Browse Items (87 total)
- Tags: Cultured
A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene.
Tags: 2007, Bile Acids and Salts/metabolism, Carcinoma, Cell Line, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, Enzyme Inhibitors/pharmacology, Gastroenterology, Genetic/drug effects/*physiology, Hepatocellular/*metabolism/pathology, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/drug effects/*metabolism/pathology, Humans, Hydroxamic Acids/pharmacology, Li Tiangang, Liver Neoplasms/*metabolism/pathology, Messenger/metabolism, NEOMED College of Medicine, RNA, Signal Transduction/physiology, Smad3 Protein/metabolism, Transcription, Transforming Growth Factor beta1/*metabolism, Tumor
The effect of various insufflation gases on tumor implantation in an animal model.
Tags: *Carbon Dioxide, *Helium, *Neoplasm Transplantation, *Nitrous Oxide, *Peritoneal Cavity, *Pneumoperitoneum, 2002, Adenocarcinoma/pathology, American journal of obstetrics and gynecology, Animals, Artificial, Cultured, Haller Nairmeen Awad, Holda Sheri, Hopkins Michael P, Inbred F344, Injections, Intraperitoneal, Peritoneal Neoplasms/pathology, Rats, Tumor Cells, von Gruenigen Vivian
Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway.
Tags: *Intracellular Signaling Peptides and Proteins, 2001, Amyloid beta-Peptides/*biosynthesis/metabolism, Apoptosis Regulatory Proteins, Apoptosis/*physiology, Carrier Proteins/genetics/*physiology, Caspases/*metabolism, Chang X, Cultured, Du H, Enzyme Activation, Guo Q, Humans, Kinetics, Leucine Zippers, Neuroblastoma, Peptide Fragments/*biosynthesis/metabolism, Recombinant Proteins/metabolism, The Journal of biological chemistry, Time Factors, Transfection, Tumor Cells, Xie J
Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.
Tags: *DNA-Binding Proteins, *Transcription, 2001, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/genetics, Cultured, Cytochrome P-450 Enzyme System/*genetics, Cytoplasmic and Nuclear/physiology, Department of Integrative Medical Sciences, Genetic, Genetic/physiology, Hepatocyte Nuclear Factor 4, Humans, Molecular Sequence Data, NEOMED College of Medicine, Phosphoproteins/*physiology, Promoter Regions, Receptors, Repressor Proteins/*pharmacology, Steroid 12-alpha-Hydroxylase, Steroid Hydroxylases/*genetics, The Journal of biological chemistry, Transcription Factors/*physiology, Tumor Cells, Zhang M
Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis.
Tags: 2005, Animals, Annexin A5/metabolism, Anti-Bacterial Agents/metabolism, Apoptosis/*physiology, Biomarkers, Carlson Sara G, Caspase 12, Caspases/metabolism, CCAAT-Enhancer-Binding Proteins/metabolism, Cell Differentiation/*physiology, Cells, Chondrocytes/cytology/*physiology, Collagen Type II/metabolism, Cultured, Department of Anatomy & Neurobiology, DNA Fragmentation, Endoplasmic Reticulum/*metabolism, Extracellular Matrix/metabolism, Gene Expression Regulation, Glucose/metabolism, Horton Walter E Jr, McBurney Denise, NEOMED College of Medicine, Proliferating Cell Nuclear Antigen/metabolism, Rats, Signal Transduction/*physiology, Thapsigargin/metabolism, The Journal of biological chemistry, Transcription Factor CHOP, Transcription Factors/metabolism, Tunicamycin/metabolism, Yang Ling
Histochemical analyses of tissue-engineered human menisci.
Tags: *Tissue Scaffolds, 2009, Animals, Cell Differentiation/physiology, Cell Proliferation, Cell Shape/physiology, Cells, Chondrocytes/*cytology/*metabolism/transplantation, Chondrogenesis/physiology, Collagen/metabolism, Connective tissue research, Cultured, Doherty Alison, Fibrocartilage/cytology/metabolism/transplantation, Graft Survival/physiology, Heterologous/methods, Histocytochemistry, Humans, Jacquet Robin, Landis William J, Leeson Mark C, Lowder Elizabeth, Male, Menisci, Mice, Middle Aged, Nude, Phenotype, Polyglycolic Acid/pharmacology/therapeutic use, Schoenfeld Andrew J, Tibial/*cytology/*metabolism/transplantation, Tissue Engineering/*methods, Transplantation
Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes.
Tags: *IL-6, *MCPIP1, *miRNA, *OSTEOARTHRITIS, *Vorinostat, 2017, Adult, Aged, CCAAT-Enhancer-Binding Proteins/genetics/metabolism, Cells, Chondrocytes/*metabolism/pathology, Connective tissue research, Cultured, Department of Anatomy & Neurobiology, Female, Gene Expression Regulation/*drug effects, Genetic, Haqqi Tariq M, Humans, Hydroxamic Acids/*pharmacology, Interleukin-1beta/genetics/*metabolism, Interleukin-6/genetics/*metabolism, Makki Mohammad S, Male, MicroRNAs/genetics/*metabolism, Middle Aged, NEOMED College of Medicine, Osteoarthritis/drug therapy/genetics/*metabolism/pathology, Promoter Regions, Ribonucleases/*biosynthesis/genetics, Transcription Factors/*biosynthesis/genetics, Vorinostat
Current challenges in dedifferentiated fat cells research.
Tags: *adult stem cells, *Biomedical Research, *Cell Dedifferentiation, *culture purity, *dedifferentiated fat cells, *dedifferentiation, *surface marker, 2016, Adipocytes/*cytology, Animals, Cells, Cultured, Evancho-Chapman M Michelle, George Richard L, Humans, Organogenesis, Phenotype, Shah Mickey, Zhang Ge
Mechanosensitive transient receptor potential vanilloid 4 regulates Dermatophagoides farinae-induced airway remodeling via 2 distinct pathways modulating matrix synthesis and degradation.
Tags: *Airway Remodeling, *fibronectin, *myofibroblasts, *PAI-1, *PI3K, *TGF-beta1, 2017, Adult, Al-Azzam Nosayba, Animals, Asthma/etiology/genetics/*metabolism/pathology, Cells, Cultured, Department of Integrative Medical Sciences, Dermatophagoides farinae/immunology, Duah Ernest, Extracellular Matrix/*metabolism/pathology, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Fibroblasts/metabolism, Fibronectins/*metabolism, Gombedza Farai, Hexter Madison, Humans, Inbred C57BL, Kondeti Vinay, Koppes Stephanie, Male, Mice, NEOMED College of Medicine, Paruchuri Sailaja, Patil Prachi, Phillips Daniel, Phosphatidylinositol 3-Kinases/metabolism, Plasminogen Activator Inhibitor 1/metabolism, Thodeti Charles K, Transforming Growth Factor beta/metabolism, TRPV Cation Channels/genetics/*metabolism
Immune response to nonspecific and altered tissue antigens in soft tissue allografts.
Tags: 1996, Anti-Infective Agents, Articular/immunology/physiology/*transplantation, Biomechanical Phenomena, Bone Transplantation/*immunology, Cells, Clinical orthopaedics and related research, Cultured, Ethanol/pharmacology, Fibroblasts/drug effects, Homologous, Humans, Hydrogen Peroxide/pharmacology, Ligaments, Local/pharmacology, Pinkowski J L, Povidone-Iodine/pharmacology, Rodrigo J J, Sharkey N A, Therapeutic Irrigation, Tissue Preservation, Transplantation, Vasseur P B
Experimental use of fibrin glue to induce site-directed osteogenesis from cultured periosteal cells.
Tags: *Fibrin Tissue Adhesive, *Osteogenesis, 2000, Animals, Bone and Bones/chemistry/cytology/diagnostic imaging, Cattle, Cells, Cultured, Experimental, Gerstenfeld L C, Gotoh Y, Implants, Injections, Isogai N, Landis W J, Mice, Mori R, Non-programmatic, Nude, Osteopontin, Periosteum/*cytology, Plastic and reconstructive surgery, Radiography, Sialoglycoproteins/analysis, Upton J, Vacanti J P
Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: 2009, Base Sequence, Calcitriol/drug effects/genetics/*physiology, Cell Line, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Cultured, Department of Integrative Medical Sciences, DNA Primers, Drug metabolism and disposition: the biological fate of chemicals, Electrophoretic Mobility Shift Assay, Gene Knockdown Techniques, Genetic/*physiology, Han Shuxin, Hepatocytes/*drug effects/enzymology, Humans, Immunoprecipitation, Lithocholic Acid/pharmacology, Messenger/genetics, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, RNA, Small Interfering, Transcription, Tumor, Two-Hybrid System Techniques
Strain-dependent structural variants of herpes simplex virus type 1 ICP34.5 determine viral plaque size, efficiency of glycoprotein processing, and viral release and neuroinvasive disease potential.
Tags: *Genetic Variation, 2003, Animals, Cercopithecus aethiops, Cultured, Encephalitis, Genetic, Herpes Simplex/*physiopathology/virology, Herpesvirus 1, Human/*classification/genetics/*pathogenicity, Inbred BALB C, Journal of virology, Male, Mao Hanwen, Mice, Recombination, Rosenthal Ken S, Transfection, Tumor Cells, Vero Cells, Viral Envelope Proteins/metabolism, Viral Plaque Assay, Viral Proteins/*chemistry/*genetics/metabolism
Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts.
Tags: *Cell Differentiation, 2014, Adapala Ravi K, Animals, Blood Glucose/metabolism, Bryant Jennifer E, Canadian journal of physiology and pharmacology, cardiac fibroblast, Cell Movement, Cell Proliferation, Cells, Collagen, Collagen/metabolism, collagene, concentration elevee de glucose, Cultured, Department of Integrative Medical Sciences, diabete, Diabetes, fibroblaste cardiaque, Fibroblasts/*metabolism/pathology, Fibrosis, high glucose, Hyperglycemia/*metabolism/pathology, Luther Daniel J, Male, Meszaros J Gary, migration, Myocardium/*metabolism/pathology, myofibroblast, myofibroblastes, NEOMED College of Medicine, Petersen Kyle A, proliferation, Rats, Shamhart Patricia E, Signal Transduction, Sprague-Dawley, Thodeti Charles K
Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways.
Tags: 2012, Adapala Ravi K, American journal of physiology. Cell physiology, Animals, Cell Movement/physiology, Cells, Chavez Ronaldo J, Cuadra Rene H, Cultured, Department of Integrative Medical Sciences, Ganguly Rituparna, Gene Expression Regulation/physiology, Haney Rebecca M, Humans, Inbred C57BL, Janus Kinase 2/*biosynthesis, Knockout, Leptin/*physiology, Male, MAP Kinase Signaling System/*physiology, Mice, Muscle, Myocytes, NEOMED College of Medicine, Raman Priya, Smooth, Smooth Muscle/enzymology/metabolism, Thodeti Charles K, Thrombospondin 1/*biosynthesis, Up-Regulation/*physiology, Vascular/enzymology/*metabolism
Leptin augments recruitment of IRF-1 and CREB to thrombospondin-1 gene promoter in vascular smooth muscle cells in vitro.
Tags: *cAMP response element-binding protein, *interferon regulatory factor-1, *leptin, *thrombospondin-1, *Transcription, *vascular smooth muscle cells, 2016, American journal of physiology. Cell physiology, Binding Sites/genetics, Cells, Chromatin Immunoprecipitation/methods, Cultured, Cyclic AMP Response Element-Binding Protein/*metabolism, Department of Integrative Medical Sciences, Ganguly Rituparna, Gene Expression Regulation/genetics, Genetic/genetics, Humans, Interferon Regulatory Factor-1/*metabolism, Leptin/*metabolism, Muscle, Mutagenesis, Myocytes, NEOMED College of Medicine, Promoter Regions, Raman Priya, Response Elements/genetics, Sahu Soumyadip, Site-Directed/methods, Smooth, Smooth Muscle/*metabolism, Thrombospondin 1/*genetics/*metabolism, Transcription, Transcriptional Activation/genetics, Transfection/methods, Up-Regulation/genetics, Vascular/*metabolism
Trivalent chromium inhibits TSP-1 expression, proliferation, and O-GlcNAc signaling in vascular smooth muscle cells in response to high glucose in vitro.
Tags: 2015, American journal of physiology. Cell physiology, Aorta/drug effects/metabolism, Cell Proliferation/*drug effects/genetics, Cells, Chavez Ronaldo J, Chromium/*pharmacology, Cultured, Department of Integrative Medical Sciences, Fructosephosphates/metabolism, Ganguly Rituparna, Genetic/drug effects/genetics, Glucose/*metabolism, Glutamine/genetics, Glycosylation/drug effects, Hexosamines/metabolism, Humans, Hyperglycemia/metabolism, Muscle, Myocytes, N-Acetylglucosaminyltransferases/genetics, NEOMED College of Medicine, O-glycosylation, Promoter Regions, Raman Priya, reactive oxygen species, Reactive Oxygen Species/metabolism, Sahu Soumyadip, Signal Transduction/*drug effects/genetics, Smooth, Smooth Muscle/*drug effects/metabolism, Thrombospondin 1/*antagonists & inhibitors/genetics, thrombospondin-1, Transcription, trivalent chromium, vascular smooth muscle cells, Vascular/*drug effects/metabolism
Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.
Tags: 2005, American journal of physiology. Gastrointestinal and liver physiology, Bile Acids and Salts/pharmacology, Chiang John Y L, Cholestasis/*physiopathology, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/pharmacology, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/pharmacology, Enzyme Inhibitors/*pharmacology, Genetic, Glucocorticoid, Hepatoblastoma/pathology, Hepatocyte Nuclear Factor 4, Humans, Li Tiangang, Liver Neoplasms/pathology, Messenger/analysis/biosynthesis, NEOMED College of Medicine, Phosphoproteins/pharmacology, Pregnane X Receptor, Receptors, Rifampin/*pharmacology, RNA, Steroid/*physiology, Transcription, Transcription Factors/pharmacology, Tumor Cells, Up-Regulation
Identification of a bile acid response element in the cholesterol 7 alpha-hydroxylase gene CYP7A.
Tags: 1997, Animals, Base Sequence, Bile Acids and Salts/*pharmacology, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Crestani M, Cultured, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Feedback, Genes, Genes/*drug effects, Luciferases/genetics, NEOMED College of Medicine, Rats, Reporter, Stroup D, The American journal of physiology, Tumor Cells
Endothelin-mediated in vivo pressor responses following TRPV1 activation.
Tags: *Blood Pressure/drug effects, *Vasoconstriction/drug effects, 2011, Adrenergic alpha-Agonists/administration & dosage, American journal of physiology. Heart and circulatory physiology, Analysis of Variance, Animal, Animals, Azepines/administration & dosage, Biphenyl Compounds/administration & dosage, Bratz Ian N, Capsaicin/administration & dosage, Cells, Cultured, Damron Derek S, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Angiopathies/genetics/*metabolism/physiopathology, Dipeptides/administration & dosage, Disease Models, Dose-Response Relationship, Drug, Endothelial Cells/metabolism, Endothelin A Receptor Antagonists, Endothelin A/metabolism, Endothelin B Receptor Antagonists, Endothelin B/metabolism, Endothelin-1/*metabolism, Enzyme-Linked Immunosorbent Assay, Femoral Artery/drug effects/*metabolism/physiopathology, Guarini Giacinta, Haney Rebecca M, Inbred C57BL, Indoles/administration & dosage, Infusions, Intravenous, Knockout, Male, Meszaros J Gary, Mice, NEOMED College of Medicine, Ohanyan Vahagn A, Phenylephrine/administration & dosage, Raman Priya, Receptor, Talasila Phani K, Thodeti Charles K, TRPV Cation Channels/agonists/deficiency/genetics/*metabolism, Type 2/genetics/*metabolism/physiopathology, Vasoconstrictor Agents/administration & dosage
PKCalpha mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells.
Tags: 2011, Acetylcholine/*pharmacology, Adapala Ravi K, American journal of physiology. Heart and circulatory physiology, Animals, Bratz Ian N, Calcium Signaling/*drug effects, Carbazoles/pharmacology, Cells, Cultured, Department of Integrative Medical Sciences, Endothelial Cells/*drug effects/enzymology, Enzyme Activation, Inbred C57BL, Knockout, Male, Mesenteric Arteries/drug effects/enzymology, Meszaros J Gary, Mice, Mutation, NEOMED College of Medicine, Nitric Oxide Synthase Type III/metabolism, Phosphorylation, Protein Kinase C-alpha/genetics/*metabolism, Protein Kinase Inhibitors/pharmacology, Suzuki Makoto, Talasila Phani K, Tetradecanoylphorbol Acetate/pharmacology, Thodeti Charles K, Time Factors, Transfection, TRPV Cation Channels/*agonists/deficiency/genetics/metabolism, Vasodilation/*drug effects, Vasodilator Agents/*pharmacology, Zhang David X
Type VI collagen induces cardiac myofibroblast differentiation: implications for postinfarction remodeling.
Tags: 2006, American journal of physiology. Heart and circulatory physiology, Angiotensin II/pharmacology, Animals, Cell Differentiation/*drug effects, Cell Proliferation/drug effects, Cells, Collagen Type I/physiology, Collagen Type III/physiology, Collagen Type VI/*physiology, Coronary Vessels/pathology, Cultured, Department of Integrative Medical Sciences, Doane Kathleen J, Extracellular Matrix/*physiology, Fibroblasts/*cytology, Fibrosis/etiology, Folkesson Hans G, Horne Walter I, Ligation, Male, Maron Michael B, Mase Sharon E, Meszaros J Gary, Myocardial Infarction/physiopathology, Naugle Jennifer E, NEOMED College of Medicine, Olson Erik R, Pilati Charles F, Rats, Sprague-Dawley, Ventricular Remodeling/*physiology, Zhang Xiaojin
Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol.
Tags: 2005, 70-kDa/metabolism, American journal of physiology. Heart and circulatory physiology, Angiotensin II/pharmacology, Animals, Antioxidants/*pharmacology, Bomser Joshua A, Cell Differentiation/drug effects, Cell Division/drug effects, Cells, Cultured, Department of Integrative Medical Sciences, Drug Interactions, Epidermal Growth Factor/pharmacology, Fibroblasts/*cytology/*drug effects, Male, Meszaros J Gary, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, Myocardium/*cytology, Naugle Jennifer E, NEOMED College of Medicine, Olson Erik R, Protein-Serine-Threonine Kinases/metabolism, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins/metabolism, Rats, Resveratrol, Ribosomal Protein S6 Kinases, Signal Transduction/drug effects, Sprague-Dawley, Stilbenes/*pharmacology, Vasoconstrictor Agents/pharmacology, Zhang Xiaojin
Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth.
Tags: *Collateral Circulation/drug effects, *Coronary Circulation/drug effects, *MAP Kinase Signaling System/drug effects, 2007, Acetophenones/pharmacology, American journal of physiology. Heart and circulatory physiology, Animal, Animals, Blood Flow Velocity, Cells, Chilian William M, Coronary Vessels/surgery, Cultured, Department of Integrative Medical Sciences, Disease Models, Ditiocarb/pharmacology, Endothelial Cells/drug effects/enzymology/*metabolism, Enzyme Inhibitors/pharmacology, Humans, Imidazoles/pharmacology, Inbred WKY, Kolz Christopher, Ligation, Male, Myocardial Reperfusion Injury/enzymology/metabolism/*physiopathology, NADPH Oxidases/antagonists & inhibitors/metabolism, NEOMED College of Medicine, Neovascularization, Onium Compounds/pharmacology, Oxygenases/antagonists & inhibitors/metabolism, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism, Physiologic, Potter Barry, Pyridines/pharmacology, Rats, Reactive Oxygen Species/*metabolism, Reed Ryan, Rocic Petra, Superoxide Dismutase/antagonists & inhibitors/metabolism, Vascular Endothelial Growth Factor A/metabolism
Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1beta Stimulated Human Chondrocytes.
Tags: 2018, Ahmad Nashrah, AMP-Activated Protein Kinases/metabolism, AMPK, Ansari Mohammad Y, Articular/cytology/pathology, Autophagy, Autophagy-Related Protein 5/antagonists & inhibitors/genetics/metabolism, Autophagy-Related Protein-1 Homolog/metabolism, Autophagy/*drug effects, Butein, Cartilage, Cell Survival/drug effects, Cells, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Chalcones/*pharmacology, Chondrocytes/cytology/drug effects/metabolism, Cultured, Department of Anatomy & Neurobiology, Haqqi Tariq M, Humans, Inflammation, Interleukin-1beta/*pharmacology, Interleukin-6/genetics/*metabolism, Intracellular Signaling Peptides and Proteins/metabolism, mTOR, NEOMED College of Medicine, Osteoarthritis, Osteoarthritis/metabolism/pathology, Phosphorylation/drug effects, Reactive Oxygen Species/metabolism, RNA, RNA Interference, Signal Transduction/*drug effects, Small Interfering/metabolism, TOR Serine-Threonine Kinases/metabolism, TSC2, Tuberous Sclerosis Complex 2 Protein, Tumor Suppressor Proteins/metabolism, ULK1
Hepatic hepatocyte nuclear factor 4alpha is essential for maintaining triglyceride and cholesterol homeostasis.
Tags: 2011, Adenoviridae/genetics, Animal, Animals, Arteriosclerosis, thrombosis, and vascular biology, Cells, Cholesterol, Cholesterol/*metabolism, Cultured, Department of Integrative Medical Sciences, Edwards Peter A, Fatty Liver/metabolism/physiopathology, Ge Xuemei, HDL/metabolism, Hepatocyte Nuclear Factor 4/drug effects/genetics/*physiology, Hepatocytes/cytology/*metabolism, Homeostasis/genetics/*physiology, Inbred C57BL, Lipid Metabolism/genetics/physiology, Ma Huiyan, Mice, Models, NEOMED College of Medicine, RNA, Small Interfering/genetics/pharmacology, Triglycerides/*metabolism, VLDL/metabolism, Yin Liya, Zhang Yanqiao
Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-alpha signaling.
Tags: 2013, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Arteriosclerosis, thrombosis, and vascular biology, Body Weight/physiology, Cells, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Collateral Circulation, Coronary Circulation, Coronary Vessels/cytology/*enzymology, Cultured, Department of Integrative Medical Sciences, Disease Models, Dyck Jason R B, Endothelial Cells/cytology/*enzymology, Enrick Molly, Hardwick James P, Humans, Inbred WKY, Ischemia/metabolism/pathology, Kolz Christopher, Mitochondria, Mitochondria/drug effects/*metabolism, Myocardium/enzymology/pathology, NEOMED College of Medicine, Oxidative Stress/*physiology, Pung Yuh Fen, Rats, reactive oxygen species, Rotenone/pharmacology, Sam Wai Johnn, Signal Transduction/*physiology, Stevanov Kelly, Thakker Prashanth, TOR Serine-Threonine Kinases/metabolism, Uncoupling Agents/pharmacology, Yin Liya
Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth.
Tags: *Collateral Circulation, *Coronary Circulation, 2012, Animal, Animals, Bailey Erin, Biomarkers/metabolism, Cell Differentiation, Cell Lineage, Cells, Chilian William M, Circulation research, Coronary Occlusion/genetics/metabolism/pathology/physiopathology/*surgery, Coronary Vessels/metabolism/pathology/*physiopathology, Cultured, Delucia Angelo, Department of Integrative Medical Sciences, Developmental, Disease Models, Endothelial Cells/metabolism/pathology/*transplantation, Enrick Molly, Epigenesis, Gene Expression Profiling, Gene Expression Regulation, Genetic, Guarini Giacinta, Induced Pluripotent Stem Cells/metabolism/*transplantation, Kolz Christopher L, Mice, Muscle, Myocytes, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Physiologic, Pung Yuh Fen, Rats, Regenerative Medicine/methods, Regional Blood Flow, Reverse Transcriptase Polymerase Chain Reaction, SCID, Smooth, Smooth Muscle/metabolism/pathology/*transplantation, Sprague-Dawley, Stevanov Kelly, Teratoma/metabolism/pathology, Time Factors, Transcription Factors/genetics/metabolism, Transduction, Vascular/metabolism/pathology/*physiopathology, Yin Liya
Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts.
Tags: 2008, Acetophenones/pharmacology, Angiotensin II/*physiology, Animals, Benzopyrans/pharmacology, Calcium/*metabolism, Cell Proliferation, Cells, Cultured, Department of Integrative Medical Sciences, Enzyme Activation, ErbB Receptors/metabolism, Fibroblasts/*metabolism, Hypertension (Dallas, Tex. : 1979), Male, Meszaros J Gary, Mitogen-Activated Protein Kinase 1/*metabolism, Mitogen-Activated Protein Kinase 3/*metabolism, Myocardium/*cytology/metabolism, Naugle Jennifer E, NEOMED College of Medicine, Olson Erik R, Phorbol Esters/pharmacology, Phosphorylation, Protein Kinase C-delta/genetics/*metabolism, Rats, Shamhart Patricia E, Signal Transduction/physiology, Sprague-Dawley
RNA interference for CFTR attenuates lung fluid absorption at birth in rats.
Tags: *RNA Interference, 2008, Animals, Biological Transport/drug effects, Cells, Cultured, Cystic Fibrosis Transmembrane Conductance Regulator/*genetics/*metabolism, Epithelial Sodium Channels/genetics/metabolism, Female, Folkesson Hans G, Gene Expression Regulation/drug effects, Koshy Shyny, Li Tianbo, Lung/cytology/drug effects/*metabolism, Messenger/metabolism, Newborn, Pregnancy, Rats, Respiratory Mucosa/cytology/drug effects/metabolism, Respiratory research, RNA, Small Interfering/*pharmacology, Sprague-Dawley, Water/*metabolism
Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: *Gene Expression Regulation, 2010, Acetylation, AMP-Activated Protein Kinases/metabolism, ATP Citrate (pro-S)-Lyase/genetics/metabolism, Bile Acids and Salts/metabolism, Cells, Chanda Dipanjan, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Epigenesis, Genes, Genetic, Glucose/*administration & dosage, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*enzymology/metabolism, Histones/metabolism, Humans, Hyperglycemia/enzymology/*metabolism, Journal of lipid research, Li Tiangang, Messenger/metabolism, Methylation, NEOMED College of Medicine, Reporter, RNA, RNA Interference, Zhang Yanqiao
Glycation Reduces the Stability of ApoAI and Increases HDL Dysfunction in Diet-Controlled Type 2 Diabetes.
Tags: 2018, Adult, Aged, Animal Studies, Animals, Apolipoprotein A-I/blood/*metabolism, Apolipoproteins – Blood, Apolipoproteins – Metabolism, Bena James, Biochemical Phenomena, Case Control Studies, Case-Control Studies, Cells, Comparative Studies, Cultured, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Dyslipidemias/complications/diet therapy/*metabolism, Evaluation Research, Female, Funding Source, Glycosylation, Golizeh Makan, HDL – Metabolism, HDL/*metabolism, Human, Humans, Hyperglycemia – Complications, Hyperglycemia – Diet Therapy, Hyperglycemia – Metabolism, Hyperglycemia/complications/diet therapy/*metabolism, Hyperlipidemia – Complications, Hyperlipidemia – Diet Therapy, Hyperlipidemia – Metabolism, Ilchenko Serguei, Kashyap Sangeeta R, Kasumov Takhar, Lee Kwangwon, Lipoproteins, Male, Mice, Middle Age, Middle Aged, Multicenter Studies, NEOMED College of Pharmacy, Osme Abdullah, Previs Stephen F, Protein Stability, Smith Jonathan D, The Journal of clinical endocrinology and metabolism, Type 2 – Complications, Type 2 – Diet Therapy, Type 2 – Metabolism, Type 2/complications/*diet therapy/metabolism, Validation Studies, Wang Shuhui
TRPA1 and TRPV1 contribute to propofol-mediated antagonism of U46619-induced constriction in murine coronary arteries.
Tags: 13-dienoic Acid/*antagonists & inhibitors/pharmacology, 15-Hydroxy-11 alpha, 2017, 9 alpha-(epoxymethano)prosta-5, Andrei Spencer R, Animals, Bratz Ian N, Cells, Coronary Vessels/*drug effects/metabolism, Cultured, Damron Derek S, Endothelial Cells/drug effects/metabolism, Inbred C57BL, Knockout, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/metabolism, Male, Mice, Microvessels/drug effects/metabolism, Nitric Oxide Synthase Type III/metabolism, PloS one, Propofol/*pharmacology, Showalter Loral E, Sinha Sayantani, Sinharoy Pritam, Transient Receptor Potential Channels/genetics/*metabolism, TRPA1 Cation Channel, TRPV Cation Channels/genetics/*metabolism, Vasoconstrictor Agents/antagonists & inhibitors/pharmacology, Vasodilation/drug effects/physiology, Vasodilator Agents/*pharmacology
Osteoactivin (GPNMB) ectodomain protein promotes growth and invasive behavior of human lung cancer cells.
Tags: *Cell Movement, *Cell Proliferation, 2016, Animals, Apoptosis, Biomarkers, Carcinoma, Cell Adhesion, Cultured, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Female, GPNMB, Humans, integrin, Lung cancer, Lung Neoplasms/metabolism/*pathology, Manickavasagam Dharani, Membrane Glycoproteins/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, NEOMED College of Pharmacy, Neoplasm Invasiveness, Non-Small-Cell Lung/metabolism/*pathology, Novak Kimberly, NSCLC, Nude, Oncotarget, Oyewumi Moses O, Paulic Nikola, Protein Domains, Safadi Fayez F, Sondag Gregory R, Tumor Cells, Tumor/*metabolism, Wehrung Daniel, Xenograft Model Antitumor Assays
Functional outcome after anal sphincter injury and treatment with mesenchymal stem cells.
Tags: *Mesenchymal Stem Cell Transplantation, *Regeneration, 2014, Anal Canal/injuries/metabolism/pathology/physiopathology/*surgery, Anal pressures, Anal sphincter, Animal, Animals, Balog Brian, Cells, Cultured, Damaser Margot, Disease Models, Fecal incontinence, Female, Fibrosis, Green Fluorescent Proteins/biosynthesis/genetics, i.v. infusion, Infusions, Injections, Intralesional, Intravenous, Mesenchymal stem cells, Mesenchymal Stem Cells/metabolism, Penn Marc, Pressure, Rats, Recovery of Function, Salcedo Levilester, Sprague-Dawley, Stem cells translational medicine, Time Factors, Transfection, Zutshi Massarat
Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids.
Tags: *Hydroxysteroid Dehydrogenases, *Membrane Glycoproteins, 2001, Animals, Bile Acids and Salts/*pharmacology, Caco-2 Cells, Carrier Proteins/genetics/physiology, Cell Line, Chen W, Chiang J Y, CHO Cells, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear/genetics/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/drug effects/genetics/physiology, DNA/metabolism, Embryo, Gene Expression/*drug effects, Genetic, Genetic/drug effects, Humans, Journal of lipid research, Kidney, Liver/metabolism, Luciferases/genetics, Mammalian, Messenger/analysis, NEOMED College of Medicine, Owsley E, Promoter Regions, Rats, Receptors, Recombinant Fusion Proteins/metabolism, Retinoic Acid/genetics/physiology, Retinoid X Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Stroup D, Taurocholic Acid/pharmacology, Transcription, Transcription Factors/drug effects/genetics/physiology, Transfection, Tumor Cells, Yang Y
Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).
Tags: *DNA-Binding Proteins, 2003, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites/genetics, Cell Line, Chen Wenling, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholestanetriol 26-Monooxygenase, Cloning, Cultured, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, DNA, DNA/chemistry/genetics, Dose-Response Relationship, Drug, gene, Gene Expression Regulation/drug effects, Genetic/*genetics, Hepatocyte Nuclear Factor 4, Humans, Luciferases/genetics/metabolism, Molecular, Molecular Sequence Data, Mutagenesis, Mutation, NEOMED College of Medicine, Phosphoproteins/genetics/*metabolism, Promoter Regions, Receptors, Recombinant Fusion Proteins/genetics/metabolism, Response Elements/genetics, Sequence Analysis, Site-Directed, Steroid Hydroxylases/*genetics, Transcription Factors/genetics/*metabolism, Transfection, Tumor Cells
Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *Transcription, 2000, Animals, Bile Acids and Salts/*pharmacology, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear, Department of Integrative Medical Sciences, DNA-Binding Proteins/*physiology, Genetic, Humans, Kimmel R, NEOMED College of Medicine, Promoter Regions, Receptors, Repressor Proteins/*physiology, Response Elements, Retinoic Acid/genetics, Retinoid X Receptors, Stroup D, The Journal of biological chemistry, Transcription Factors/genetics/*physiology, Tumor Cells, Weinberger C
Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
Tags: 2001, Animals, Binding Sites, Cells, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/drug effects/*genetics/metabolism, Cricetinae, Cultured, Department of Integrative Medical Sciences, gene, Gene Expression Regulation/drug effects, Genetic, Humans, Hydroxycholesterols, Kimmel R, Liver/physiology, Lovastatin/pharmacology, Luciferases/genetics/metabolism, Mevalonic Acid/metabolism/pharmacology, NEOMED College of Medicine, Nicotinic Acids/pharmacology, Organ Specificity, Polyisoprenyl Phosphates/pharmacology, Rats, Receptors, Response Elements, Retinoic Acid/genetics/metabolism, Retinoid X Receptors, Species Specificity, Steroid/genetics/*metabolism, Stroup D, Tetrahydronaphthalenes/pharmacology, Transcription, Transcription Factors/genetics/metabolism, Transfection
Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7).
Tags: *Promoter Regions, *Transcription, 1995, Animals, Base Sequence, Cell Count, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Crestani M, Cultured, Cyclic AMP/pharmacology, Department of Integrative Medical Sciences, Enzymologic/*physiology, Gene Expression Regulation, Genetic, Hormones/*pharmacology, Journal of lipid research, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Phorbol Esters/pharmacology, Rats, Second Messenger Systems/physiology, Stroup D, Transfection, Tumor Cells