Browse Items · NEOMED Bibliography Database

Autoschizis: a novel cell death.

Vitamin C (VC) and vitamin K(3) (VK(3)) administered in a VC:VK(3) ratio of 100:1 exhibit synergistic antitumor activity and preferentially kill tumor cells by autoschizis, a novel type of necrosis characterized by exaggerated membrane damage and…

Tags: 2002, Animals, Antioxidants/chemistry/*pharmacology/therapeutic use, Ascorbic Acid/chemistry/*pharmacology/therapeutic use, Biochemical pharmacology, Calderon Pedro Buc, Cell Death/*physiology, Gilloteaux Jacques, Humans, Jamison James M, Necrosis, Neoplasms/drug therapy/metabolism/*pathology, Oxidative Stress/*drug effects, Summers Jack L, Taper Henryk S, Vitamin K/chemistry/*pharmacology/therapeutic use

Baclofen-induced disinhibition in area CA1 of rat hippocampus is resistant to extracellular Ba2+.

The mechanism of disinhibition produced by (+/-)-baclofen was studied using intracellular recording in area CA1 of rat hippocampal slices. Baclofen reversibly depressed monosynaptic IPSPs evoked by direct activation of interneurons in the presence of…

Tags: 1991, 2-Amino-5-phosphonovalerate/pharmacology, Animals, Baclofen/antagonists & inhibitors/*pharmacology, Barium/*pharmacology, Brain research, Drug Resistance/physiology, Evoked Potentials/drug effects, GABA-A/*drug effects, Harrison N L, Hippocampus/*drug effects, In Vitro Techniques, Interneurons/drug effects, Lambert N A, Neural Inhibition/drug effects, Quinoxalines/pharmacology, Rats, Receptors, Teyler T J

Basic transcription element binding protein (BTEB) transactivates the cholesterol 7 alpha-hydroxylase gene (CYP7A).

Cholesterol 7 alpha-hydroxylase catalyzes the first and rate-limiting step in the conversion of cholesterol to bile acids in the liver. Previously, we have identified two bile acid response elements located in nt -74 to -54 (BARE-I) and -148 to -118…

Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway.

Bcl-2 is an anti-apoptotic protein that has recently been shown to regulate other cellular functions. We previously reported that Bcl-2 regulates chondrocyte matrix gene expression, independent of its anti-apoptotic function. Here, we further…

Tags: *Gene Expression Regulation, 2005, Adenoviridae/genetics, Animals, Apoptosis, beta-Galactosidase/metabolism, Blotting, Butadienes/pharmacology, Caspase Inhibitors, Cell Differentiation, Cell Line, Chondrocytes/*metabolism, Collagen Type II/metabolism, Department of Anatomy & Neurobiology, Down-Regulation, Enzyme Inhibitors/pharmacology, Fibroblasts/metabolism, Fluorescence, Genetic, High Mobility Group Proteins/*metabolism, Horton Walter E Jr, Lac Operon, Luciferases/metabolism, MAP Kinase Kinase Kinases/*metabolism, McBurney Denise, Messenger/metabolism, Microscopy, Mitogen-Activated Protein Kinase 1/*metabolism, Mitogen-Activated Protein Kinase 3/*metabolism, NEOMED College of Medicine, NF-kappa B/metabolism, Nitriles/pharmacology, Phenotype, Phosphorylation, Promoter Regions, Protein Kinase C-alpha, Protein Kinase C/antagonists & inhibitors, Proteoglycans/metabolism, Proto-Oncogene Proteins c-bcl-2/*metabolism, Rats, Reverse Transcriptase Polymerase Chain Reaction, RNA, Signal Transduction, Small Interfering/metabolism, SOX9 Transcription Factor, Sprague-Dawley, The Journal of biological chemistry, Time Factors, Transcription, Transcription Factors/*metabolism, Transfection, Western, Yagi Rieko

BCNU-induced gR2 defect mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium.

A deficiency of mitochondrial glutathione reductase (or GR2) is capable of adversely affecting the reduction of GSSG and increasing mitochondrial oxidative stress. BCNU [1,3-bis (2-chloroethyl)-1-nitrosourea] is an anticancer agent and known…

Tags: 2014, Alkylating/*adverse effects/pharmacology, Animals, Antineoplastic Agents, Biochemical pharmacology, Cardiotoxins/adverse effects/pharmacology, Carmustine/*adverse effects/pharmacology, Cattle, Cell Line, Chen Chwen-Lih, Chen Yeong-Renn, Complex I, Department of Integrative Medical Sciences, Electron Transport Complex I/chemistry/*metabolism, Fatty Acids, Glutathione reductase, Glutathione Reductase/*antagonists & inhibitors/metabolism, Glutathione/*metabolism, Guarini Giacinta, Heart Ventricles/drug effects/metabolism/physiopathology, Heart/*drug effects/metabolism, Ion Channels/metabolism, Kang Patrick T, Left/*chemically induced/metabolism/physiopathology, Male, Mice, Mitochondria, Mitochondrial Proteins/metabolism, NEOMED College of Medicine, Nonesterified/metabolism, Oxidative Stress, Oxidative Stress/drug effects, Post-Translational/drug effects, Protein Processing, Rats, Ren Pei, S-Glutathionylation, Sprague-Dawley, Superoxide Dismutase/genetics/metabolism, Systolic dysfunction, Transgenic, Uncoupling Protein 3, Ventricular Dysfunction

Behavioral effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE; "EVE").

Eight male rats were trained to discriminate 2.0 mg/kg

Tags: 1987, 3, 4-methylenedioxyamphetamine, 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology, Amphetamines/*pharmacology, Animals, Boja J W, Discrimination (Psychology), Dose-Response Relationship, Drug, Inbred Strains, Legislation, Male, N-Methyl-3, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Time Factors, United States

Behavioral implications of ontogenetic changes in intrinsic hand and foot proportions in olive baboons (Papio Anubis).

OBJECTIVES: Relatively long digits are considered to enhance grasping performance in primates. We tested whether growth-related changes in intrinsic hand and foot proportions may have behavioral implications for growing animals, by examining whether…

Beta-adrenoceptor stimulation of alveolar fluid clearance is increased in rats with heart failure.

The alveolar epithelium plays a critical role in resolving pulmonary edema. We thus hypothesized that its function might be upregulated in rats with heart failure, a condition that severely challenges the lung's ability to maintain fluid balance.…

Beyond thermoregulation: metabolic function of cetacean blubber in migrating bowhead and beluga whales.

The processes of lipid deposition and utilization, via the gene leptin (Lep), are poorly understood in taxa with varying degrees of adipose storage. This study examines how these systems may have adapted in marine aquatic environments inhabited by…

Bile acid metabolism and signaling.

Bile acids are important physiological agents for intestinal nutrient absorption and biliary secretion of lipids, toxic metabolites, and xenobiotics. Bile acids also are signaling molecules and metabolic regulators that activate nuclear receptors and…

Bile acid receptors in non-alcoholic fatty liver disease.

Accumulating data have shown that bile acids are important cell signaling molecules, which may activate several signaling pathways to regulate biological processes. Bile acids are endogenous ligands for the farnesoid X receptor (FXR) and TGR5, a…

Bile acid regulation of gene expression: roles of nuclear hormone receptors.

Bile acids derived from cholesterol and oxysterols derived from cholesterol and bile acid synthesis pathways are signaling molecules that regulate cholesterol homeostasis in mammals. Many nuclear receptors play pivotal roles in the regulation of bile…

Tags: 2002, Animals, Bile Acids and Salts/*physiology, Chiang John Y L, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Endocrine reviews, Gene Expression Regulation/*physiology, Humans, NEOMED College of Medicine, Receptors

Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors.

Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Recent studies reveal that bile acids also are signaling molecules that activate several nuclear receptors…

Tags: 2003, American journal of physiology. Gastrointestinal and liver physiology, Animals, Bile Acids and Salts/biosynthesis/genetics/*physiology, Bile/*physiology, Cardiovascular Diseases/genetics/physiopathology, Chiang John Y L, Cholesterol/physiology, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Feedback/physiology, Gene Expression Regulation/physiology, Humans, Liver Diseases/genetics/physiopathology, Liver/*physiology, NEOMED College of Medicine, Receptors

Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.

Bile acid synthesis is the major pathway for catabolism of cholesterol. Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme in the bile acid biosynthetic pathway in the liver and plays an important role in regulating lipid, glucose…

Tags: 2015, Animals, Bile acid metabolism, Bile Acids and Salts/genetics/*metabolism, Biochimica et biophysica acta, Cheng Jie, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/metabolism, CYP7A1, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism, Diet, farnesoid X receptor (FXR), Female, Ferrell Jessica M, Glucose/genetics/metabolism, Gonzalez Frank J, High-Fat/methods, Homeostasis, Inbred C57BL, Insulin Resistance, Intestinal Mucosa/metabolism, Jiang Changtao, Krausz Kristopher W, Li Tiangang, Lipid Metabolism/*physiology, lipidomics, Liver/metabolism, Male, Metabolome/*genetics, Metabolomics/methods, Mice, NEOMED College of Medicine, Obesity/genetics/*metabolism, Qi Yunpeng, Rats, Signal Transduction, tauro-beta-muricholic acid, Taurocholic Acid/analogs & derivatives/genetics/metabolism, Transgenic

Bile acid signaling in metabolic disease and drug therapy.

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile acids generates bile flow and facilitates hepatobiliary secretion…

Bile acids: regulation of synthesis.

Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear…

Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Biological, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Humans, Journal of lipid research, Models, NEOMED College of Medicine, Receptors, Signal Transduction/physiology

Binding of sequence-specific proteins to the 3'-untranslated region of vasoactive intestinal peptide mRNA.

Multimeric AUUUA elements in an AU-rich 3'-untranslated region (3'-UTR) have been shown to confer message instability to numerous ephemeral transcripts through the formation of RNA-protein complexes. We show here that the 3'-UTR of VIP mRNA, which…

Biocompatibility and in vivo tolerability of a new class of photoresponsive alkoxylphenacyl-based polycarbonates.

Potential toxicities of chromophoric or polymeric units of most photoresponsive delivery systems have impacted clinical relevance. Herein, we evaluated the biocompatibility and tolerability of alkoxylphenacyl-based polycarbonates (APPs) as a new…

Biocompatibility, efficacy and biodistribution of Gelucire-stabilized nanoparticles engineered for docetaxel delivery.

Docetaxel is a potent anticancer agent that will benefit greatly from alternative delivery systems that can overcome several reported adverse effects due to the drug itself and/or the solvent system in the current clinical formulation. In this…

Tags: *Biocompatible Materials, *Nanoparticles, 2012, Animals, Antineoplastic Agents/*administration & dosage/pharmacokinetics/pharmacology, Bi Lipeng, Department of Pharmaceutical Sciences, Docetaxel, Geldenhuys Werner J, Journal of nanoscience and nanotechnology, Macrophage Activation/drug effects, NEOMED College of Pharmacy, Oyewumi Moses O, Platelet Aggregation/drug effects, Rats, Reactive Oxygen Species/metabolism, Taxoids/*administration & dosage/pharmacokinetics/pharmacology, Tissue Distribution, Wehrung Daniel

Biphasic effects of ethanol tested with drug discrimination in HAD and LAD rats.

Seventh-generation selectively bred high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats were trained to make differential responses for ethanol (0.75 g/kg, IP) and saline vehicle, following postadministration intervals (PI) of 2 min…

Tags: 1992, Alcohol Drinking/genetics/*psychology, Animals, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Inbred Strains, Krimmer E C, Male, Pentobarbital/pharmacology, Pharmacology, biochemistry, and behavior, Rats, Serotonin Antagonists/pharmacology, Sleep/drug effects, Time Factors, Tropanes/pharmacology

Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC), considered to be one of the most lethal cancers with almost \textgreater 1 million deaths reported annually worldwide, remains a devastating disease with no known effective cure. Hence, chemopreventive strategies come…

Tags: *Phytotherapy, 2012, Alkylating Agents/toxicity, Animals, Anthocyanins/*therapeutic use, Antioxidants/therapeutic use, Barnes Kendra F, Bhatia Deepak, Bishayee Anupam, Blotting, Carcinoma, Current cancer drug targets, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diet, Diethylnitrosamine/toxicity, Experimental/chemically induced/metabolism/*prevention & control, Glutathione Transferase, Haznagy-Radnai Erzsebet, Hepatocellular/chemically induced/metabolism/*prevention & control, Hohmann Judit, Immunoenzyme Techniques, Lipid Peroxidation/drug effects, Liver Neoplasms, Male, Messenger/genetics, NEOMED College of Pharmacy, NF-E2-Related Factor 2/genetics/*metabolism, Nitric Oxide Synthase Type II/genetics/metabolism, Oxidative Stress/*drug effects, Rats, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Ribes/*chemistry, RNA, Signal Transduction, Sprague-Dawley, Thoppil Roslin J, Tyrosine/analogs & derivatives/metabolism, Western

Blockade of cocaine-induced conditioned place preference: relevance to cocaine abuse therapeutics.

Conditioned place preference/aversion testing is a behavioral method believed capable of measuring the affective (positive, neutral or negative) properties of psychoactive drugs. Cocaine injections in rats reliably produces a positive place…

Tags: 1995, Animals, Calcagnetti D J, Calcium Channel Blockers/pharmacology/therapeutic use, Cocaine/*antagonists & inhibitors, Conditioning (Psychology)/*drug effects, Humans, Keck B J, Life sciences, Narcotic Antagonists/pharmacology, Quatrella L A, Schechter M D, Serotonin Antagonists/pharmacology, Substance-Related Disorders/*drug therapy

Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen.

The effects of the GABAB receptor antagonist 2-hydroxy-saclofen were studied using intracellular recording of synaptic potential from CA1 hippocampal neurons.

Tags: 1989, Action Potentials/drug effects, Animals, Baclofen/*analogs & derivatives/pharmacology, GABA-A Receptor Antagonists, GABA-A/*physiology, Harrison N L, Hippocampus/drug effects/*physiology, In Vitro Techniques, Kerr D I, Lambert N A, Neural Inhibition/*drug effects, Neuroscience letters, Ong J, Prager R H, Rats, Receptors, Teyler T J

Body size and the small branch niche: using marsupial ontogeny to model primate locomotor evolution.

Recently proposed ancestral locomotor and morphological 'stages' leading to the evolution of primates have emphasized small body size, and a transition from a clawed non-grasping stage, to a clawed, grasping stage with clawless opposable hallux, to a…

Bone marrow SSEA1+ cells support the myocardium in cardiac pressure overload.

RATIONALE: Stage specific embryonic antigen 1+ (SSEA1+) cells have been described as the most primitive mesenchymal progenitor cell in the bone marrow. Cardiac injury mobilizes SSEA1+ cells into the peripheral blood but their in vivo function has not…

Brain reactive antibodies and the blood-brain barrier: observations in aging rodents and the effects of peripheral kainic acid.

This study was initiated to confirm the existence of brain-reactive autoantibodies and to determine if such antibodies have higher affinity for brain regions especially affected in Alzheimer's disease. Serum collected from 90, 300, and 600 day old…

Tags: 1987, Aging/*immunology/physiology, Albrecht J W, Animals, Autoantibodies/blood/*physiology, Blood-Brain Barrier/*drug effects, Boja J W, Brain/*immunology/physiology, Experimental aging research, Hippocampus/immunology/physiology, Hutton J T, Inbred C57BL, Inbred Strains, Kainic Acid/*pharmacology, Kulmala H K, Male, Mice, Rats

Brain-targeted delivery of doxorubicin using glutathione-coated nanoparticles for brain cancers.

OBJECTIVES: To prepare and characterize in vitro a novel brain-targeted delivery of doxorubicin using glutathione-coated nanoparticles (NPs) for the treatment of brain cancer. METHODS: Doxorubicin-loaded NPs were prepared by the nanoprecipitation…

Brain-targeted delivery of paclitaxel using glutathione-coated nanoparticles for brain cancers.

Paclitaxel is not effective for treatment of brain cancers because it cannot cross the blood-brain barrier (BBB) due to efflux by P-glycoprotein (P-gp). In this work, glutathione-coated poly-(lactide-co-glycolide) (PLGA) nanoparticles (NPs) of…

Tags: *Drug Delivery Systems, 2011, Adenosine Triphosphatases/metabolism, Animals, Antineoplastic Agents, ATP Binding Cassette Transporter, Blood-Brain Barrier/metabolism, Brain Neoplasms/drug therapy, Bui Thong, Cell Death/drug effects, Cell Line, Coumarins/administration & dosage/pharmacokinetics, Delayed-Action Preparations, Geldenhuys Werner, Glioma/drug therapy/pathology, Glutathione/*chemistry, Harrison Kimberly, Humans, Inbred C57BL, Journal of drug targeting, Male, Mbimba Thomas, Member 1/metabolism, Mice, Microtubules/metabolism, Nanoparticles, Paclitaxel/administration & dosage/*pharmacokinetics/pharmacology, Particle Size, Permeability, Phytogenic/administration & dosage/*pharmacokinetics/pharmacology, Rats, Subfamily B, Sutariya Vijaykumar, Thiazoles/administration & dosage/pharmacokinetics, Tubulin/metabolism, Tumor

Brain-targeted delivery of Tempol-loaded nanoparticles for neurological disorders.

Brain-targeted Tempol-loaded poly-(lactide-co-glycolide) (PLGA) nanoparticles (NPs) conjugated with a transferrin antibody (OX 26) were developed using the nanoprecipitation method. These NPs may have utility in treating neurodegenerative diseases…

Brainstem neurons with descending projections to the spinal cord of two elasmobranch fishes: thornback guitarfish, Platyrhinoidis triseriata, and horn shark, Heterodontus francisci.

We studied two cartilaginous fishes and described their brainstem supraspinal projections because most nuclei in the reticular formation can be identified that way. A retrogradely transported tracer, horseradish peroxidase or Fluoro-Gold, was…

Brief Stimulus Exposure Fully Remediates Temporal Processing Deficits Induced by Early Hearing Loss.

In childhood, partial hearing loss can produce prolonged deficits in speech perception and temporal processing. However, early therapeutic interventions targeting temporal processing may improve later speech-related outcomes. Gap detection is a…

Calcitonin gene-related peptide-receptor component protein expression in the uterine cervix, lumbosacral spinal cord, and dorsal root ganglia.

The neuropeptide calcitonin gene-related peptide (CGRP) may play a role in neurogenic inflammation, tissue remodeling of the uterine cervix, promoting vasodilation, parturition, and processing of sensory information in the spinal cord.…

Tags: 2002, Animals, Calcitonin Gene-Related Peptide/*biosynthesis/immunology/metabolism, Cervix Uteri/*metabolism, Dickerson I M, Female, Ganglia, Lumbosacral Region, Papka R E, Peptides, Pokabla M J, Rats, Receptors, Spinal Cord/*metabolism, Spinal/*metabolism, Sprague-Dawley, Uterus/metabolism

Calcium channel blockade attenuates angiotensin II-induced drinking in rats.

Lateral ventricular administration of angiotensin II (ANG II) produces potent dipsogenic effects in water-sated rats. ANG II seems to require functional voltage-gated calcium channels on neurons throughout circumventricular brain sites to exert its…

Tags: 1993, Amino Acid Sequence, Angiotensin II/*antagonists & inhibitors/pharmacology, Animals, Brain research bulletin, Calcagnetti D J, Calcium Channel Blockers/administration & dosage/*pharmacology, Dimethyl Sulfoxide/pharmacology, Dose-Response Relationship, Drinking Behavior/*drug effects, Drug, Injections, Intraventricular, Isradipine/pharmacology, Male, Molecular Sequence Data, Rats, Schechter M D, Sprague-Dawley

Calculation of the reflection coefficient from measurements of endogenous vascular indicators.

The solvent drag reflection coefficient (sigma) for total proteins can be estimated by comparing the relative degrees of concentration of erythrocytes and plasma proteins that occur during fluid filtration in an isolated perfused organ. In this…

Tags: 1988, Animals, Blood Proteins/*analysis, Blood Volume, Capillary Permeability, Filtration, Humans, Journal of applied physiology (Bethesda, Md. : 1985), Maron M B, Mathematics, Methods, Models, Pilati C F, Theoretical

Calretinin-immunoreactive nerves in the uterus, pelvic autonomic ganglia, lumbosacral dorsal root ganglia and lumbosacral spinal cord.

Nerves containing the calcium-binding protein calretinin have been reported in several organs but not in female reproductive organs and associated ganglia. This study was undertaken to determine if nerves associated with the uterus contain calretinin…

Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials.

Resveratrol (3,4',5-trihydroxy-trans-stilbene) is a dietary polyphenol derived from grapes, berries, peanuts, and other plant sources. During the last decade, resveratrol has been shown to possess a fascinating spectrum of pharmacologic properties.…

Tags: 2009, Animals, Antineoplastic Agents/*therapeutic use, Bishayee Anupam, Cancer prevention research (Philadelphia, Pa.), Clinical Trials as Topic, Humans, Neoplasms/*prevention & control, Resveratrol, Stilbenes/*therapeutic use

Candyflipping': synergistic discriminative effect of LSD and MDMA.

The co-administration of D-lysergic acid diethylamide (LSD; 'Acid') and 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy'; 'XTC'), has reached a prevalence that has allowed for the street terminology 'candyflipping' to describe the combination.…

Tags: 1998, 4-methylenedioxyamphetamine/administration & dosage/*pharmacology, Animal/*drug effects, Animals, Behavior, Discrimination Learning/*drug effects, Drug Synergism, European journal of pharmacology, Hallucinogens/administration & dosage/*pharmacology, Lysergic Acid Diethylamide/administration & dosage/*pharmacology, Male, N-Methyl-3, Rats, Schechter M D, Serotonin Agents/administration & dosage/*pharmacology

Canertinib induces ototoxicity in three preclinical models.

Neuregulin-1 (NRG1) ligand and its epidermal growth factor receptor (EGFR)/ERBB family regulate normal cellular proliferation and differentiation in many tissues including the cochlea. Aberrant NRG1 and ERBB signaling cause significant hearing…

Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury.

The liver is a major organ that controls hepatic and systemic homeostasis. Dysregulation of liver metabolism may cause liver injury. Previous studies have demonstrated that carboxylesterase 1 (CES1) regulates hepatic triglyceride metabolism and…

Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice.

UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease that ranges from simple steatosis to nonalcoholic steatohepatitis (NASH). So far, the underlying mechanism remains poorly understood. Here, we show that hepatic…

Tags: *Lipid Metabolism, 2016, Adiposity, Animals, Carboxylesterase/*metabolism, Carboxylic Ester Hydrolases/genetics/*metabolism, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Endoplasmic Reticulum Stress, Energy Metabolism, Experimental/enzymology, Gene Knockdown Techniques, Glucose Tolerance Test, Glucose/metabolism, Hepatocyte Nuclear Factor 4/*metabolism, Hepatology (Baltimore, Md.), High-Fat/adverse effects, Homeostasis, Humans, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Li Yuanyuan, Lipogenesis, Lipolysis, Liver/enzymology, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*etiology/metabolism, Obesity/enzymology/etiology, Sterol Regulatory Element Binding Protein 1/metabolism, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao

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