Browse Items (47 total)
- Tags: Gene Expression Regulation
Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.
Tags: 2016, Adapala R K, Animals, Calcium Signaling/genetics, Cappelli H C, Carcinoma, Cell Line, Cell Proliferation/drug effects, Chilian W M, Cisplatin/administration & dosage, Department of Integrative Medical Sciences, Dudley A C, Endothelium, Gene Expression Regulation, Ghosh K, Humans, Ingber D E, Keshamouni V, Klagsbrun M, Leucine/administration & dosage/analogs & derivatives, Lewis Lung/drug therapy/*genetics/pathology, Meszaros J G, Mice, NEOMED College of Medicine, Neoplastic/drug effects, Neovascularization, Oncogene, Paruchuri S, Pathologic/drug therapy/*genetics/pathology, Sulfonamides/administration & dosage, Thodeti C K, Thoppil R J, TRPV Cation Channels/agonists/biosynthesis/*genetics, Tumor, Vascular Endothelial Growth Factor A/genetics, Vascular/drug effects/*pathology
Interleukin-1beta induced Stress Granules Sequester COX-2 mRNA and Regulates its Stability and Translation in Human OA Chondrocytes.
Tags: *Protein Biosynthesis, 2016, Ansari Mohammad Y, Cells, Chondrocytes/drug effects/metabolism/pathology, Cultured, Cyclooxygenase 2/*genetics, Department of Anatomy & Neurobiology, Dinoprostone/genetics, Fluorescence, Gene Expression Regulation, Haqqi Tariq M, Humans, Immunoprecipitation, In Situ Hybridization, Interleukin-1beta/administration & dosage/*genetics, Messenger/genetics, NEOMED College of Medicine, Nitric Oxide/metabolism, Osteoarthritis/drug therapy/*genetics/pathology, RNA, Scientific reports
Osteoactivin regulates head and neck squamous cell carcinoma invasion by modulating matrix metalloproteases.
Tags: *Cell Movement, 2018, Arosarena Oneida A, Barr Eric W, Carcinoma, Cell Line, cell lines, Department of Anatomy & Neurobiology, Enzymologic, Extracellular Matrix, Gene Expression Regulation, Head and Neck Neoplasms/*enzymology/genetics/pathology, Human, Humans, Journal of cellular physiology, matrix metalloproteinases, Membrane Glycoproteins/genetics/*metabolism, Messenger/genetics/metabolism, NEOMED College of Medicine, neoplasm invasion, Neoplasm Invasiveness, Neoplastic, RNA, RNA Interference, Safadi Fayez F, Secreted/genetics/*metabolism, Signal Transduction, Squamous Cell Carcinoma of Head and Neck, Squamous Cell/*enzymology/genetics/pathology, Tarr Joseph T, Thorpe Ryan, Transfection, Tumor, Yankey Hilary
Osteoactivin Promotes Migration of Oral Squamous Cell Carcinomas.
Tags: *Cell Movement, 2016, Arosarena Oneida A, Barr Eric W, Bryant Evan, Carcinoma, Cell Adhesion, Cell Line, Cell Proliferation, Cell Survival, Dela Cadena Raul A, Denny Michael F, Department of Anatomy & Neurobiology, Enzyme Activation, Gene Expression Regulation, Head and Neck Neoplasms/genetics/*metabolism/pathology, Humans, Integrin beta1/metabolism, Journal of cellular physiology, Membrane Glycoproteins/genetics/*metabolism, Messenger/metabolism, Mitogen-Activated Protein Kinases/metabolism, Mouth Neoplasms/genetics/*metabolism/pathology, NEOMED College of Medicine, Neoplasm Invasiveness, Neoplastic, Protein Binding, RNA, RNA Interference, Safadi Fayez F, Signal Transduction, Squamous Cell Carcinoma of Head and Neck, Squamous Cell/genetics/*metabolism/pathology, Thorpe Ryan, Time Factors, Transfection, Tumor
Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.
Tags: *Punicaceae/chemistry, 10-Dimethyl-1, 2-benzanthracene, 2016, 9, Animal Studies, Animals, Anticarcinogenic Agents/*therapeutic use, Apoptosis, Apoptosis/*drug effects, Bhatia Deepak, Bhattacharyya Piyali, Bishayee Anupam, Breast Neoplasms – Mortality, Breast Neoplasms – Prevention and Control, Breast Neoplasms – Risk Factors, Cell Physiology, Cell Proliferation/*drug effects, Diet – Evaluation, Experimental/pathology/*prevention & control, Female, Funding Source, Gene Expression Regulation, Genes, Human, Immunohistochemistry, Mammary Neoplasms, Mandal Animesh, Mutation, National Institutes of Health (U.S.), Neoplasms – Prevention and Control, Nutrition and cancer, Phytotherapy, Pomegranate, Proto-Oncogene Proteins c-bcl-2/analysis, Rats, Sprague-Dawley, Tamoxifen, United States
Alterations in gene array patterns in dendritic cells from aged humans.
Tags: *Gene Expression Profiling, *Transcriptome, 2014, 80 and over, Adaptive Immunity/genetics, Adult, Age Factors, Aged, Agrawal Anshu, Antigen-Presenting Cells/immunology/metabolism, Cao Jia-ning, Cluster Analysis, Dendritic Cells/immunology/*metabolism, Female, G1 Phase, Gene Expression Regulation, Gupta Sudhir, Healthy Volunteers, Humans, Immunity, Innate/genetics, Jia Zhenyu, Male, PloS one, Sharman Edward, Young Adult
Regulation of bile acid synthesis.
Tags: 1998, Animals, Bile Acids and Salts/*biosynthesis, Chiang J Y, Cholestanetriol 26-Monooxygenase, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cholesterol/metabolism, Cytochrome P-450 Enzyme System/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, Frontiers in bioscience : a journal and virtual library, Gene Expression Regulation, Humans, Liver/metabolism, NEOMED College of Medicine, Steroid 12-alpha-Hydroxylase/metabolism, Steroid Hydroxylases/metabolism
Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter.
Tags: *Promoter Regions, 1994, Animals, Antigens, Base Sequence, Bile Acids and Salts/*metabolism, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cloning, Deoxyribonuclease I, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Gene Expression Regulation, Genetic, Humans, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Nuclear Proteins/metabolism, Oligodeoxyribonucleotides, Polyomavirus Transforming/genetics, Rats, Recombinant Fusion Proteins/genetics/metabolism, Sprague-Dawley, Stroup D, The Journal of biological chemistry, Thyroid Hormones/genetics
Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism.
Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Chiang John Y L, Department of Integrative Medical Sciences, Expert opinion on drug metabolism & toxicology, Gene Expression Regulation, Genetic Predisposition to Disease, Hepatocyte Nuclear Factor 4/genetics/*metabolism, Humans, Lipid Metabolism, Liver/metabolism, Mutation, NEOMED College of Medicine, Pharmaceutical Preparations/*metabolism, Signal Transduction/physiology
Inhibition of human papillomavirus type 16 gene expression by nordihydroguaiaretic acid plant lignan derivatives.
Tags: 2000, Antiviral Agents/*pharmacology, Antiviral research, Callahan M, Craigo J, Cultured, DeLucia A L, Department of Integrative Medical Sciences, Female, Gene Expression Regulation, Genetic/drug effects, HIV Long Terminal Repeat/drug effects, Huang R C, Humans, Lignans/chemistry/pharmacology, Masoprocol/*analogs & derivatives/*pharmacology, NEOMED College of Medicine, Papillomaviridae/*genetics, Promoter Regions, Simian virus 40/genetics, Tumor Cells, Viral/*drug effects
Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells.
Tags: 1994, Animals, Bile Acids and Salts/*pharmacology, Biochemical and biophysical research communications, Cells, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Crestani M, Cultured, Department of Integrative Medical Sciences, Enzymologic/*drug effects, Gene Expression Regulation, Genetic, Genetic/genetics, Humans, Karam W G, Luciferases/biosynthesis/genetics, Messenger/*biosynthesis, NEOMED College of Medicine, Promoter Regions, Rats, Recombinant Fusion Proteins/biosynthesis, RNA, Steroids/*pharmacology, Thyroid Hormones/*pharmacology, Transcription, Transfection
Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7).
Tags: *Promoter Regions, *Transcription, 1995, Animals, Base Sequence, Cell Count, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Crestani M, Cultured, Cyclic AMP/pharmacology, Department of Integrative Medical Sciences, Enzymologic/*physiology, Gene Expression Regulation, Genetic, Hormones/*pharmacology, Journal of lipid research, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Phorbol Esters/pharmacology, Rats, Second Messenger Systems/physiology, Stroup D, Transfection, Tumor Cells
Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes.
Tags: *Ceruloplasmin, *Deamidation, *Heavy water metabolic labeling, *High resolution mass spectrometry, *Iron metabolism, *LC-MS/MS, *Non-enzymatic glycation, *Oxidative Stress, *Protein Processing, *Proteome dynamics, *Serotransferrin, *Type 2 diabetes mellitus, 2017, Adult, Amino Acid Sequence, Bena James, Case-Control Studies, Ceruloplasmin/genetics/*metabolism, Department of Pharmaceutical Sciences, Deuterium/metabolism, Diabetes Mellitus, Diabetic, Diet, Female, Free radical biology & medicine, Gene Expression Regulation, Glycated Hemoglobin A/genetics/metabolism, Glycosylation, Golizeh Makan, Humans, Ilchenko Serguei, Iron/*metabolism, Isotope Labeling, Kashyap Sangeeta R, Kasumov Takhar, Lee Kwangwon, Male, Middle Aged, NEOMED College of Pharmacy, Osme Abdullah, Oxidation-Reduction, Oxidative Stress, Post-Translational, Proteolysis, Sadygov Rovshan G, Transferrin/genetics/*metabolism, Type 2/diet therapy/genetics/*metabolism/pathology
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Tags: *Cytochrome P-450 Enzyme System/genetics/metabolism/physiology, 2008, Animals, Biochemical pharmacology, Cytochrome P-450 CYP4A/genetics/metabolism/physiology, Department of Integrative Medical Sciences, Enzymologic, Fatty Acids/*metabolism, Gene Expression Regulation, Hardwick James P, Humans, Metabolic Diseases/enzymology/*metabolism, NEOMED College of Medicine
Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol.
Tags: 2013, Alcohol-Induced Injury, Alcoholic Liver Disease, Alcoholic/genetics/*metabolism/prevention & control, Animals, Cannabinoid, CB1/*physiology, Chiang John Y L, Choi Hueng-Sik, Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 CYP2E1/genetics/*metabolism, Department of Integrative Medical Sciences, Enzyme Inhibitors/pharmacology/therapeutic use, Enzymologic/drug effects/physiology, Estrogen/deficiency/genetics/*physiology, Ethanol/pharmacology, Gene Expression Profiling/methods, Gene Expression Regulation, Gene Regulation, Genetic/physiology, Gut, Inbred C57BL, Jang Hyun-Hee, Jeong Won-Il, Kim Don-Kyu, Kim Jung Ran, Kim Yong-Hoon, Knockout, Koh Minseob, Koo Seung-Hoi, Lee Chul-Ho, Liver, Liver Diseases, Liver Metabolism, Liver/metabolism, Male, Mice, NEOMED College of Medicine, Oxidation-Reduction, Oxidative Stress/physiology, Park Jinyoung, Park Seung Bum, Park Tae-Sik, Receptor, Receptors, Signal Transduction/drug effects/physiology, Tamoxifen/analogs & derivatives/pharmacology/therapeutic use, Transcription, Yun Chul-Ho
All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade.
Tags: 2014, Animals, Axe David, Basic Helix-Loop-Helix Transcription Factors/genetics, Blood Glucose/analysis, Chiang John Y L, Cook Aaron, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Fatty Liver/*drug therapy/metabolism, Gene Expression Regulation, Genetic, Hardwick James P, Hepatology (Baltimore, Md.), Inbred C57BL, Kim Chun-Ki, Kim Seong-Chul, Lee Mikang, Lee Yoon-Kwang, Li Tiangang, Lipid Metabolism, Liver/metabolism, Male, Mice, Moore David D, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease, PPAR gamma/*genetics, Receptors, Repressor Proteins/genetics, Retinoic Acid Receptor alpha, Retinoic Acid/physiology, Smallwood Nicole, Transcription, Tretinoin/pharmacology/*therapeutic use
Coordinate down-regulation of cartilage matrix gene expression in Bcl-2 deficient chondrocytes is associated with decreased SOX9 expression and decreased mRNA stability.
Tags: 2003, Aggrecans, Animals, C-Type, Cell Line, Chondrocytes/*physiology, Collagen Type II/genetics/metabolism, Dactinomycin, Down-Regulation, Extracellular Matrix Proteins/analysis/genetics/*metabolism, Gene Expression Regulation, Glycoproteins/analysis/genetics/*metabolism, High Mobility Group Proteins/genetics/*metabolism, Horton Walter E Jr, Journal of cellular biochemistry, Kinkel Mary D, Lectins, Matrilin Proteins, Messenger/analysis/biosynthesis, Polymerase Chain Reaction/methods, Proteoglycans/genetics/metabolism, Proto-Oncogene Proteins c-bcl-2/deficiency/genetics/*physiology, Rats, RNA, RNA Stability, Signal Transduction, SOX9 Transcription Factor, Transcription Factors/genetics/*metabolism, Transfection
Age-related expression patterns of Bag-1 and Bcl-2 in growth plate and articular chondrocytes.
Tags: 2004, Aging/*metabolism, Animals, Articular/cytology/*metabolism, Carrier Proteins/genetics/*metabolism, Cartilage, Cell Division/physiology, Cells, Chondrocytes/cytology/*metabolism, Cultured, Department of Anatomy & Neurobiology, DNA-Binding Proteins, Gene Expression Regulation, Growth Plate/*metabolism, Horton Walter E Jr, Inbred C57BL, Kinkel Mary D, McBurney Denise, Mice, NEOMED College of Medicine, Nugent Ashleigh, Proto-Oncogene Proteins c-bcl-2/*metabolism, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology, Tissue Distribution, Transcription Factors, Yagi Rieko
Lipopolysaccharide supports maintaining the stemness of CD133(+) hepatoma cells through activation of the NF-kappaB/HIF-1alpha pathway.
Tags: *Cancer stem cells, *Lipopolysaccharide, *Plasticity, *Stemness maintenance, *Tumor microenvironment, 2016, AC133 Antigen/genetics/*metabolism, alpha Subunit/genetics/*metabolism, Animals, Antineoplastic Agents – Pharmacodynamics, Antineoplastic Agents/pharmacology, Body Weights and Measures, Cancer letters, Carcinoma, Cell Line, Cell Movement – Drug Effects, Cell Movement/drug effects, Cell Physiology, Cell Physiology – Drug Effects, Cell Proliferation/drug effects, Department of Integrative Medical Sciences, Drug Resistance, Gene Expression Regulation, Genes, Genetic Techniques, Han Zhi-Peng, Hepatocellular, Hepatocellular – Drug Therapy, Hepatocellular – Metabolism, Hepatocellular – Pathology, Hepatocellular/drug therapy/genetics/*metabolism/pathology, Humans, Hypoxia-Inducible Factor 1, Inbred BALB C, Jing Ying-Ying, Lai Fo-Bao, Li Rong, Li Xiao-Yong, Lipopolysaccharides – Pharmacodynamics, Lipopolysaccharides/*pharmacology, Liu Jing-Feng, Liu Wen-Ting, Liver Neoplasms, Liver Neoplasms – Drug Therapy, Liver Neoplasms – Metabolism, Liver Neoplasms – Pathology, Liver Neoplasms/drug therapy/genetics/*metabolism/pathology, Male, Mice, NEOMED College of Medicine, Neoplasm, Neoplasm Invasiveness, Neoplastic, Neoplastic Stem Cells/*drug effects/metabolism/pathology, NF-kappa B – Metabolism, NF-kappa B/*metabolism, Nude, Pan Xiao-Rong, Phenotype, Proteins, Proteins – Metabolism, RNA Interference, Shi Rong-Yu, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Stem Cells – Drug Effects, Stem Cells – Metabolism, Stem Cells – Pathology, Time Factors, Transfection, Tumor Burden, Tumor Microenvironment, Wei Li-Xin, Wu Meng-Chao, Yang Xue, Yu Guo-Feng, Zeng Jian-Xing, Zhang Hang-Jie, Zhang Ping, Zhao Qiu-Dong
Aflatoxin B1 metabolism by 3-methylcholanthrene-induced hamster hepatic cytochrome P-450s.
Tags: 1990, Aflatoxin B1, Aflatoxins/immunology/*metabolism, Animals, Antibodies/immunology, Chiang J Y, Cricetinae, Cytochrome P-450 Enzyme System/biosynthesis/isolation & purification/*metabolism, Department of Integrative Medical Sciences, Enzyme Induction/drug effects, Enzymologic, Gene Expression Regulation, Inbred Strains, Journal of biochemical toxicology, Lai T S, Liver/drug effects/*enzymology, Liver/enzymology, Mesocricetus, Methylcholanthrene/*pharmacology, Microsomes, Mutagenicity Tests, NEOMED College of Medicine, Rats, Salmonella typhimurium/enzymology/genetics, Subcellular Fractions/drug effects/enzymology
Rat alpha(2)-macroglobulin inhibits NGF-promoted neurite outgrowth, TrK phosphorylation, and gene expression of pheochromocytoma PC12 cells.
Tags: 1999, Adrenal Gland Neoplasms/metabolism, alpha-Macroglobulins/*pharmacology, Animals, Gene Expression Regulation, Journal of neuroscience research, Koo P H, Lee P G, Neoplastic/*drug effects, Nerve Growth Factors/*antagonists & inhibitors, Neurites/*drug effects, PC12 Cells, Pheochromocytoma/metabolism, Phosphorylation, Proto-Oncogene Proteins c-jun/genetics, Rats, Receptor, Sprague-Dawley, trkA/*metabolism
Establishing reliable miRNA-cancer association network based on text-mining method.
Tags: 2014, Algorithms, Area Under Curve, Computational and mathematical methods in medicine, Computational Biology/*methods, Data Mining/*methods, False Positive Reactions, Fang Ming, Gene Expression Profiling/methods, Gene Expression Regulation, Gene Regulatory Networks, Hu Xingchi, Humans, Jia Zhenyu, Li Lun, MicroRNAs/*genetics/*metabolism, Neoplasms/*genetics/metabolism, Neoplastic, Probability, Reproducibility of Results, Yang Zhaowan, Zhang Libin, Zhou Yanhong
Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells.
Tags: 2006, Bile Acids and Salts/*metabolism, Cells, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cultured, Cytokines/*metabolism, Department of Integrative Medical Sciences, Gene Expression Regulation, Genetic, Hepatocytes/*cytology/drug effects, Hepatology (Baltimore, Md.), Humans, Immunoblotting, In Vitro Techniques, Interleukin-1/pharmacology, Jahan Asmeen, Li Tiangang, Messenger/analysis, NEOMED College of Medicine, Probability, Proto-Oncogene Proteins c-jun/*metabolism, Reverse Transcriptase Polymerase Chain Reaction, RNA, Sensitivity and Specificity, Signal Transduction/genetics, Transcription
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.
Tags: 2009, Adenoviridae/genetics, Animals, Bile Acids and Salts/biosynthesis, Biochimica et biophysica acta, Cell Line, Cell Nucleus/drug effects/metabolism, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*antagonists & inhibitors/genetics/metabolism, Department of Integrative Medical Sciences, Dietary Fats/*administration & dosage/*pharmacology, Down-Regulation/drug effects, Enzymologic/drug effects, Feeding Behavior/*drug effects, Forkhead Box Protein O1, Forkhead Transcription Factors/genetics/*metabolism, Gene Expression Regulation, Gene Knockdown Techniques, Gene Transfer Techniques, Hepatocytes/drug effects/*enzymology, Humans, Inbred C57BL, Insulin Resistance, Insulin/metabolism, Lee Yoon-Kwang, Li Tiangang, Ma Huiyan, Male, Messenger/genetics/metabolism, Mice, Moore David D, NEOMED College of Medicine, Park Young Joo, RNA, RNA Interference/drug effects, Strom Stephen, Tumor
miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes.
Tags: *Apoptosis, 2015, 3' Untranslated Regions, Aged, Chondrocytes/*metabolism/pathology, Department of Anatomy & Neurobiology, Down-Regulation, Experimental & molecular medicine, Female, Gene Expression Regulation, Haqqi Tariq M, Humans, Interleukin-6/*genetics, Makki Mohammad Shahidul, Male, Messenger/genetics, MicroRNAs/*genetics, Middle Aged, NEOMED College of Medicine, Osteoarthritis/*genetics/pathology, Ribonucleases/*genetics, RNA, Transcription Factors/*genetics, Up-Regulation
Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-kappaB and Nrf2 Signaling Pathways.
Tags: 10-Dimethyl-1, 2-benzanthracene/toxicity, 2017, 9, Animal Studies, Animals, Anti-Inflammatory Agents/*pharmacology, anti-inflammatory effects, Anticarcinogenic Agents/pharmacology, Apoptosis/drug effects, Bhatia Deepak, Bishayee Anupam, Breast Neoplasms, breast tumor, Cell Transformation, Chemoprevention, COX-2, Cyclooxygenase 2/genetics/metabolism, DMBA, Dose-Response Relationship, Drug, Experimental/*prevention & control, Female, Gene Expression Regulation, HSP90, HSP90 Heat-Shock Proteins/genetics/metabolism, I-kappa B Kinase/genetics/metabolism, Inflammation Mediators, Mammary Neoplasms, Mandal Animesh, Neoplasms – Prevention and Control, Neoplastic, Neoplastic/drug effects, NF-E2-Related Factor 2/genetics/*metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, Nrf2, Nutrients, Physical Education and Training, Plant Preparations/*pharmacology, Pomegranate, Punica granatum, Punicaceae/*chemistry, Rats, Signal Transduction
Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *DNA-Binding Proteins, *Regulatory Sequences, 2000, Animals, Anticholesteremic Agents/pharmacology, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Clofibric Acid/pharmacology, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Enzymologic, Gene Expression Regulation, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Marrapodi M, Models, NEOMED College of Medicine, Nucleic Acid, Peroxisome Proliferators/pharmacology, Phosphoproteins/metabolism, Promoter Regions, Protein Binding, Pyrimidines/pharmacology, Rats, Receptors, Reporter, Response Elements, Retinoic Acid/metabolism, Retinoid X Receptors, Species Specificity, Transcription, Transcription Factors/*agonists/metabolism, Transcriptional Activation
MiR-21 enhances melanoma invasiveness via inhibition of tissue inhibitor of metalloproteinases 3 expression: in vivo effects of MiR-21 inhibitor.
Tags: 2015, Carson Mary, Carson William E 3rd, Cell Line, Cell Movement/genetics, Cell Proliferation/genetics, Chan Anthony N, Dao Thao-Vi, Fairchild Ene T, Ganju Akaansha, Gene Expression Regulation, Grignol Valerie P, Humans, Jaime-Ramirez Alena Cristina, Karpa Volodymyr I, Latchana Nicholas, Levine Kala M, Martin del Campo Sara E, Melanoma/*genetics/metabolism/pathology, MicroRNAs/*genetics/metabolism, Neoplasm Invasiveness/*genetics/pathology, Neoplastic, PloS one, RNA, Skin Neoplasms/*genetics/metabolism/pathology, Small Interfering, Tissue Inhibitor of Metalloproteinase-3/*genetics/metabolism, Tumor
The nature and role of periosteum in bone and cartilage regeneration.
Tags: 2011, Animals, Bone Regeneration/genetics/*physiology, Cartilage/*physiology, Cattle, Cells, tissues, organs, Collagen Type I/genetics/metabolism, Collagen Type II/genetics/metabolism, Core Binding Factor Alpha 1 Subunit/genetics/metabolism, Gene Expression Regulation, Integrin-Binding Sialoprotein/genetics/metabolism, Isogai Noritaka, Jacquet Robin, Landis William J, Lowder Elizabeth, Matsushima Seika, Mice, Nude, Periosteum/anatomy & histology/diagnostic imaging/*physiology, Prosthesis Implantation, Radiography, Tissue Engineering, Tissue Scaffolds, Tokui Taku
TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review).
Tags: *Disease Susceptibility, *Signal Transduction, 2018, Animals, Carrier Proteins/chemistry/genetics/*metabolism, Gene Expression Regulation, Humans, Hussein Nazar J, International journal of molecular medicine, Mbimba Thomas, Najeed Ayesha, Protein Binding, Protein Interaction Domains and Motifs, Protein Transport, Safadi Fayez F, Structure-Activity Relationship
LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis.
Tags: 2016, Affo Silvia, Alcoholic/*immunology, Altamirano Jose, Animals, Arroyo Vicente, Bataller Ramon, Caballeria Juan, Cell Proliferation, Cells, Chen Jiegen, Collagen/genetics/metabolism, Common/*pathology, Crews Fulton, Cultured, Department of Pharmaceutical Sciences, Dumitru Raluca, Female, Gene Expression Profiling, Gene Expression Regulation, Gines Pere, Hepatic Duct, Hepatitis, Hepatocytes/*metabolism/pathology, Humans, Inbred BALB C, Keratins, Knockout, Lipopolysaccharides/metabolism, Lozano Juan Jose, Male, Matsushita Hiroshi, Mice, Middle Aged, Morales-Ibanez Oriol, NEOMED College of Pharmacy, Odena Gemma, Rautou Pierre-Emmanuel, Rodrigo-Torres Daniel, Sancho-Bru Pau, Scientific reports, Seki Ekihiro, Signal Transduction, Toll-Like Receptor 4/genetics/*metabolism, Type I/genetics/*metabolism, Valla Dominique, You Min, Zou Jian
Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner.
Tags: 2015, Animals, Cytochrome P-450 CYP2D6/*biosynthesis, Cytochrome P-450 Enzyme Inhibitors/*pharmacology, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Drug metabolism and disposition: the biological fate of chemicals, Enzymologic/drug effects, Gene Expression Regulation, Genetic/drug effects/genetics, HEK293 Cells, Hepatocytes/drug effects/enzymology/metabolism, Humans, Isoxazoles/*pharmacology, Jeong Hyunyoung, Knockout, Lee Yoon-Kwang, Mice, NEOMED College of Medicine, Pan Xian, Receptors, Transcription, Transgenic
Osteoactivin induces transdifferentiation of C2C12 myoblasts into osteoblasts.
Tags: 2014, Abdelmagid Samir M, Alkaline Phosphatase/biosynthesis, Animals, Cell Line, Cell Transdifferentiation/*genetics, Core Binding Factor Alpha 1 Subunit/biosynthesis, Crowder Douglas C, Department of Anatomy & Neurobiology, Developmental/genetics, Eye Proteins/*genetics/metabolism, Focal Adhesion Protein-Tyrosine Kinases/biosynthesis, Gene Expression Regulation, Humans, Journal of cellular physiology, Lababidi Suzanne L, Membrane Glycoproteins/*genetics/metabolism, Mice, Moussa Fouad M, Myoblasts/cytology/*metabolism, NEOMED College of Medicine, Osteoblasts/cytology/*metabolism, Safadi Fayez F, Salihoglu Sibel, Sondag Gregory R
Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis.
Tags: *Gluconeogenesis, 2006, 8-Bromo Cyclic Adenosine Monophosphate/*pharmacology, Adolescent, Bile Acids and Salts/*biosynthesis, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Chromatin/metabolism, Cultured, Cyclic AMP-Dependent Protein Kinases/physiology, Department of Integrative Medical Sciences, Enzymologic/*drug effects, Female, Gene Expression Regulation, Genetic/drug effects, Glucagon/*pharmacology, Hepatocyte Nuclear Factor 4/genetics/metabolism, Hepatocytes/*enzymology, Hepatology (Baltimore, Md.), Humans, Male, Messenger/analysis, Middle Aged, NEOMED College of Medicine, Organ Specificity, Phosphorylation, RNA, Song Kwang-Hoon, Transcription
A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.
Tags: 2010, 3' Untranslated Regions/genetics, Base Sequence, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Department of Integrative Medical Sciences, Enzymologic/drug effects/*genetics, Fibroblast Growth Factors/pharmacology, Gene Expression Regulation, Genetic/drug effects/genetics, Hep G2 Cells, Hepatocytes/drug effects/enzymology/*metabolism, Humans, Isoxazoles/pharmacology, Journal of lipid research, Li Tiangang, MicroRNAs/*genetics/*metabolism, NEOMED College of Medicine, Oligonucleotide Array Sequence Analysis, Owsley Erika, Post-Transcriptional/drug effects/genetics, RNA Processing, Song Kwang-Hoon, Transcription
Developmental basis for hind-limb loss in dolphins and origin of the cetacean bodyplan.
Tags: *Body Patterning, 2006, Animals, Bajpai S, Cell Polarity, Cohn M J, Department of Anatomy & Neurobiology, Developmental, Dolphins/*embryology/genetics/metabolism, Gene Expression Regulation, Heyning J, Hindlimb/cytology/*embryology/metabolism, Horton W E Jr, Limb Buds/cytology/embryology/metabolism, NEOMED College of Medicine, Phylogeny, Proceedings of the National Academy of Sciences of the United States of America, Stevens L S, Thewissen J G M
Why adult mammalian intrafusal and extrafusal fibers contain different myosin heavy-chain isoforms.
Tags: *Muscle Development, 1999, Afferent Pathways/physiology, Aging/metabolism, Animals, Cell Lineage, Developmental, Fetal Proteins/metabolism, Gene Expression Regulation, Knockout, Kucera J, Mammals/anatomy & histology/*metabolism, Mice, Morphogenesis, Muscle, Muscle Contraction, Muscle Fibers, Muscle Proteins/deficiency/physiology, Muscle Spindles/physiology, Myosin Heavy Chains/*metabolism, Nerve Tissue Proteins/deficiency/physiology, Protein Isoforms/*metabolism, Rats, Skeletal/*chemistry/classification, Skeletal/chemistry/embryology/*growth & development/ultrastructure, Transgenic, Trends in neurosciences, Walro J M
Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells.
Tags: *Promoter Regions, *Transcription, *Transcription Factors, 1996, Base Sequence, Binding Sites, Cell Line, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Consensus Sequence, Crestani M, Department of Integrative Medical Sciences, DNA-Binding Proteins/genetics/metabolism, Enzyme Repression, Enzymologic/*drug effects, Galli G, Gene Expression Regulation, Genes, Genetic, Glucocorticoid/genetics/metabolism, Glucocorticoids/pharmacology, Hepatocyte Nuclear Factor 3-alpha, Humans, Insulin/pharmacology, Journal of lipid research, Marrapodi M, Molecular Sequence Data, NEOMED College of Medicine, Nuclear Proteins/genetics/metabolism, Phorbol Esters/pharmacology, Receptors, Recombinant Fusion Proteins/biosynthesis, Reporter, Stroup D, Thyroid Hormones/pharmacology, Transfection, Wang D P
Binding of sequence-specific proteins to the 3'-untranslated region of vasoactive intestinal peptide mRNA.
Tags: 1995, Animals, Anterior/*metabolism, Base Sequence, Binding, Biochemical and biophysical research communications, Competitive, Cytoplasm/chemistry, Gene Expression Regulation, Genomic Library, Male, Messenger/*metabolism, Molecular Sequence Data, Pituitary Gland, Post-Transcriptional, Protein Binding, Proto-Oncogene Proteins c-fos/genetics, Rats, RNA, RNA Processing, RNA-Binding Proteins/*metabolism, RNA/metabolism, Signs S A, Sprague-Dawley, Subcellular Fractions, Tissue Distribution, Vasoactive Intestinal Peptide/*genetics, Wolford J K
Transcriptional regulation of human oxysterol 7 alpha-hydroxylase gene (CYP7B1) by Sp1.
Tags: 2001, Base Sequence, Binding, Binding Sites/genetics, Cell Line, Chiang J Y, Competitive, CpG Islands/genetics, Cultured, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA/genetics, Enzymologic, gene, Gene Expression Regulation, Genetic, Humans, Luciferases/genetics/metabolism, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid/genetics, Protein Binding, Recombinant Fusion Proteins/genetics/metabolism, Regulatory Sequences, Sequence Deletion, Site-Directed, Sp1 Transcription Factor/metabolism/*physiology, Steroid Hydroxylases/*genetics/metabolism, Transcription, Transfection, Tumor Cells, Wu Z