Browse Items (109 total)
- Tags: Animal
G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice.
Tags: *Gene Expression Regulation, 2017, Analysis of Variance, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Department of Integrative Medical Sciences, Disease Models, Donepudi Ajay C, Energy Metabolism/physiology, Fasting, Fatty Liver/*metabolism/pathology, G-Protein-Coupled/*genetics, Hepatology (Baltimore, Md.), Homeostasis/genetics, Inbred C57BL, Li Feng, Lipid Metabolism/genetics, Male, Mice, NEOMED College of Medicine, Oxygen Consumption/physiology, Random Allocation, Receptors, RNA-Binding Proteins/*metabolism, Signal Transduction
Gender differences in neurotoxicity of the nigrostriatal dopaminergic system: implications for Parkinson's disease.
Tags: 2000, Animal, Corpus Striatum/pathology/*physiopathology, Disease Models, Dluzen D E, Dopamine/metabolism, Estrogens/*pharmacology, Female, Humans, Male, McDermott J L, Neurotoxins/*antagonists & inhibitors, Parkinson Disease/metabolism/pathology/*physiopathology, Postmenopause, Sex Distribution, Sex Factors, Substantia Nigra/pathology/*physiopathology, The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia
Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy.
Tags: 2018, Alzheimer's disease, Animal, Animals, Antigens, Bemiller Shane M, Bhaskar Kiran, Biological, Calcium Binding Proteins – Metabolism, Calcium-Binding Proteins/metabolism, Cannon Judy L, Cardona Astrid E, Cells – Drug Effects, Cells – Metabolism, Cells – Pathology, Chemokine CX3CL1/*genetics/metabolism, Cognition Disorders – Etiology, Cognition Disorders/etiology, Crish Samuel D, CX3CL1, CX3CR1, Cytokines, Cytokines – Metabolism, Cytokines/metabolism, Department of Pharmaceutical Sciences, Differentiation/genetics/metabolism, Disease Models, Formica Shane V, Gene Expression Regulation/drug effects/*genetics, Genes, Genes – Drug Effects, Journal of neuroinflammation, Jung Steffen, Kim Ki-Wook, Kokiko-Cochran Olga N, Lamb Bruce T, Learning, Lipopolysaccharides, Lipopolysaccharides/toxicity, Maphis Nicole M, Maze Learning, Mice, Microfilament Proteins – Metabolism, Microfilament Proteins/metabolism, Microglia, Microglia/drug effects/*metabolism/pathology, Miller Crystal M, Models, Mutation, Mutation/genetics, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurodegenerative Diseases – Pathology, Neuroinflammation, Surface, Surface – Metabolism, Tau, tau Proteins/genetics/metabolism, Tauopathies, Tauopathies/complications/genetics/*pathology, Transgenic, Wilson Gina N, Xu Guixiang
Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair.
Tags: 2018, Administration, Alboslemy Talib, Animal, Animals, Cell Communication/*physiology, Cell Differentiation, Cells, Cultured, Cutaneous, Diabetes Mellitus, Disease Models, Eye Proteins/administration & dosage/genetics/*physiology, Humans, Inbred C57BL, Kim Min-Ho, Macrophages/*physiology, Male, Membrane Glycoproteins/administration & dosage/genetics/*physiology, Mesenchymal Stem Cells/*physiology, Mice, Recombinant Proteins/administration & dosage/genetics/metabolism, Safadi Fayez, Skin/*injuries/metabolism, The Journal of investigative dermatology, Type 2/complications/pathology, Wound Healing/*physiology, Yu Bing
Growth hormone injections improve bone quality in a mouse model of osteogenesis imperfecta.
Tags: 2005, Animal, Animals, Askew Michael J, Biomechanical Phenomena, Body Weight/drug effects, Bone and Bones/drug effects, Bone/prevention & control, Collagen Type I, Collagen/genetics, Densitometry, Department of Family & Community Medicine, Disease Models, Femur/drug effects/pathology, Fractures, Growth Hormone/*therapeutic use, Heterozygote, Humans, Inbred C57BL, Jarjoura David, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, King Donna, Lumbar Vertebrae/drug effects, McEwen Heather A, Mice, Mutation, NEOMED College of Medicine, Osteoblasts/*drug effects/metabolism, Osteogenesis Imperfecta/*drug therapy, Phenotype, Time Factors, Transgenic
Hepatic hepatocyte nuclear factor 4alpha is essential for maintaining triglyceride and cholesterol homeostasis.
Tags: 2011, Adenoviridae/genetics, Animal, Animals, Arteriosclerosis, thrombosis, and vascular biology, Cells, Cholesterol, Cholesterol/*metabolism, Cultured, Department of Integrative Medical Sciences, Edwards Peter A, Fatty Liver/metabolism/physiopathology, Ge Xuemei, HDL/metabolism, Hepatocyte Nuclear Factor 4/drug effects/genetics/*physiology, Hepatocytes/cytology/*metabolism, Homeostasis/genetics/*physiology, Inbred C57BL, Lipid Metabolism/genetics/physiology, Ma Huiyan, Mice, Models, NEOMED College of Medicine, RNA, Small Interfering/genetics/pharmacology, Triglycerides/*metabolism, VLDL/metabolism, Yin Liya, Zhang Yanqiao
Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage.
Tags: 2016, Animal, Animals, Basic research in cardiology, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Coronary Circulation, Coronary microcirculation, Coronary Vessels/metabolism/*physiopathology, Department of Integrative Medical Sciences, Diabetes, Disease Models, DNA, DNA Damage/physiology, DNA Fragmentation, Dobson James G Jr, Fenton Richard, Guarini Giacinta, Hardwick James P, Kang Patrick T, Kiyooka Takahiko, Kolz Christopher L, Marzilli Mario, Metabolic Syndrome/metabolism/*physiopathology, Mitochondria, Mitochondria/*metabolism, Mitochondrial/*metabolism, NEOMED College of Medicine, Obesity, Ohanyan Vahagn, Oxidative Stress/physiology, Pung Yuh Fen, Rats, Reactive Oxygen Species/metabolism, Shokolenko Inna, Vasodilation/physiology, Wilson Glenn L, Yin Liya, Zucker
Impairment of Hematopoietic Precursor Cell Activation during the Granulopoietic Response to Bacteremia in Mice with Chronic-Plus-Binge Alcohol Administration.
Tags: *alcohol, *bacteremia, *cell signaling, *granulocytes, *granulopoietic response, *Stem cells, 2017, Animal, Animals, Antigens, Bacteremia/genetics/*immunology/pathology, Binge Drinking/genetics/*immunology/pathology, Bone Marrow Cells/drug effects/immunology/pathology, CCAAT-Enhancer-Binding Protein-beta/genetics/immunology, Cyclin D1/genetics/immunology, Department of Integrative Medical Sciences, Disease Models, Escherichia coli Infections/genetics/*immunology/pathology, Escherichia coli/growth & development/immunology, Ethanol/*pharmacology, Gao Bin, Gene Expression Regulation/*drug effects/immunology, Granulocytes/drug effects/immunology/pathology, Hematopoiesis/*drug effects/genetics/immunology, Inbred BALB C, Infection and immunity, Lin Yuan-Ping, Ly/genetics/immunology, Male, Membrane Proteins/genetics/immunology, Mice, Mitogen-Activated Protein Kinase 1/genetics/immunology, Mitogen-Activated Protein Kinase 3/genetics/immunology, NEOMED College of Medicine, Nucleotidyltransferases/deficiency/genetics/immunology, Proto-Oncogene Proteins c-kit/genetics/immunology, Shi Xin, Signal Transduction/*drug effects/immunology, Toll-Like Receptor 4/genetics/immunology, Zhang Ping
Impairment of pH gradient and membrane potential mediates redox dysfunction in the mitochondria of the post-ischemic heart.
Tags: *Energy Metabolism, *Membrane potential, *Mitochondria, *Myocardial ischemia and reperfusion, *Oxidative Stress, *pH gradient, *Redox dysfunction, 2017, Aconitate Hydratase/metabolism, Animal, Animals, Basic research in cardiology, Cell Line, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Department of Family & Community Medicine, Department of Integrative Medical Sciences, Disease Models, Electron Transport Chain Complex Proteins/metabolism, Heart/*metabolism/pathology, Hydrogen Peroxide/metabolism, Hydrogen-Ion Concentration, Ionophores/pharmacology, Kang Patrick T, Lin Paul, Male, Mitochondria, Mitochondrial, Myocardial Infarction/*metabolism/pathology, Myocardium/*metabolism/pathology, NEOMED College of Medicine, Oxidation-Reduction, Potassium/metabolism, Rats, Sprague-Dawley, Superoxides/metabolism
Increased transperitoneal bacterial translocation in laparoscopic surgery.
Tags: *Bacterial Translocation, *Laparoscopy, 2003, Animal, Animals, Artificial/*adverse effects/methods, Carbon Dioxide/administration & dosage, Escherichia coli Infections/*microbiology, Escherichia coli/isolation & purification/physiology, Gases, Haller N, Helium/administration & dosage, Horattas M C, Insufflation/adverse effects, Male, Models, Peritonitis/*microbiology, Pneumoperitoneum, Pressure, Rats, Ricchiuti D, Sprague-Dawley, Surgical endoscopy
Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth.
Tags: *Collateral Circulation, *Coronary Circulation, 2012, Animal, Animals, Bailey Erin, Biomarkers/metabolism, Cell Differentiation, Cell Lineage, Cells, Chilian William M, Circulation research, Coronary Occlusion/genetics/metabolism/pathology/physiopathology/*surgery, Coronary Vessels/metabolism/pathology/*physiopathology, Cultured, Delucia Angelo, Department of Integrative Medical Sciences, Developmental, Disease Models, Endothelial Cells/metabolism/pathology/*transplantation, Enrick Molly, Epigenesis, Gene Expression Profiling, Gene Expression Regulation, Genetic, Guarini Giacinta, Induced Pluripotent Stem Cells/metabolism/*transplantation, Kolz Christopher L, Mice, Muscle, Myocytes, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Physiologic, Pung Yuh Fen, Rats, Regenerative Medicine/methods, Regional Blood Flow, Reverse Transcriptase Polymerase Chain Reaction, SCID, Smooth, Smooth Muscle/metabolism/pathology/*transplantation, Sprague-Dawley, Stevanov Kelly, Teratoma/metabolism/pathology, Time Factors, Transcription Factors/genetics/metabolism, Transduction, Vascular/metabolism/pathology/*physiopathology, Yin Liya
Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis.
Tags: *Phytotherapy, *Punicaceae, 2017, ACLT, Akhtar Nahid, Animal, Animals, Anterior Cruciate Ligament/drug effects/metabolism/pathology, Apoptosis, Ashruf Omer S, Cartilage/cytology/*drug effects/metabolism/pathology, Chondrocytes/drug effects/metabolism/pathology, Collagen Type II/genetics/metabolism, Department of Anatomy & Neurobiology, Dinoprostone/*metabolism, Disease Models, Disease Progression, Female, Fruit, Haqqi Tariq M, Interleukins/metabolism, Joints/cytology/*drug effects/metabolism/pathology, Khan Nazir M, Male, Messenger/metabolism, Metalloproteases/genetics/*metabolism, Mitogen-Activated Protein Kinases/metabolism, MMPs, NEOMED College of Medicine, NF-kappa B/metabolism, Nutrition (Burbank, Los Angeles County, Calif.), Osteoarthritis, Osteoarthritis/*drug therapy/etiology/metabolism/pathology, PGE(2), Plant Extracts/pharmacology/therapeutic use, Pomegranate, Rabbit, Rabbits, RNA, Synovial Fluid/metabolism
Injury models to study cardiac remodeling in the mouse: myocardial infarction and ischemia-reperfusion.
Tags: *Ventricular Remodeling, 2013, Animal, Animals, Cardiovascular Surgical Procedures, Coronary Vessels/surgery, Department of Integrative Medical Sciences, Disease Models, Ligation, Luther Daniel J, Meszaros J Gary, Methods in molecular biology (Clifton, N.J.), Mice, Myocardial Infarction/*etiology/*pathology, Myocardial Reperfusion Injury/*etiology/*pathology, NEOMED College of Medicine, Perfusion/methods, Thodeti Charles K, Wound Healing
Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus.
Tags: *Axon regeneration, *Axotomy, *Diabetes, *Neuropathy, *Peripheral nervous system, 2017, Animal, Animals, Antibiotics, Antineoplastic/toxicity, Blood Glucose/drug effects, Body Weight/drug effects, Crish Samuel D, Cytokine Receptor gp130/genetics/*metabolism, Cytokines/metabolism, DeFrancesco Alicia, Department of Pharmaceutical Sciences, Diabetes Mellitus, Disease Models, Experimental neurology, Experimental/chemically induced/complications/*pathology, Fasting/blood, Filous Angela R, Gene Expression Regulation/*physiology, Hyperalgesia/etiology, Hyperglycemia/etiology, Inbred C57BL, Lindborg Jane A, Male, Malhotra Nisha A, Mice, NEOMED College of Pharmacy, Nerve Degeneration/*etiology/pathology, Nerve Tissue Proteins/metabolism, Niemi Jon P, Pain Measurement, Signal Transduction/drug effects/*physiology, Streptozocin/toxicity, Superior Cervical Ganglion/drug effects/*metabolism, Sweating/drug effects, Wilson Gina N, Zhou Bowen, Zigmond Richard E
Innate and adaptive host response during the initial phase of herpes simplex virus encephalitis in the neonatal mouse.
Tags: *Immunity, 2006, Active, Animal, Animals, B-Lymphocytes/immunology, Brain/pathology/*virology, Cell Line, Disease Models, Docherty John J, Encephalitis, Fu Ming Ming, Herpes Simplex/*immunology, Innate, Journal of neurovirology, Kumaraswamy Guttalu K, Mice, Microglia/pathology/virology, Newborn, Simplexvirus/*isolation & purification/physiology, T-Lymphocytes/immunology, Virus Replication
Intestinal Flora Modification of Arthritis Pattern in Spondyloarthropathy.
Tags: *Bacteria/classification/genetics/isolation & purification, *Diarrhea/complications/microbiology, *Gastrointestinal Microbiome, *Spondylarthropathies/diagnosis/etiology/physiopathology, 16S/analysis, 2015, Animal, Animals, Disease Models, Gastrointestinal Tract/*microbiology, Gorilla gorilla, Humans, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, Pan troglodytes, Protective Factors, Ribosomal, RNA, Rothschild Bruce M
Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.
Tags: *Signal Transduction, 2018, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/*antagonists & inhibitors/pharmacology, Department of Integrative Medical Sciences, Disease Models, Ferrell Jessica M, G-Protein-Coupled/*metabolism, Gastrointestinal Microbiome/*drug effects, Glucagon-Like Peptide 1/metabolism, Gonzalez Frank J, GTP-Binding Proteins/*metabolism, Hepatology (Baltimore, Md.), Inbred C57BL, Krausz Kristopher W, Lipid Metabolism, Male, Mice, NEOMED College of Medicine, Nichols Robert G, Pathak Preeti, Patterson Andrew D, Random Allocation, Receptors, Sensitivity and Specificity, Xie Cen
Intrastrain variants of herpes simplex virus type 1 isolated from a neonate with fatal disseminated infection differ in the ICP34.5 gene, glycoprotein processing, and neuroinvasiveness.
Tags: *Genetic Variation, *Protein Processing, 1999, Amino Acid, Amino Acid Sequence, Animal, Animals, Base Sequence, Bower J R, Deoxyribonuclease BamHI, Deoxyribonuclease EcoRI, Detwiler M, Disease Models, DNA, Durishin C, Genes, Glycoproteins/metabolism, Herpesvirus 1, Human/*genetics/growth & development/isolation & purification, Humans, Inbred BALB C, Journal of virology, Karban T L, Male, Mao H, Mice, Molecular Sequence Data, Nucleic Acid, Polymerase Chain Reaction/methods, Polymorphism, Post-Translational, Rempinski D, Restriction Fragment Length, Rosenthal K S, Rozenbom E, Sequence Analysis, Sequence Homology, Viral, Viral Envelope Proteins/analysis, Viral Proteins/*genetics
Isolation of canine coronary sinus musculature from the atria by radiofrequency catheter ablation prevents induction of atrial fibrillation.
Tags: *Catheter Ablation, 2014, Acetylcholine, Action Potentials, Animal, Animal Studies, Animals, Artificial, Atrial fibrillation, Atrial Fibrillation – Etiology, Atrial Fibrillation – Physiopathology, Atrial Fibrillation – Prevention and Control, Atrial Fibrillation/etiology/physiopathology/*prevention & control, Biological, Body Surface Potential Mapping, Cardiac Pacing, Catheter Ablation, Circulation. Arrhythmia and electrophysiology, coronary sinus, Coronary Sinus/physiopathology/*surgery, Coronary Vessels – Physiopathology, Coronary Vessels – Surgery, Disease Models, Dogs, Heart Atria/physiopathology/surgery, Heart Atrium – Physiopathology, Heart Atrium – Surgery, Male, Models, Morita Hiroshi, Morita Shiho T, optical Vm mapping, Time Factors, Wu Jiashin, Zipes Douglas P
Lack of bone stiffness/strength contribution to osteoarthritis–evidence for primary role of cartilage damage.
Tags: 2007, Animal, Animals, Articular/physiopathology, Biomechanical Phenomena, Bird Diseases/*physiopathology, Birds, Bone and Bones/*physiopathology, Cartilage, Disease Models, Mechanical, Osteoarthritis/*physiopathology/*veterinary, Panza R K, Rheumatology (Oxford, England), Rothschild B M, Species Specificity, Stress
LEAPS Vaccine Incorporating HER-2/neu Epitope Elicits Protection That Prevents and Limits Tumor Growth and Spread of Breast Cancer in a Mouse Model.
Tags: *Cancer Vaccines/genetics/immunology/therapeutic use, 2017, Animal, Animals, Breast Neoplasms/genetics/immunology/prevention & control/therapy, CD8-Positive T-Lymphocytes/immunology, Cell Line, Cytotoxic/immunology, Disease Models, Disease Progression, Epitopes, erbB-2, Experimental/immunology/pathology/*prevention & control/*therapy, Female, Genes, Immunoglobulin G/blood, Inbred BALB C, Journal of immunology research, Koski Gary, Mammary Neoplasms, Mice, Neoplasm Metastasis/prevention & control, Proof of Concept Study, Rosenthal Ken S, Stone Sarah, T-Lymphocyte/immunology, T-Lymphocytes, Tumor, Zimmerman Daniel H
LVC Timing in Infant Pig Swallowing and the Effect of Safe Swallowing.
Tags: *Animal model, *Aspiration, *Deglutition, *Deglutition disorders, *Dysphagia, *Infant, *Laryngeal vestibule closure, *Recurrent laryngeal nerve, 2018, Animal, Animal Population Groups, Animals, Aspiration – Etiology, Aspiration/*etiology, Biological, Deglutition – Physiology, Deglutition Disorders – Etiology, Deglutition Disorders/*etiology, Deglutition/*physiology, Department of Anatomy & Neurobiology, Disease Models, Dysphagia, German Rebecca, Gould Francois, Gross Andrew, Humans, Laryngeal Nerve Injuries/*complications, Laryngeal Nerves – Injuries, Larynx, Models, NEOMED College of Medicine, Newborn, Ohlemacher Jocelyn, Oropharynx, Pneumonia, Questionnaires, Swine
Maturation of the Coordination Between Respiration and Deglutition with and Without Recurrent Laryngeal Nerve Lesion in an Animal Model.
Tags: *Animal model, *Deglutition, *Development, *Infant, *Recurrent laryngeal nerve, *Respiration, *Sensorimotor, 2018, Animal, Animal Population Groups, Animals, Ballester Ashley, Biological, Bond Laura, Buddington Karyl, Buddington Randall, Danos Nicole, Deglutition – Physiology, Deglutition disorders, Deglutition/*physiology, DeLozier Katherine R, Department of Anatomy & Neurobiology, Disease Models, Dysphagia, German Rebecca, Gould Francois, Gross Andrew, Humans, Laryngeal Nerves – Injuries, Laryngeal Nerves – Physiology, Larynx – Physiology, Larynx/*physiology, Models, NEOMED College of Medicine, Newborn, Ohlemacher Jocelyn, Questionnaires, Recurrent Laryngeal Nerve Injuries/*complications, Recurrent Laryngeal Nerve/physiology, Respiration, Stricklen Bethany, Swine
Mechanisms of Chinese Medicine Xinmailong's protection against heart failure in pressure-overloaded mice and cultured cardiomyocytes.
Tags: 2017, Animal, Animals, Cardiac/cytology/*drug effects/metabolism, Cell Nucleus/metabolism, Cell Survival/drug effects, Cells, Chen Renshan, Chen Yanfen, Chinese Herbal/*administration & dosage/pharmacology, Constriction, Cultured, Disease Models, Drugs, Echocardiography, GABA Plasma Membrane Transport Proteins/*metabolism, Gene Expression Regulation/drug effects, Glycogen Synthase Kinase 3 beta/metabolism, Gu Weiwang, Heart Failure/etiology/metabolism/physiopathology/*prevention & control, Humans, Liu Qin, Lu Jun, MAP Kinase Signaling System/drug effects, Mice, Myocytes, Pathologic, Phosphorylation, Proto-Oncogene Proteins c-akt/metabolism, Qi Jianyong, Rats, Scientific reports, Tan Yafang, Wu Jiashin, Xu Wen, Yu Juan, Zhang Minzhou
MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes.
Tags: 2015, Academic Medical Centers, Aged, Akhtar Nahid, Analysis of Variance, Animal, Animals, Anterior Cruciate Ligament/surgery, Arthritis & rheumatology (Hoboken, N.J.), Blotting, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism/pathology, Cultured, Department of Anatomy & Neurobiology, Disease Models, Female, Funding Source, Gene Expression Regulation/genetics/*physiology, Haqqi Tariq M, Hedgehog Proteins/genetics/*metabolism, HEK293 Cells, Human, Humans, Immunohistochemistry, In Vitro Techniques, Interleukin-1beta/pharmacology, Knee/etiology/*metabolism/pathology, Makki Mohammad S, Male, Matrix Metalloproteinase 13/metabolism, MicroRNAs/genetics/*metabolism, Middle Age, Middle Aged, NEOMED College of Medicine, Ohio, Open Reading Frames/genetics/*physiology, Osteoarthritis, Osteoarthritis – Epidemiology, Osteoarthritis – Physiopathology, Polymerase Chain Reaction, Rabbits, Signal Transduction/genetics/physiology, T-Tests, Transfection, Up-Regulation/drug effects/genetics/physiology, Western
Mitochondrial morphology differences and mitophagy deficit in murine glaucomatous optic nerve.
Tags: *Disease Models, 2015, Adenosine Triphosphate/metabolism, Age Factors, Animal, Animals, autophagosome, Axons/pathology, Coughlin Lucy, Department of Pharmaceutical Sciences, Electron, Horner Philip J, Inbred DBA, Inman Denise M, Investigative ophthalmology & visual science, Mice, Microscopy, Mitochondria, Mitochondria/*pathology, Mitochondrial Degradation/*physiology, mitophagy, Morrison Richard S, Myelinated/pathology, NEOMED College of Pharmacy, Nerve Fibers, Optic Nerve/*pathology
Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-alpha signaling.
Tags: 2013, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Arteriosclerosis, thrombosis, and vascular biology, Body Weight/physiology, Cells, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Collateral Circulation, Coronary Circulation, Coronary Vessels/cytology/*enzymology, Cultured, Department of Integrative Medical Sciences, Disease Models, Dyck Jason R B, Endothelial Cells/cytology/*enzymology, Enrick Molly, Hardwick James P, Humans, Inbred WKY, Ischemia/metabolism/pathology, Kolz Christopher, Mitochondria, Mitochondria/drug effects/*metabolism, Myocardium/enzymology/pathology, NEOMED College of Medicine, Oxidative Stress/*physiology, Pung Yuh Fen, Rats, reactive oxygen species, Rotenone/pharmacology, Sam Wai Johnn, Signal Transduction/*physiology, Stevanov Kelly, Thakker Prashanth, TOR Serine-Threonine Kinases/metabolism, Uncoupling Agents/pharmacology, Yin Liya
MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
Tags: *Aging, *Disease Models, *drug discovery, *mitochondrial dysfunction, *mitoNEET, 2017, ACS chemical neuroscience, Animal, Animals, Benkovic Stanley A, Brown Candice M, Corpus Striatum/*metabolism/*pathology, Crish Samuel D, Darvesh Altaf S, Department of Pharmaceutical Sciences, Geldenhuys Werner J, Inbred C57BL, Iron-Binding Proteins/genetics/*metabolism, Knockout, Lin Li, Male, Membrane Proteins/genetics/*metabolism, Mice, Mitochondria/*metabolism/*pathology, NEOMED College of Pharmacy, Parkinson Disease/*metabolism/pathology, Richardson Jason R, Sullivan Patrick G, Yonutas Heather M
Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice.
Tags: 2016, Animal, Animals, Blackwood Rachel, Calcium Signaling/genetics, Dantrolene/*administration & dosage, Dasgupta Nupur, Department of Pharmaceutical Sciences, Disease Models, Fleming Sheila, Gaucher Disease/*drug therapy/genetics/physiopathology, Grabowski Gregory A, Human molecular genetics, Humans, Inskeep Venette, Li Ronghua, Liou Benjamin, Marshall John, Mice, Mitochondria/*drug effects/genetics/pathology, NEOMED College of Pharmacy, Neurons/drug effects/pathology, Neuroprotective Agents/administration & dosage, Peng Yanyan, Quinn Brian, Ryanodine Receptor Calcium Release Channel/*genetics/metabolism, Setchell Kenneth D R, Sun Ying, Zhang Wujuan
MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains.
Tags: *QTL, *Recombinant inbred mice, *Sex Characteristics, *Sex differences, 1-Methyl-4-phenyl-1, 2, 2016, 3, 4-Dihydroxyphenylacetic Acid/metabolism, 6-tetrahydropyridine/pharmacology, Alam Gelareh, Animal, Animals, Corpus Striatum/drug effects/*metabolism, Department of Family & Community Medicine, Disease Models, Dopamine/metabolism, Female, Gene Expression Regulation/drug effects/*genetics, Glial Fibrillary Acidic Protein/*metabolism, Homovanillic Acid/metabolism, Inbred Strains, Jones Byron C, Lu Lu, Male, Mice, Miller Diane B, MPTP Poisoning/chemically induced/*pathology, NEOMED College of Medicine, Neurotoxicology, O'Callaghan James P, Serotonin/metabolism, Species Specificity, Tyrosine 3-Monooxygenase/metabolism, Williams Robert W
Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.
Tags: 2016, Adiponectin/*blood, Alcoholic/blood/*genetics/metabolism, Animal, Animals, Chrast Roman, Department of Pharmaceutical Sciences, Disease Models, Fatty Liver, Fibroblast Growth Factors/*blood, Finck Brian N, Gene Knockout Techniques, Han Yoonhee, Hu Xudong, Jogasuria Alvin, Kim Chunki, Lipid Metabolism, Male, Mice, Myeloid Cells/*metabolism, NEOMED College of Pharmacy, NF-kappa B/metabolism, Nuclear Proteins/*deficiency, Organ Specificity, Phosphatidate Phosphatase/*deficiency, Scientific reports, Shen Hong, Signal Transduction, Wang Jiayou, Wu Jiashin, You Min
Neuropathic pain in aged rats: behavioral responses and astrocytic activation.
Tags: 2001, Aging/*physiology, Animal, Animal/*physiology, Animals, Astrocytes/*metabolism, Behavior, Cell Count, Crisp T, Cruce W L, Department of Anatomy & Neurobiology, Disease Models, Experimental brain research, Functional Laterality/physiology, Glial Fibrillary Acidic Protein/metabolism, Hyperalgesia/physiopathology, Immunohistochemistry, Inbred F344, Lovell J A, Lumbar Vertebrae, Male, McBurney D L, NEOMED College of Medicine, Nerve Crush/methods, Neuralgia/*metabolism/pathology/physiopathology, Pain Measurement, Peripheral Nervous System Diseases/*metabolism/pathology/physiopathology, Posterior Horn Cells/*metabolism, Rats, Schechter J B, Stuesse S L, Thermosensing/physiology, Touch/physiology, Up-Regulation/*physiology
Novel models for assessing blood-brain barrier drug permeation.
Tags: *Capillary Permeability, 2012, Allen David D, Animal, Animals, Blood-Brain Barrier/*metabolism, Bloomquist Jeffrey R, Drosophila melanogaster/metabolism, Expert opinion on drug metabolism & toxicology, Geldenhuys Werner J, Grasshoppers/metabolism, High-Throughput Screening Assays, Humans, Models, Pharmaceutical Preparations/*metabolism, Zebrafish/metabolism
Oestrogen and nigrostriatal dopaminergic neurodegeneration: animal models and clinical reports of Parkinson's disease.
Tags: 2007, Animal, Animals, Basal Ganglia/drug effects/*metabolism/pathology, Clinical and experimental pharmacology & physiology, Disease Models, Dluzen Dean E, Dopamine/*metabolism, Estrogens/*metabolism/pharmacology/therapeutic use, Humans, Liu Bin, Nerve Degeneration/drug therapy/*metabolism/pathology, Neurons/metabolism/pathology, Neuroprotective Agents/*metabolism/pharmacology/therapeutic use, Parkinson Disease/drug therapy/*metabolism/pathology, Parkinsonian Disorders/drug therapy/*metabolism/pathology, Substantia Nigra/drug effects/*metabolism/pathology
On the mechanisms of biliary flux.
Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth.
Tags: *Collateral Circulation/drug effects, *Coronary Circulation/drug effects, *MAP Kinase Signaling System/drug effects, 2007, Acetophenones/pharmacology, American journal of physiology. Heart and circulatory physiology, Animal, Animals, Blood Flow Velocity, Cells, Chilian William M, Coronary Vessels/surgery, Cultured, Department of Integrative Medical Sciences, Disease Models, Ditiocarb/pharmacology, Endothelial Cells/drug effects/enzymology/*metabolism, Enzyme Inhibitors/pharmacology, Humans, Imidazoles/pharmacology, Inbred WKY, Kolz Christopher, Ligation, Male, Myocardial Reperfusion Injury/enzymology/metabolism/*physiopathology, NADPH Oxidases/antagonists & inhibitors/metabolism, NEOMED College of Medicine, Neovascularization, Onium Compounds/pharmacology, Oxygenases/antagonists & inhibitors/metabolism, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism, Physiologic, Potter Barry, Pyridines/pharmacology, Rats, Reactive Oxygen Species/*metabolism, Reed Ryan, Rocic Petra, Superoxide Dismutase/antagonists & inhibitors/metabolism, Vascular Endothelial Growth Factor A/metabolism
Origins of spondyloarthropathy in Perissodactyla.
Tags: *Fossils, *Paleopathology, *Perissodactyla, 2001, Ancient, Animal, Animals, Ankylosing/history/*pathology, Clinical and experimental rheumatology, Disease Models, History, Horse Diseases/history/*pathology, Horses, North America, Prothero D R, Rothschild B M, Rothschild C, Sacroiliac Joint/pathology, Spine/pathology, Spondylitis
Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucoma.
Tags: *Axonal Transport/physiology, *bouton, *Mitochondria, *neurodegeneration, *retinal, *RRID:IMSRJAX:000671, *RRID:IMSRJAX:007048, *RRID:SCR002716, *RRID:SCR002865, *superior colliculus, *synapse, 2016, Animal, Animals, Crish Samuel D, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Disease Models, Electron, Fening Kelly M, Glaucoma/metabolism/*pathology, Imaging, Inbred DBA, Inman Denise M, Mice, Microscopy, Mitochondria/pathology, NEOMED College of Medicine, NEOMED College of Pharmacy, Neuroanatomical Tract-Tracing Techniques, Regression Analysis, Retinal Ganglion Cells/metabolism/*pathology, Scanning, Schofield Brett R, Smith Matthew A, Superior Colliculi/metabolism/*pathology, Synapses/metabolism/*pathology, The Journal of comparative neurology, Three-Dimensional, Visual Pathways/metabolism/pathology, Xia Christina Z
Postnatal developmental changes in the medial nucleus of the trapezoid body in a mouse model of auditory pathology.
Tags: *Disease Models, 2014, AHL, Animal, Animals, Auditory brainstem responses, Auditory Pathways/*growth & development/*pathology, Auditory system, DBA/2, Grimsley Calum A, Hearing Loss/*pathology, Inbred CBA, Inbred DBA, Mice, MNTB, Neuroscience letters, Newborn, Olivary Nucleus/*growth & development/*pathology, Organ Culture Techniques, Sivaramakrishnan Shobhana
Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.
Tags: 2016, aerodigestive and gastrointestinal tract, Animal, Animal Studies, Animals, Anthocyanins/analysis/pharmacology, Anticarcinogenic Agents/*analysis/pharmacology, Antineoplastic Agents – Analysis, Antineoplastic Agents – Pharmacodynamics, Benzopyrans – Analysis, Benzopyrans – Pharmacodynamics, Berry, Biological, Bishayee Anupam, Cancer, Chemoprevention, Clinical Trials, Clinical Trials as Topic, Critical reviews in food science and nutrition, Digestion – Drug Effects, Digestion/drug effects, Disease Models, Do Chau, Ellagic Acid/analysis/pharmacology, Fruit, Fruit/*chemistry, Gastrointestinal Neoplasms – Prevention and Control, Gastrointestinal Neoplasms/*prevention & control, Haskell Yennie, Human, Humans, Models, Mohandas Nima, Phytochemicals – Analysis, Phytochemicals – Pharmacodynamics, Phytochemicals/analysis/pharmacology, Plant Extracts – Analysis, Plant Extracts – Pharmacodynamics, Plant Extracts/*analysis/pharmacology, Polyphenols – Analysis, Polyphenols – Pharmacodynamics, Polyphenols/analysis/pharmacology, Sethi Gautam, Siveen Kodappully Sivaraman, Stoner Gary D, Treatment