Browse Items · NEOMED Bibliography Database

The effect of reserpine treatment in vivo upon L-dopa and amphetamine evoked dopamine and DOPAC efflux in vitro from the corpus striatum of male rats.

In the present experiment we tested the effects of L-DOPA and amphetamine upon dopamine and DOPAC efflux in vitro from superfused corpus striatal tissue fragments of male rats who had been pretreated with reserpine. Male rats were treated with…

Tags: 1994, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Amphetamine/*pharmacology, Animals, Cell Compartmentation, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Drug Interactions, Journal of neural transmission. General section, Levodopa/*pharmacology, Liu B, Male, Rats, Research Design, Reserpine/*pharmacology, Secretory Rate/drug effects, Sprague-Dawley

The effect of long-term treatment with deprenyl on basal and L-dopa evoked dopamine release in vitro from the corpus striatum of aged rats.

In the present experiment, male rats (15-17 months) were injected with deprenyl (0.25 mg/kg) three times per week for six months. At 21-23 months of age the male rats were sacrificed, the corpus striatum removed and superfused in vitro. Basal and…

Tags: 1991, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Aging/metabolism, Amphetamine/pharmacology, Animals, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, In Vitro Techniques, Journal of neural transmission. General section, Levodopa/pharmacology, Male, McDermott J L, Rats, Selegiline/*pharmacology

The effect of intermittent-release intraperitoneal chemotherapy on wound healing.

OBJECTIVE: Our purpose was to study the effect on wound healing when intraperitoneal chemotherapy was instilled on a daily basis. STUDY DESIGN: Intraperitoneal carboplatin, Taxol, or saline solution was instilled daily into 70 rats after they…

Tags: 1997, American journal of obstetrics and gynecology, Animals, Antineoplastic Agents/administration & dosage/*pharmacology, Carboplatin/administration & dosage/*pharmacology, Holda S, Hopkins M P, Infusions, Laparotomy, Male, Paclitaxel/administration & dosage/*pharmacology, Parenteral, Rats, Sprague-Dawley, Tissue Adhesions/chemically induced, von Gruenigen V E, Weber B, Wound Healing/*drug effects

The effect of immediate intraperitoneal carboplatinum on wound healing.

The effect of introducing intraperitoneal carboplatinum on wound healing immediately after wound closure was studied using a rat model. All animals were opened through a midline incision. A bowel anastomosis was then performed in a single-or…

Tags: 1993, Animals, Carboplatin/*administration & dosage/pharmacology, Clark T, Dose-Response Relationship, Drug, Gynecologic oncology, Hopkins M P, Injections, Intraperitoneal, Jenison E L, Male, Postoperative Period, Rats, Shellhaas C, Sprague-Dawley, Stakleff K S, Tissue Adhesions/etiology, Wound Healing/*drug effects

The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.

We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion…

The discriminative properties of the D1 dopamine agonist dihydrexidine in the rat.

The objective of this study was to train rats to discriminate the interoceptive stimuli produced by a selective dopamine D1 agonist. Fourteen male Sprague-Dawley rats acquired the discrimination of the fully effective, high potency, D1 agonist…

Tags: 1995, Amphetamine/pharmacology, Animals, Apomorphine/pharmacology, Benzazepines/pharmacology, Cocaine/pharmacology, Discrimination (Psychology), Dopamine Agonists/pharmacology, Dopamine D1/*agonists, Dose-Response Relationship, Drug, Male, Phenanthridines/*pharmacology, Psychopharmacology, Rats, Receptors, Schechter M D, Sprague-Dawley

The development of long-term potentiation in hippocampus and neocortex.

The development of long-term potentiation (LTP), an enduring alteration in synaptic efficacy following afferent activation, was examined in CA1 hippocampus and primary visual cortex of rat. Both regions show little LTP prior to postnatal day 5,…

The development of GABAB-mediated activity in the rat dentate gyrus.

We examined the effects of GABAB receptor activation in the dentate gyrus of hippocampal slices prepared from 6-8-day-old rat pup. Baclofen (0.25-1.0 microM), a GABAB agonist, rapidly and potently disinhibited the developing dentate, similar to its…

Tags: 1994, Animals, Baclofen/analogs & derivatives/pharmacology, Brain research. Developmental brain research, DiScenna P G, Electric Stimulation, Evoked Potentials/drug effects, GABA-A Receptor Antagonists, GABA-A/drug effects/physiology, GABA-B Receptor Antagonists, GABA-B/*metabolism, Hippocampus/*growth & development/*metabolism, In Vitro Techniques, Nowicky A V, Organophosphorus Compounds/pharmacology, Rats, Receptors, Teyler T J

The aromatic amino acid decarboxylase inhibitor, NSD-1015, increases release of dopamine: response characteristics.

Addition of the aromatic amino acid decarboxylase inhibitor, NSD-1015 (10 microM), to Krebs'-Ringer phosphate (KRP) superfusion medium, significantly increased the release of dopamine in vitro from superfused corpus striatum tissue fragments of male…

Tags: *Aromatic Amino Acid Decarboxylase Inhibitors, 1992, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Animals, Brain/*drug effects/metabolism, Dluzen D, Dopamine/*metabolism, Hydrazines/*pharmacology, Male, McDermott J, Neuropharmacology, Rats, Reddy A, Sprague-Dawley

The antinociceptive effects of 3,4-methylenedioxymethamphetamine (MDMA) in the rat.

The antinociceptive effects of MDMA and morphine were examined in rats using the tail-flick and hot-plate analgesiometric tests. MDMA, in the dose range of 1.5-6.0 mg/kg IP, produced a dose-dependent elevation in hot-plate latency, but did not…

The analysis of RNA by in situ agarose gel hybridization is more sensitive than the equivalent northern blot analysis.

Tags: *Blotting, *Molecular Probe Techniques, *Nucleic Acid Hybridization, 1990, Agar Gel, Ahmad I, Animals, BioTechniques, Electrophoresis, Finkelstein J A, Growth Hormone/genetics, Messenger/*analysis, Northern, Rats, RNA, Steggles A W, Zucker

The anabolic effects of vitamin D-binding protein-macrophage activating factor (DBP-MAF) and a novel small peptide on bone.

Vitamin D-binding protein-macrophage activating factor (DBP-MAF) has previously been shown to stimulate bone resorption and correct the skeletal defects associated with osteopetrosis in two nonallelic mutations in rats. This same protein and a small…

The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats.

There is a significant unmet need for treatments of patients with acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). The primary mechanism that leads to resolution of alveolar and pulmonary edema is active vectorial Na(+) and…

Tags: 2012, Acute Lung Injury/*drug therapy/metabolism/pathology, Adenosine A2A/*chemistry, Adenosine/*analogs & derivatives/therapeutic use, American journal of physiology. Lung cellular and molecular physiology, Amiloride/pharmacology, Animals, Biological Transport, Bronchoalveolar Lavage, Cystic Fibrosis Transmembrane Conductance Regulator/metabolism, Endotoxemia/*drug therapy/metabolism/microbiology, Epithelial Sodium Channel Blockers, Epithelial Sodium Channels/metabolism, Escherichia coli, Escherichia coli Infections/drug therapy/metabolism/microbiology, Folkesson Hans G, Immunoblotting, Kuzenko Stephanie R, Lipson David A, Male, Matthay Michael A, Pneumonia/*drug therapy/metabolism/microbiology, Pulmonary Alveoli/cytology/*drug effects/metabolism, Pulmonary Edema/*drug therapy/metabolism/pathology, Rats, Receptor, Respiratory Physiological Phenomena, Simmons Mark A, Sodium Channel Blockers/pharmacology, Sprague-Dawley, Triazoles/*therapeutic use

The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.

The effects of the recently classified Schedule I amphetamine analog, 3,4-methylenedioxymethamphetamine [+/-)-MDMA) on caudate and nucleus accumbens dopamine release and metabolism were studied by in vivo voltammetry and HPLC with electrochemical…

Tags: 1988, 3, 4-Dihydroxyphenylacetic Acid/metabolism, 4-methylenedioxyamphetamine, 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology, Amphetamines/*pharmacology, Animals, Brain/drug effects/metabolism, Caudate Nucleus/drug effects/metabolism, Consciousness, Dopamine/*metabolism, European journal of pharmacology, Inbred Strains, Male, N-Methyl-3, Nucleus Accumbens/drug effects/metabolism, Rats, Spanos L J, Yamamoto B K

TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression.

The TGFbeta1/Smad pathway plays a critical role in cholestasis and liver fibrosis. Previous studies show that TGFbeta1, TNFalpha, and insulin inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene transcription and bile acid synthesis in human…

Tetrahydro-beta-carboline may produce its stimulus effects via 5HT1B receptors.

To further clarify the role of 5-hydroxytryptamine (5HT) in the behavioral effects of tetrahydro-beta-carboline, male rats were trained to discriminate either 20 mg/kg THBC from its vehicle (n = 10) or 2.0 mg/kg fenfluramine from saline (n = 5). THBC…

Tags: 1987, Animals, Carbolines/*pharmacology, Discrimination Learning/drug effects, Inbred Strains, Male, Metergoline/pharmacology, Pharmacology, biochemistry, and behavior, Piperazines/pharmacology, Rats, Receptors, Schechter M D, Serotonin Antagonists/pharmacology, Serotonin/*metabolism

Testosterone causes direct relaxation of rat thoracic aorta.

Several recent studies have provided evidence that gonadal steroid hormones can exert acute (nongenomic) effects on both neural and vascular tissues. This study examines the acute effects of testosterone (T) on vascular reactivity of the rat thoracic…

Temporal parameters of cathinone, amphetamine and cocaine.

Rats were trained to discriminate intraperitoneally administered 0.8 mg/kg

Tags: 1989, Alkaloids/*pharmacology, Amphetamines/*pharmacology, Animals, Cocaine/*pharmacology, Conditioning, Discrimination (Psychology)/*drug effects, Inbred Strains, Male, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Task Performance and Analysis, Time Factors

Temporal differences in behavioral effect of fenfluramine and norfenfluramine.

Ten male rats were trained to discriminate the anorectic drug d,l-fenfluramine (2.0 mg/kg intraperitoneally administered) from its vehicle using a food-reinforced (fixed-ratio 10 schedule) two-lever operant task. Once learned, the fenfluramine…

Tags: 1990, Animal/*drug effects, Animals, Behavior, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Fenfluramine/*analogs & derivatives/*pharmacology, Inbred Strains, Injections, Intraperitoneal, Male, Norfenfluramine/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Stereoisomerism

Synthesis and Biological Evaluation of Pentacycloundecylamines and Triquinylamines as Voltage-Gated Calcium Channel Blockers.

Preclinical studies for neurodegenerative diseases have shown a multi-targeted approach to be successful in the treatment of these complex disorders with several pathoetiological pathways. Polycyclic compounds, such as NGP1-01 (7a), have demonstrated…

SYNOVITIS EQUIVALENT TO EROSIONS IN RHEUMATOID-ARTHRITIS - IMPLICATIONS OF SKELETAL ANALYSIS FOR THE CLINICAL MANAGEMENT OF CONTEMPORARY RHEUMATOID-ARTHRITIS

Examination of a contemporary skeletal collection revealed a rheumatoid subgroup with parameters mirroring those of contemporary clinical populations. This rheumatoid population was also indistinguishable from contemporary (live) clinical…

Tags: 1992, Clinical and experimental rheumatology, erosions, Hand, joint disease, Journal Article, lesions, Mortality, Radiographs, radiologic assessment, Rats, rheumatoid-arthritis, Rheumatology, Rothschild B M, skeletal radiology, synoviocytes, therapy, Woods R J, wrist

Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins.

BACKGROUND: Metabotropic glutamate receptors (mGluRs) regulate neuronal excitability and synaptic strength. The group I mGluRs, mGluR1 and 5, are widespread in the brain and localize to post-synaptic sites. The Homer protein family regulates group I…

Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis.

PURPOSE: Resveratrol, present in grapes and red wine, has been found to prevent diethylnitrosamine (DENA)-initiated rat liver tumorigenesis, though the chemopreventive mechanisms are not completely elucidated. The current study was designed to…

Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis.

Breast cancer represents the second leading cause of cancer-related deaths among women worldwide and preventive therapy could reverse or delay the devastating impact of this disease. Methyl-amooranin (methyl-25-hydroxy-3-oxoolean-12-en-28-oate,…

Substance P in the uterine cervix, dorsal root ganglia and spinal cord during pregnancy and the effect of estrogen on SP synthesis.

Prior to parturition the non-pliable uterine cervix undergoes a ripening process ("softens" and dilates) to allow a timely passage of the fetus at term. The exact mechanism(s) triggering and involved in cervical ripening are unknown, though evidence…

Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET.

Several PPAR-gamma agonists containing a thiazolidinedione moiety (referred to as glitazones) have been proposed to be neuroprotective and appear to alter mitochondrial function. Recently, a search for mitochondrial proteins that bind pioglitazone…

Striatal dopamine release in vitro from immature male rats shows enhanced responsiveness to pulsatile, but not continuous, infusions of L-dopa.

In the present experiment we compared the effects of continuous versus pulsed infusions of L-beta-3,4,dihydroxyphenylalanine (L-DOPA) upon dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro from superfused corpus striatal tissue…

Tags: 1991, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Aging/*metabolism, Animals, Brain research. Developmental brain research, Corpus Striatum/*metabolism, Dluzen D, Dopamine/*metabolism, Inbred Strains, Levodopa/*administration & dosage/pharmacology, Male, McDermott J, Pulsatile Flow, Rats

Strain differences in neuropathic hyperalgesia.

The purpose of this study was to investigate strain-related differences in the onset and maintenance of thermal hyperalgesia following the induction of peripheral nerve injury in two inbred strains of rats (Fischer 344 and Lewis) and two outbred…

Tags: 2000, Animals, Chronic Disease, Crisp T, Cruce W L, Cytokines/physiology, Hyperalgesia/*etiology, Inbred F344, Inbred Lew, Ligation, Lovell J A, Male, Pharmacology, biochemistry, and behavior, Rats, Sciatic Nerve/physiology, Species Specificity, Sprague-Dawley, Stuesse S L, Wistar

Stimulation of MAP kinase pathways after maternal IL-1beta exposure induces fetal lung fluid absorption in guinea pigs.

BACKGROUND: We tested the hypothesis that maternal interleukin-1beta (IL-1beta) pretreatment and induction of fetal cortisol synthesis activates MAP kinases and thereby affects lung fluid absorption in preterm guinea pigs. METHODS: IL-1beta was…

Stability of the stimulus properties of drugs over time.

Three separate groups of rats were trained to discriminate the stimulus effects of either 600 mg/kg ethanol (n = 5), 0.8 mg/kg d-amphetamine (n = 8) or 1.0 mg/kg

Tags: *Discrimination (Psychology), 1989, Animals, Boja J W, Dextroamphetamine/*pharmacology, Dose-Response Relationship, Drug, Drug Tolerance, Ethanol/*pharmacology, Inbred Strains, Pharmacology, biochemistry, and behavior, Piperazines/*pharmacology, Rats, Schechter M D, Signs S A

Stability of myosin heavy chain isoforms in selectively denervated adult rat muscle spindles.

BACKGROUND: Rat intrafusal fibers consist of multiple isoforms of myosin heavy chains (MHCs) whose expression involves complex interactions among motor neurons, sensory neurons, and muscle cells during spindle development. Little is known about the…

Spinal beta-endorphin analgesia involves an interaction with local monoaminergic systems.

beta-Endorphin administered intrathecally (i.t.) in rats produced a dose-dependent elevation in tail-flick latency. Naltrexone administered i.t. as a pretreatment reversed the spinal antinociceptive action of beta-endorphin, suggesting that the…

Spermine depresses NMDA, K/AMPA and GABAA-mediated synaptic transmission in the rat hippocampal slice preparation.

The effects of spermine, an endogenous polyamine, were examined in area CA1 of the rat hippocampal slice preparation. Spermine, at low millimolar concentrations, rapidly and potently depressed NMDA and K/AMPA-mediated population EPSPs, and…

Specificity of metabotropic glutamate receptor 2 coupling to G proteins.

Metabotropic glutamate receptor 2 (mGluR2) is a class 3 G protein-coupled receptor and an important mediator of synaptic activity in the central nervous system. Previous work demonstrated that mGluR2 couples to pertussis toxin (PTX)-sensitive G…

Something completely different?

Tags: 1996, Animals, Blotting, Brain/*enzymology, Chen L, Cloning, Complementary, Cytochrome P-450 Enzyme System/*genetics/isolation & purification, Department of Integrative Medical Sciences, DNA, Hardwick J P, Human & experimental toxicology, Kidney/enzymology, Liver/enzymology, Molecular, NEOMED College of Medicine, Northern, Rats

Sinoaortic denervation prevents postexercise reductions in arterial pressure and cardiac sympathetic tonus.

Arterial pressure, cardiac sympathetic tonus (ST), and heart rate (HR) are reduced after a single bout of dynamic exercise in spontaneously hypertensive rats (SHR). To test if the arterial baroreflex is required for these postexercise responses,…

Tags: *Muscle Denervation, 1997, Animals, Autonomic Nervous System/physiology/physiopathology, Blood Pressure/*physiology, Chandler M P, DiCarlo S E, Heart Rate/*physiology, Heart/innervation/*physiology/physiopathology, Hypertension/*physiopathology, Inbred SHR, Male, Muscle Tonus, Physical Exertion/*physiology, Rats, Sinoatrial Node/*innervation, Sympathetic Nervous System/*physiology/physiopathology, The American journal of physiology

Sharing of sensory terminals between the dynamic bag1 and static bag2 fibers in the rat muscle spindle.

The nuclear bag1 intrafusal fiber mediates the dynamic (velocity) sensitivity, whereas the nuclear bag2 and nuclear chain fibers mediate the static (length) sensitivity of muscle spindles to stretch. The pattern of branching of primary and secondary…

Tags: 1987, Afferent/*ultrastructure, Animals, Axons/ultrastructure, Brain research, Female, Inbred Strains, Kucera J, Muscle Spindles/*ultrastructure, Nerve Fibers/*ultrastructure, Neurons, Rats, Walro J M

Sexual dimorphism in vasopressin-induced contraction of rat aorta.

Previously, we reported that, in the rat, pressor responsiveness to vasopressin (VP) is higher in males than in females during most phases of the estrous cycle. To explore the role of the vasculature in this phenomenon, we examined vascular…

Tags: *Sex Characteristics, *Vasoconstriction, 1991, Animals, Aorta/*drug effects, Arginine Vasopressin/*pharmacology, Crofton J T, Dose-Response Relationship, Drug, Female, Male, Osmolar Concentration, Phenylephrine/pharmacology, Rats, Share L, Stallone J N, The American journal of physiology

Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids.

The effects of constrictor prostanoid (CP) pathway inhibitors on vascular reactivity to vasopressin (VP) and phenylephrine (PE) were examined in thoracic aortas of male, female, and ovariectomized (OVX) female Sprague-Dawley rats. Maximal contractile…

Sex differences in nitric oxide-mediated attenuation of vascular reactivity to vasopressin are abolished by gonadectomy.

In the rat thoracic aorta, contractile responses to vasopressin are two-fold higher in females than in males, primarily because nitric oxide-mediated attenuation of contraction is greater in males than in females. To determine the role of the gonadal…

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