Browse Items (77 total)
- Tags: Disease Models
Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis.
Tags: *Phytotherapy, *Punicaceae, 2017, ACLT, Akhtar Nahid, Animal, Animals, Anterior Cruciate Ligament/drug effects/metabolism/pathology, Apoptosis, Ashruf Omer S, Cartilage/cytology/*drug effects/metabolism/pathology, Chondrocytes/drug effects/metabolism/pathology, Collagen Type II/genetics/metabolism, Department of Anatomy & Neurobiology, Dinoprostone/*metabolism, Disease Models, Disease Progression, Female, Fruit, Haqqi Tariq M, Interleukins/metabolism, Joints/cytology/*drug effects/metabolism/pathology, Khan Nazir M, Male, Messenger/metabolism, Metalloproteases/genetics/*metabolism, Mitogen-Activated Protein Kinases/metabolism, MMPs, NEOMED College of Medicine, NF-kappa B/metabolism, Nutrition (Burbank, Los Angeles County, Calif.), Osteoarthritis, Osteoarthritis/*drug therapy/etiology/metabolism/pathology, PGE(2), Plant Extracts/pharmacology/therapeutic use, Pomegranate, Rabbit, Rabbits, RNA, Synovial Fluid/metabolism
MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes.
Tags: 2015, Academic Medical Centers, Aged, Akhtar Nahid, Analysis of Variance, Animal, Animals, Anterior Cruciate Ligament/surgery, Arthritis & rheumatology (Hoboken, N.J.), Blotting, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism/pathology, Cultured, Department of Anatomy & Neurobiology, Disease Models, Female, Funding Source, Gene Expression Regulation/genetics/*physiology, Haqqi Tariq M, Hedgehog Proteins/genetics/*metabolism, HEK293 Cells, Human, Humans, Immunohistochemistry, In Vitro Techniques, Interleukin-1beta/pharmacology, Knee/etiology/*metabolism/pathology, Makki Mohammad S, Male, Matrix Metalloproteinase 13/metabolism, MicroRNAs/genetics/*metabolism, Middle Age, Middle Aged, NEOMED College of Medicine, Ohio, Open Reading Frames/genetics/*physiology, Osteoarthritis, Osteoarthritis – Epidemiology, Osteoarthritis – Physiopathology, Polymerase Chain Reaction, Rabbits, Signal Transduction/genetics/physiology, T-Tests, Transfection, Up-Regulation/drug effects/genetics/physiology, Western
MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains.
Tags: *QTL, *Recombinant inbred mice, *Sex Characteristics, *Sex differences, 1-Methyl-4-phenyl-1, 2, 2016, 3, 4-Dihydroxyphenylacetic Acid/metabolism, 6-tetrahydropyridine/pharmacology, Alam Gelareh, Animal, Animals, Corpus Striatum/drug effects/*metabolism, Department of Family & Community Medicine, Disease Models, Dopamine/metabolism, Female, Gene Expression Regulation/drug effects/*genetics, Glial Fibrillary Acidic Protein/*metabolism, Homovanillic Acid/metabolism, Inbred Strains, Jones Byron C, Lu Lu, Male, Mice, Miller Diane B, MPTP Poisoning/chemically induced/*pathology, NEOMED College of Medicine, Neurotoxicology, O'Callaghan James P, Serotonin/metabolism, Species Specificity, Tyrosine 3-Monooxygenase/metabolism, Williams Robert W
Effects of neonatal and prepubertal hormonal manipulations upon estrogen neuroprotection of the nigrostriatal dopaminergic system within female and male mice.
Tags: *Sex Characteristics, 2005, Aging/metabolism, Anderson L I, Animal, Animals, Disease Models, Dluzen D E, Dopamine/metabolism, Estrogens/metabolism/*pharmacology, Female, Gonads/growth & development/metabolism, Leipheimer R E, Male, Methamphetamine/antagonists & inhibitors/toxicity, Mice, Neostriatum/*drug effects/metabolism/physiopathology, Neural Pathways/drug effects/metabolism/physiopathology, Neuroprotective Agents/metabolism/*pharmacology, Neuroscience, Newborn, Orchiectomy, Ovariectomy, Sexual Maturation/physiology, Substantia Nigra/*drug effects/metabolism/physiopathology, Testosterone/metabolism/*pharmacology
Maturation of the Coordination Between Respiration and Deglutition with and Without Recurrent Laryngeal Nerve Lesion in an Animal Model.
Tags: *Animal model, *Deglutition, *Development, *Infant, *Recurrent laryngeal nerve, *Respiration, *Sensorimotor, 2018, Animal, Animal Population Groups, Animals, Ballester Ashley, Biological, Bond Laura, Buddington Karyl, Buddington Randall, Danos Nicole, Deglutition – Physiology, Deglutition disorders, Deglutition/*physiology, DeLozier Katherine R, Department of Anatomy & Neurobiology, Disease Models, Dysphagia, German Rebecca, Gould Francois, Gross Andrew, Humans, Laryngeal Nerves – Injuries, Laryngeal Nerves – Physiology, Larynx – Physiology, Larynx/*physiology, Models, NEOMED College of Medicine, Newborn, Ohlemacher Jocelyn, Questionnaires, Recurrent Laryngeal Nerve Injuries/*complications, Recurrent Laryngeal Nerve/physiology, Respiration, Stricklen Bethany, Swine
Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy.
Tags: 2018, Alzheimer's disease, Animal, Animals, Antigens, Bemiller Shane M, Bhaskar Kiran, Biological, Calcium Binding Proteins – Metabolism, Calcium-Binding Proteins/metabolism, Cannon Judy L, Cardona Astrid E, Cells – Drug Effects, Cells – Metabolism, Cells – Pathology, Chemokine CX3CL1/*genetics/metabolism, Cognition Disorders – Etiology, Cognition Disorders/etiology, Crish Samuel D, CX3CL1, CX3CR1, Cytokines, Cytokines – Metabolism, Cytokines/metabolism, Department of Pharmaceutical Sciences, Differentiation/genetics/metabolism, Disease Models, Formica Shane V, Gene Expression Regulation/drug effects/*genetics, Genes, Genes – Drug Effects, Journal of neuroinflammation, Jung Steffen, Kim Ki-Wook, Kokiko-Cochran Olga N, Lamb Bruce T, Learning, Lipopolysaccharides, Lipopolysaccharides/toxicity, Maphis Nicole M, Maze Learning, Mice, Microfilament Proteins – Metabolism, Microfilament Proteins/metabolism, Microglia, Microglia/drug effects/*metabolism/pathology, Miller Crystal M, Models, Mutation, Mutation/genetics, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurodegenerative Diseases – Pathology, Neuroinflammation, Surface, Surface – Metabolism, Tau, tau Proteins/genetics/metabolism, Tauopathies, Tauopathies/complications/genetics/*pathology, Transgenic, Wilson Gina N, Xu Guixiang
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.
Tags: *Alzheimers disease, *Immunity, *Inflammation, *Tauopathy, *TREM2, 2017, Allan Kevin, Animal, Animals, Bemiller Shane M, Crish Samuel D, Department of Pharmaceutical Sciences, Disease Models, Formica Shane V, Humans, Immunologic/*deficiency, Inbred C57BL, Kokiko-Cochran Olga N, Lamb Bruce T, Landreth Gary E, Lasagna-Reeves Cristian A, McCray Tyler J, Membrane Glycoproteins/*deficiency, Mice, Microglia/metabolism, Molecular neurodegeneration, NEOMED College of Pharmacy, Protein Kinases/*metabolism, Ransohoff Richard M, Receptors, Signal Transduction/physiology, tau Proteins/*metabolism, Tauopathies/metabolism/*pathology, Transgenic, Wilson Gina, Xu Guixiang
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.
Tags: 2009, Animal, Animals, Anticarcinogenic Agents/*antagonists & inhibitors/pharmacology, Antitumor, Apoptosis/*drug effects, Bishayee Anupam, Body Weight/drug effects, Cell Proliferation/drug effects, Chemico-biological interactions, Dhir Neetika, Diethylnitrosamine, Disease Models, Dose-Response Relationship, Drinking/drug effects, Drug, Drug Screening Assays, Eating/drug effects, Experimental/chemically induced/pathology/*prevention & control, Female, Immunohistochemistry, Liver Neoplasms, Organ Size/drug effects, Phenobarbital, Proto-Oncogene Proteins c-bcl-2/biosynthesis, Rats, Resveratrol, Sprague-Dawley, Stilbenes/*pharmacology
Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.
Tags: 2016, aerodigestive and gastrointestinal tract, Animal, Animal Studies, Animals, Anthocyanins/analysis/pharmacology, Anticarcinogenic Agents/*analysis/pharmacology, Antineoplastic Agents – Analysis, Antineoplastic Agents – Pharmacodynamics, Benzopyrans – Analysis, Benzopyrans – Pharmacodynamics, Berry, Biological, Bishayee Anupam, Cancer, Chemoprevention, Clinical Trials, Clinical Trials as Topic, Critical reviews in food science and nutrition, Digestion – Drug Effects, Digestion/drug effects, Disease Models, Do Chau, Ellagic Acid/analysis/pharmacology, Fruit, Fruit/*chemistry, Gastrointestinal Neoplasms – Prevention and Control, Gastrointestinal Neoplasms/*prevention & control, Haskell Yennie, Human, Humans, Models, Mohandas Nima, Phytochemicals – Analysis, Phytochemicals – Pharmacodynamics, Phytochemicals/analysis/pharmacology, Plant Extracts – Analysis, Plant Extracts – Pharmacodynamics, Plant Extracts/*analysis/pharmacology, Polyphenols – Analysis, Polyphenols – Pharmacodynamics, Polyphenols/analysis/pharmacology, Sethi Gautam, Siveen Kodappully Sivaraman, Stoner Gary D, Treatment
Vanadium in the detection, prevention and treatment of cancer: the in vivo evidence.
Tags: 10-Dimethyl-1, 2-benzanthracene, 2010, 9, Animal, Animals, Biological, Bishayee Anupam, Breast Neoplasms – Chemically Induced, Breast Neoplasms – Diagnosis, Breast Neoplasms – Drug Therapy, Cancer letters, Cell Division – Drug Effects, Cell Division/drug effects, Chatterjee Malay, Disease Models, Experimental/chemically induced/diagnosis/drug therapy, Experimental/drug therapy/pathology, Female, Glioblastoma/drug therapy, Glioma – Drug Therapy, Heterologous, Humans, Hydrocarbons, Male, Mammary Neoplasms, Metals, Metals – Diagnostic Use, Metals – Therapeutic Use, Models, Neoplasm Staging, Neoplasm Transplantation, Neoplasms, Neoplasms – Diagnosis, Neoplasms – Drug Therapy, Neoplasms – Pathology, Neoplasms – Prevention and Control, Neoplasms/*diagnosis/drug therapy/prevention & control, Organometallic Compounds – Therapeutic Use, Organometallic Compounds/therapeutic use, Patel Mehool A, Rats, Trace Elements – Diagnostic Use, Trace Elements – Therapeutic Use, Trace Elements/therapeutic use, Transplantation, Vanadium Compounds, Vanadium Compounds – Therapeutic Use, Vanadium Compounds/therapeutic use/toxicity, Vanadium/*therapeutic use/toxicity, Waghray Abhijeet, Xenografts
Intrastrain variants of herpes simplex virus type 1 isolated from a neonate with fatal disseminated infection differ in the ICP34.5 gene, glycoprotein processing, and neuroinvasiveness.
Tags: *Genetic Variation, *Protein Processing, 1999, Amino Acid, Amino Acid Sequence, Animal, Animals, Base Sequence, Bower J R, Deoxyribonuclease BamHI, Deoxyribonuclease EcoRI, Detwiler M, Disease Models, DNA, Durishin C, Genes, Glycoproteins/metabolism, Herpesvirus 1, Human/*genetics/growth & development/isolation & purification, Humans, Inbred BALB C, Journal of virology, Karban T L, Male, Mao H, Mice, Molecular Sequence Data, Nucleic Acid, Polymerase Chain Reaction/methods, Polymorphism, Post-Translational, Rempinski D, Restriction Fragment Length, Rosenthal K S, Rozenbom E, Sequence Analysis, Sequence Homology, Viral, Viral Envelope Proteins/analysis, Viral Proteins/*genetics
The Detrimental Role Played by Lipocalin-2 in Alcoholic Fatty Liver in Mice.
Tags: 2016, Alcoholic/*metabolism, Animal, Animals, Blotting, Cai Yan, Department of Pharmaceutical Sciences, Disease Models, Fatty Liver, Gao Bin, Hu Xudong, Humans, Inbred C57BL, Jogasuria Alvin, Kim Chunki, Knockout, Lee Kwangwon, Lipocalin-2/*metabolism, Mice, NEOMED College of Pharmacy, Polymerase Chain Reaction, The American journal of pathology, Wang Jiayou, Western, Wu Jiashin, Xu Ming-Jiang, Yin Huquan, You Min
Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma.
Tags: *Astrocyte, *Axonopathy, *Glaucoma, *Gliosis, *neurodegeneration, *Retinal ganglion cell, 2016, Animal, Animals, Astrocytes/*pathology, Axons/pathology, Calkins David J, Cooper Melissa L, Crish Samuel D, Department of Pharmaceutical Sciences, Disease Models, Experimental eye research, Glaucoma, Horner Philip J, Imaging, Inbred DBA, Inman Denise M, Mice, NEOMED College of Pharmacy, Nerve Degeneration/etiology/*pathology, Open-Angle/*pathology, Optic Nerve Diseases/etiology/*pathology, Optic Nerve/*pathology, Photomicrography, Retinal Ganglion Cells/*pathology, Three-Dimensional, Time Factors
Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target.
Tags: 2013, Animal, Animals, Astrocytes/*metabolism, Axonal Transport/*physiology, Balaram P, Brain-Derived Neurotrophic Factor/*metabolism, Calkins D J, Crish S D, Dapper J D, Department of Pharmaceutical Sciences, Disease Models, Glaucoma/genetics/*metabolism, Lambert W S, MacNamee S E, Messenger/genetics/metabolism, Mice, NEOMED College of Pharmacy, Neuroscience, Optic Nerve Diseases/genetics/metabolism, Rats, Retinal Ganglion Cells/*metabolism, RNA, Sidorova T N, Superior Colliculi/metabolism, Synapses/*metabolism, Visual Pathways/metabolism
Anterograde Tract Tracing for Assaying Axonopathy and Transport Deficits in Glaucoma.
Tags: *Axonal transport, *Axonopathy, *Neuronal tracing, *Optic nerve, *superior colliculus, 2018, Animal, Animals, Axonal Transport, Axons/metabolism/*pathology/physiology, Cholera Toxin/*metabolism, Confocal, Crish Samuel D, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Disease Models, Glaucoma/*diagnostic imaging/metabolism/physiopathology, Humans, Methods in molecular biology (Clifton, N.J.), Mice, Microscopy, NEOMED College of Medicine, NEOMED College of Pharmacy, Rats, Schofield Brett R, Visual Pathways
Chemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancer.
Tags: *Anticarcinogenic Agents, 2013, Animal, Animals, Anti-Inflammatory Agents, Antioxidants, Biological Availability, Biological Markers, Bishayee Anupam, Carcinoma, Catechin/administration & dosage/analogs & derivatives, Chemoprevention, Darvesh Altaf S, Department of Pharmaceutical Sciences, Disease Models, Hepatocellular – Physiopathology, Hepatocellular – Prevention and Control, Hepatocellular – Therapy, Human, Humans, In Vitro Studies, In Vivo Studies, Liver Neoplasms/*drug therapy/*prevention & control, Mice, NEOMED College of Pharmacy, Neoplasms – Prevention and Control, nutrition, Nutrition and cancer, Outcomes (Health Care), Phenols – Therapeutic Use, Polyphenols/*administration & dosage/pharmacology, Tea – Therapeutic Use, Tea/*chemistry, Xenograft Model Antitumor Assays
4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling.
Tags: *4-Hydroxynonenal, *Coronary regulation, *Lipid peroxidation, *Post-translational modification, *Protein Processing, *Reactive oxygen species, *Signal Transduction, *TRPV1, 2016, Action Potentials/drug effects, Aldehydes/antagonists & inhibitors/metabolism/*pharmacology, Animal, Animals, Blood Flow Velocity, Bratz Ian N, Calcium Signaling/drug effects, Cappelli Holly C, Capsaicin/*pharmacology, Cardiovascular Agents/*pharmacology, Connell Patrick J, Coronary Circulation/drug effects, Coronary Vessels/metabolism/physiopathology, Cysteine/genetics/metabolism, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/*metabolism/physiopathology, Disease Models, Fahmy Joseph N, Femoral Artery/metabolism/physiopathology, Free radical biology & medicine, Geldenhuys Werner J, HEK293 Cells, Humans, Inbred C57BL, Lipid Peroxidation, Male, Mice, NEOMED College of Medicine, Patch-Clamp Techniques, Post-Translational, Sinharoy Pritam, Thodeti Charles K, TRPV Cation Channels/genetics/*metabolism, Vasodilation/drug effects
Evidence of Wnt/beta-catenin alterations in brain and bone of a tauopathy mouse model of Alzheimer's disease.
Tags: *Alzheimer's disease, *Beta catenin, *Bone mineral density, *neurodegeneration, *Tauopathy, *Wnt proteins, *Wnt Signaling Pathway, 2018, Alzheimer Disease/*genetics/*metabolism, Animal, Animals, Ball Hope C, beta Catenin/metabolism, Bone and Bones/*metabolism, Bone Density, Bone Remodeling/genetics, Brain/*metabolism, Cooper Lisa Noelle, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Disease Models, Female, Gene Expression, Lin Li, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Neurobiology of aging, Novak Kimberly M, Osteogenesis/genetics, Osteoporosis/etiology/genetics, tau Proteins/*metabolism, Tauopathies/genetics/*metabolism, Wnt Proteins/metabolism
Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease.
Tags: *Alzheimer Disease/complications/genetics/pathology, *Alzheimer's disease, *bone density, *microtubule-associated protein, *serotonin, *tau proteins, *tauopathies, 2017, Age Factors, Alzheimer's disease, Alzheimer's Disease – Complications, Alzheimer's Disease – Pathology, Animal, Animal Studies, Animals, Biological, Body Composition, Body Composition/genetics, Body Weight, Body Weight/genetics, Bone Density – Physiology, Bone Density/*physiology, Bone Diseases – Etiology, Bone Diseases/*etiology, Brain Stem – Pathology, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Disease Models, Dorsal Raphe Nucleus/*pathology, Female, Inbred C57BL, Journal of Alzheimer's disease : JAD, Male, Mice, Models, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurons – Metabolism, Neurons – Pathology, Neurons/metabolism/pathology, Oxidoreductases – Metabolism, Phosphorylation, Serotonin – Metabolism, Serotonin/*metabolism, Smith Matthew A, tau Proteins/*genetics/metabolism, Tauopathies/complications/genetics, Transgenic, Tryptophan Hydroxylase/metabolism, Wilson Gina N
Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein.
Tags: *Alpha-synuclein, *ATP13A2, *Mice, *Phenotype, *Sensorimotor, 2018, Adenosine Triphosphatases/*deficiency/genetics, alpha-Synuclein/genetics/*metabolism, Animal, Animals, Behavioural brain research, Blackwood Rachel, Body Temperature, Body Weight, Department of Pharmaceutical Sciences, Dirr Emily R, Disease Models, Ekhator Osunde R, Female, Fleming Sheila M, Gait Disorders, Holden John G, Humans, Inbred C57BL, Male, Masliah Eliezer, Membrane Proteins/*deficiency/genetics, Mice, Motor Skills/physiology, NEOMED College of Pharmacy, Neurologic/*metabolism, Phenotype, Schultheis Patrick J, Severity of Illness Index, Sex Characteristics, Transgenic
Estrogen decreases corpus striatal neurotoxicity in response to
Tags: 1997, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Animal, Animals, Brain research, Corpus Striatum/*drug effects, Disease Models, Dluzen D, Dopamine/metabolism, Estradiol/*pharmacology, Female, Neurotoxins/*toxicity, Oxidopamine/*toxicity, Parkinson Disease/*physiopathology, Rats, Sprague-Dawley
Gender differences in neurotoxicity of the nigrostriatal dopaminergic system: implications for Parkinson's disease.
Tags: 2000, Animal, Corpus Striatum/pathology/*physiopathology, Disease Models, Dluzen D E, Dopamine/metabolism, Estrogens/*pharmacology, Female, Humans, Male, McDermott J L, Neurotoxins/*antagonists & inhibitors, Parkinson Disease/metabolism/pathology/*physiopathology, Postmenopause, Sex Distribution, Sex Factors, Substantia Nigra/pathology/*physiopathology, The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia
G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice.
Tags: *Gene Expression Regulation, 2017, Analysis of Variance, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Department of Integrative Medical Sciences, Disease Models, Donepudi Ajay C, Energy Metabolism/physiology, Fasting, Fatty Liver/*metabolism/pathology, G-Protein-Coupled/*genetics, Hepatology (Baltimore, Md.), Homeostasis/genetics, Inbred C57BL, Li Feng, Lipid Metabolism/genetics, Male, Mice, NEOMED College of Medicine, Oxygen Consumption/physiology, Random Allocation, Receptors, RNA-Binding Proteins/*metabolism, Signal Transduction
Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.
Tags: *bile acids and salt/metabolism, *cholesterol/diet, *Lipids, *Liver, 2016, Animal, Animals, Bile Acids and Salts/genetics/metabolism, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Diet, Disease Models, Exhalation/genetics, Ferrell Jessica M, Glucose/metabolism, High-Fat, Homeostasis, Humans, Journal of lipid research, Li Feng, Lipid Metabolism/genetics, Liver/enzymology/pathology, Metabolic Diseases/*genetics/metabolism, Mice, NEOMED College of Medicine
Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis.
Tags: *Aldehyde Reductase/genetics/metabolism, 2011, Adenoviridae, Animal, Animals, Blood Glucose/*metabolism, Chiang John Y L, Cholesterol/analysis, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism/physiopathology, Disease Models, Fatty Liver/genetics/*metabolism/physiopathology, Ge Xuemei, Gene Expression, Genetic Vectors, Gluconeogenesis/genetics, Homeostasis, Humans, Journal of lipid research, Li Tiangang, Liver/*metabolism/physiopathology, Ma Huiyan, Malondialdehyde/blood, Mice, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, Transfection, Transgenic, Triglycerides/analysis, Yin Liya, Zhang Yanqiao
Sex steroid induction of gallstones in the male Syrian hamster.
Tags: 1993, Animal, Animals, Body Weight, Cholelithiasis/*etiology, Cricetinae, Disease Models, Drug Combinations, Endoplasmic Reticulum/drug effects/ultrastructure, Estradiol/*pharmacology, Gallbladder/*drug effects/ultrastructure, Gilloteaux J, Golgi Apparatus/drug effects/ultrastructure, Journal of submicroscopic cytology and pathology, Kelly T R, Kosek E, Male, Medroxyprogesterone/*pharmacology, Mesocricetus, Organ Size
The ability of an HSV strain to initiate zosteriform spread correlates with its neuroinvasive disease potential.
Tags: 2002, Animal, Animals, Archives of virology, Disease Models, Docherty J J, Ganglia, Goel N, Herpes Simplex/*physiopathology/virology, Herpesvirus 1, Human/*pathogenicity, Inbred BALB C, Mao H, Mice, Rong Q, Rosenthal K S, Skin Diseases/*physiopathology/virology, Spinal/*virology, Time Factors, Virulence, Zimmerman D
A modification of the epidermal scarification model of herpes simplex virus infection to achieve a reproducible and uniform progression of disease.
Tags: *Herpesvirus 1, 2002, Animal, Animals, Disease Models, Disease Progression, Docherty John J, Female, Fu Ming Ming, Goel Neena, Herpes Simplex/pathology/physiopathology/*transmission, Human, Humans, Inbred BALB C, Journal of virological methods, Mice, Reproducibility of Results, Rosenthal Kenneth S, Skin/virology, Zimmerman Daniel H
The Physiologic Impact of Unilateral Recurrent Laryngeal Nerve (RLN) Lesion on Infant Oropharyngeal and Esophageal Performance.
Tags: 2015, Animal, Animals, Aspiration, Ballester Ashley, Biological, Deglutition, Deglutition – Physiology, Deglutition disorders, Deglutition Disorders – Etiology, Deglutition Disorders – Physiopathology, Deglutition Disorders/*etiology/physiopathology, Deglutition/*physiology, Department of Anatomy & Neurobiology, Disease Models, Dysphagia, Esophagus, Esophagus – Physiopathology, Esophagus/*physiopathology, Fraley Luke, German Rebecca Z, Gould François D H, Gross Andrew, Human, Infant, Lammers Andrew R, Laryngeal Nerves – Injuries, Laryngeal Nerves – Physiopathology, Models, NEOMED College of Medicine, Ohlemacher Jocelyn, Oropharynx – Physiopathology, Oropharynx/*physiopathology, Recurrent laryngeal nerve, Recurrent Laryngeal Nerve Injuries/*complications/physiopathology, Recurrent Laryngeal Nerve/*physiopathology, Swine
LVC Timing in Infant Pig Swallowing and the Effect of Safe Swallowing.
Tags: *Animal model, *Aspiration, *Deglutition, *Deglutition disorders, *Dysphagia, *Infant, *Laryngeal vestibule closure, *Recurrent laryngeal nerve, 2018, Animal, Animal Population Groups, Animals, Aspiration – Etiology, Aspiration/*etiology, Biological, Deglutition – Physiology, Deglutition Disorders – Etiology, Deglutition Disorders/*etiology, Deglutition/*physiology, Department of Anatomy & Neurobiology, Disease Models, Dysphagia, German Rebecca, Gould Francois, Gross Andrew, Humans, Laryngeal Nerve Injuries/*complications, Laryngeal Nerves – Injuries, Larynx, Models, NEOMED College of Medicine, Newborn, Ohlemacher Jocelyn, Oropharynx, Pneumonia, Questionnaires, Swine
Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage.
Tags: 2016, Animal, Animals, Basic research in cardiology, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Coronary Circulation, Coronary microcirculation, Coronary Vessels/metabolism/*physiopathology, Department of Integrative Medical Sciences, Diabetes, Disease Models, DNA, DNA Damage/physiology, DNA Fragmentation, Dobson James G Jr, Fenton Richard, Guarini Giacinta, Hardwick James P, Kang Patrick T, Kiyooka Takahiko, Kolz Christopher L, Marzilli Mario, Metabolic Syndrome/metabolism/*physiopathology, Mitochondria, Mitochondria/*metabolism, Mitochondrial/*metabolism, NEOMED College of Medicine, Obesity, Ohanyan Vahagn, Oxidative Stress/physiology, Pung Yuh Fen, Rats, Reactive Oxygen Species/metabolism, Shokolenko Inna, Vasodilation/physiology, Wilson Glenn L, Yin Liya, Zucker
Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma.
Tags: 2018, AMP-activated protein kinase, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Biological, Calcium Binding Proteins – Metabolism, Calcium-Binding Proteins/metabolism, Cells – Drug Effects, Cells – Pathology, Department of Pharmaceutical Sciences, Diet, Disease Models, Eye Proteins/genetics, Female, G-Protein-Coupled – Metabolism, G-Protein-Coupled/*metabolism, Glaucoma, Glaucoma – Complications, Glaucoma – Pathology, Glaucoma/*complications/pathology, Harun-Or-Rashid Mohammad, Impact of Events Scale, Inbred DBA, Inflammation – Etiology, Inflammation – Prevention and Control, Inflammation hydroxycarboxylic acid receptor, Inflammation/*etiology/*prevention & control, Inman Denise M, Journal of neuroinflammation, Ketogenic diet, Ketogenic/methods, Male, Membrane Glycoproteins, Membrane Glycoproteins/genetics, Mice, Microfilament Proteins – Metabolism, Microfilament Proteins/metabolism, Microglia/drug effects/pathology, Models, Mutation, Mutation/genetics, NEOMED College of Pharmacy, Neuroprotection/drug effects/*physiology, NLR Family, Optic Nerve – Pathology, Optic Nerve/pathology, Phosphotransferases – Metabolism, Proteins, Pyrin Domain-Containing 3 Protein/genetics/metabolism, Receptors, Retina – Drug Effects, Retina – Pathology, Retinal Ganglion Cells/drug effects/*pathology, Transgenic
Alignment of inducible vascular progenitor cells on a micro-bundle scaffold improves cardiac repair following myocardial infarction.
Tags: *Cardiovascular regeneration, *Ischemic heart diseases, *Micro-bundle scaffold, *Myocardial infarction, *Neovascularization, *Stem cells, *Tissue Scaffolds, *Vascular progenitor cells, 2017, Animal, Animals, Basic research in cardiology, Cell Differentiation, Cell Proliferation, Cell Survival, Cells, Chilian William M, Coculture Techniques, Cultured, Cumpston Devan, Department of Integrative Medical Sciences, Disease Models, Dong Feng, Endothelial Progenitor Cells/metabolism/*transplantation, Enrick Molly, Fibroblast Growth Factor 2/metabolism, Hakobyan Tatev, Jamaiyar Anurag, Janota Danielle, Kolz Christopher L, Lactic Acid/*chemistry, Muscle, Myocardial Infarction/metabolism/pathology/physiopathology/*surgery, Myocardium/metabolism/*pathology, Myocytes, NEOMED College of Medicine, Newby Bi-Min Zhang, Ohanyan Vahagn, Paracrine Communication, Phenotype, Physiologic, Polyglycolic Acid/*chemistry, Polylactic Acid-Polyglycolic Acid Copolymer, Rats, Signal Transduction, Smooth, Smooth Muscle/metabolism/*transplantation, Song Hokyung, Sprague-Dawley, Stevanov Kelly, Time Factors, Tissue Engineering/*methods, Vascular Endothelial Growth Factor A/metabolism, Vascular/metabolism/*transplantation, Ventricular Remodeling, Wan Weiguo, Yin Liya
Impairment of pH gradient and membrane potential mediates redox dysfunction in the mitochondria of the post-ischemic heart.
Tags: *Energy Metabolism, *Membrane potential, *Mitochondria, *Myocardial ischemia and reperfusion, *Oxidative Stress, *pH gradient, *Redox dysfunction, 2017, Aconitate Hydratase/metabolism, Animal, Animals, Basic research in cardiology, Cell Line, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Department of Family & Community Medicine, Department of Integrative Medical Sciences, Disease Models, Electron Transport Chain Complex Proteins/metabolism, Heart/*metabolism/pathology, Hydrogen Peroxide/metabolism, Hydrogen-Ion Concentration, Ionophores/pharmacology, Kang Patrick T, Lin Paul, Male, Mitochondria, Mitochondrial, Myocardial Infarction/*metabolism/pathology, Myocardium/*metabolism/pathology, NEOMED College of Medicine, Oxidation-Reduction, Potassium/metabolism, Rats, Sprague-Dawley, Superoxides/metabolism
Effects of growth hormone transgene expression on vertebrae in a mouse model of osteogenesis imperfecta.
Tags: 2005, Animal, Animals, Beamer Wesley G, Biomechanical Phenomena, Bone Density, Chase Jeff, Department of Family & Community Medicine, Disease Models, Female, Gene Expression, Genetic Therapy/*methods, Havey Robert M, Heterozygote, Human Growth Hormone/*genetics, Humans, Inbred C57BL, King Donna, Male, McEwen Heather A, Mice, NEOMED College of Medicine, Osteogenesis Imperfecta/pathology/physiopathology/*therapy, Patwardhan Avinash G, Sartori Mark, Spine, Spine/pathology/*physiology, Tail, Transgenic, Voronov Leonard
Growth hormone injections improve bone quality in a mouse model of osteogenesis imperfecta.
Tags: 2005, Animal, Animals, Askew Michael J, Biomechanical Phenomena, Body Weight/drug effects, Bone and Bones/drug effects, Bone/prevention & control, Collagen Type I, Collagen/genetics, Densitometry, Department of Family & Community Medicine, Disease Models, Femur/drug effects/pathology, Fractures, Growth Hormone/*therapeutic use, Heterozygote, Humans, Inbred C57BL, Jarjoura David, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, King Donna, Lumbar Vertebrae/drug effects, McEwen Heather A, Mice, Mutation, NEOMED College of Medicine, Osteoblasts/*drug effects/metabolism, Osteogenesis Imperfecta/*drug therapy, Phenotype, Time Factors, Transgenic
Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease.
Tags: 2016, Alzheimer Disease/etiology/*metabolism/pathology, Alzheimer's disease, Amyloid beta-Peptides/*metabolism, Animal, Animal/physiology, Animals, Behavior, Bemiller Shane M, Bhaskar Kiran, Blotting, Brain Injuries, Brain/*metabolism/pathology, Crish Samuel, Department of Pharmaceutical Sciences, Disease Models, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Immunohistochemistry, Inbred C57BL, Inflammation/*metabolism/pathology, Journal of neurotrauma, Kokiko-Cochran Olga N, Lamb Bruce T, Lee Sungho, Lee Yu-Shang, macrophage, Mice, NEOMED College of Pharmacy, Neuroinflammation, Ransohoff Lena, Ransohoff Richard M, Saber Maha, Sikora Matt, Teknipp Ryan, Transgenic, Traumatic brain injury, Traumatic/complications/*metabolism/*pathology, Veenstra Mike, Western, Wilson Gina, Xu Guixiang
Weighted Lin-Wang tests for crossing hazards.
Tags: *Survival Analysis, 2014, Algorithms, Animal, Animals, Computational and mathematical methods in medicine, Computer Simulation, Data Interpretation, Disease Models, Humans, Jia Zhenyu, Kaplan-Meier Estimate, Koziol James A, Leukemia/drug therapy, Mice, Models, Reproducibility of Results, Statistical
Innate and adaptive host response during the initial phase of herpes simplex virus encephalitis in the neonatal mouse.
Tags: *Immunity, 2006, Active, Animal, Animals, B-Lymphocytes/immunology, Brain/pathology/*virology, Cell Line, Disease Models, Docherty John J, Encephalitis, Fu Ming Ming, Herpes Simplex/*immunology, Innate, Journal of neurovirology, Kumaraswamy Guttalu K, Mice, Microglia/pathology/virology, Newborn, Simplexvirus/*isolation & purification/physiology, T-Lymphocytes/immunology, Virus Replication
Renal Calcium Oxalate Deposits Induce a Pro-Atherosclerotic and Pro-Osteoporotic Response in Mice.
Tags: *CARDIOVASCULAR DISEASE, *Gene Expression Regulation, *KIDNEY STONES, *METABOLIC BONE DISEASE, *MURINE MODEL, 2017, Animal, Animals, Atherosclerosis/*metabolism/pathology, Barr-Beare Evan, Calcium Oxalate/*metabolism, Disease Models, Journal of cellular biochemistry, Kidney/*metabolism/pathology, Kusumi Kirsten, Mice, Osteoporosis/*metabolism/pathology, Safedi Fayez, Saxena Vijay, Schwaderer Andrew, Urinary Calculi/*metabolism/pathology