Browse Items · NEOMED Bibliography Database

Trimethyltin intoxication induces the migration of ventricular/subventricular zone cells to the injured murine hippocampus.

Following the postnatal decline of cell proliferation in the mammalian central nervous system, the adult brain retains progenitor cells with stem cell-like properties in the subventricular zone (SVZ) and the subgranular zone (SGZ) of the hippocampus.…

Triethyltin exposure suppresses synaptic transmission in area CA1 of the rat hippocampal slice.

To examine the effects of TET on the electrophysiology of area CA1 of hippocampus, hippocampal slices were obtained from adult hooded rats and were maintained in vitro using standard techniques. Stimulating and recording electrodes were placed in the…

Tags: 1988, Animals, Evoked Potentials/drug effects, Female, Fountain S B, Hennes S K, Hippocampus/drug effects/*pathology/physiology, In Vitro Techniques, Neurotoxicology and teratology, Pyramidal Tracts/drug effects/*pathology/physiology, Rats, Synapses/drug effects/*physiology, Synaptic Transmission/*drug effects, Teyler T J, Ting Y L, Trialkyltin Compounds/*toxicity, Triethyltin Compounds/*toxicity

Trianthema portulacastrum Linn. exerts chemoprevention of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats.

Due to limited treatment options for advanced-stage metastatic breast cancer, a high priority should be given to develop non-toxic chemopreventive drugs. The value of various natural and dietary agents to reduce the risk of developing breast cancer…

Trianthema portulacastrum Linn. displays anti-inflammatory responses during chemically induced rat mammary tumorigenesis through simultaneous and differential regulation of NF-kappaB and Nrf2 signaling pathways.

Trianthema portulacastrum, a medicinal and dietary plant, has gained substantial importance due to its various pharmacological properties, including anti-inflammatory and anticarcinogenic activities. We have recently reported that a characterized T.…

Trends in place preference conditioning with a cross-indexed bibliography;

The purpose of this work is to present a perspective of the conditioned place preference (CPP) test by offering an overview of the empirical research from

Tags: *Choice Behavior, *Conditioning, 1993, Animals, Calcagnetti D J, Experimental/*trends, Neuroscience and biobehavioral reviews, Operant, Psychology, Schechter M D

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.

BACKGROUND: Genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) confer increased risk of developing late-onset Alzheimer's Disease (LOAD) and other neurodegenerative disorders. Recent studies provided insight into the…

TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review).

Trafficking protein particle complex 9 (TRAPPC9) is a protein subunit of the transport protein particle II (TRAPPII), which has been reported to be important in the trafficking of cargo from the endoplasmic reticulum (ER) to the Golgi, and in…

Tags: *Disease Susceptibility, *Signal Transduction, 2018, Animals, Carrier Proteins/chemistry/genetics/*metabolism, Gene Expression Regulation, Humans, Hussein Nazar J, International journal of molecular medicine, Mbimba Thomas, Najeed Ayesha, Protein Binding, Protein Interaction Domains and Motifs, Protein Transport, Safadi Fayez F, Structure-Activity Relationship

Transplacental cardiotoxicity of cocaine: atrial damage following treatment in early pregnancy.

Using light, transmission (TEM) and scanning (SEM) electron microscopy, cocaine-induced defects were observed in hamster atria. Compared with controls, the treated atria from neonates show endocardial and myocardial damages as the atrial walls…

Tags: 1991, Animals, Cocaine/*toxicity, Congenital/chemically induced/*pathology, Cricetinae, Dalbec J P, Electron, Endocardium/ultrastructure, Female, Gilloteaux J, Heart Atria/*ultrastructure, Heart Defects, Maternal-Fetal Exchange, Mesocricetus, Microscopy, Pregnancy, Random Allocation, Scanning, Scanning microscopy

Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease.

Fat accumulation (hepatic steatosis) in alcoholic and nonalcoholic fatty liver disease is a potentially pathologic condition which can progress to steatohepatitis (inflammation), fibrosis, cirrhosis, and carcinogenesis. Many clinically used drugs or…

Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo.

Initial identification of osteoactivin (OA)/glycoprotein non-melanoma clone B (gpnmb) was demonstrated in an osteopetrotic rat model, where OA expression was increased threefold in mutant bones, compared to normal. OA mRNA and protein expression…

Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice.

UNLABELLED: Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme in the bile acid biosynthetic pathway that converts cholesterol into bile acids in the liver. Recent studies have shown that bile acids may play an important role in…

Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.

The gene encoding cholesterol 7alpha-hydroxylase (CYP7A), the rate-limiting enzyme in bile acid synthesis, is transcriptionally regulated by bile acids and hormones. Previously, we have identified two bile acid response elements (BARE) in the…

Tags: *Receptors, *Transcriptional Activation, 1998, Animals, Base Sequence, Bile Acids and Salts/biosynthesis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, DNA/metabolism, Galli G, Genes, Genetic, Hepatocyte Nuclear Factor 4, Hormones/*physiology, Journal of lipid research, Luciferases/genetics, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid, Oligonucleotide Probes/metabolism, Phosphoproteins/metabolism, Promoter Regions, Rats, Receptors, Repetitive Sequences, Reporter, Retinoic Acid/metabolism, Retinoid X Receptors, Sadeghpour A, Site-Directed, Steroid, Stroup D, Transcription Factors/metabolism, Tumor Cells

Topographical distribution of delay-tuned responses in the mustached bat inferior colliculus.

In the mustached bat, delay-tuned neurons respond best to specific delays between the first harmonic frequency modulated (FM) component (FM1; 24-29 kHz) of the emitted biosonar pulse and a higher harmonic FM component in returning echoes (e.g. FM3,…

Tags: 2001, Acoustic Stimulation, Animals, Auditory Cortex/anatomy & histology/physiology, Chiroptera/*anatomy & histology/*physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Echolocation/physiology, Hearing research, Inferior Colliculi/*anatomy & histology/*physiology, NEOMED College of Medicine, Neurons/physiology, Portfors C V, Ultrasonics, Wenstrup J J

Topographic organization of efferent projections of medial frontal cortex.

By using fluorescent retrograde tracers, we compared efferent projections of the medial frontal cortex to two subcortical areas: the superior colliculus, a somatic motor area, and the laterodorsal tegmental nucleus, a visceral motor area. Neurons…

Tags: 1993, Animals, Brain Mapping/*methods, Brain research bulletin, Efferent Pathways/physiology, Female, Fluorescent Dyes, Frontal Lobe/*physiology, Male, Microinjections, Rats, Sprague-Dawley, Stuesse S L, Superior Colliculi/physiology, Tegmentum Mesencephali/physiology, Zeng D

Tissue engineering models of human digits: effect of periosteum on growth plate cartilage development.

Tissue-engineered middle phalanx constructs of human digits were investigated to determine whether periosteum wrapped partly about model midshafts mediated cartilage growth plate formation. Models were fabricated by suturing ends of polymer midshafts…

Tinnitus and underlying brain mechanisms.

PURPOSE OF REVIEW: Tinnitus is the sensation of hearing a sound when no external auditory stimulus is present. Most individuals experience tinnitus for brief, unobtrusive periods. However, chronic sensation of tinnitus affects approximately 17% (44…

Timing of sound-evoked potentials and spike responses in the inferior colliculus of awake bats.

Neurons in the inferior colliculus (IC), one of the major integrative centers of the auditory system, process acoustic information converging from almost all nuclei of the auditory brain stem. During this integration, excitatory and inhibitory inputs…

Time-dependent effect of ethanol upon discrimination behavior.

The discriminative stimulus properties produced by ethanol were employed to demonstrate differences in discriminative performance over time in rats trained at different postinjection times. Thus, one group of rats was trained to discriminate between…

Tags: 1989, Alcohol (Fayetteville, N.Y.), Animals, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Inbred Strains, Male, Rats, Schechter M D, Time Factors

Time-dependent changes in norepinephrine-induced left ventricular dysfunction and histopathologic condition.

BACKGROUND: Intense activation of the sympathetic nervous system or administration of high concentrations of catecholamines diminishes myocardial contractility and produces infarct-like lesions throughout the heart. This study was conducted to…

Time course of blood volume changes in an isolated lung lobe after venous pressure elevation.

The elevation of venous pressure (Pv) in isolated perfused organs causes organ weight to increase in a biphasic manner. The initial rapid phase results primarily from an increase in blood volume (BV), whereas the second slower phase is generally…

Tags: *Blood Volume/drug effects, *Pulmonary Circulation, *Venous Pressure, 1994, Animals, Dogs, Extravascular Lung Water/metabolism, Female, In Vitro Techniques, Indicator Dilution Techniques, Indocyanine Green, Journal of applied physiology (Bethesda, Md. : 1985), Lane S M, Lung/*physiology, Male, Maron M B, Papaverine/pharmacology, Perfusion, Time Factors

Time and dose dependency of the suppression of pulmonary metastases of rat mammary cancer by amiloride.

Amiloride is an inhibitor of urokinase plasminogen activator (uPA), an essential component of the plasminogen/plasmin enzyme system. Inhibition of uPA prevents the conversion of plasminogen to tumor cell surface bound plasmin which is required for…

Thyroid hormone fluctuations indicate a thermoregulatory function in both a tropical (Alouatta palliata) and seasonally cold-habitat (Macaca fuscata) primate.

Thyroid hormones boost animals' basal metabolic rate and represent an important thermoregulatory pathway for mammals that face cold temperatures. Whereas the cold thermal pressures experienced by primates in seasonal habitats at high latitudes and…

Thrombospondin-4 mediates TGF-beta-induced angiogenesis.

TGF-beta is a multifunctional cytokine affecting many cell types and implicated in tissue remodeling processes. Due to its many functions and cell-specific effects, the consequences of TGF-beta signaling are process-and stage-dependent, and it is not…

Thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor

The purpose of this study is to investigate a thermoreversible gel using Pluronic

Tags: *Drug Delivery Systems, 2013, Animal, Animals, Benzodioxoles/*administration & dosage/pharmacokinetics/toxicity, Bhatia Deepak, Body Temperature, Delayed-Action Preparations, Disease Models, Drug Carriers/chemistry/toxicity, Fibroblasts/drug effects/metabolism, Filtering Surgery/*methods, Geldenhuys Werner, Gels, Glaucoma/*surgery, Imidazoles/*administration & dosage/pharmacokinetics/toxicity, Miladore Nicholas, Nakamura Hiroshi, Pharmaceutical development and technology, Poloxamer/chemistry/toxicity, Protein-Serine-Threonine Kinases/antagonists & inhibitors, Pyridines/*administration & dosage/pharmacokinetics/toxicity, Rabbits, Receptor, Receptors, Sutariya Vijaykumar, Temperature, Time Factors, Transforming Growth Factor beta/antagonists & inhibitors, Transforming Growth Factor-beta Type I, Viscosity, Wehrung Daniel

Therapeutic Delivery of Simvastatin Loaded in PLA-PEG Polymersomes Resulted in Amplification of Anti-inflammatory Effects in Activated Microglia.

Simvastatin (Sim), a lipid-lowering drug has been studied in chronic neuroinflammation associated with degenerative brain disorders due to its potential protective properties against inflammatory reaction, oxidative damage, neuronal dysfunction, and…

The versatility and paradox of GDF 11.

In addition to its roles in embryonic development, Growth and Differentiation Factor 11 (GDF 11) has recently drawn much interest about its roles in other processes, such as aging. GDF 11 has been shown to play pivotal roles in the rescue of the…

The structure and function of normally mineralizing avian tendons.

The leg tendons of certain avian species normally calcify. The gastrocnemius, or Achilles, tendon of the domestic turkey, Meleagris gallopavo, is one such example. Its structure and biomechanical properties have been studied to model the adaptive…

Tags: 2002, Animals, Biomechanical Phenomena, Birds/*anatomy & histology/*physiology, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, Landis William J, Minerals/*metabolism, Non-programmatic, Silver Frederick H, Tendons/anatomy & histology/*cytology/*physiology

The stabilizing function of the tail during arboreal quadrupedalism.

Locomotion on the narrow and compliant supports of the arboreal environment is inherently precarious. Previous studies have identified a host of morphological and behavioral specializations in arboreal animals broadly thought to promote stability…

Tags: 2021, Animals, Biomechanical Phenomena, Body Size, Locomotion, Platyrrhini/anatomy & histology/*physiology

The spiral ganglion and Rosenthal's canal in beluga whales.

With the increase of human activity and corresponding increase in anthropogenic sounds in marine waters of the Arctic, it is necessary to understand its effect on the hearing of marine wildlife. We have conducted a baseline study on the spiral…

The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease.

The serotonin 6 receptor is attracting attention as an etiological contributor in cognition deficits in diseases such as Alzheimer's disease, anxiety/depression and schizophrenia. In this review, we discuss the role of this recently discovered G…

Tags: 2009, Alzheimer Disease/*complications, Animals, Biological, Cognition Disorders/*drug therapy/*etiology, Drug Design, Expert review of neurotherapeutics, Geldenhuys Werner J, Humans, Models, Receptors, Serotonin Antagonists/chemistry/*therapeutic use, Serotonin/*metabolism, Structure-Activity Relationship, Van der Schyf Cornelis J

The role of the N-terminal and mid-region residues of substance P in regulating functional selectivity at the tachykinin NK1 receptor.

Previous studies have shown that tachykinin peptide ligands of the tachykinin NK1 receptor exhibit functional selectivity with respect to signal activation and desensitization. The differences are most dramatic between the naturally occurring…

The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex.

The purpose of the present study was to improve our understanding of the role of NMDA receptors in neocortical synaptic plasticity. In slices of rat visual cortex the field potential elicited in layer III in response to white matter stimulation…

The role of mitochondrial bioenergetics and reactive oxygen species in coronary collateral growth.

Coronary collateral growth is a process involving coordination between growth factors expressed in response to ischemia and mechanical forces. Underlying this response is proliferation of vascular smooth muscle and endothelial cells, resulting in an…

The role of dopamine and serotonin receptors in the mediation of the ethanol interoceptive cue.

The drug discrimination paradigm was used to evaluate the contribution of dopamine or serotonin receptors in the mediation of the stimulus properties of ethanol. Briefly, rats were trained to discriminate between ethanol (600 mg/kg, IP) and water…

Tags: 1988, Animals, Conditioning, Cues, Discrimination (Psychology)/*physiology, Dopamine/drug effects/*physiology, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Inbred Strains, Male, Operant/physiology, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Serotonin/drug effects/*physiology, Signs S A

The relation between hand morphology and quadrupedalism in primates.

Primate hands can be classified into two broad categories on the basis of ray proportions and other features. Ectaxonic hands are characterized by a longer fourth ray and are found in most strepsirhines. Most haplorhines possess mesaxonic hands which…

Tags: *Walking, 1998, American journal of physical anthropology, Animals, Gait, Hand Strength, Hand/*anatomy & histology/diagnostic imaging, Lemelin P, Primates/*anatomy & histology/classification, Radiography, Schmitt D, Species Specificity, Ulna/anatomy & histology, Videotape Recording

The re-expression of two myosin heavy chains in regenerated rat muscle spindles.

The vascular supply and tendons of the extensor digitorum longus (EDL) muscles of two adult rats were unilaterally severed and the muscles were allowed to regenerate for 40 days. Serial frozen sections of muscle grafts were cut and stained for…

Tags: *Gene Expression Regulation, *Regeneration, 1989, Afferent/*physiology, Animals, Fei C, Female, Immunohistochemistry, Inbred F344, Muscle Denervation, Muscles/innervation/*metabolism, Myosins/*metabolism, Neurons, Neuroscience letters, Rats, Walro J M

The presence of extracellular matrix alters the chondrocyte response to endoplasmic reticulum stress.

The objective of this study was to test the hypothesis that extracellular matrix (ECM) would alter the endoplasmic reticulum (ER) stress response of chondrocytes. Chondrocytes were isolated from calf knees and maintained in monolayer culture or…

The power of the claw.

Scratches on bones have routinely been attributed to tooth marks (a predominantly untested speculation), ignoring the effects of claws, perhaps because of the general assumption that claws are too soft to damage bone. However, some pathologies…

Tags: *Hoof and Claw, *Mechanical Phenomena, 2013, Animals, Biomechanical Phenomena, Bryant Bill, Feeding Behavior, Femur/injuries, Hubbard Christopher, Kilgore Ginny Penn, Martin Larry, Naples Virginia, PloS one, Predatory Behavior, Rothschild Bruce M, Ruminants, Tigers, Tuxhorn Kent

The potential of tissue engineering in orthopedics.

This article presents models of human phalanges and small joints developed by tissue engineering. Biodegradable polymer scaffolds support growth of osteoblasts, chondrocytes, and tenocytes after implantation of the models in athymic mice. The…

The Physiologic Impact of Unilateral Recurrent Laryngeal Nerve (RLN) Lesion on Infant Oropharyngeal and Esophageal Performance.

Recurrent laryngeal nerve (RLN) injury in neonates, a complication of patent ductus arteriosus corrective surgery, leads to aspiration and swallowing complications. Severity of symptoms and prognosis for recovery are variable. We transected the RLN…

Tags: 2015, Animal, Animals, Aspiration, Ballester Ashley, Biological, Deglutition, Deglutition – Physiology, Deglutition disorders, Deglutition Disorders – Etiology, Deglutition Disorders – Physiopathology, Deglutition Disorders/*etiology/physiopathology, Deglutition/*physiology, Department of Anatomy & Neurobiology, Disease Models, Dysphagia, Esophagus, Esophagus – Physiopathology, Esophagus/*physiopathology, Fraley Luke, German Rebecca Z, Gould François D H, Gross Andrew, Human, Infant, Lammers Andrew R, Laryngeal Nerves – Injuries, Laryngeal Nerves – Physiopathology, Models, NEOMED College of Medicine, Ohlemacher Jocelyn, Oropharynx – Physiopathology, Oropharynx/*physiopathology, Recurrent laryngeal nerve, Recurrent Laryngeal Nerve Injuries/*complications/physiopathology, Recurrent Laryngeal Nerve/*physiopathology, Swine

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