Browse Items · NEOMED Bibliography Database

The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice.

BACKGROUND: Small heterodimer partner (SHP, NR0B2) is involved in diverse metabolic pathways, including hepatic bile acid, lipid and glucose homeostasis, and has been implicated in effects on the peroxisome proliferator-activated receptor gamma…

The opposing effects of retinoic acid and phorbol esters converge to a common response element in the promoter of the rat cholesterol 7 alpha-hydroxylase gene (CYP7A).

The activity of the rat CYP7A/luciferase reporter gene was increased five-fold by all-trans retinoic acid (atRA) or 9-cis retinoic acid (9cRA) in transient transfection assay in HepG2 cells. Cotransfection with retinoid X receptor (RXR) stimulated…

The nucleotide sequence of rabbit liver cytochrome b5 mRNA.

Using a synthetic 26 base pair (bp) oligonucleotide, we have screened a rabbit liver cDNA library in lambda gt11 and isolated a 1000 bp DNA clone corresponding to cytochrome b5 mRNA. The clone contains the complete coding region and long 5' and 3'…

Tags: 1988, Amino Acid Sequence, Animals, Base Sequence, Chromosome Deletion, Cloning, Cytochrome b Group/*genetics, Cytochromes b5, Dariush N, Fisher C W, Genes, Liver/*metabolism, Messenger/*genetics, Molecular, Molecular Sequence Data, Protein sequences & data analysis, Rabbits, RNA, Steggles A W

The noradrenergic component contributing to spinal fentanyl-induced antinociception is supraspinally mediated.

1. Male Sprague-Dawley rats were fitted with intrathecal (i.t.) and intracerebroventricular (i.c.v.) catheters. Fentanyl was injected either i.t. or i.c.v., and the antinociceptive efficacy of fentanyl was evaluated using the tail-flick…

The NMDA receptor antagonist MK-801 produces ethanol-like discrimination in the rat.

Two groups of rats, one derived from N/Nih stock and the second from the (putatively) serotonin-compromised Fawn-Hooded line, were trained to discriminate ethanol from its vehicle in a drug discrimination paradigm. Once each of the two groups…

Tags: 1993, Alcohol (Fayetteville, N.Y.), Animals, Department of Anatomy & Neurobiology, Discrimination Learning/*drug effects, Dizocilpine Maleate/*pharmacology, Ethanol/*pharmacology, Gordon T L, McBurney D M, Meehan S M, N-Methyl-D-Aspartate/physiology, NEOMED College of Medicine, Rats, Receptors, Schechter M D

The neural basis of the behaviorally relevant N1 component of the somatosensory-evoked potential in SI cortex of awake monkeys: evidence that backward cortical projections signal conscious touch sensation.

Studies of touch intensity discrimination in monkeys have identified a component of the somatosensory-evoked cortical potential, N1, generated within 50 ms of the stimulus, that predicts their behavioral performance. This study employed…

The nature and role of periosteum in bone and cartilage regeneration.

This study was undertaken to determine whether periosteum from different bone sources in a donor results in the same formation of bone and cartilage. In this case, periosteum obtained from the cranium and mandible (examples of tissue supporting…

The modulation of long-term potentiation by delta-9-tetrahydrocannabinol in the rat hippocampus, in vitro.

The duration of long-term potentiation (LTP) of the CA1 evoked field potential in rat hippocampal slices was significantly modulated by pre-treatment of slices with delta-9-tetrahydrocannabinol (THC) added to the incubation media. The three THC doses…

Tags: 1987, Animals, Brain research bulletin, Dronabinol/*pharmacology, Evoked Potentials/drug effects, Hippocampus/*drug effects/physiology, In Vitro Techniques, Kinetics, Male, Nowicky A V, Pyramidal Tracts/drug effects/physiology, Rats, Teyler T J, Time Factors, Vardaris R M

The mechanistic basis for the disparate effects of angiotensin II on coronary collateral growth.

OBJECTIVE: We hypothesize that controversial effects of angiotensin II (Ang II) are attributable to its regulation of reactive oxygen species (ROS) and

The lethal effects of ethanol and cocaine and their combination in mice: implications for cocaethylene formation.

The HS line of mice was used to determine the LD50 values for cocaine and ethanol, as well as for cocaethylene, the enzymatic product of their coadministration. The LD50 of cocaethylene was found to be significantly lower than that of cocaine, and…

Tags: 1995, Animals, Central Nervous System Depressants/*toxicity, Cocaine/*analogs & derivatives/metabolism/toxicity, Dopamine Uptake Inhibitors/*toxicity, Dose-Response Relationship, Drug, Drug Interactions, Ethanol/*toxicity, Female, Lethal Dose 50, Male, Meehan S M, Mice, Pharmacology, biochemistry, and behavior, Schechter M D, Sex Characteristics

The large protein 'L' of Peste-des-petits-ruminants virus exhibits RNA triphosphatase activity, the first enzyme in mRNA capping pathway.

Peste-des-petits-ruminants is a highly contagious and fatal disease of goats and sheep caused by non-segmented, negative strand RNA virus belonging to the Morbillivirus genus-Peste-des-petits-ruminants virus (PPRV) which is evolutionarily closely…

The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis.

Although there are multiple rodent models of the metabolic syndrome, very few develop vascular complications. In contrast, the JCR:LA-cp rat develops both metabolic syndrome and early atherosclerosis in predisposed areas. However, the pathology of…

The isolation and characterization of the soluble and membrane-bound porcine cytochrome b5 cDNAs.

In some male pigs, there is an increased production of the testicular 16 androstene steroids which end up being concentrated in fatty tissue. When the meat is cooked, a disagreeable odor/flavor is produced, a phenomenon known as "boar taint." All…

Tags: 1997, Amino Acid Sequence, Animals, Base Sequence, Biochemical and biophysical research communications, Blotting, Complementary/blood/*chemistry/*isolation & purification, Cytochromes b5/blood/*chemistry/genetics/*isolation & purification, DNA, Male, Membrane Proteins/*chemistry/genetics/*isolation & purification, Molecular Sequence Data, Solubility, Southern, Steggles A W, Swine, Testis/enzymology, VanDerMark P K

The isolation and characterization of the human cytochrome b5 gene.

From a series of lambda and cosmid libraries, we isolated DNA sequences corresponding to the complete coding region for the human cytochrome b5 (CYB5) gene. The overall gene organization was the same as the bovine and rabbit CYB5 genes. One cosmid…

The isolation and characterization of the bovine cytochrome b5 gene, and a transcribed pseudogene.

This is the first isolation and characterization of a cytochrome b5(b5) gene. The bovine b5 gene is quite large, spanning about 28 kb and contains six exons. One of these exons appears to code for a reticulocyte-specific sequence similar to that…

The human cytochrome b5 gene and two of its pseudogenes are located on chromosomes 18q23, 14q31-32.1 and 20p11.2, respectively.

Using very high stringency hybridization conditions for the Southern blot hybridization analysis of hamster-human cell hybrid DNA, we were able to map the human cytochrome b5 gene and two of its pseudogenes (psgb(5)1 and psgb(5)2) unambiguously to…

The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor.

BACKGROUND: Neuroinflammation is one of the hallmarks of neurodegenerative diseases, such as Parkinson's disease (PD). Activation of glial cells, including microglia and astrocytes, is a characteristic of the inflammatory response. Glycoprotein…

The effects of pregnancy and estrogen on the expression of calcitonin gene-related peptide (CGRP) in the uterine cervix, dorsal root ganglia and spinal cord.

Before parturition the uterine cervix undergoes a ripening process ("softens" and dilates) to allow passage of the fetus at term. The exact mechanism(s) responsible for cervical ripening are unknown, though a role for peptidergic sensory neurons is…

The effects of nicotine on dopamine and DOPAC output from rat striatal tissue.

The effects of varying doses of nicotine infusion upon spontaneous (basal) and subsequent potassium chloride-stimulated dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) output from superfused corpus striatal tissue fragments of male rats were…

Tags: 1998, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Amphetamine/pharmacology, Anderson L I, Animals, Central Nervous System Stimulants/pharmacology, Corpus Striatum/*drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Dose-Response Relationship, Drug, European journal of pharmacology, Ganglionic Stimulants/administration & dosage/*pharmacology, Male, Nicotine/administration & dosage/*pharmacology, Potassium Chloride/pharmacology, Rats, Sprague-Dawley

The effects of intranasal infusion of

Male C57/B1 mice received bilateral intranasal infusions of saline, MPTP or an intraperitoneal injection of MPTP. Infusions were performed using a peristaltic pump at a setting of 100 microliters/min. The MPTP, diluted in saline at concentrations of…

The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats.

In the present report, the peptides arginine vasopressin (AVP), oxytocin (OXT) or their respective antagonists were infused bilaterally into the olfactory bulb to assess their effects upon recognition responses. Recognition responses were determined…

Tags: *Social Behavior, 1998, Aging, Animals, Arginine Vasopressin/*pharmacology, Discrimination Learning/*drug effects, Dluzen D E, Engelmann M, Landgraf R, Male, Memory/drug effects, Muraoka S, Olfactory Bulb/*drug effects, Oxytocin/*pharmacology, Peptides, Rats

The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus.

The effects of phenobarbital, phenytoin, and valproic acid on pharmacologically isolated NMDA-EPSP, AMPA-EPSP, and GABA-IPSPs were examined in rat hippocampal slices. Phenobarbital (0.05 mg/ml) had no effect on the NMDA-EPSP, but decreased the slope…

Tags: 1997, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/*pharmacology, Animals, Anticonvulsants/*pharmacology, Brain research bulletin, Brown-Croyts L M, Electrophysiology, gamma-Aminobutyric Acid/*pharmacology, Hippocampus/*drug effects/physiology, Inbred Strains, Ko G Y, Male, N-Methylaspartate/*pharmacology, Phenobarbital/pharmacology, Phenytoin/pharmacology, Rats, Teyler T J, Valproic Acid/pharmacology

The effects of anticonvulsant drugs on long-term potentiation (LTP) in the rat hippocampus.

In hippocampal CA1 area, there are at least two forms of long-term potentiation (LTP): one is N-methyl-D-aspartate (NMDA) receptor-dependent LTP (NMDA LTP), which is induced with a 25 Hz tetanus and blocked by 50 microM

The effects of aging on spinal neurochemistry in the rat.

The purpose of this study was to investigate how the aging process alters the basal levels of serotonin, norepinephrine, dopamine, and their respective metabolites in the spinal cord using high-performance liquid chromatography and electrochemical…

Tags: 1997, Aging/*metabolism, Animals, Brain research bulletin, Chromatography, Crisp T, Dopamine/metabolism, Electrochemistry/methods, Gordon T L, High Pressure Liquid, Inbred F344, King M A, Ko M L, Male, Norepinephrine/metabolism, Rats, Serotonin/metabolism, Spinal Cord/*metabolism

The effects of aging on mu and delta opioid receptors in the spinal cord of Fischer-344 rats.

Previous research has demonstrated that the antinociceptive efficacy of opioids decreases with advancing age. This study utilized radioligand binding techniques to determine if this decline is due to a change in the receptor density (Bmax) and/or…

The effect of various insufflation gases on tumor implantation in an animal model.

OBJECTIVE: The expanded use of laparoscopy has led to reports of tumor dissemination and spread to laparoscopic port sites. We previously showed that carbon dioxide insufflation produced tumor dissemination compared with laparotomy. It is unknown…

The effect of testosterone upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.

The gonadal steroid hormone estrogen (E) can function as a neuroprotectant of nigrostriatal dopaminergic (NSDA) neurotoxicity, however, there exists very limited information on the role of testosterone (T) in this capacity. In the present report, the…

Tags: 2001, Animals, Brain research, Corpus Striatum/drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Drug Implants, Female, Gao X, Male, Methamphetamine/*toxicity, Mice, Neuroprotective Agents/pharmacology, Neurotoxins/*toxicity, Orchiectomy, Ovariectomy, Potassium/pharmacology, Substantia Nigra/drug effects/*metabolism, Testosterone/administration & dosage/*pharmacology

The effect of rubrospinal tractotomy on a conditioned limb response in the cat.

Five cats were trained to perform a forelimb conditioned response to a paired tone CS/shock UCS. Rubrospinal tract section ipsilateral to the trained limb was carried out following criterion CR performance. Lesion sites were identified histologically…

Tags: 1999, Animal/physiology, Animals, Behavior, Behavioural brain research, Cats, Conditioning, Forelimb/innervation/*physiology, Functional Laterality/physiology, Neural Pathways/anatomy & histology/physiology, Operant/*physiology, Red Nucleus/anatomy & histology/*physiology, Spinal Cord/anatomy & histology/*physiology, Stereotaxic Techniques, Voneida T J

The effect of reserpine treatment in vivo upon L-dopa and amphetamine evoked dopamine and DOPAC efflux in vitro from the corpus striatum of male rats.

In the present experiment we tested the effects of L-DOPA and amphetamine upon dopamine and DOPAC efflux in vitro from superfused corpus striatal tissue fragments of male rats who had been pretreated with reserpine. Male rats were treated with…

Tags: 1994, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Amphetamine/*pharmacology, Animals, Cell Compartmentation, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Drug Interactions, Journal of neural transmission. General section, Levodopa/*pharmacology, Liu B, Male, Rats, Research Design, Reserpine/*pharmacology, Secretory Rate/drug effects, Sprague-Dawley

The effect of renal range dopamine and norepinephrine infusions on the renal vasculature.

Renal range dopamine's value was assessed in 15 hypotensive canines using an endotoxin shock model and concurrent pharmacological pressor support. The dogs were prospectively randomized into three treatment groups (fluid resuscitation, fluid and…

Tags: 1990, Animals, Cardiac Output, Creatine/pharmacokinetics, Dogs, Dopamine/*pharmacology, Kidney/*drug effects/metabolism, Norepinephrine/*pharmacology, Petrinec D, Renal Circulation/*drug effects, Strigle T R, The American surgeon

The effect of manganese exposure in Atp13a2-deficient mice.

Loss of function mutations in the P5-ATPase ATP13A2 are associated with Kufor-Rakeb Syndrome and Neuronal Ceroid Lipofuscinosis. While the function of ATP13A2 is unclear, in vitro studies suggest it is a lysosomal protein that interacts with the…

The effect of long-term treatment with deprenyl on basal and L-dopa evoked dopamine release in vitro from the corpus striatum of aged rats.

In the present experiment, male rats (15-17 months) were injected with deprenyl (0.25 mg/kg) three times per week for six months. At 21-23 months of age the male rats were sacrificed, the corpus striatum removed and superfused in vitro. Basal and…

Tags: 1991, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Aging/metabolism, Amphetamine/pharmacology, Animals, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, In Vitro Techniques, Journal of neural transmission. General section, Levodopa/pharmacology, Male, McDermott J L, Rats, Selegiline/*pharmacology

The effect of intermittent-release intraperitoneal chemotherapy on wound healing.

OBJECTIVE: Our purpose was to study the effect on wound healing when intraperitoneal chemotherapy was instilled on a daily basis. STUDY DESIGN: Intraperitoneal carboplatin, Taxol, or saline solution was instilled daily into 70 rats after they…

Tags: 1997, American journal of obstetrics and gynecology, Animals, Antineoplastic Agents/administration & dosage/*pharmacology, Carboplatin/administration & dosage/*pharmacology, Holda S, Hopkins M P, Infusions, Laparotomy, Male, Paclitaxel/administration & dosage/*pharmacology, Parenteral, Rats, Sprague-Dawley, Tissue Adhesions/chemically induced, von Gruenigen V E, Weber B, Wound Healing/*drug effects

The effect of immediate intraperitoneal carboplatinum on wound healing.

The effect of introducing intraperitoneal carboplatinum on wound healing immediately after wound closure was studied using a rat model. All animals were opened through a midline incision. A bowel anastomosis was then performed in a single-or…

Tags: 1993, Animals, Carboplatin/*administration & dosage/pharmacology, Clark T, Dose-Response Relationship, Drug, Gynecologic oncology, Hopkins M P, Injections, Intraperitoneal, Jenison E L, Male, Postoperative Period, Rats, Shellhaas C, Sprague-Dawley, Stakleff K S, Tissue Adhesions/etiology, Wound Healing/*drug effects

The effect of gender and the neurotrophin, BDNF, upon methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system in mice.

The interactive effects between gender and a selective alteration in the neurotrophin, brain-derived neurotrophic factor (BDNF) upon methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic (NSDA) system were assessed. MA…

The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.

We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion…

The effect of freezing and extraction upon striatal dopaminergic function.

Determinations of striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were compared under conditions where tissue was either frozen followed by extraction (FE) or extracted followed by freezing (EF). In Experiment 1,…

Tags: *Freezing, 2011, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Analysis of Variance, Animals, Chemical Fractionation/methods, Corpus Striatum/*metabolism, Cryopreservation/methods, Dluzen Dean E, Dopamine/*metabolism, Journal of neuroscience methods, Male, Mice, Time Factors

The effect of estrogen administration in vivo upon catecholamine release in vitro from superfused hypothalamic tissue of ovariectomized pre-pubertal and adult mice.

In the present report we examined the effects of estrogen upon catecholamine release from superfused medial basal hypothalamic tissue fragments of pre-pubertal ovariectomized CD-1 mice. Prepubertal mice treated with estradiol benzoate (EB–5…

Tags: *Ovariectomy, 1994, Aging/*metabolism, Animals, Attaran M, Catecholamines/*metabolism, Dluzen D, Dopamine/metabolism, Estradiol/*pharmacology, Female, Hypothalamus/*drug effects/metabolism, Journal of endocrinological investigation, Liu B, Mice, Norepinephrine/metabolism, Organ Size/drug effects, Potassium/pharmacology, Uterus/drug effects/growth & development

The effect of brachium conjunctivum transection on a conditioned limb response in the cat.

Seven cats were trained to perform a forelimb conditioned response to a paired tone conditioned stimulus (CS)/shock unconditioned stimulus (UCS). Brachium conjunctivum section ipsilateral to the trained limb was carried out following criterion…

Tags: *Conditioning (Psychology), 2000, Animals, Behavioural brain research, Cats, Cerebellar Nuclei/physiology, Cerebellum/injuries/pathology/*physiology, Memory/*physiology, Nerve Net/injuries/*physiology, Voneida T J

The Dunlop-Dottridge Memorial Lecture. Paleopathology as a clinical science with implications for patient care, education, and research.

Tags: *Paleopathology, 1996, Ancient, Animals, History, Humans, Rheumatic Diseases/*history, Rothschild B M, The Journal of rheumatology

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