tags: *Animal Communication, *Behavior, 2012, Acoustics, Animal, Animals, Chiroptera/*physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Electrocardiography, Faure Paul A, Gadziola Marie A, Grimsley Jasmine M S, NEOMED College of Medicine, PloS one, Wenstrup Jeffrey J

Similarities Between Large Animal-Related and Motor Vehicle Crash-Related Injuries.

OBJECTIVE: Many Americans sustain large animal-related injuries (LARIs) from blunt trauma. We compare the injuries and management of LARI in our region of the United States with those of motor vehicle crashes (MVCs). METHODS: A 15-year retrospective…

Sex steroid induction of gallstones in the male Syrian hamster.

Light (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques were used to characterize morphologic changes induced in the gallbladder of Syrian hamsters following a one-month estradiol (E) and estradiol + medroxyprogesterone…

Sensory nerves and neuropeptides in uterine cervical ripening.

At the time of parturition (fetal delivery) the uterine cervix must "ripen," becoming soft, pliable, and dilated to accommodate the fetus' delivery. The fundamental processes underlying cervical ripening remain poorly understood. Knowledge that…

Selenium in the prevention and treatment of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) happens to be one of the most lethal cancers in the world. Even though most cases occur in the developing world, reported cases in Western Europe as well as North America are on a steep rise. Human HCC etiology includes…

Tags: 2010, Animal, Animals, Anti-cancer agents in medicinal chemistry, Anticarcinogenic Agents/*therapeutic use, Bishayee Anupam, Carcinoma, Darvesh Altaf S, Department of Pharmaceutical Sciences, Hepatocellular/chemically induced/*drug therapy/etiology/*prevention & control, Humans, Liver Neoplasms/chemically induced/*drug therapy/etiology/*prevention & control, Models, NEOMED College of Pharmacy, Oxidative Stress, Selenium/*therapeutic use

Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice.

BACKGROUND: Heart failure(HF) is a dangerous disease that affects millions of patients. Radix Salvia is widely used in Chinese clinics to treat heart diseases. Salvianolic acid B(SalB) is the major active component of Radix Salvia. This study…

Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.

Hepatocellular carcinoma (HCC) is one of the most common cancers and lethal diseases. In view of the limited treatment and a grave prognosis of liver cancer, preventive control has been emphasized. Resveratrol, a polyphenol found in grape skins,…

Responses in the inferior colliculus of the guinea pig to concurrent harmonic series and the effect of inactivation of descending controls.

One of the fundamental questions of auditory research is how sounds are segregated because, in natural environments, multiple sounds tend to occur at the same time. Concurrent sounds, such as two talkers, physically add together and arrive at the ear…

Tags: *Acoustic Stimulation, 2010, Action Potentials/physiology, Animal, Animals, Auditory Cortex/*physiology, Auditory Pathways/*physiology, Female, Guinea Pigs, Inferior Colliculi/*physiology, Journal of neurophysiology, Male, Models, Nakamoto Kyle T, Palmer Alan R, Pitch Perception/physiology, Shackleton Trevor M

Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats.

OBJECTIVE: We have previously found abrogated ischemia-induced coronary collateral growth in Zucker obese fatty (ZOF) rats compared with Zucker lean (ZLN) rats. Because ZOF rats have structural abnormalities in their mitochondria suggesting…

Tags: 2012, Animal, Animals, Antioxidants/*pharmacology, Arteriosclerosis, thrombosis, and vascular biology, Chilian William M, Collateral Circulation/*drug effects/physiology, Coronary Vessels/drug effects/*growth & development, Department of Integrative Medical Sciences, Disease Models, Guarini Giacinta, Hafemeister Jennifer, Heart/*drug effects/physiology, Lipid Peroxidation/drug effects/physiology, Lipid Peroxides/metabolism, Male, Metabolic Syndrome/*metabolism/physiopathology, Mitochondria, Mitochondrial Proteins/metabolism, Murphy Michael P, NEOMED College of Medicine, Obesity/*metabolism/physiopathology, Ohanyan Vahagn, Organophosphorus Compounds/pharmacology, Oxidative Stress/*drug effects/physiology, Piperidines/pharmacology, Pung Yuh Fen, Rats, Reactive Oxygen Species/metabolism, Rocic Petra, Smith Robin A J, Ubiquinone/pharmacology, Yin Liya, Zucker

Renal Calcium Oxalate Deposits Induce a Pro-Atherosclerotic and Pro-Osteoporotic Response in Mice.

Urinary stone disease (USD) is increasing in adult and pediatric populations. Adult and pediatric studies have demonstrated decreased bone mineral density and increased fracture rates. USD has also been independently linked to increased rates of…

Regulation of cholesterol and bile acid homeostasis by the cholesterol 7alpha-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice.

UNLABELLED: Bile acid synthesis not only produces physiological detergents required for intestinal nutrient absorption, but also plays a critical role in regulating hepatic and whole-body metabolic homeostasis. We recently reported that…

Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma.

BACKGROUND: Glaucoma is a chronic degenerative disease for which inflammation is considered to play a pivotal role in the pathogenesis and progression. In this study, we examined the impact of a ketogenic diet on the inflammation evident in glaucoma…

Tags: 2018, AMP-activated protein kinase, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Biological, Calcium Binding Proteins – Metabolism, Calcium-Binding Proteins/metabolism, Cells – Drug Effects, Cells – Pathology, Department of Pharmaceutical Sciences, Diet, Disease Models, Eye Proteins/genetics, Female, G-Protein-Coupled – Metabolism, G-Protein-Coupled/*metabolism, Glaucoma, Glaucoma – Complications, Glaucoma – Pathology, Glaucoma/*complications/pathology, Harun-Or-Rashid Mohammad, Impact of Events Scale, Inbred DBA, Inflammation – Etiology, Inflammation – Prevention and Control, Inflammation hydroxycarboxylic acid receptor, Inflammation/*etiology/*prevention & control, Inman Denise M, Journal of neuroinflammation, Ketogenic diet, Ketogenic/methods, Male, Membrane Glycoproteins, Membrane Glycoproteins/genetics, Mice, Microfilament Proteins – Metabolism, Microfilament Proteins/metabolism, Microglia/drug effects/pathology, Models, Mutation, Mutation/genetics, NEOMED College of Pharmacy, Neuroprotection/drug effects/*physiology, NLR Family, Optic Nerve – Pathology, Optic Nerve/pathology, Phosphotransferases – Metabolism, Proteins, Pyrin Domain-Containing 3 Protein/genetics/metabolism, Receptors, Retina – Drug Effects, Retina – Pathology, Retinal Ganglion Cells/drug effects/*pathology, Transgenic

Qualitative skeletal correlates of wing shape in extant birds (Aves: Neoaves).

BACKGROUND: Among living fliers (birds, bats, and insects), birds display relatively high aspect ratios, a dimensionless shape variable that distinguishes long and narrow vs. short and broad wings. Increasing aspect ratio results in a functional…

Tags: *Flight, 2015, Animal, Animal/*anatomy & histology/physiology, Animals, Biological Evolution, Birds/*anatomy & histology/classification/*physiology, BMC evolutionary biology, Bone and Bones/anatomy & histology, Department of Anatomy & Neurobiology, Feathers, Fossils, Hieronymus Tobin L, NEOMED College of Medicine, Phylogeny, Wings

Pulmonary vasoconstriction in a canine model of neurogenic pulmonary edema.

The intracisternal administration of veratrine to the chloralose-anesthetized dog produces pulmonary hypertension (PH) and neurogenic pulmonary edema (NPE). To determine whether pulmonary vasoconstriction, mediated by a circulating agent, contributes…

Primate spondyloarthropathy.

Spondyloarthropathy is a common occurrence in Old World primates, with only limited presence in New World monkeys. Clearly distinguished from rheumatoid arthritis, this erosive arthritis afflicts 20% of great apes, baboons, and rhesus macaques and…

Tags: *Primate Diseases/classification/epidemiology, 2005, Animal, Animals, Current rheumatology reports, Disease Models, Incidence, Primates, Rothschild Bruce M, Spondylarthropathies/classification/epidemiology/*veterinary

Prepulse inhibition of the acoustic startle reflex vs. auditory brainstem response for hearing assessment.

The high prevalence of noise-induced and age-related hearing loss in the general population has warranted the use of animal models to study the etiology of these pathologies. Quick and accurate auditory threshold determination is a prerequisite for…

Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.

Epidemiological reports as well as experimental studies have demonstrated the significant health benefits provided by regular berry consumption. Berries possess both prophylactic and therapeutic potential against several chronic illnesses, such as…

Tags: 2016, aerodigestive and gastrointestinal tract, Animal, Animal Studies, Animals, Anthocyanins/analysis/pharmacology, Anticarcinogenic Agents/*analysis/pharmacology, Antineoplastic Agents – Analysis, Antineoplastic Agents – Pharmacodynamics, Benzopyrans – Analysis, Benzopyrans – Pharmacodynamics, Berry, Biological, Bishayee Anupam, Cancer, Chemoprevention, Clinical Trials, Clinical Trials as Topic, Critical reviews in food science and nutrition, Digestion – Drug Effects, Digestion/drug effects, Disease Models, Do Chau, Ellagic Acid/analysis/pharmacology, Fruit, Fruit/*chemistry, Gastrointestinal Neoplasms – Prevention and Control, Gastrointestinal Neoplasms/*prevention & control, Haskell Yennie, Human, Humans, Models, Mohandas Nima, Phytochemicals – Analysis, Phytochemicals – Pharmacodynamics, Phytochemicals/analysis/pharmacology, Plant Extracts – Analysis, Plant Extracts – Pharmacodynamics, Plant Extracts/*analysis/pharmacology, Polyphenols – Analysis, Polyphenols – Pharmacodynamics, Polyphenols/analysis/pharmacology, Sethi Gautam, Siveen Kodappully Sivaraman, Stoner Gary D, Treatment

Postnatal developmental changes in the medial nucleus of the trapezoid body in a mouse model of auditory pathology.

Age-related hearing loss (AHL) is a multifactorial disorder characterized by a decline in peripheral and central auditory function. Here, we examined synaptic transmission in DBA/2 mice, which carry the AHL8 gene, at the identifiable glutamatergic…

Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucoma.

Axonal transport defects are an early pathology occurring within the retinofugal projection of the DBA/2J mouse model of glaucoma. Retinal ganglion cell (RGC) axons and terminals are detectable after transport is affected, yet little is known about…

Tags: *Axonal Transport/physiology, *bouton, *Mitochondria, *neurodegeneration, *retinal, *RRID:IMSRJAX:000671, *RRID:IMSRJAX:007048, *RRID:SCR002716, *RRID:SCR002865, *superior colliculus, *synapse, 2016, Animal, Animals, Crish Samuel D, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Disease Models, Electron, Fening Kelly M, Glaucoma/metabolism/*pathology, Imaging, Inbred DBA, Inman Denise M, Mice, Microscopy, Mitochondria/pathology, NEOMED College of Medicine, NEOMED College of Pharmacy, Neuroanatomical Tract-Tracing Techniques, Regression Analysis, Retinal Ganglion Cells/metabolism/*pathology, Scanning, Schofield Brett R, Smith Matthew A, Superior Colliculi/metabolism/*pathology, Synapses/metabolism/*pathology, The Journal of comparative neurology, Three-Dimensional, Visual Pathways/metabolism/pathology, Xia Christina Z

Origins of spondyloarthropathy in Perissodactyla.

OBJECTIVE: Spondyloarthropathy has clearly been documented as not limited in occurrence to humans. Transmammalian in nature, it is of interest to understand the antiquity, and perhaps the origins, of this disorder in animal groups sufficiently…

Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth.

Reactive oxygen species (ROS) are implicated in coronary collateral growth (CCG). We evaluated the requirement for ROS in human coronary artery endothelial cell (HCAEC) tube formation, CCG in vivo, and signaling (p38 MAP kinase) by which ROS may…

Tags: *Collateral Circulation/drug effects, *Coronary Circulation/drug effects, *MAP Kinase Signaling System/drug effects, 2007, Acetophenones/pharmacology, American journal of physiology. Heart and circulatory physiology, Animal, Animals, Blood Flow Velocity, Cells, Chilian William M, Coronary Vessels/surgery, Cultured, Department of Integrative Medical Sciences, Disease Models, Ditiocarb/pharmacology, Endothelial Cells/drug effects/enzymology/*metabolism, Enzyme Inhibitors/pharmacology, Humans, Imidazoles/pharmacology, Inbred WKY, Kolz Christopher, Ligation, Male, Myocardial Reperfusion Injury/enzymology/metabolism/*physiopathology, NADPH Oxidases/antagonists & inhibitors/metabolism, NEOMED College of Medicine, Neovascularization, Onium Compounds/pharmacology, Oxygenases/antagonists & inhibitors/metabolism, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism, Physiologic, Potter Barry, Pyridines/pharmacology, Rats, Reactive Oxygen Species/*metabolism, Reed Ryan, Rocic Petra, Superoxide Dismutase/antagonists & inhibitors/metabolism, Vascular Endothelial Growth Factor A/metabolism

On the mechanisms of biliary flux.

Since the late 1950s, transport of bile in the liver has been described by the “osmotic concept,” according to which bile flows into the canaliculi toward the ducts, countercurrent to the blood flow in the sinusoids. However, because of the small…

Tags: 2021, Animal, Bile, Humans, Liver/metabolism, Mice, Osmosis

Oestrogen and nigrostriatal dopaminergic neurodegeneration: animal models and clinical reports of Parkinson's disease.

1. The exact nature of oestrogen (positive, negative or no effect) in the dopaminergic neurodegenerative disorder Parkinson's disease is controversial. 2. In the present review, we summarize the data on oestrogen and nigrostriatal dopaminergic…

Tags: 2007, Animal, Animals, Basal Ganglia/drug effects/*metabolism/pathology, Clinical and experimental pharmacology & physiology, Disease Models, Dluzen Dean E, Dopamine/*metabolism, Estrogens/*metabolism/pharmacology/therapeutic use, Humans, Liu Bin, Nerve Degeneration/drug therapy/*metabolism/pathology, Neurons/metabolism/pathology, Neuroprotective Agents/*metabolism/pharmacology/therapeutic use, Parkinson Disease/drug therapy/*metabolism/pathology, Parkinsonian Disorders/drug therapy/*metabolism/pathology, Substantia Nigra/drug effects/*metabolism/pathology

Novel models for assessing blood-brain barrier drug permeation.

INTRODUCTION: The blood-brain barrier (BBB) is a selectively permeable micro-vascular unit which prevents many central nervous system (CNS)-targeted compounds from reaching the brain. A significant problem in CNS drug development is the ability to…

Tags: *Capillary Permeability, 2012, Allen David D, Animal, Animals, Blood-Brain Barrier/*metabolism, Bloomquist Jeffrey R, Drosophila melanogaster/metabolism, Expert opinion on drug metabolism & toxicology, Geldenhuys Werner J, Grasshoppers/metabolism, High-Throughput Screening Assays, Humans, Models, Pharmaceutical Preparations/*metabolism, Zebrafish/metabolism

Neuropathic pain in aged rats: behavioral responses and astrocytic activation.

We used the Bennett and Xie (1988) model of chronic neuropathic pain to study the effect of age on thermal and tactile sensitivity and on astrocytic activation in the dorsal horn of the spinal cord after nerve injury. Fischer 344 FBNF1 hybrid rats in…

Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.

Lipin-1 is a phosphatidate phosphohydrolase (PAP) required for the generation of diacylglycerol during glycerolipid synthesis, and exhibits dual functions in the regulation of lipid metabolism. Lipin-1 has been implicated in the pathogenesis of…

MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains.

Continuing our previous work in which we showed wide-ranging strain differences in MPTP neurotoxicity in male mice among ten BXD recombinant inbred strains, we replicated our work in females from nine of the same strains. Mice received a single s.c.…

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