Browse Items (77 total)
- Tags: Disease Models
Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice.
Tags: 2016, Animal, Animals, Aorta, Benzofurans/chemistry/*pharmacology, Blood Pressure/drug effects, Brain/blood, Cardiac/cytology/drug effects/metabolism, Cell Line, Chen Renshan, Chinese Herbal/chemistry/pharmacology, Disease Models, Drugs, GATA4 Transcription Factor/metabolism, Gu Weiwang, Heart Failure/metabolism/*pathology, Heart Ventricles/diagnostic imaging, Inbred C57BL, Male, Mice, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, Myocardium/metabolism/pathology, Myocytes, Natriuretic Peptide, Phosphorylation/drug effects, PloS one, Proto-Oncogene Proteins c-akt/metabolism, Qi Jianyong, Rats, Signal Transduction/*drug effects, Tan Yafang, Thoracic/surgery, Wu Jiashin, Yu Juan, Zhang Minzhou
Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair.
Tags: 2018, Administration, Alboslemy Talib, Animal, Animals, Cell Communication/*physiology, Cell Differentiation, Cells, Cultured, Cutaneous, Diabetes Mellitus, Disease Models, Eye Proteins/administration & dosage/genetics/*physiology, Humans, Inbred C57BL, Kim Min-Ho, Macrophages/*physiology, Male, Membrane Glycoproteins/administration & dosage/genetics/*physiology, Mesenchymal Stem Cells/*physiology, Mice, Recombinant Proteins/administration & dosage/genetics/metabolism, Safadi Fayez, Skin/*injuries/metabolism, The Journal of investigative dermatology, Type 2/complications/pathology, Wound Healing/*physiology, Yu Bing
Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth.
Tags: *Collateral Circulation, *Coronary Circulation, 2012, Animal, Animals, Bailey Erin, Biomarkers/metabolism, Cell Differentiation, Cell Lineage, Cells, Chilian William M, Circulation research, Coronary Occlusion/genetics/metabolism/pathology/physiopathology/*surgery, Coronary Vessels/metabolism/pathology/*physiopathology, Cultured, Delucia Angelo, Department of Integrative Medical Sciences, Developmental, Disease Models, Endothelial Cells/metabolism/pathology/*transplantation, Enrick Molly, Epigenesis, Gene Expression Profiling, Gene Expression Regulation, Genetic, Guarini Giacinta, Induced Pluripotent Stem Cells/metabolism/*transplantation, Kolz Christopher L, Mice, Muscle, Myocytes, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Physiologic, Pung Yuh Fen, Rats, Regenerative Medicine/methods, Regional Blood Flow, Reverse Transcriptase Polymerase Chain Reaction, SCID, Smooth, Smooth Muscle/metabolism/pathology/*transplantation, Sprague-Dawley, Stevanov Kelly, Teratoma/metabolism/pathology, Time Factors, Transcription Factors/genetics/metabolism, Transduction, Vascular/metabolism/pathology/*physiopathology, Yin Liya
Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.
Tags: 2016, Adiponectin/*blood, Alcoholic/blood/*genetics/metabolism, Animal, Animals, Chrast Roman, Department of Pharmaceutical Sciences, Disease Models, Fatty Liver, Fibroblast Growth Factors/*blood, Finck Brian N, Gene Knockout Techniques, Han Yoonhee, Hu Xudong, Jogasuria Alvin, Kim Chunki, Lipid Metabolism, Male, Mice, Myeloid Cells/*metabolism, NEOMED College of Pharmacy, NF-kappa B/metabolism, Nuclear Proteins/*deficiency, Organ Specificity, Phosphatidate Phosphatase/*deficiency, Scientific reports, Shen Hong, Signal Transduction, Wang Jiayou, Wu Jiashin, You Min
Thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor
Tags: *Drug Delivery Systems, 2013, Animal, Animals, Benzodioxoles/*administration & dosage/pharmacokinetics/toxicity, Bhatia Deepak, Body Temperature, Delayed-Action Preparations, Disease Models, Drug Carriers/chemistry/toxicity, Fibroblasts/drug effects/metabolism, Filtering Surgery/*methods, Geldenhuys Werner, Gels, Glaucoma/*surgery, Imidazoles/*administration & dosage/pharmacokinetics/toxicity, Miladore Nicholas, Nakamura Hiroshi, Pharmaceutical development and technology, Poloxamer/chemistry/toxicity, Protein-Serine-Threonine Kinases/antagonists & inhibitors, Pyridines/*administration & dosage/pharmacokinetics/toxicity, Rabbits, Receptor, Receptors, Sutariya Vijaykumar, Temperature, Time Factors, Transforming Growth Factor beta/antagonists & inhibitors, Transforming Growth Factor-beta Type I, Viscosity, Wehrung Daniel
Neuropathic pain in aged rats: behavioral responses and astrocytic activation.
Tags: 2001, Aging/*physiology, Animal, Animal/*physiology, Animals, Astrocytes/*metabolism, Behavior, Cell Count, Crisp T, Cruce W L, Department of Anatomy & Neurobiology, Disease Models, Experimental brain research, Functional Laterality/physiology, Glial Fibrillary Acidic Protein/metabolism, Hyperalgesia/physiopathology, Immunohistochemistry, Inbred F344, Lovell J A, Lumbar Vertebrae, Male, McBurney D L, NEOMED College of Medicine, Nerve Crush/methods, Neuralgia/*metabolism/pathology/physiopathology, Pain Measurement, Peripheral Nervous System Diseases/*metabolism/pathology/physiopathology, Posterior Horn Cells/*metabolism, Rats, Schechter J B, Stuesse S L, Thermosensing/physiology, Touch/physiology, Up-Regulation/*physiology
Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucoma.
Tags: *Axonal Transport/physiology, *bouton, *Mitochondria, *neurodegeneration, *retinal, *RRID:IMSRJAX:000671, *RRID:IMSRJAX:007048, *RRID:SCR002716, *RRID:SCR002865, *superior colliculus, *synapse, 2016, Animal, Animals, Crish Samuel D, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Disease Models, Electron, Fening Kelly M, Glaucoma/metabolism/*pathology, Imaging, Inbred DBA, Inman Denise M, Mice, Microscopy, Mitochondria/pathology, NEOMED College of Medicine, NEOMED College of Pharmacy, Neuroanatomical Tract-Tracing Techniques, Regression Analysis, Retinal Ganglion Cells/metabolism/*pathology, Scanning, Schofield Brett R, Smith Matthew A, Superior Colliculi/metabolism/*pathology, Synapses/metabolism/*pathology, The Journal of comparative neurology, Three-Dimensional, Visual Pathways/metabolism/pathology, Xia Christina Z
Impairment of Hematopoietic Precursor Cell Activation during the Granulopoietic Response to Bacteremia in Mice with Chronic-Plus-Binge Alcohol Administration.
Tags: *alcohol, *bacteremia, *cell signaling, *granulocytes, *granulopoietic response, *Stem cells, 2017, Animal, Animals, Antigens, Bacteremia/genetics/*immunology/pathology, Binge Drinking/genetics/*immunology/pathology, Bone Marrow Cells/drug effects/immunology/pathology, CCAAT-Enhancer-Binding Protein-beta/genetics/immunology, Cyclin D1/genetics/immunology, Department of Integrative Medical Sciences, Disease Models, Escherichia coli Infections/genetics/*immunology/pathology, Escherichia coli/growth & development/immunology, Ethanol/*pharmacology, Gao Bin, Gene Expression Regulation/*drug effects/immunology, Granulocytes/drug effects/immunology/pathology, Hematopoiesis/*drug effects/genetics/immunology, Inbred BALB C, Infection and immunity, Lin Yuan-Ping, Ly/genetics/immunology, Male, Membrane Proteins/genetics/immunology, Mice, Mitogen-Activated Protein Kinase 1/genetics/immunology, Mitogen-Activated Protein Kinase 3/genetics/immunology, NEOMED College of Medicine, Nucleotidyltransferases/deficiency/genetics/immunology, Proto-Oncogene Proteins c-kit/genetics/immunology, Shi Xin, Signal Transduction/*drug effects/immunology, Toll-Like Receptor 4/genetics/immunology, Zhang Ping
Conditioned place aversion produced by dopamine release inhibition.
Tags: 1994, Analysis of Variance, Animal, Animals, Antipsychotic Agents/administration & dosage/*pharmacology, Aversive Therapy, Conditioning (Psychology), Disease Models, Dopamine Antagonists/administration & dosage/*pharmacology, Dose-Response Relationship, Drug, European journal of pharmacology, Injections, Intraperitoneal, Male, Meechan S M, Motor Activity/*drug effects, Random Allocation, Rats, Schechter M D, Sprague-Dawley, Thiazepines/administration & dosage/*pharmacology
Functional outcome after anal sphincter injury and treatment with mesenchymal stem cells.
Tags: *Mesenchymal Stem Cell Transplantation, *Regeneration, 2014, Anal Canal/injuries/metabolism/pathology/physiopathology/*surgery, Anal pressures, Anal sphincter, Animal, Animals, Balog Brian, Cells, Cultured, Damaser Margot, Disease Models, Fecal incontinence, Female, Fibrosis, Green Fluorescent Proteins/biosynthesis/genetics, i.v. infusion, Infusions, Injections, Intralesional, Intravenous, Mesenchymal stem cells, Mesenchymal Stem Cells/metabolism, Penn Marc, Pressure, Rats, Recovery of Function, Salcedo Levilester, Sprague-Dawley, Stem cells translational medicine, Time Factors, Transfection, Zutshi Massarat
Intestinal Flora Modification of Arthritis Pattern in Spondyloarthropathy.
Tags: *Bacteria/classification/genetics/isolation & purification, *Diarrhea/complications/microbiology, *Gastrointestinal Microbiome, *Spondylarthropathies/diagnosis/etiology/physiopathology, 16S/analysis, 2015, Animal, Animals, Disease Models, Gastrointestinal Tract/*microbiology, Gorilla gorilla, Humans, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, Pan troglodytes, Protective Factors, Ribosomal, RNA, Rothschild Bruce M
Primate spondyloarthropathy.
Origins of spondyloarthropathy in Perissodactyla.
Tags: *Fossils, *Paleopathology, *Perissodactyla, 2001, Ancient, Animal, Animals, Ankylosing/history/*pathology, Clinical and experimental rheumatology, Disease Models, History, Horse Diseases/history/*pathology, Horses, North America, Prothero D R, Rothschild B M, Rothschild C, Sacroiliac Joint/pathology, Spine/pathology, Spondylitis
Lack of bone stiffness/strength contribution to osteoarthritis–evidence for primary role of cartilage damage.
Tags: 2007, Animal, Animals, Articular/physiopathology, Biomechanical Phenomena, Bird Diseases/*physiopathology, Birds, Bone and Bones/*physiopathology, Cartilage, Disease Models, Mechanical, Osteoarthritis/*physiopathology/*veterinary, Panza R K, Rheumatology (Oxford, England), Rothschild B M, Species Specificity, Stress
LEAPS Vaccine Incorporating HER-2/neu Epitope Elicits Protection That Prevents and Limits Tumor Growth and Spread of Breast Cancer in a Mouse Model.
Tags: *Cancer Vaccines/genetics/immunology/therapeutic use, 2017, Animal, Animals, Breast Neoplasms/genetics/immunology/prevention & control/therapy, CD8-Positive T-Lymphocytes/immunology, Cell Line, Cytotoxic/immunology, Disease Models, Disease Progression, Epitopes, erbB-2, Experimental/immunology/pathology/*prevention & control/*therapy, Female, Genes, Immunoglobulin G/blood, Inbred BALB C, Journal of immunology research, Koski Gary, Mammary Neoplasms, Mice, Neoplasm Metastasis/prevention & control, Proof of Concept Study, Rosenthal Ken S, Stone Sarah, T-Lymphocyte/immunology, T-Lymphocytes, Tumor, Zimmerman Daniel H
Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth.
Tags: *Collateral Circulation/drug effects, *Coronary Circulation/drug effects, *MAP Kinase Signaling System/drug effects, 2007, Acetophenones/pharmacology, American journal of physiology. Heart and circulatory physiology, Animal, Animals, Blood Flow Velocity, Cells, Chilian William M, Coronary Vessels/surgery, Cultured, Department of Integrative Medical Sciences, Disease Models, Ditiocarb/pharmacology, Endothelial Cells/drug effects/enzymology/*metabolism, Enzyme Inhibitors/pharmacology, Humans, Imidazoles/pharmacology, Inbred WKY, Kolz Christopher, Ligation, Male, Myocardial Reperfusion Injury/enzymology/metabolism/*physiopathology, NADPH Oxidases/antagonists & inhibitors/metabolism, NEOMED College of Medicine, Neovascularization, Onium Compounds/pharmacology, Oxygenases/antagonists & inhibitors/metabolism, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism, Physiologic, Potter Barry, Pyridines/pharmacology, Rats, Reactive Oxygen Species/*metabolism, Reed Ryan, Rocic Petra, Superoxide Dismutase/antagonists & inhibitors/metabolism, Vascular Endothelial Growth Factor A/metabolism
The mechanistic basis for the disparate effects of angiotensin II on coronary collateral growth.
Tags: 2008, Angiotensin, Angiotensin II/*physiology, Animal, Animals, Arteriosclerosis, thrombosis, and vascular biology, Coronary Occlusion/drug therapy/*physiopathology, Disease Models, Hemorheology, Ischemia/drug therapy/*physiopathology, Kolz Christopher, Male, Neovascularization, Oxidative Stress/*physiology, Physiologic/*physiology, Potter Barry, Rats, Reactive Oxygen Species/adverse effects/metabolism, Receptor, Reed Ryan, Rocic Petra, Type 1/*drug effects/physiology, Vasoconstrictor Agents/pharmacology
Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure.
Tags: *2H2O-labeling, *Brain, *Genetic Variation, *Histone, *Mass spectrometry, *Post-translational modifications, *Postnatal alcohol exposure, *Turnover, 2017, Acetylation, Animal, Animals, Cell Proliferation, Clinical epigenetics, Department of Pharmaceutical Sciences, Disease Models, DNA Damage, Epigenesis, Female, Fetal Alcohol Spectrum Disorders/genetics/*metabolism, Genetic, Histones/*genetics/*metabolism, Humans, Kasumov Takhar, Li Ling, NEOMED College of Pharmacy, Post-Translational, Pregnancy, Previs Stephen, Protein Processing, Proteomics/*methods, Rachdaoui Nadia, Rats, Sarkar Dipak, Sprague-Dawley, Willard Belinda
Mechanisms of Chinese Medicine Xinmailong's protection against heart failure in pressure-overloaded mice and cultured cardiomyocytes.
Tags: 2017, Animal, Animals, Cardiac/cytology/*drug effects/metabolism, Cell Nucleus/metabolism, Cell Survival/drug effects, Cells, Chen Renshan, Chen Yanfen, Chinese Herbal/*administration & dosage/pharmacology, Constriction, Cultured, Disease Models, Drugs, Echocardiography, GABA Plasma Membrane Transport Proteins/*metabolism, Gene Expression Regulation/drug effects, Glycogen Synthase Kinase 3 beta/metabolism, Gu Weiwang, Heart Failure/etiology/metabolism/physiopathology/*prevention & control, Humans, Liu Qin, Lu Jun, MAP Kinase Signaling System/drug effects, Mice, Myocytes, Pathologic, Phosphorylation, Proto-Oncogene Proteins c-akt/metabolism, Qi Jianyong, Rats, Scientific reports, Tan Yafang, Wu Jiashin, Xu Wen, Yu Juan, Zhang Minzhou
Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-alpha signaling.
Tags: 2013, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Arteriosclerosis, thrombosis, and vascular biology, Body Weight/physiology, Cells, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Collateral Circulation, Coronary Circulation, Coronary Vessels/cytology/*enzymology, Cultured, Department of Integrative Medical Sciences, Disease Models, Dyck Jason R B, Endothelial Cells/cytology/*enzymology, Enrick Molly, Hardwick James P, Humans, Inbred WKY, Ischemia/metabolism/pathology, Kolz Christopher, Mitochondria, Mitochondria/drug effects/*metabolism, Myocardium/enzymology/pathology, NEOMED College of Medicine, Oxidative Stress/*physiology, Pung Yuh Fen, Rats, reactive oxygen species, Rotenone/pharmacology, Sam Wai Johnn, Signal Transduction/*physiology, Stevanov Kelly, Thakker Prashanth, TOR Serine-Threonine Kinases/metabolism, Uncoupling Agents/pharmacology, Yin Liya
Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats.
Tags: 2012, Animal, Animals, Antioxidants/*pharmacology, Arteriosclerosis, thrombosis, and vascular biology, Chilian William M, Collateral Circulation/*drug effects/physiology, Coronary Vessels/drug effects/*growth & development, Department of Integrative Medical Sciences, Disease Models, Guarini Giacinta, Hafemeister Jennifer, Heart/*drug effects/physiology, Lipid Peroxidation/drug effects/physiology, Lipid Peroxides/metabolism, Male, Metabolic Syndrome/*metabolism/physiopathology, Mitochondria, Mitochondrial Proteins/metabolism, Murphy Michael P, NEOMED College of Medicine, Obesity/*metabolism/physiopathology, Ohanyan Vahagn, Organophosphorus Compounds/pharmacology, Oxidative Stress/*drug effects/physiology, Piperidines/pharmacology, Pung Yuh Fen, Rats, Reactive Oxygen Species/metabolism, Rocic Petra, Smith Robin A J, Ubiquinone/pharmacology, Yin Liya, Zucker
The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis.
Tags: *Rats, 2017, American journal of physiology. Heart and circulatory physiology, Animal, Animals, Aortic Aneurysm, Atherosclerosis/pathology, Bennett Martin R, Blood Glucose/metabolism, Blood Vessels/pathology, Body Weight, Chilian William M, Collagen/biosynthesis, Cysts/*genetics/pathology, Department of Integrative Medical Sciences, Disease Models, Figg Nichola, hypoxia, Inbred Strains, Kamarulzaman Mohd Hamzah, leptin, Lipids/blood, Male, Metabolic syndrome, Metabolic Syndrome/*genetics/pathology, Necrosis, NEOMED College of Medicine, Proteoglycans/biosynthesis, Pung Yuh Fen, Rats, rodent model, Thoracic/*genetics/pathology
Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.
Tags: *Signal Transduction, 2018, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/*antagonists & inhibitors/pharmacology, Department of Integrative Medical Sciences, Disease Models, Ferrell Jessica M, G-Protein-Coupled/*metabolism, Gastrointestinal Microbiome/*drug effects, Glucagon-Like Peptide 1/metabolism, Gonzalez Frank J, GTP-Binding Proteins/*metabolism, Hepatology (Baltimore, Md.), Inbred C57BL, Krausz Kristopher W, Lipid Metabolism, Male, Mice, NEOMED College of Medicine, Nichols Robert G, Pathak Preeti, Patterson Andrew D, Random Allocation, Receptors, Sensitivity and Specificity, Xie Cen
Endothelin-mediated in vivo pressor responses following TRPV1 activation.
Tags: *Blood Pressure/drug effects, *Vasoconstriction/drug effects, 2011, Adrenergic alpha-Agonists/administration & dosage, American journal of physiology. Heart and circulatory physiology, Analysis of Variance, Animal, Animals, Azepines/administration & dosage, Biphenyl Compounds/administration & dosage, Bratz Ian N, Capsaicin/administration & dosage, Cells, Cultured, Damron Derek S, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Angiopathies/genetics/*metabolism/physiopathology, Dipeptides/administration & dosage, Disease Models, Dose-Response Relationship, Drug, Endothelial Cells/metabolism, Endothelin A Receptor Antagonists, Endothelin A/metabolism, Endothelin B Receptor Antagonists, Endothelin B/metabolism, Endothelin-1/*metabolism, Enzyme-Linked Immunosorbent Assay, Femoral Artery/drug effects/*metabolism/physiopathology, Guarini Giacinta, Haney Rebecca M, Inbred C57BL, Indoles/administration & dosage, Infusions, Intravenous, Knockout, Male, Meszaros J Gary, Mice, NEOMED College of Medicine, Ohanyan Vahagn A, Phenylephrine/administration & dosage, Raman Priya, Receptor, Talasila Phani K, Thodeti Charles K, TRPV Cation Channels/agonists/deficiency/genetics/*metabolism, Type 2/genetics/*metabolism/physiopathology, Vasoconstrictor Agents/administration & dosage
Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus.
Tags: *Axon regeneration, *Axotomy, *Diabetes, *Neuropathy, *Peripheral nervous system, 2017, Animal, Animals, Antibiotics, Antineoplastic/toxicity, Blood Glucose/drug effects, Body Weight/drug effects, Crish Samuel D, Cytokine Receptor gp130/genetics/*metabolism, Cytokines/metabolism, DeFrancesco Alicia, Department of Pharmaceutical Sciences, Diabetes Mellitus, Disease Models, Experimental neurology, Experimental/chemically induced/complications/*pathology, Fasting/blood, Filous Angela R, Gene Expression Regulation/*physiology, Hyperalgesia/etiology, Hyperglycemia/etiology, Inbred C57BL, Lindborg Jane A, Male, Malhotra Nisha A, Mice, NEOMED College of Pharmacy, Nerve Degeneration/*etiology/pathology, Nerve Tissue Proteins/metabolism, Niemi Jon P, Pain Measurement, Signal Transduction/drug effects/*physiology, Streptozocin/toxicity, Superior Cervical Ganglion/drug effects/*metabolism, Sweating/drug effects, Wilson Gina N, Zhou Bowen, Zigmond Richard E
Isolation of canine coronary sinus musculature from the atria by radiofrequency catheter ablation prevents induction of atrial fibrillation.
Tags: *Catheter Ablation, 2014, Acetylcholine, Action Potentials, Animal, Animal Studies, Animals, Artificial, Atrial fibrillation, Atrial Fibrillation – Etiology, Atrial Fibrillation – Physiopathology, Atrial Fibrillation – Prevention and Control, Atrial Fibrillation/etiology/physiopathology/*prevention & control, Biological, Body Surface Potential Mapping, Cardiac Pacing, Catheter Ablation, Circulation. Arrhythmia and electrophysiology, coronary sinus, Coronary Sinus/physiopathology/*surgery, Coronary Vessels – Physiopathology, Coronary Vessels – Surgery, Disease Models, Dogs, Heart Atria/physiopathology/surgery, Heart Atrium – Physiopathology, Heart Atrium – Surgery, Male, Models, Morita Hiroshi, Morita Shiho T, optical Vm mapping, Time Factors, Wu Jiashin, Zipes Douglas P
Early upregulation of myocardial CXCR4 expression is critical for dimethyloxalylglycine-induced cardiac improvement in acute myocardial infarction.
Tags: 2016, alpha Subunit/metabolism, American journal of physiology. Heart and circulatory physiology, Amino Acids, Animal, Animals, Apoptosis/drug effects, Cardiotonic Agents/*pharmacology, Cell Hypoxia, Cell Line, Chilian William M, CXCR4/deficiency/genetics/*metabolism, Department of Integrative Medical Sciences, Dicarboxylic/*pharmacology, Disease Models, Dong Feng, Enzyme Inhibitors/pharmacology, Forudi Farhad, hypoxia, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor-Proline Dioxygenases/antagonists & inhibitors/metabolism, Inbred C57BL, Kiedrowski Matthew, Knockout, Left/*drug effects, Mayorga Mari, Mice, myocardial infarction, Myocardial Infarction/*drug therapy/genetics/metabolism/pathology/physiopathology, Myocardium/*metabolism/pathology, NEOMED College of Medicine, Penn Marc S, Rats, Receptors, Recovery of Function, Shamhart Patricia, Signal Transduction/drug effects, stem cells, Stem Cells/drug effects/metabolism, Stroke Volume/drug effects, Time Factors, Up-Regulation, Ventricular Function, Weber Kristal
Pulmonary vasoconstriction in a canine model of neurogenic pulmonary edema.
Tags: 1990, Animal, Animals, Catecholamines/physiology, Disease Models, Dogs, Female, Hypertension, In Vitro Techniques, Journal of applied physiology (Bethesda, Md. : 1985), Male, Maron M B, Perfusion, Pulmonary Circulation/drug effects/*physiology, Pulmonary Edema/chemically induced/*physiopathology, Pulmonary/chemically induced/physiopathology, Splenectomy, Sympathetic Nervous System/drug effects/physiopathology, Vasoconstriction/drug effects/*physiology, Veratrine
Absence of type VI collagen paradoxically improves cardiac function, structure, and remodeling after myocardial infarction.
Tags: 2012, Adapala Ravi K, Animal, Animals, Apoptosis/physiology, Bonaldo Paolo, Cardiac/pathology/physiology, Chilian William M, Circulation research, Collagen Type VI/*genetics/*metabolism, Department of Integrative Medical Sciences, Disease Models, Echocardiography, Extracellular Matrix/metabolism/pathology, Fibrosis/genetics/pathology/physiopathology, Hodnichak Cheryl, Knockout, Luther Daniel J, Male, Meszaros J Gary, Mice, Myocardial Infarction/diagnostic imaging/*genetics/*physiopathology, Myocytes, NEOMED College of Medicine, Shamhart Patricia E, Thodeti Charles K, Ventricular Remodeling/*physiology, Weihrauch Dorothee
Injury models to study cardiac remodeling in the mouse: myocardial infarction and ischemia-reperfusion.
Tags: *Ventricular Remodeling, 2013, Animal, Animals, Cardiovascular Surgical Procedures, Coronary Vessels/surgery, Department of Integrative Medical Sciences, Disease Models, Ligation, Luther Daniel J, Meszaros J Gary, Methods in molecular biology (Clifton, N.J.), Mice, Myocardial Infarction/*etiology/*pathology, Myocardial Reperfusion Injury/*etiology/*pathology, NEOMED College of Medicine, Perfusion/methods, Thodeti Charles K, Wound Healing
Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma.
Tags: *Chemoprevention, 2011, Analysis of Variance, Animal, Animal Studies, Animal/drug effects, Animals, Antioxidants, Behavior, Bishayee Anupam, Blotting, Booth Tristan D, Carcinoma, Cardiotoxicity, Cardiotoxins/*toxicity, Chemoprevention, Data Analysis Software, Department of Integrative Medical Sciences, Descriptive Statistics, Disease Models, Doppler, Dose-Response Relationship, Drug, Echocardiography, Feeding Behavior/drug effects, Female, Fisher's Exact Test, Funding Source, Heart – Drug Effects, Heart/drug effects/physiopathology, Hepatocellular – Prevention and Control, Hepatocellular/*drug therapy/pathology/physiopathology, Hepatocytes/drug effects/pathology, Hodnichak Cheryl M, Humans, Investigational new drugs, Liver Neoplasms/*drug therapy/pathology/physiopathology, Liver/drug effects/pathology/physiopathology, Luther Daniel J, Meszaros J Gary, NEOMED College of Medicine, Ohanyan Vahagn, Polyphenols – Therapeutic Use, Rats, Resveratrol, Shamhart Patricia E, Sisakian Hamayak, Sprague-Dawley, Stilbenes/*therapeutic use, Systole/drug effects, Western
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.
Tags: 2008, Animal, Animals, Brain Injuries/blood/epidemiology/genetics/*physiopathology, Cerebral Cortex/physiopathology, Chemokine CCL2/genetics/physiology, Chemokines/*genetics, Cytokines/*antagonists & inhibitors, Disease Models, Hippocampus/physiopathology, Inflammation/genetics/*physiopathology, Interleukin-1beta/genetics/physiology, Interleukin-6/genetics/physiology, Journal of neuroinflammation, Lloyd Eric, Male, Mice, Somera-Molina Kathleen, Tumor Necrosis Factor-alpha/genetics/physiology, United States/epidemiology, Up-Regulation, Van Eldik Linda J, Wainwright Mark S, Watterson D Martin
Oestrogen and nigrostriatal dopaminergic neurodegeneration: animal models and clinical reports of Parkinson's disease.
Tags: 2007, Animal, Animals, Basal Ganglia/drug effects/*metabolism/pathology, Clinical and experimental pharmacology & physiology, Disease Models, Dluzen Dean E, Dopamine/*metabolism, Estrogens/*metabolism/pharmacology/therapeutic use, Humans, Liu Bin, Nerve Degeneration/drug therapy/*metabolism/pathology, Neurons/metabolism/pathology, Neuroprotective Agents/*metabolism/pharmacology/therapeutic use, Parkinson Disease/drug therapy/*metabolism/pathology, Parkinsonian Disorders/drug therapy/*metabolism/pathology, Substantia Nigra/drug effects/*metabolism/pathology
Effect of estrogen upon methamphetamine-induced neurotoxicity within the impaired nigrostriatal dopaminergic system.
Tags: 2006, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Adrenergic Uptake Inhibitors/antagonists & inhibitors/toxicity, Animal, Animals, Corpus Striatum/*drug effects/metabolism/physiopathology, Disease Models, Dluzen Dean E, Dopamine/metabolism, Estrogens/metabolism/*pharmacology/therapeutic use, Female, Liu Bin, Male, Methamphetamine/*antagonists & inhibitors/toxicity, Mice, Nerve Degeneration/chemically induced/*drug therapy/prevention & control, Neural Pathways/drug effects/metabolism/physiopathology, Neuroprotective Agents/metabolism/*pharmacology/therapeutic use, Neurotoxins/antagonists & inhibitors/toxicity, Orchiectomy, Ovariectomy, Parkinsonian Disorders/*drug therapy/physiopathology/prevention & control, Substantia Nigra/*drug effects/metabolism/physiopathology, Synapse (New York, N.Y.)
Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice.
Tags: 2016, Animal, Animals, Blackwood Rachel, Calcium Signaling/genetics, Dantrolene/*administration & dosage, Dasgupta Nupur, Department of Pharmaceutical Sciences, Disease Models, Fleming Sheila, Gaucher Disease/*drug therapy/genetics/physiopathology, Grabowski Gregory A, Human molecular genetics, Humans, Inskeep Venette, Li Ronghua, Liou Benjamin, Marshall John, Mice, Mitochondria/*drug effects/genetics/pathology, NEOMED College of Pharmacy, Neurons/drug effects/pathology, Neuroprotective Agents/administration & dosage, Peng Yanyan, Quinn Brian, Ryanodine Receptor Calcium Release Channel/*genetics/metabolism, Setchell Kenneth D R, Sun Ying, Zhang Wujuan
A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis.
Tags: *Flux, *Glutathione, *Heavy water, *Mass spectrometer, *NAFLD, *NASH, *Oxidative Stress, *Western Diet, 2016, Animal, Animals, Antioxidants/metabolism, Department of Pharmaceutical Sciences, Diet, Disease Models, Free radical biology & medicine, Glutathione/blood/*metabolism, Humans, Kasumov Takhar, LDL/blood/*genetics/metabolism, Lee Kwangwon, Li Ling, Liver/*metabolism/pathology, Lopez Rocio, McCullough Arthur, Mice, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/blood/*genetics/pathology, Oxidative Stress/genetics, Previs Stephen F, Receptors, Western/adverse effects, Willard Belinda, Zhang Guo-Fang
Adrenal epinephrine increases alveolar liquid clearance in a canine model of neurogenic pulmonary edema.
Tags: 1998, Adrenal Glands/*metabolism, Adrenalectomy, Adrenergic beta-Agonists/blood/*pharmacology/therapeutic use, Adrenergic beta-Antagonists/therapeutic use, American journal of respiratory and critical care medicine, Amiloride/therapeutic use, Animal, Animals, Awender N E, Blood, Blood Pressure, Brain Diseases/chemically induced/*complications, Central Nervous System Agents/adverse effects, Cisterna Magna, Disease Models, Diuretics/therapeutic use, Dogs, Epinephrine/blood/*physiology/therapeutic use, Extravascular Lung Water/chemistry/*metabolism, Female, Hypertension, Injections, Lane S M, Maender K C, Male, Maron M B, Propanolamines/therapeutic use, Proteins/analysis, Pulmonary Alveoli/*metabolism, Pulmonary Artery, Pulmonary Edema/etiology/*metabolism/prevention & control, Pulmonary/prevention & control, Sodium Channel Blockers, Veratrine/adverse effects
Renal Calcium Oxalate Deposits Induce a Pro-Atherosclerotic and Pro-Osteoporotic Response in Mice.
Tags: *CARDIOVASCULAR DISEASE, *Gene Expression Regulation, *KIDNEY STONES, *METABOLIC BONE DISEASE, *MURINE MODEL, 2017, Animal, Animals, Atherosclerosis/*metabolism/pathology, Barr-Beare Evan, Calcium Oxalate/*metabolism, Disease Models, Journal of cellular biochemistry, Kidney/*metabolism/pathology, Kusumi Kirsten, Mice, Osteoporosis/*metabolism/pathology, Safedi Fayez, Saxena Vijay, Schwaderer Andrew, Urinary Calculi/*metabolism/pathology
Innate and adaptive host response during the initial phase of herpes simplex virus encephalitis in the neonatal mouse.
Tags: *Immunity, 2006, Active, Animal, Animals, B-Lymphocytes/immunology, Brain/pathology/*virology, Cell Line, Disease Models, Docherty John J, Encephalitis, Fu Ming Ming, Herpes Simplex/*immunology, Innate, Journal of neurovirology, Kumaraswamy Guttalu K, Mice, Microglia/pathology/virology, Newborn, Simplexvirus/*isolation & purification/physiology, T-Lymphocytes/immunology, Virus Replication
Weighted Lin-Wang tests for crossing hazards.
Tags: *Survival Analysis, 2014, Algorithms, Animal, Animals, Computational and mathematical methods in medicine, Computer Simulation, Data Interpretation, Disease Models, Humans, Jia Zhenyu, Kaplan-Meier Estimate, Koziol James A, Leukemia/drug therapy, Mice, Models, Reproducibility of Results, Statistical