Browse Items (328 total)
- Tags: Department of Integrative Medical Sciences
Myocardial CXCR4 expression is required for mesenchymal stem cell mediated repair following acute myocardial infarction.
Tags: 2012, Agarwal Udit, Animals, Apoptosis/physiology, Cardiac/cytology/physiology, Cell Movement/physiology, Chemokine CXCL12/*metabolism, Circulation, Coronary Circulation/physiology, CXCR4/*genetics/metabolism, Department of Integrative Medical Sciences, Dong Feng, Finan Amanda, Gene Expression/physiology, Green Fluorescent Proteins/genetics, Harvey James, Inbred C57BL, Knockout, Mesenchymal Stem Cell Transplantation/*methods, Mesenchymal Stem Cells/*metabolism, Mice, Myocardial Infarction/genetics/pathology/*therapy, Myocardium/cytology, Myocytes, NEOMED College of Medicine, Paracrine Communication/physiology, Penn Marc S, Receptors, Ventricular Remodeling/physiology, Weber Kristal
A Novel Role for CAMKK1 in the Regulation of the Mesenchymal Stem Cell Secretome.
Tags: 2017, Calcium/calmodulin-dependent protein kinase kinase-1, Cardiac disease, Cardiac regeneration, Department of Integrative Medical Sciences, Dong Feng, Duan Zhong-Hui, Kiedrowski Matthew, Mayorga Maritza E, Mesenchymal stem cells, NEOMED College of Medicine, Patnaik Shyam, Penn Marc S, Secretome, Stem cells translational medicine
Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis.
Tags: *angiogenesis, *cysteinyl leukotriene receptors, *endothelial cells, *metastasis, *tumor growth, 2019, Adapala Ravi K, Austen K Frank, Department of Integrative Medical Sciences, Duah Ernest, Kanaoka Yoshihide, Keshamouni Venkateshwar G, Kondeti Vinay, NEOMED College of Medicine, Paruchuri Sailaja, Proceedings of the National Academy of Sciences of the United States of America, Teegala Lakshminarayan Reddy, Thodeti Charles K
Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis.
Tags: *angiogenesis, *cysteinyl leukotriene receptors, *endothelial cells, *metastasis, *tumor growth, 2019, Adapala Ravi K, Animals, Austen K Frank, Capillary Permeability/drug effects, Cyclohexanecarboxylic Acids/pharmacology, Department of Integrative Medical Sciences, Duah Ernest, Endothelial Cells/*drug effects, Experimental, Gene Knockout Techniques, Inbred C57BL, Kanaoka Yoshihide, Keshamouni Venkateshwar G, Kondeti Vinay, Leukotriene Antagonists/pharmacology, Leukotriene/drug effects/*metabolism, Lung Neoplasms/drug therapy, Male, Mice, NEOMED College of Medicine, Neoplasm Metastasis/drug therapy, Neoplasm Transplantation, Neoplasms, Neovascularization, Paruchuri Sailaja, Pathologic/*chemically induced/drug therapy, Phthalic Acids/pharmacology, Proceedings of the National Academy of Sciences of the United States of America, Receptors, Teegala Lakshminarayan Reddy, Thodeti Charles K
Coronary microvascular Kv1 channels as regulatory sensors of intracellular pyridine nucleotide redox potential.
Tags: * NADH, *endothelium, *ion channels, *vascular smooth muscle, *vasodilation, 2018, Animals, Coronary Vessels/chemistry, Department of Integrative Medical Sciences, Dwenger Marc M, Humans, Microcirculation, Microcirculation (New York, N.Y. : 1994), Navedo Manuel F, NEOMED College of Medicine, Nystoriak Matthew A, Ohanyan Vahagn, Oxidation-Reduction, Potassium Channels, Pyrimidine Nucleotides/*metabolism, Reactive Nitrogen Species/metabolism, Reactive Oxygen Species/metabolism, Voltage-Gated/*physiology
A brief etymology of the collateral circulation.
Tags: *Cardiology, *Collateral Circulation/physiology, *Terminology as Topic, 2014, Arteriosclerosis, thrombosis, and vascular biology, Blood Vessels/embryology/growth & development, Chilian William M, Collateral Circulation, Deindl Elisabeth, Department of Integrative Medical Sciences, Faber James E, Humans, myocardial ischemia, NEOMED College of Medicine, Neovascularization, peripheral arterial disease, Physiologic/physiology, Simons Michael, stroke, van Royen Niels
Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.
Tags: *bile acids and salt/metabolism, *cholesterol/diet, *Lipids, *Liver, 2016, Animal, Animals, Bile Acids and Salts/genetics/metabolism, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Diet, Disease Models, Exhalation/genetics, Ferrell Jessica M, Glucose/metabolism, High-Fat, Homeostasis, Humans, Journal of lipid research, Li Feng, Lipid Metabolism/genetics, Liver/enzymology/pathology, Metabolic Diseases/*genetics/metabolism, Mice, NEOMED College of Medicine
Circadian rhythms in liver metabolism and disease.
Tags: 2015, Acta pharmaceutica Sinica. B, ARC, arcuate nucleus, BMAL1, brain and muscle ARNT-like 1, CAR, Chiang John Y L, cholesterol 7alpha-hydroxylase, circadian locomotor output cycles kaput, Circadian Rhythm, CLOCK, constitutive androstane receptor, CRY, cryptochrome, CYP7A1, CYPs, cytochrome P450 enzymes, D-site binding protein, DBP, Department of Integrative Medical Sciences, E-box, emergency medical technician, EMT, enhance box, FAA, familial advanced sleep-phase syndrome, farnesoid-X receptor, FASPS, FEO, Ferrell Jessica M, food anticipatory activity, food entrainable oscillator, forkhead box O3, FOXO3, FXR, G protein-coupled bile acid receptor, glucose transporter 2, GLUT2, HDAC3, hepatic leukemia factor, Hip, histone deacetylase 3, HLF, hypoxia inducing protein, LDL, Liver, liver receptor homolog 1, Low-density lipoprotein, LRH1, Metabolic syndrome, NAD+, NEOMED College of Medicine, nicotinamide adenine dinucleotide, PER, period, retinohypothalamic tract, retinoid-related orphan receptor alpha, RHT, ROR-response element, RORalpha, RORE, SCN, SHP, SIRT1, sirtuin 1, small heterodimer partner, suprachiasmatic nucleus, TEF, TGR5, thyrotroph embryonic factor, transcriptional translational feedback loop, TTFL, Type 2 diabetes
Short-term circadian disruption impairs bile acid and lipid homeostasis in mice.
Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets
Tags: 2019, Bile Acids and Salts, Chiang John Y L, Cytoplasmic and Nuclear, Department of Integrative Medical Sciences, Diabetes & Metabolism Journal, Ferrell Jessica M, G-protein-coupled, Gastrointestinal Microbiome, June 2019 Update, NEOMED College of Medicine, Non-alcoholic Fatty Liver Disease, Receptors
Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets.
Tags: 2019, BILE acids, Bile Acids and Salts, Chiang John Y L, cholesterol 7-alpha-hydroxylase, Cytoplasmic and Nuclear, Department of Integrative Medical Sciences, Diabetes & Metabolism Journal, Endocrinology & Metabolism, Farnesoid X receptor, farnesoid-x-receptor, Fatty Liver, fatty liver-disease, Ferrell Jessica M, G protein coupled receptors, G-protein-coupled, Gastrointestinal Microbiome, growth-factor 19, gut microbiota, hepatic steatosis, improves insulin sensitivity, Liver disease, Metabolic, NEOMED College of Medicine, Non-alcoholic fatty, Non-alcoholic Fatty Liver Disease, nuclear, Receptor, Receptors, September 2019 Update, serum fgf21 levels, Syndrome
Deficiency of both farnesoid X receptor and Takeda G protein-coupled receptor 5 exacerbated liver fibrosis in mice.
Bone marrow SSEA1+ cells support the myocardium in cardiac pressure overload.
Tags: *Bone Marrow Transplantation, 2013, Animals, Bone Marrow Cells/cytology/*metabolism, Cardiac/cytology/metabolism, Cell Tracking, Department of Integrative Medical Sciences, Dong Feng, Finan Amanda, Kiedrowski Matthew, Lewis X Antigen/*metabolism, Male, Mesenchymal Stem Cells/cytology/metabolism, Mice, Myocardium/cytology/*metabolism/pathology, Myocytes, NEOMED College of Medicine, Penn Marc S, PloS one, Sopko Nikolai, Turturice Ben, Ventricular Remodeling
Chemotherapy Strategies for Young Children Newly-Diagnosed with Medulloblastoma up to the Era of Molecular Profiling - A Comparative Outcomes Analysis
Tags: 2019, Akron Children's Hospital, Ashley D, Cohen B H, Department of Integrative Medical Sciences, Department of Pediatrics, Dhall G, Finlay J, Gajjar A, Gerber N, Geyer J R, Journal Article, Lafay-Cousin L, Leary S, Mazewski C M, Mynarek M, NEOMED College of Medicine, November 2019 Update, Pediatric blood & cancer, Rutkowski S, Tait D, von Bueren A O
Basic transcription element binding protein (BTEB) transactivates the cholesterol 7 alpha-hydroxylase gene (CYP7A).
Tags: *Gene Expression Regulation, 1998, Animals, Bile Acids and Salts/genetics, Binding Sites/genetics, Biochemical and biophysical research communications, Carcinoma, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Complementary/analysis, Cultured, Department of Integrative Medical Sciences, DNA, DNA-Binding Proteins/metabolism/*physiology, Electrophoresis, Enzyme Activation/genetics, Foti D, Genetic, Hepatocellular, Humans, Kruppel-Like Transcription Factors, Liver/enzymology, NEOMED College of Medicine, Podophyllin/analogs & derivatives/metabolism, Podophyllotoxin/analogs & derivatives, Polyacrylamide Gel, Promoter Regions, Protein Binding/genetics, Rats, Stroup D, Transcription Factors/metabolism/*physiology, Tumor Cells
Differences in the integration pattern and episomal forms of human papillomavirus type 16 DNA found within an invasive cervical neoplasm and its metastasis.
Tags: 1992, Carcinoma, DeLucia A, Department of Integrative Medical Sciences, DNA, Electrophoresis, Female, Galehouse D, Gel, Humans, Jenison E, NEOMED College of Medicine, Neoplasm Metastasis, Papillomaviridae/*genetics, Plasmids, Squamous Cell/*microbiology/pathology, Two-Dimensional, Uterine Cervical Neoplasms/*microbiology/pathology, Vaginal Neoplasms/microbiology/pathology/secondary, Viral/analysis, Virology, Virus Integration
TSP-1 (thrombospondin-1) deficiency protects APOE(-/-) mice against leptin-induced atherosclerosis.
Tags: 2020, and vascular biology, Arteriosclerosis, Arteriosclerosis, thrombosis, and vascular biology, Atherosclerosis, Datta S, Department of Integrative Medical Sciences, Ganguly R, Gupta S, January 2021 List, journalArticle, Khanal S, Lallo J, leptin, Mathias A, NEOMED College of Medicine, Obesity, Ohanyan VA, Patel A, Raman P, Sahu S, smooth muscle, Storm K, Thrombosis, thrombospondins
Trivalent chromium inhibits TSP-1 expression, proliferation, and O-GlcNAc signaling in vascular smooth muscle cells in response to high glucose in vitro.
Tags: 2015, American journal of physiology. Cell physiology, Aorta/drug effects/metabolism, Cell Proliferation/*drug effects/genetics, Cells, Chavez Ronaldo J, Chromium/*pharmacology, Cultured, Department of Integrative Medical Sciences, Fructosephosphates/metabolism, Ganguly Rituparna, Genetic/drug effects/genetics, Glucose/*metabolism, Glutamine/genetics, Glycosylation/drug effects, Hexosamines/metabolism, Humans, Hyperglycemia/metabolism, Muscle, Myocytes, N-Acetylglucosaminyltransferases/genetics, NEOMED College of Medicine, O-glycosylation, Promoter Regions, Raman Priya, reactive oxygen species, Reactive Oxygen Species/metabolism, Sahu Soumyadip, Signal Transduction/*drug effects/genetics, Smooth, Smooth Muscle/*drug effects/metabolism, Thrombospondin 1/*antagonists & inhibitors/genetics, thrombospondin-1, Transcription, trivalent chromium, vascular smooth muscle cells, Vascular/*drug effects/metabolism
Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE(-/-) mice.
Tags: 2017, Animals, Aorta/drug effects/metabolism, Apolipoproteins E/*metabolism, Atherosclerosis/*drug therapy/metabolism, Chavez Ronaldo J, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Angiopathies/drug therapy/metabolism, Experimental/chemically induced/drug therapy/metabolism, Ganguly Rituparna, Glucose/metabolism, Glycosylation/drug effects, Haney Rebecca, Hyperglycemia/*drug therapy/metabolism, Inbred C57BL, Knockout, Male, Mice, Myocytes, NEOMED College of Medicine, NEOMED Student Publications, Ohanyan Vahagn, Picolinic Acids/*pharmacology, Raman Priya, Sahu Soumyadip, Scientific reports, Shah Shivani, Smooth Muscle/drug effects, Streptozocin/*pharmacology, Thrombospondin 1/*metabolism, Type 1/chemically induced/*drug therapy/metabolism, Yalamanchili Siri
Anti-atherogenic effect of trivalent chromium-loaded CPMV nanoparticles in human aortic smooth muscle cells under hyperglycemic conditions in vitro.
Tags: *Comovirus, 2016, Aorta/*metabolism, Atherosclerosis/*drug therapy/therapy, Azo Compounds/chemistry, Cell Proliferation, Cells, Chlorides/*chemistry, Chromium Compounds/*chemistry, Cultured, Cytokines/metabolism, Czech Tori, Department of Integrative Medical Sciences, Drug Delivery Systems, Electron, Fluorescence, Ganguly Rituparna, Glucose/chemistry, Humans, Hyperglycemia/*metabolism, Lipids/chemistry, Microscopy, Myer Ashley B, Myocytes, Nanoparticles/chemistry, Nanoscale, NEOMED College of Medicine, NF-kappa B/metabolism, Proliferating Cell Nuclear Antigen/chemistry, Raman Priya, Sahu Soumyadip, Smooth Muscle/*metabolism, Spectrophotometry, Steinmetz Nicole F, Transforming Growth Factor beta/metabolism, Transmission, Ultraviolet, Wen Amy M
Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis.
Tags: *Aldehyde Reductase/genetics/metabolism, 2011, Adenoviridae, Animal, Animals, Blood Glucose/*metabolism, Chiang John Y L, Cholesterol/analysis, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism/physiopathology, Disease Models, Fatty Liver/genetics/*metabolism/physiopathology, Ge Xuemei, Gene Expression, Genetic Vectors, Gluconeogenesis/genetics, Homeostasis, Humans, Journal of lipid research, Li Tiangang, Liver/*metabolism/physiopathology, Ma Huiyan, Malondialdehyde/blood, Mice, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, Transfection, Transgenic, Triglycerides/analysis, Yin Liya, Zhang Yanqiao
Drug Delivery and Nanoformulations for the Cardiovascular System.
High-content screen using zebrafish (Danio rerio) embryos identifies a novel kinase activator and inhibitor.
Tags: *Cancer, *Compound library, *Kinase, *Notochord, *Phenotypic screen, *Somites, *Zebrafish, 2017, Aljammal Rowaa, Animals, Antineoplastic Agents/chemistry/pharmacology, Antitumor/methods, Benzoic Acid/chemistry/pharmacology, Bergeron Sadie A, Bioorganic & medicinal chemistry letters, Chen Wei-Chi, Death-Associated Protein Kinases/metabolism, Department of Integrative Medical Sciences, Drug Discovery/*methods, Drug Screening Assays, Embryo, Enzyme Activation/drug effects, Enzyme Activators/*chemistry/*pharmacology, Gaasch Briah L, Geldenhuys Werner J, Hazlehurst Lori A, Mullins Jackie E, NEOMED College of Medicine, Neoplasms/drug therapy/enzymology, Nonmammalian/*drug effects/enzymology, Protein Kinase Inhibitors/*chemistry/*pharmacology, Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism, Yun June, Zebrafish Proteins/antagonists & inhibitors/metabolism, Zebrafish/*embryology
Structure-activity and in vivo evaluation of a novel lipoprotein lipase (LPL) activator.
Tags: *Diabetes, *High-fat diet, *Homology modeling, *Hyperlipidemia, *Lipoprotein lipase, *Liver cirrhosis, *Obesity, 2017, Animals, Benzeneacetamides/chemical synthesis/chemistry/*pharmacology, Bioorganic & medicinal chemistry letters, Caporoso Joel, Darvesh Altaf S, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dose-Response Relationship, Drug, Geldenhuys Werner J, Imidazoles/chemical synthesis/chemistry/*pharmacology, Lee Yoon-Kwang, Leeper Thomas C, Lin Li, Lipoprotein Lipase/*metabolism, Mice, Molecular Docking Simulation, Molecular Structure, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED College of Pharmacy, Sadana Prabodh, Structure-Activity Relationship
Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases.
Tags: *drug discovery, *Ligands, 2017, Adenosine/metabolism, Animals, Atherosclerosis, Cardiac death, Cardiovascular Diseases/drug therapy/metabolism, Cardiovascular System/metabolism, Department of Integrative Medical Sciences, Geldenhuys Werner J, Hanif Ahmad, Humans, Hydrogen Bonding, Models, Molecular, Molecular Structure, Molecules (Basel, Switzerland), myocardial infarction, Nayeem Mohammed A, NEOMED College of Medicine, Protein Binding, Purinergic P1/*chemistry/*metabolism, Receptors, Signal Transduction, Structure-Activity Relationship, Vascular tone, Yun June
Mechanosensitive transient receptor potential vanilloid 4 regulates Dermatophagoides farinae-induced airway remodeling via 2 distinct pathways modulating matrix synthesis and degradation.
Tags: *Airway Remodeling, *fibronectin, *myofibroblasts, *PAI-1, *PI3K, *TGF-beta1, 2017, Adult, Al-Azzam Nosayba, Animals, Asthma/etiology/genetics/*metabolism/pathology, Cells, Cultured, Department of Integrative Medical Sciences, Dermatophagoides farinae/immunology, Duah Ernest, Extracellular Matrix/*metabolism/pathology, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Fibroblasts/metabolism, Fibronectins/*metabolism, Gombedza Farai, Hexter Madison, Humans, Inbred C57BL, Kondeti Vinay, Koppes Stephanie, Male, Mice, NEOMED College of Medicine, Paruchuri Sailaja, Patil Prachi, Phillips Daniel, Phosphatidylinositol 3-Kinases/metabolism, Plasminogen Activator Inhibitor 1/metabolism, Thodeti Charles K, Transforming Growth Factor beta/metabolism, TRPV Cation Channels/genetics/*metabolism
Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage.
Tags: 2016, Animal, Animals, Basic research in cardiology, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Coronary Circulation, Coronary microcirculation, Coronary Vessels/metabolism/*physiopathology, Department of Integrative Medical Sciences, Diabetes, Disease Models, DNA, DNA Damage/physiology, DNA Fragmentation, Dobson James G Jr, Fenton Richard, Guarini Giacinta, Hardwick James P, Kang Patrick T, Kiyooka Takahiko, Kolz Christopher L, Marzilli Mario, Metabolic Syndrome/metabolism/*physiopathology, Mitochondria, Mitochondria/*metabolism, Mitochondrial/*metabolism, NEOMED College of Medicine, Obesity, Ohanyan Vahagn, Oxidative Stress/physiology, Pung Yuh Fen, Rats, Reactive Oxygen Species/metabolism, Shokolenko Inna, Vasodilation/physiology, Wilson Glenn L, Yin Liya, Zucker
Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels.
Tags: 13-dienoic Acid/pharmacology, 15-Hydroxy-11 alpha, 2012, 9 alpha-(epoxymethano)prosta-5, American journal of physiology. Heart and circulatory physiology, Anilides/pharmacology, Animals, Bratz Ian N, Capsaicin/analogs & derivatives/pharmacology, Cinnamates/pharmacology, Coronary Vessels/drug effects/*metabolism/physiopathology, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Cardiomyopathies/drug therapy/*metabolism, Enzyme Inhibitors/pharmacology, Guarini Giacinta, Inbred C57BL, Kmetz John G, Large-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors/*metabolism, Male, Meszaros J Gary, Mice, Microvessels/drug effects/physiopathology, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Nitric Oxide/*metabolism, Ohanyan Vahagn A, Peptides/pharmacology, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/agonists/antagonists & inhibitors/biosynthesis/*metabolism, Type 2/drug therapy/*metabolism, Vasoconstrictor Agents/pharmacology, Vasodilation/drug effects
Extracellular vesicles from tumor microenvironment transforms endothelial cell phenotype via downregulation of TRPV4 channels
Tags: 2020, Adapala R, Department of Integrative Medical Sciences, Dougherty J, Faseb Journal, Guarino B, journalArticle, Kanugula A, Mahmood K, NEOMED College of Medicine Postdoc, NEOMED College of Medicine Student, NEOMED Postdoc Publications, NEOMED Student Publications, Paruchuri S, September 2020 List, Thodeti CK
The role of TRPV4 channels in ocular function and pathologies.
Tags: 2020, angiogenesis, calcium channel, Cornea, Department of Integrative Medical Sciences, diabetic retinopathy, Experimental eye research, Glaucoma, Guarino BD, journalArticle, Lens, NEOMED College of Medicine, NEOMED College of Medicine Student, NEOMED Student Publications, Osmolarity, Paruchuri S, retina, September 2020 List, Thodeti CK, TRPV4
Doxorubicin-induced cardiomyopathy: Prevention and treatment by a coronary specific vasodilator
Tags: 2019, Chilian William, Department of Integrative Medical Sciences, Enrick Molly, Faseb Journal, Gyulkhasyan Tigran, Hakobyan Tatevik, Kolz Christopher L, NEOMED College of Medicine, NEOMED College of Medicine Student, NEOMED Student Publications, Ohanyan Vahagn, Parikh Ankur, Peketi Punita, Shockling Lindsay
Procyanidin A1 Alleviates Inflammatory Response induced by LPS through NF-κB, MAPK, and Nrf2/HO-1 Pathways in RAW264.7 cells
Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: 2009, Base Sequence, Calcitriol/drug effects/genetics/*physiology, Cell Line, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Cultured, Department of Integrative Medical Sciences, DNA Primers, Drug metabolism and disposition: the biological fate of chemicals, Electrophoretic Mobility Shift Assay, Gene Knockdown Techniques, Genetic/*physiology, Han Shuxin, Hepatocytes/*drug effects/enzymology, Humans, Immunoprecipitation, Lithocholic Acid/pharmacology, Messenger/genetics, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, RNA, Small Interfering, Transcription, Tumor, Two-Hybrid System Techniques
A novel bile acid-activated vitamin D receptor signaling in human hepatocytes.
Tags: 2010, Calcitriol/*metabolism, Calcitriol/pharmacology, Cell Membrane/drug effects/metabolism, Cell Nucleus/drug effects/metabolism, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors/genetics, Department of Integrative Medical Sciences, Ellis Ewa, Enzyme Activation/drug effects, Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors, Genetic/genetics, Han Shuxin, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*drug effects/enzymology/*metabolism, Humans, Intracellular Space/drug effects/metabolism, Li Tiangang, Ligands, Lithocholic Acid/*pharmacology, Mitogen-Activated Protein Kinase Kinases/metabolism, Molecular endocrinology (Baltimore, Md.), NEOMED College of Medicine, Phosphorylation/drug effects, Phosphotyrosine/metabolism, Promoter Regions, Protein Kinase Inhibitors/pharmacology, Protein Transport/drug effects, Proto-Oncogene Proteins c-raf/metabolism, Receptors, Retinoid X Receptor alpha/metabolism, Signal Transduction/*drug effects, src-Family Kinases/metabolism, Steroid Hydroxylases/genetics/metabolism, Strom Stephen, Vitamin D3 24-Hydroxylase
Something completely different?
Tags: 1996, Animals, Blotting, Brain/*enzymology, Chen L, Cloning, Complementary, Cytochrome P-450 Enzyme System/*genetics/isolation & purification, Department of Integrative Medical Sciences, DNA, Hardwick J P, Human & experimental toxicology, Kidney/enzymology, Liver/enzymology, Molecular, NEOMED College of Medicine, Northern, Rats
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Tags: *Cytochrome P-450 Enzyme System/genetics/metabolism/physiology, 2008, Animals, Biochemical pharmacology, Cytochrome P-450 CYP4A/genetics/metabolism/physiology, Department of Integrative Medical Sciences, Enzymologic, Fatty Acids/*metabolism, Gene Expression Regulation, Hardwick James P, Humans, Metabolic Diseases/enzymology/*metabolism, NEOMED College of Medicine